The Lasso Linear Mixed Model For Mapping Quantitative Trait Loci

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The Applications of New Multi-Locus GWAS Methodologies in the Genetic Dissection of Complex Traits

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Author : Yuan-Ming Zhang
Publisher : Frontiers Media SA
ISBN 13 : 2889458342
Total Pages : 236 pages
Book Rating : 4.8/5 (894 download)

Book Synopsis The Applications of New Multi-Locus GWAS Methodologies in the Genetic Dissection of Complex Traits by : Yuan-Ming Zhang

Download or read book The Applications of New Multi-Locus GWAS Methodologies in the Genetic Dissection of Complex Traits written by Yuan-Ming Zhang and published by Frontiers Media SA. This book was released on 2019-06-19 with total page 236 pages. Available in PDF, EPUB and Kindle. Book excerpt: Genome-Wide Association Studies (GWAS) are widely used in the genetic dissection of complex traits. Most existing methods are based on single-marker association in genome-wide scans with population structure and polygenic background controls. To control the false positive rate, the Bonferroni correction for multiple tests is frequently adopted. This stringent correction results in the exclusion of important loci, especially for GWAS in crop genetics. To address this issue, multi-locus GWAS methodologies have been recommended, i.e., FASTmrEMMA, ISIS EM-BLASSO, mrMLM, FASTmrMLM, pLARmEB, pKWmEB and FarmCPU. In this Research Topic, our purpose is to clarify some important issues in the application of multi-locus GWAS methods. Here we discuss the following subjects: First, we discuss the advantages of new multi-locus GWAS methods over the widely-used single-locus GWAS methods in the genetic dissection of complex traits, metabolites and gene expression levels. Secondly, large experiment error in the field measurement of phenotypic values for complex traits in crop genetics results in relatively large P-values in GWAS, indicating the existence of small number of significantly associated SNPs. To solve this issue, a less stringent P-value critical value is often adopted, i.e., 0.001, 0.0001 and 1/m (m is the number of markers). Although lowering the stringency with which an association is made could identify more hits, confidence in these hits would significantly drop. In this Research Topic we propose a new threshold of significant QTN (LOD=3.0 or P-value=2.0e-4) in multi-locus GWAS to balance high power and low false positive rate. Thirdly, heritability missing in GWAS is a common phenomenon, and a series of scientists have explained the reasons why the heritability is missing. In this Research Topic, we also add one additional reason and propose the joint use of several GWAS methodologies to capture more QTNs. Thus, overall estimated heritability would be increased. Finally, we discuss how to select and use these multi-locus GWAS methods.

Statistical Methods, Computing, and Resources for Genome-Wide Association Studies

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Author : Riyan Cheng
Publisher : Frontiers Media SA
ISBN 13 : 2889712125
Total Pages : 148 pages
Book Rating : 4.8/5 (897 download)

Book Synopsis Statistical Methods, Computing, and Resources for Genome-Wide Association Studies by : Riyan Cheng

Download or read book Statistical Methods, Computing, and Resources for Genome-Wide Association Studies written by Riyan Cheng and published by Frontiers Media SA. This book was released on 2021-08-24 with total page 148 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Genomic Prediction of Complex Traits

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Author : Nourollah Ahmadi
Publisher : Springer Nature
ISBN 13 : 1071622056
Total Pages : 651 pages
Book Rating : 4.0/5 (716 download)

Book Synopsis Genomic Prediction of Complex Traits by : Nourollah Ahmadi

Download or read book Genomic Prediction of Complex Traits written by Nourollah Ahmadi and published by Springer Nature. This book was released on 2022-04-22 with total page 651 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume explores the conceptual framework and the practical issues related to genomic prediction of complex traits in human medicine and in animal and plant breeding. The book is organized into five parts. Part One reminds molecular genetics approaches intending to predict phenotypic variations. Part Two presents the principles of genomic prediction of complex traits, and reviews factors that affect its reliability. Part Three describes genomic prediction methods, including machine-learning approaches, accounting for different degree of biological complexity, and reviews the associated computer-packages. Part Four reports on emerging trends such as phenomic prediction and incorporation into genomic prediction models of “omics” data and crop growth models. Part Five is dedicated to lessons learned from cases studies in the fields of human health and animal and plant breeding, and to methods for analysis of the economic effectiveness of genomic prediction. Written in the highly successful Methods in Molecular Biology series format, the book provides theoretical bases and practical guidelines for an informed decision making of practitioners and identifies pertinent routes for further methodological researches. Cutting-edge and thorough, Complex Trait Predictions: Methods and Protocols is a valuable resource for scientists and researchers who are interested in learning more about this important and developing field. Chapters 3, 9, 13, 14, and 21 are available open access under a Creative Commons Attribution 4.0 International License via link.springer.com.

The Model Legume Medicago truncatula, 2 Volume Set

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Author : Frans J. de Bruijn
Publisher : John Wiley & Sons
ISBN 13 : 1119409160
Total Pages : 1264 pages
Book Rating : 4.1/5 (194 download)

Book Synopsis The Model Legume Medicago truncatula, 2 Volume Set by : Frans J. de Bruijn

Download or read book The Model Legume Medicago truncatula, 2 Volume Set written by Frans J. de Bruijn and published by John Wiley & Sons. This book was released on 2020-01-29 with total page 1264 pages. Available in PDF, EPUB and Kindle. Book excerpt: Fully covers the biology, biochemistry, genetics, and genomics of Medicago truncatula Model plant species are valuable not only because they lead to discoveries in basic biology, but also because they provide resources that facilitate translational biology to improve crops of economic importance. Plant scientists are drawn to models because of their ease of manipulation, simple genome organization, rapid life cycles, and the availability of multiple genetic and genomic tools. This reference provides comprehensive coverage of the Model Legume Medicago truncatula. It features review chapters as well as research chapters describing experiments carried out by the authors with clear materials and methods. Most of the chapters utilize advanced molecular techniques and biochemical analyses to approach a variety of aspects of the Model. The Model Legume Medicago truncatula starts with an examination of M. truncatula plant development; biosynthesis of natural products; stress and M. truncatula; and the M. truncatula-Sinorhizobium meliloti symbiosis. Symbiosis of Medicago truncatula with arbuscular mycorrhiza comes next, followed by chapters on the common symbiotic signaling pathway (CSSP or SYM) and infection events in the Rhizobium-legume symbiosis. Other sections look at hormones and the rhizobial and mycorrhizal symbioses; autoregulation of nodule numbers (AON) in M. truncatula; Medicago truncatula databases and computer programs; and more. Contains reviews, original research chapters, and methods Covers most aspects of the M. truncatula Model System, including basic biology, biochemistry, genetics, and genomics of this system Offers molecular techniques and advanced biochemical analyses for approaching a variety of aspects of the Model Legume Medicago truncatula Includes introductions by the editor to each section, presenting the summary of selected chapters in the section Features an extensive index, to facilitate the search for key terms The Model Legume Medicago truncatula is an excellent book for researchers and upper level graduate students in microbial ecology, environmental microbiology, plant genetics and biochemistry. It will also benefit legume biologists, plant molecular biologists, agrobiologists, plant breeders, bioinformaticians, and evolutionary biologists.

Integrative Analysis of Genome-Wide Association Studies and Single-Cell Sequencing Studies

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Author : Sheng Yang
Publisher : Frontiers Media SA
ISBN 13 : 2889714675
Total Pages : 113 pages
Book Rating : 4.8/5 (897 download)

Book Synopsis Integrative Analysis of Genome-Wide Association Studies and Single-Cell Sequencing Studies by : Sheng Yang

Download or read book Integrative Analysis of Genome-Wide Association Studies and Single-Cell Sequencing Studies written by Sheng Yang and published by Frontiers Media SA. This book was released on 2021-09-09 with total page 113 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Association Analysis Techniques and Applications in Bioinformatics

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Author : Qingfeng Chen
Publisher : Springer Nature
ISBN 13 : 9819982510
Total Pages : 396 pages
Book Rating : 4.8/5 (199 download)

Book Synopsis Association Analysis Techniques and Applications in Bioinformatics by : Qingfeng Chen

Download or read book Association Analysis Techniques and Applications in Bioinformatics written by Qingfeng Chen and published by Springer Nature. This book was released on with total page 396 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Advances in Statistical Methods for the Genetic Dissection of Complex Traits in Plants

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Author : Yuan-Ming Zhang
Publisher : Frontiers Media SA
ISBN 13 : 2832543693
Total Pages : 278 pages
Book Rating : 4.8/5 (325 download)

Book Synopsis Advances in Statistical Methods for the Genetic Dissection of Complex Traits in Plants by : Yuan-Ming Zhang

Download or read book Advances in Statistical Methods for the Genetic Dissection of Complex Traits in Plants written by Yuan-Ming Zhang and published by Frontiers Media SA. This book was released on 2024-01-26 with total page 278 pages. Available in PDF, EPUB and Kindle. Book excerpt: Genome-wide association studies (GWAS) have been widely used in the genetic dissection of complex traits. However, there are still limits in current GWAS statistics. For example, (1) almost all the existing methods do not estimate additive and dominance effects in quantitative trait nucleotide (QTN) detection; (2) the methods for detecting QTN-by-environment interaction (QEI) are not straightforward and do not estimate additive and dominance effects as well as additive-by-environment and dominance-by-environment interaction effects, leading to unreliable results; and (3) no or too simple polygenic background controls have been employed in QTN-by-QTN interaction (QQI) detection. As a result, few studies of QEI and QQI for complex traits have been reported based on multiple-environment experiments. Recently, new statistical tools, including 3VmrMLM, have been developed to address these needs in GWAS. In 3VmrMLM, all the trait-associated effects, including QTN, QEI and QQI related effects, are compressed into a single effect-related vector, while all the polygenic backgrounds are compressed into a single polygenic effect matrix. These compressed parameters can be accurately and efficiently estimated through a unified mixed model analysis. To further validate these new GWAS methods, particularly 3VmrMLM, they should be rigorously tested in real data of various plants and a wide range of other species.

Handbook of Statistical Genomics

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Author : David J. Balding
Publisher : John Wiley & Sons
ISBN 13 : 1119429250
Total Pages : 1740 pages
Book Rating : 4.1/5 (194 download)

Book Synopsis Handbook of Statistical Genomics by : David J. Balding

Download or read book Handbook of Statistical Genomics written by David J. Balding and published by John Wiley & Sons. This book was released on 2019-07-09 with total page 1740 pages. Available in PDF, EPUB and Kindle. Book excerpt: A timely update of a highly popular handbook on statistical genomics This new, two-volume edition of a classic text provides a thorough introduction to statistical genomics, a vital resource for advanced graduate students, early-career researchers and new entrants to the field. It introduces new and updated information on developments that have occurred since the 3rd edition. Widely regarded as the reference work in the field, it features new chapters focusing on statistical aspects of data generated by new sequencing technologies, including sequence-based functional assays. It expands on previous coverage of the many processes between genotype and phenotype, including gene expression and epigenetics, as well as metabolomics. It also examines population genetics and evolutionary models and inference, with new chapters on the multi-species coalescent, admixture and ancient DNA, as well as genetic association studies including causal analyses and variant interpretation. The Handbook of Statistical Genomics focuses on explaining the main ideas, analysis methods and algorithms, citing key recent and historic literature for further details and references. It also includes a glossary of terms, acronyms and abbreviations, and features extensive cross-referencing between chapters, tying the different areas together. With heavy use of up-to-date examples and references to web-based resources, this continues to be a must-have reference in a vital area of research. Provides much-needed, timely coverage of new developments in this expanding area of study Numerous, brand new chapters, for example covering bacterial genomics, microbiome and metagenomics Detailed coverage of application areas, with chapters on plant breeding, conservation and forensic genetics Extensive coverage of human genetic epidemiology, including ethical aspects Edited by one of the leading experts in the field along with rising stars as his co-editors Chapter authors are world-renowned experts in the field, and newly emerging leaders. The Handbook of Statistical Genomics is an excellent introductory text for advanced graduate students and early-career researchers involved in statistical genetics.

Animal Breeding and Genetics

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Author : Matthew L. Spangler
Publisher : Springer Nature
ISBN 13 : 1071624601
Total Pages : 421 pages
Book Rating : 4.0/5 (716 download)

Book Synopsis Animal Breeding and Genetics by : Matthew L. Spangler

Download or read book Animal Breeding and Genetics written by Matthew L. Spangler and published by Springer Nature. This book was released on 2022-11-01 with total page 421 pages. Available in PDF, EPUB and Kindle. Book excerpt: This newly updated and revised volume of the Encyclopedia of Sustainability Science and Technology (ESST) details the role of Animal Breeding and Genetics in the sustainability of animal agriculture. The volume covers scientific principles and applications includes the current science used to advance cattle, poultry, swine,sheep, and equine populations, as well as the future role of techniques such as gene editing. International leaders in the field explain foundational concepts such as heritability, the covariance between relatives, statistical approaches to predicting the genetic merit of individuals, and the development and advancement of molecular techniques to elucidate changes in the DNA sequence that underly phenotypic variation. The use of genetic-based tools to improve animal agriculture and meet consumer demands across species is treated in detail. Readers will gain an understanding of how global livestock producers have implemented advanced genetic selection tools and used them to improve reproduction, production, efficiency, health, and sustainability. The interactions of genetics and production environments, and the genetic components of the complex interactions among animals are also discussed. The future of Animal Breeding and Genetics, including the challenges and opportunities that exist in feeding a growing world population, are addressed.

The Catharanthus Genome

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Author : Chittaranjan Kole
Publisher : Springer Nature
ISBN 13 : 3030892697
Total Pages : 201 pages
Book Rating : 4.0/5 (38 download)

Book Synopsis The Catharanthus Genome by : Chittaranjan Kole

Download or read book The Catharanthus Genome written by Chittaranjan Kole and published by Springer Nature. This book was released on 2022-01-24 with total page 201 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is the first comprehensive compilation of deliberations on botany, medicinal importance, genetic diversity, classical genetics and breeding, in vitro biosynthesis, somatic embryogenesis, genetic transformation, molecular mapping, genome sequence, and functional genomics of Catharanthus roseus. Catharanthus is the most important medicinal plant in the world that contains about 130 therapeutic alkaloids out of which vinblastine and vincristine are the two highly used anticancer drugs sold by the pharmaceutically industries. Altogether, the book contains about 10 chapters authored by globally reputed experts on the relevant field of this plant. This book is useful to the students, teachers and scientists in the academia and relevant private companies interested in horticulture, genetics, breeding, pathology, entomology, physiology, molecular genetics and breeding, in vitro culture and genetic engineering, and structural and functional genomics. This book is also useful to pharmaceutical industries.

Soybean molecular breeding and genetics

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Author : Guo-Liang Jiang
Publisher : Frontiers Media SA
ISBN 13 : 2832519229
Total Pages : 351 pages
Book Rating : 4.8/5 (325 download)

Book Synopsis Soybean molecular breeding and genetics by : Guo-Liang Jiang

Download or read book Soybean molecular breeding and genetics written by Guo-Liang Jiang and published by Frontiers Media SA. This book was released on 2023-03-29 with total page 351 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Quantitative Methods for Precision Medicine

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Author : Rongling Wu
Publisher : CRC Press
ISBN 13 : 1482219468
Total Pages : 307 pages
Book Rating : 4.4/5 (822 download)

Book Synopsis Quantitative Methods for Precision Medicine by : Rongling Wu

Download or read book Quantitative Methods for Precision Medicine written by Rongling Wu and published by CRC Press. This book was released on 2022-12-26 with total page 307 pages. Available in PDF, EPUB and Kindle. Book excerpt: Modern medicine is undergoing a paradigm shift from a "one-size-fits-all" strategy to a more precise patient-customized therapy and medication plan. While the success of precision medicine relies on the level of pharmacogenomic knowledge, dissecting the genetic mechanisms of drug response in a sufficient detail requires powerful computational tools. Quantitative Methods for Precision Medicine: Pharmacogenomics in Action presents the advanced statistical methods for mapping pharmacogenetic control by integrating pharmacokinetic and pharmacodynamic principles of drug-body interactions. Beyond traditional reductionist-based statistical genetic approaches, statistical formulization in this book synthesizes elements of multiple disciplines to infer, visualize, and track how pharmacogenes interact together as an intricate but well-coordinated system to mediate patient-specific drug response. Features: Functional and systems mapping models to characterize the genetic architecture of multiple medication processes Statistical methods for analyzing informative missing data in pharmacogenetic association studies Functional graph theory of inferring genetic interaction networks from association data Leveraging the concept of epistasis to capture its bidirectional, signed and weighted properties Modeling gene-induced cell-cell crosstalk and its impact on drug response A graph model of drug-drug interactions in combination therapies Critical methodological issues to improve pharmacogenomic research as the cornerstone of precision medicine This book is suitable for graduate students and researchers in the fields of biology, medicine, bioinformatics and drug design and delivery who are interested in statistical and computational modelling of biological processes and systems. It may also serve as a major reference for applied mathematicians, computer scientists, and statisticians who attempt to develop algorithmic tools for genetic mapping, systems pharmacogenomics and systems biology. It can be used as both a textbook and research reference. Professionals in pharmaceutical sectors who design drugs and clinical doctors who deliver drugs will also find it useful.

Solanaceae VII: Biology, Genetics, and Evolution

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Author : Peter Poczai
Publisher : Frontiers Media SA
ISBN 13 : 2889765970
Total Pages : 226 pages
Book Rating : 4.8/5 (897 download)

Book Synopsis Solanaceae VII: Biology, Genetics, and Evolution by : Peter Poczai

Download or read book Solanaceae VII: Biology, Genetics, and Evolution written by Peter Poczai and published by Frontiers Media SA. This book was released on 2023-02-10 with total page 226 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Genomic Selection in Animals

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Author : Joel Weller
Publisher : John Wiley & Sons
ISBN 13 : 1119213630
Total Pages : 189 pages
Book Rating : 4.1/5 (192 download)

Book Synopsis Genomic Selection in Animals by : Joel Weller

Download or read book Genomic Selection in Animals written by Joel Weller and published by John Wiley & Sons. This book was released on 2016-01-04 with total page 189 pages. Available in PDF, EPUB and Kindle. Book excerpt: The field of whole genome selection has quickly developed into the breeding methodology of the future. As efforts to map a wide variety of animal genomes have matured and full animal genomes are now available for many animal scientists and breeders are looking to apply these techniques to livestock production. Providing a comprehensive, forward-looking review of animal genomics, Genomic Selection in Animals provides coverage of genomic selection in a variety of economically important species including cattle, swine, and poultry. The historical foundations of genomic selection are followed by chapters that review and assess current techniques. The final chapter looks toward the future and what lies ahead for field as application of genomic selection becomes more widespread. A concise, useful summary of the field by one of the world’s leading researchers, Genomic Selection in Animals fills an important gap in the literature of animal breeding and genomics.

Genomic Designing for Biotic Stress Resistant Oilseed Crops

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Author : Chittaranjan Kole
Publisher : Springer Nature
ISBN 13 : 3030910350
Total Pages : 360 pages
Book Rating : 4.0/5 (39 download)

Book Synopsis Genomic Designing for Biotic Stress Resistant Oilseed Crops by : Chittaranjan Kole

Download or read book Genomic Designing for Biotic Stress Resistant Oilseed Crops written by Chittaranjan Kole and published by Springer Nature. This book was released on 2022-03-18 with total page 360 pages. Available in PDF, EPUB and Kindle. Book excerpt: Biotic stresses cause yield loss of 31-42% in crops in addition to 6-20% during post-harvest stage. Understanding interaction of crop plants to the biotic stresses caused by insects, bacteria, fungi, viruses, and oomycetes, etc. is important to develop resistant crop varieties. Knowledge on the advanced genetic and genomic crop improvement strategies including molecular breeding, transgenics, genomic-assisted breeding and the recently emerging genome editing for developing resistant varieties in oilseed crops is imperative for addressing FPNEE (food, health, nutrition. energy and environment) security. Whole genome sequencing of these crops followed by genotyping-by-sequencing have facilitated precise information about the genes conferring resistance useful for gene discovery, allele mining and shuttle breeding which in turn opened up the scope for 'designing' crop genomes with resistance to biotic stresses. The eight chapters each dedicated to an oilseed crop in this volume elucidate on different types of biotic stress agents and their effects on and interaction with the crop plants; enumerate on the available genetic diversity with regard to biotic stress resistance among available cultivars; illuminate on the potential gene pools for utilization in interspecific gene transfer; present brief on the classical genetics of stress resistance and traditional breeding for transferring them to their cultivated counterparts; depict the success stories of genetic engineering for developing biotic stress resistant varieties; discuss on molecular mapping of genes and QTLs underlying biotic stress resistance and their marker-assisted introgression into elite varieties; enunciate on different emerging genomics-aided techniques including genomic selection, allele mining, gene discovery and gene pyramiding for developing resistant crop varieties with higher quantity and quality of yields; and also elaborate some case studies on genome editing focusing on specific genes for generating disease and insect resistant crops.

Biocomputing 2022 - Proceedings Of The Pacific Symposium

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Author : Russ B Altman
Publisher : World Scientific
ISBN 13 : 9811250480
Total Pages : 380 pages
Book Rating : 4.8/5 (112 download)

Book Synopsis Biocomputing 2022 - Proceedings Of The Pacific Symposium by : Russ B Altman

Download or read book Biocomputing 2022 - Proceedings Of The Pacific Symposium written by Russ B Altman and published by World Scientific. This book was released on 2021-11-29 with total page 380 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Pacific Symposium on Biocomputing (PSB) 2022 is an international, multidisciplinary conference for the presentation and discussion of current research in the theory and application of computational methods in problems of biological significance. Presentations are rigorously peer reviewed and are published in an archival proceedings volume. PSB 2022 will be held on January 3 - 7, 2022 in Kohala Coast, Hawaii. Tutorials and workshops will be offered prior to the start of the conference.PSB 2022 will bring together top researchers from the US, the Asian Pacific nations, and around the world to exchange research results and address open issues in all aspects of computational biology. It is a forum for the presentation of work in databases, algorithms, interfaces, visualization, modeling, and other computational methods, as applied to biological problems, with emphasis on applications in data-rich areas of molecular biology.The PSB has been designed to be responsive to the need for critical mass in sub-disciplines within biocomputing. For that reason, it is the only meeting whose sessions are defined dynamically each year in response to specific proposals. PSB sessions are organized by leaders of research in biocomputing's 'hot topics.' In this way, the meeting provides an early forum for serious examination of emerging methods and approaches in this rapidly changing field.

A Guide to QTL Mapping with R/qtl

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Author : Karl W. Broman
Publisher : Springer
ISBN 13 : 9781461417088
Total Pages : 400 pages
Book Rating : 4.4/5 (17 download)

Book Synopsis A Guide to QTL Mapping with R/qtl by : Karl W. Broman

Download or read book A Guide to QTL Mapping with R/qtl written by Karl W. Broman and published by Springer. This book was released on 2011-12-02 with total page 400 pages. Available in PDF, EPUB and Kindle. Book excerpt: Comprehensive discussion of QTL mapping concepts and theory Detailed instructions on the use of the R/qtl software, the most featured and flexible software for QTL mapping Two case studies illustrate QTL analysis in its entirety