The Immortal Mitochondria

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The Immortal Mitochondria

Author : Triveni P. Shukla
Publisher : Litfire Publishing
ISBN 13 : 9781643988283
Total Pages : 494 pages
Book Rating : 4.9/5 (882 download)

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Book Synopsis The Immortal Mitochondria by : Triveni P. Shukla

Download or read book The Immortal Mitochondria written by Triveni P. Shukla and published by Litfire Publishing. This book was released on 2019-06-02 with total page 494 pages. Available in PDF, EPUB and Kindle. Book excerpt: I entitled this book "Immortal Mitochondria" because thousands of them in every one of my cells with their own genome make me live, grow, and function as a person with power to feel and heal. I inherited this old eukaryotic symbiont from my maternal mothers may be a 1000 years ago and there may me a 1000 or more males and females out there with mitochondrial genome similar to mine. This biological truth relates to our daily life in terms of foods we eat for energy and our vitality, our electro-magnetic life processes, life span, aging and death. As mitochondria do all this, they fuse, split, change shape, and get destroyed under their own specification of purposeful quality control. I wish to tell my readers that the mitochondrial genome talks to our nuclear genome regularly and caring for it is critical to our health and longevity. The first chapter is about biochemistry of chemical energy production from glucose, the second is about "how, how often, and what kind" of foods that we should eat, the third is about vital signs and organ failures due to failing mitochondria, and the fourth is about diseases controlled my mitochondrial genes. The fifth chapter is an integrated summation of all. It describes the evolution of and power production by mitochondria, mitochondrial health as it relates to aging, and the e ects of how we choose to live on the health of mitochondria. I should emphasize that "How we choose to live" includes exercise, yoga, meditation, mindfulness, acupuncture, self-message, and even the way we use our mind. We live by 3,750 million of these nanomagnets in our cells and our life is all about the life of mitochondria within us. We can live long and well only by healthy mitochondria. We must help them remain immortal by good foods.

Mitochondria and the Future of Medicine

Author : Lee Know
Publisher : Chelsea Green Publishing
ISBN 13 : 1603587675
Total Pages : 274 pages
Book Rating : 4.6/5 (35 download)

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Book Synopsis Mitochondria and the Future of Medicine by : Lee Know

Download or read book Mitochondria and the Future of Medicine written by Lee Know and published by Chelsea Green Publishing. This book was released on 2018 with total page 274 pages. Available in PDF, EPUB and Kindle. Book excerpt: With information for patients and practitioners on optimizing mitochondrial function for greater health and longevity Why do we age? Why does cancer develop? What's the connection between heart failure and Alzheimer's disease, or infertility and hearing loss? Can we extend lifespan, and if so, how? What is the Exercise Paradox? Why do antioxidant supplements sometimes do more harm than good? Many will be amazed to learn that all these questions, and many more, can be answered by a single point of discussion: mitochondria and bioenergetics. In Mitochondria and the Future of Medicine, Naturopathic Doctor Lee Know tells the epic story of mitochondria, the widely misunderstood and often-overlooked powerhouses of our cells. The legendary saga began over two billion years ago, when one bacterium entered another without being digested, which would evolve to create the first mitochondrion. Since then, for life to exist beyond single-celled bacteria, it's the mitochondria that have been responsible for this life-giving energy. By understanding how our mitochondria work, in fact, it is possible to add years to our lives, and life to our years. Current research, however, has revealed a dark side: many seemingly disconnected degenerative diseases have tangled roots in dysfunctional mitochondria. However, modern research has also endowed us with the knowledge on how to optimize its function, which is of critical importance to our health and longevity. Lee Know offers cutting-edge information on supplementation and lifestyle changes for mitochondrial optimization, such as CoQ10, D-Ribose, cannabinoids, and ketogenic dietary therapy, and how to implement their use successfully. Mitochondria and the Future of Medicine is an invaluable resource for practitioners interested in mitochondrial medicine and the true roots of chronic illness and disease, as well as anyone interested in optimizing their health.

Mitochondria

Author : Immo E. Scheffler
Publisher : John Wiley & Sons
ISBN 13 : 1118209850
Total Pages : 377 pages
Book Rating : 4.1/5 (182 download)

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Book Synopsis Mitochondria by : Immo E. Scheffler

Download or read book Mitochondria written by Immo E. Scheffler and published by John Wiley & Sons. This book was released on 2011-09-20 with total page 377 pages. Available in PDF, EPUB and Kindle. Book excerpt: "This volume inspires. It certainly will be much appreciated by cell biologists all over the world." Quarterly Review of Biology, March 2009 This book is the eagerly awaited second edition of the best-selling Mitochondria, a book widely acknowledged as the first modern, truly comprehensive authored work on the important, scientifically fundamental topic of the cellular organelles known as mitochondria. This new edition brings readers completely up to date on the many significant findings that have occurred in the eight years since the book was first published. As in that seminal first edition, the second edition tackles the biochemistry, genetics, and pathology of mitochondria in different organisms. The new edition provides thorough updates of all literature concerning this vital organelle, its functions, ongoing research surrounding it, and its importance vis-à-vis a broad range of issues in cellular and molecular biology. The book includes detailed descriptions of current and developing technologies around mitochondrial research and discovery, and highlights subjects that are growing, such as the use of proteomics. This book is an invaluable resource for all geneticists, biologists, and educators in life sciences. It is also of interest for advanced students in genetics and molecular biology.

Mitochondria and Longevity

Author :
Publisher : Academic Press
ISBN 13 : 0128157372
Total Pages : 356 pages
Book Rating : 4.1/5 (281 download)

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Book Synopsis Mitochondria and Longevity by :

Download or read book Mitochondria and Longevity written by and published by Academic Press. This book was released on 2018-07-31 with total page 356 pages. Available in PDF, EPUB and Kindle. Book excerpt: Mitochondria and Longevity, Volume 340, the latest release in the International Review of Cell and Molecular Biology series reviews and details current advances in cell and molecular biology. The IRCMB series has a worldwide readership, maintaining a high standard by publishing invited articles on important and timely topics with this release focusing on topics such as Mitochondria metabolism and aging, Mitohormesis, Mitochondrial dynamics in the aging stem cell compartment, Mitochondrial proteostasis and aging, Mitochondrial DNA mutations and aging, Mitochondrial sirtuins, NAD+, NADH and aging, Mitophagy and aging, Mitochondria, calcium transport and aging. Publishes only invited review articles on selected topics in cell and molecular biology Authored by established and active cell and molecular biologists Drawn from international sources Offers a wide range of perspectives on specific subjects

Mitochondrial DNA, Mitochondria, Disease and Stem Cells

Author : Justin C. St. John
Publisher : Springer Science & Business Media
ISBN 13 : 1627031006
Total Pages : 193 pages
Book Rating : 4.6/5 (27 download)

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Book Synopsis Mitochondrial DNA, Mitochondria, Disease and Stem Cells by : Justin C. St. John

Download or read book Mitochondrial DNA, Mitochondria, Disease and Stem Cells written by Justin C. St. John and published by Springer Science & Business Media. This book was released on 2012-09-27 with total page 193 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume investigates how the mitochondrial genome is transmitted, segregated, and inherited. It starts by describing mtDNA mutations and deletions and how these impact on the offspring’s well-being. It progresses to discuss how mutations to the mtDNA-nuclear-encoded transcription, replication and translational factors lead to mtDNA-depletion syndromes and how these affect cellular function and lead to the pathology of human mitochondrial disease. It also highlights the importance of the mitochondrial assembly factors and how mutations to these can lead to mitochondrial disease. The reader is then introduced to how mtDNA is transmitted through the oocyte and how stem cells can be used to study mitochondrial biogenesis and mtDNA replication and transcription in undifferentiated pluripotent and differentiating cells and how mitochondria adapt during this process. It then discusses how diseases like cancer are initiated and regulated by mutations to mitochondrial DNA and dysfunctional mitochondria. Finally, it draws on assisted reproductive technologies to discuss how some of these approaches might be adapted to prevent the transmission of mutant and deleted mtDNA from one generation to the next.

Power, Sex, Suicide

Author : Nick Lane
Publisher : OUP Oxford
ISBN 13 : 0192804812
Total Pages : 370 pages
Book Rating : 4.1/5 (928 download)

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Book Synopsis Power, Sex, Suicide by : Nick Lane

Download or read book Power, Sex, Suicide written by Nick Lane and published by OUP Oxford. This book was released on 2005-10-13 with total page 370 pages. Available in PDF, EPUB and Kindle. Book excerpt: Mitochondria are tiny structures within all our cells, believed to have once evolved from bacteria living independent lives. Drawing on cutting edge research, this book explores the fundamental role they play in some of the biggest themes in biology: evolution, the origin of the sexes, in growth, ageing, disease, and in death. - ;Power, Sex, Suicide, Complexity, Individuality, Fertility, Prehistory, Ageing, Death. These universal themes are all linked by mitochondria - the tiny structures located inside our cells - miniature powerhouses that use oxygen to generate power. There are hundreds of them in each cell, some 10 million billion in a human being. Once considered menial slaves, mere workhorses for complex cells with nuclei, their significance is now undergoing a radical revision. Mitochondria are now seen as the key ingredient that made complex life possible at all. For two billion years, bacteria ruled the earth without ever generating true complexity - a stasis that may still grip life on other planets. Then the union of two bacterial cells led to an evolutionary big bang, from which algae, fungi, plants and animals emerged. For mitochondria were once free-living bacteria, and still retain unmistakable traits of their ancestry, including some of their original DNA. Ever since their fateful absorption, the tortuous and unpredictable relationship between the mitochondria and their host cells has forced one evolutionary innovation after another. Without mitochondria, nothing would exist of the world we know and love. Their story is the story of life itself. Today, mitochondria are central to research into human prehistory, genetic diseases, cell suicide, fertility, ageing, bioenergetics, sex and the eukaryotic cell. Piecing together puzzles from the forefront of research, this book paints a sweeping canvas that will thrill all who are interested in biology, while also contributing to evolutionary thinking and debate. This is a book full of startling insights into the nature and evolution of life, and should be read by anyone who wants to know why we're here. - ;Challenging, but rewarding. - Observer;Full of startling insights into the nature and evolution of life as we know it. - Economist Best Books of the Year, 2005;An enthralling account...The author has accomplished something quite breathtaking...moreover,he brings the science alive...he is always accessible, livley, thought-provoking, and informative. Every biologist should read this book - ;'Power, Sex, Suicide is an enjoyable and readable book....anyone interested in the broader and more philosophical aspects of their discipline will profit from reading the book' - David G. Nicholls, Science;impressive....a polemical book...readable, provocative and often persuasive....This is an exciting and unusual book. - Jonathan Hodgkin, Times Literary Supplement

Life - The Epic Story of Our Mitochondria

Author : Lee Know ND
Publisher : FriesenPress
ISBN 13 : 1460251814
Total Pages : 266 pages
Book Rating : 4.4/5 (62 download)

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Book Synopsis Life - The Epic Story of Our Mitochondria by : Lee Know ND

Download or read book Life - The Epic Story of Our Mitochondria written by Lee Know ND and published by FriesenPress. This book was released on 2014-08-19 with total page 266 pages. Available in PDF, EPUB and Kindle. Book excerpt: "Why do we age? Why does cancer develop? What's the connection between heart failure and Alzheimer's disease, or infertility and hearing loss? Can we extend lifespan, and if so, how? What is the Exercise Paradox? Why do antioxidant supplements sometimes do more harm than good? Many will be amazed to learn that all these questions, and many more, can be answered by a single point of discussion-mitochondria and bioenergetics. This legendary saga began over two billion years ago, when one bacterium entered another without being digested, ultimately creating the first mitochondrion. Since then, for life to exist beyond single-celled bacteria, it's the mitochondria that are responsible for this life-giving energy. Yet, current research has also revealed a dark side; many seemingly unconnected degenerative diseases have their roots in dysfunctional mitochondria. Modern research, however, has also endowed us with the knowledge on how to optimize its function, which is of critical importance to our health and longevity. By reading this book, you are about to dive into this epic story, and learn how to add years to your life, and life to your years."--Back cover.

Cellular and Molecular Basis of Mitochondrial Inheritance

Author : Peter Sutovsky
Publisher : Springer
ISBN 13 : 3030045706
Total Pages : 126 pages
Book Rating : 4.0/5 (3 download)

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Book Synopsis Cellular and Molecular Basis of Mitochondrial Inheritance by : Peter Sutovsky

Download or read book Cellular and Molecular Basis of Mitochondrial Inheritance written by Peter Sutovsky and published by Springer. This book was released on 2019-05-09 with total page 126 pages. Available in PDF, EPUB and Kindle. Book excerpt: This new volume of our successful book series Advances in Anatomy, Embryology and Cell Biology is focused on mitochondrial inheritance in humans and both vertebrate and invertrebate animals including Drosophila, C. elegans, bivalve molusc Mytilus and livestock mammals. Special consideration is given to cellular mechanisms promoting uniparental inheritance of mitochondria and mitochondrial genes, evolutionary perspectives, and biomedical and epidemiological considerations. Contributed by five distinguished mitochondrial research teams from around the world, this volume will target a wide audience of physiologists, anatomists, cell, and developmental and evolutionary biologists, as well as physicians, veterinarians, livestock specialists and biomedical researchers.

The Mitochondrion in Aging and Disease

Author :
Publisher : Academic Press
ISBN 13 : 0123948401
Total Pages : 300 pages
Book Rating : 4.1/5 (239 download)

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Book Synopsis The Mitochondrion in Aging and Disease by :

Download or read book The Mitochondrion in Aging and Disease written by and published by Academic Press. This book was released on 2014-08-19 with total page 300 pages. Available in PDF, EPUB and Kindle. Book excerpt: Mitochondria, the "power plants" of eukaryotic cells, are best known for the generation of adenosine triphosphate (ATP), the universal cellular "energy currency" of the cell, and the synthesis of different essential components. Mitochondrial dysfunction is known to lead to various degenerative disorders, disease, and aging. The Mitochondrion in Aging and Disease works to unravel the processes leading to mitochondrial impairments and of pathways involved in mitochondrial quality control and their impact on health and aging will be addressed. - Reviews current topics of interest - Written by experts in the field

Mitochondria Diet

Author : Jeffrey Winzant
Publisher : Independently Published
ISBN 13 :
Total Pages : 56 pages
Book Rating : 4.5/5 (463 download)

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Book Synopsis Mitochondria Diet by : Jeffrey Winzant

Download or read book Mitochondria Diet written by Jeffrey Winzant and published by Independently Published. This book was released on 2021-07-30 with total page 56 pages. Available in PDF, EPUB and Kindle. Book excerpt: Did you know that mitochondrial health is an essential key to longevity and overall well-being? Mitochondria are often overlooked in the body's complex cellular structure. They may not get as much attention as the brain or heart, but they are integral to overall health just like any other organ, and your health can be affected by the inner workings of these tiny organelles. For example, when your cells don't use energy properly from food because they cannot metabolize glucose (a type of sugar), your mitochondria cellular structures stop functioning efficiently, resulting in insulin resistance as well-both upstream triggers for health problems like cardiovascular disease, diabetes, cancer, Alzheimer's Disease, Parkinson's Disease and much more. Fortunately, there are many steps that you can take to manage these mitochondrial dysfunctions through nutrition. That's why we have outlined a 3-weeks meal plan designed with your mitochondria in mind. First things first, it's a good idea to understand what mitochondria are and why they are vital for optimal health. Stay tuned for a deep dive into what they do, why you should care about them, and how you can take better care of them through nutrition. In this guide, you'll discover: What are mitochondria Diet tips to help improve your mitochondria function Symptoms you can tell your cellular structures are not working properly A seven-day weekly plan Sample recipes to follow Imagine what changes you can see in your life if you take action today. Scroll up and click buy now to get started.

The Immortal Germline

Author :
Publisher : Academic Press
ISBN 13 : 0128097531
Total Pages : 368 pages
Book Rating : 4.1/5 (28 download)

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Book Synopsis The Immortal Germline by :

Download or read book The Immortal Germline written by and published by Academic Press. This book was released on 2019-05-31 with total page 368 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Immortal Germline, Volume 135 in the Current Topics in Developmental Biology series, highlights new advances in the field, with this new volume presenting interesting chapters on a variety of topics, including Balbiani body, germ plasm and polarity, Wolbachia and the germline, Human germ line biology, Reproduction/immunity and sperm success, Mammalian spermatogenesis, Reproduction/regeneration and germ cells in planarians, Germline stem cell homeostasis, Germline soma interactions/sex determination, Reconstituting the mouse germ-cell specification pathway in vitro, Maternal Germ line inheritance of mitochondria, Transposon strategies, and more. - Provides the authority and expertise of leading contributors from an international board of authors - Presents the latest release in the Current Topics in Developmental Biology series - Includes the latest information on germ cells

Mitochondrial Biology and Experimental Therapeutics

Author : Paulo J. Oliveira
Publisher : Springer
ISBN 13 : 3319733443
Total Pages : 696 pages
Book Rating : 4.3/5 (197 download)

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Book Synopsis Mitochondrial Biology and Experimental Therapeutics by : Paulo J. Oliveira

Download or read book Mitochondrial Biology and Experimental Therapeutics written by Paulo J. Oliveira and published by Springer. This book was released on 2018-03-21 with total page 696 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book addresses the therapeutic strategies to target mitochondrial metabolism in diseases where the function of that organelle is compromised, and it discusses the effective strategies used to create mitochondrial-targeted agents that can become commercially available drug delivery platforms. The consistent growth of research focused in understanding the multifaceted role of mitochondria in cellular metabolism, controlling pathways related with cell death, and ionic/redox regulation has extended the research of mitochondrial chemical-biological interactions to include various pharmacological and toxicological applications. Not only does the book extensively cover basic mitochondrial physiology, but it also links the molecular interactions within these pathways to a variety of diseases. It is one of the first books to combine state-of-the-art reviews regarding basic mitochondrial biology, the role of mitochondrial alterations in different diseases, and the importance of that organelle as a target for pharmacological and non-pharmacological interventions to improve human health. The different chapters highlight the chemical-biological linkages of the mitochondria in context with drug development and clinical applications.

The Mitochondrion in Health and Disease

Author : David D. Tyler
Publisher :
ISBN 13 :
Total Pages : 584 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis The Mitochondrion in Health and Disease by : David D. Tyler

Download or read book The Mitochondrion in Health and Disease written by David D. Tyler and published by . This book was released on 1992 with total page 584 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Mitochondrial Dysfunction: A Functional Medicine Approach to Diagnosis and Treatment: Get Rid of Fat, Fatigue, and Brain Fog

Author : Michael T. Chang
Publisher :
ISBN 13 : 9781733397315
Total Pages : 194 pages
Book Rating : 4.3/5 (973 download)

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Book Synopsis Mitochondrial Dysfunction: A Functional Medicine Approach to Diagnosis and Treatment: Get Rid of Fat, Fatigue, and Brain Fog by : Michael T. Chang

Download or read book Mitochondrial Dysfunction: A Functional Medicine Approach to Diagnosis and Treatment: Get Rid of Fat, Fatigue, and Brain Fog written by Michael T. Chang and published by . This book was released on 2019-09-08 with total page 194 pages. Available in PDF, EPUB and Kindle. Book excerpt: Are of sick and tired of being tired, overweight, brain fogged and depressed? You have tried everything and nothing makes a difference. The answer may lie deep inside your cells called the mitochondria, the energy factories that power the cell. By rebooting them in a proven treatment method, you can not only get rid of your symptoms but also prevent chronic degenerative diseases like cancer and Alzheimer's and even slow the aging process. Functional medicine can help you diagnose and treat mitochondrial dysfunction.Dr. Michael Chang, MD, CFMP, Board certified in Pathology and Laboratory Medicine, draws from his experience at Healed and Whole Clinic using a validated treatment approach to this condition. He has also personally experienced mitochondrial fatigue stemming from biomechanical leg pain from which he has now recovered by applying the same treatments as outlined in this book.

Your Mitochondria

Author : Warren Cargal L. Ac.
Publisher :
ISBN 13 : 9781973466291
Total Pages : 232 pages
Book Rating : 4.4/5 (662 download)

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Book Synopsis Your Mitochondria by : Warren Cargal L. Ac.

Download or read book Your Mitochondria written by Warren Cargal L. Ac. and published by . This book was released on 2018-04-19 with total page 232 pages. Available in PDF, EPUB and Kindle. Book excerpt: Your Mitochondria: Key to Health and Longevity is a must read for anyone who wants a healthier lifestyle. The book provides a deep dive into the relationship between mitochondrial health and cardiovascular diseases; cardiometabolic syndrome; neurodegenerative diseases; arthritis; cancer; and the aging effects on the skin, eyes, and muscles. Want to live longer and live better?Want to stave off age-related diseases?Want to look younger and maintain vitality? Read Your Mitochondria - Start Living Better. Reading this ebook requires a Kindle app, which is available as a free download at the link below. The Kindle app allows you to read Your Mitochondria on your Mac or PC as well as iOS and Android platforms.https://www.amazon.com/kindle-dbs/fd/kcpABOUT THE AUTHOR: Warren L. Cargal, L. Ac. is a leader in his field, specializing in age-related diseases tied to diabetes, cardiovascular and neurodegenerative issues, and cancer. He is a licensed acupuncturist and herbalist and is also founder and clinical director of Acupuncture Atlanta. He has practiced Chinese medicine for over 20 years and has helped hundreds of men and women during this time."His splendidly approachable writing will powerfully allow non-biologists to appreciate the efforts that specialists are making in the pursuit of what is now, and arguably has always been, the foremost goal of humanity: the medical defeat of aging."Aubrey de Grey, PhD, AuthorEnding Aging"Cargal not only carefully explains the mitochondrial essence of aging and illness, but as a traditional Chinese medicine expert suggests herbal, nutraceutical, and vitamin and mineral solutions supporting the most important organelles of our cells -- the mitochondria."Dr. Stephen Sinatra, Author The Sinatra Solution -- Metabolic Cardiology

Power, Sex, Suicide

Author : Nick Lane
Publisher : OUP Oxford
ISBN 13 : 9780191513015
Total Pages : 370 pages
Book Rating : 4.5/5 (13 download)

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Book Synopsis Power, Sex, Suicide by : Nick Lane

Download or read book Power, Sex, Suicide written by Nick Lane and published by OUP Oxford. This book was released on 2005-10-13 with total page 370 pages. Available in PDF, EPUB and Kindle. Book excerpt: Mitochondria are tiny structures located inside our cells that carry out the essential task of producing energy for the cell. They are found in all complex living things, and in that sense, they are fundamental for driving complex life on the planet. But there is much more to them than that. Mitochondria have their own DNA, with their own small collection of genes, separate from those in the cell nucleus. It is thought that they were once bacteria living independent lives. Their enslavement within the larger cell was a turning point in the evolution of life, enabling the development of complex organisms and, closely related, the origin of two sexes. Unlike the DNA in the nucleus, mitochondrial DNA is passed down exclusively (or almost exclusively) via the female line. That's why it has been used by some researchers to trace human ancestry daughter-to-mother, to 'Mitochondrial Eve'. Mitochondria give us important information about our evolutionary history. And that's not all. Mitochondrial genes mutate much faster than those in the nucleus because of the free radicals produced in their energy-generating role. This high mutation rate lies behind our ageing and certain congenital diseases. The latest research suggests that mitochondria play a key role in degenerative diseases such as cancer, through their involvement in precipitating cell suicide. Mitochondria, then, are pivotal in power, sex, and suicide. In this fascinating and thought-provoking book, Nick Lane brings together the latest research findings in this exciting field to show how our growing understanding of mitochondria is shedding light on how complex life evolved, why sex arose (why don't we just bud?), and why we age and die. This understanding is of fundamental importance, both in understanding how we and all other complex life came to be, but also in order to be able to control our own illnesses, and delay our degeneration and death. 'An extraordinary account of groundbreaking modern science... The book abounds with interesting and important ideas.' Mark Ridley, Department of Zoology, University of Oxford

The Human Mitochondrial Genome

Author : Giuseppe Gasparre
Publisher : Academic Press
ISBN 13 : 0128196564
Total Pages : 594 pages
Book Rating : 4.1/5 (281 download)

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Book Synopsis The Human Mitochondrial Genome by : Giuseppe Gasparre

Download or read book The Human Mitochondrial Genome written by Giuseppe Gasparre and published by Academic Press. This book was released on 2020-08-19 with total page 594 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Human Mitochondrial Genome: From Basic Biology to Disease offers a comprehensive, up-to-date examination of human mitochondrial genomics, connecting basic research to translational medicine across a range of disease types. Here, international experts discuss the essential biology of human mitochondrial DNA (mtDNA), including its maintenance, repair, segregation, and heredity. Furthermore, mtDNA evolution and exploitation, mutations, methods, and models for functional studies of mtDNA are dealt with. Disease discussion is accompanied by approaches for treatment strategies, with disease areas discussed including cancer, neurodegenerative, age-related, mtDNA depletion, deletion, and point mutation diseases. Nucleosides supplementation, mitoTALENs, and mitoZNF nucleases are among the therapeutic approaches examined in-depth. With increasing funding for mtDNA studies, many clinicians and clinician scientists are turning their attention to mtDNA disease association. This book provides the tools and background knowledge required to perform new, impactful research in this exciting space, from distinguishing a haplogroup-defining variant or disease-related mutation to exploring emerging therapeutic pathways. Fully examines recent advances and technological innovations in the field, enabling new mtDNA studies, variant and mutation identification, pathogenic assessment, and therapies Disease discussion accompanied by diagnostic and therapeutic strategies currently implemented clinically Outlines and discusses essential research protocols and perspectives for young scientists to pick up Features an international team of authoritative contributors from basic biologists to clinician-scientists