The Hsp60 Chaperonin

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The Hsp60 Chaperonin

Author : Peter Bross
Publisher : Springer
ISBN 13 : 331926088X
Total Pages : 92 pages
Book Rating : 4.3/5 (192 download)

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Book Synopsis The Hsp60 Chaperonin by : Peter Bross

Download or read book The Hsp60 Chaperonin written by Peter Bross and published by Springer. This book was released on 2015-12-08 with total page 92 pages. Available in PDF, EPUB and Kindle. Book excerpt: In this unique overview of the Hsp60 chaperonin, Peter Bross addresses molecular biologists, medical research scientists and individuals interested in molecular or general biology. First, Bross discusses the basics of the Hsp60 chaperonin in terms of its structure and the molecular mechanisms determining its function. Second, the author highlights the multiple roles of Hsp60 for cellular systems and regulatory pathways, especially in connection with neurodegenerative diseases caused by Hsp60 deficiency. Finally, the author highlights controversial observations suggesting additional, non-standard functions of Hsp60 in and outside mitochondria as well as possible gaps in our understanding of the chaperonin. This volume serves as a snapshot suitable for experienced researcher working in fields related to molecular chaperones yet still accessible to researchers entering the field.

The Chaperonopathies

Author : Alberto J.L. Macario
Publisher : Springer Science & Business Media
ISBN 13 : 9400746679
Total Pages : 126 pages
Book Rating : 4.4/5 (7 download)

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Book Synopsis The Chaperonopathies by : Alberto J.L. Macario

Download or read book The Chaperonopathies written by Alberto J.L. Macario and published by Springer Science & Business Media. This book was released on 2013-04-10 with total page 126 pages. Available in PDF, EPUB and Kindle. Book excerpt: This Brief provides a concise review of chaperonopathies, i.e., diseases in which molecular chaperones play an etiologic-pathogenic role. Introductory chapters deal with the chaperoning system and chaperoning teams and networks, HSP-chaperone subpopulations, the locations and functions of chaperones, and chaperone genes in humans. Other chapters present the chaperonopathies in general, including their molecular features and mechanistic classification into by defect, excess, or mistake. Subsequent chapters discuss the chaperonopathies in more detail, focusing on their distinctive characteristics: primary or secondary; quantitative and/or qualitative; structural and hereditary or acquired; genetic polymorphisms; gene dysregulation; age-related; associated with cancer, chronic inflammatory conditions, and autoimmune diseases. The interconnections between the chaperoning and the immune systems in cancer development, chronic inflammation, autoimmunity, and ageing are outlined, which leads to a discussion on the future prospects of chaperonotherapy. The latter may consist of chaperone gene and protein replacement/supplementation in cases of deficiency and of gene or protein blocking when the chaperone actively promotes disease. The last chapter presents the extracellular chaperones and details on how the chaperone Hsp60 is secreted into the extracellular space and, thus, appears in the blood of cancer patients with potential to participate in carcinogenesis and chronic inflammation and autoimmunity. Chaperones as clinically useful biomarkers are mentioned when pertinent. Likewise, guidelines for clinical evaluation of chaperonopathies and for their histopathological and molecular identification are provided throughout. The book also provides extensive bibliography organized by chapter and topic with comments.

HSP60 Family of Chaperonins

Author : Kevin Patrick O'Reilly
Publisher :
ISBN 13 :
Total Pages : 328 pages
Book Rating : 4.:/5 (318 download)

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Book Synopsis HSP60 Family of Chaperonins by : Kevin Patrick O'Reilly

Download or read book HSP60 Family of Chaperonins written by Kevin Patrick O'Reilly and published by . This book was released on 1997 with total page 328 pages. Available in PDF, EPUB and Kindle. Book excerpt:

The Chaperonins

Author : Robert L. Ellis
Publisher : Elsevier
ISBN 13 : 0080528880
Total Pages : 339 pages
Book Rating : 4.0/5 (85 download)

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Book Synopsis The Chaperonins by : Robert L. Ellis

Download or read book The Chaperonins written by Robert L. Ellis and published by Elsevier. This book was released on 1996-04-01 with total page 339 pages. Available in PDF, EPUB and Kindle. Book excerpt: The first of its kind, this volume presents the latest research findings on the chaperonins, the best studied family of a class of proteins known as molecular chaperones. These findings are changing our view of some fundamental cellular processes involving proteins, especially how proteins fold into their functional conformations. Origins of the new view of protein folding Prokaryotic chaperonins Eukaryotic chaperonins Evolution of the chaperonins Refolding of denatured proteins Organelle biosynthesis Biomedical aspects

Heat Shock Protein 60 in Human Diseases and Disorders

Author : Alexzander A. A. Asea
Publisher : Springer Nature
ISBN 13 : 3030231542
Total Pages : 363 pages
Book Rating : 4.0/5 (32 download)

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Book Synopsis Heat Shock Protein 60 in Human Diseases and Disorders by : Alexzander A. A. Asea

Download or read book Heat Shock Protein 60 in Human Diseases and Disorders written by Alexzander A. A. Asea and published by Springer Nature. This book was released on 2019-10-31 with total page 363 pages. Available in PDF, EPUB and Kindle. Book excerpt: The book Heat Shock Protein 60 in Human Diseases and Disorders provides the most comprehensive review on contemporary knowledge on the role of HSP60 in human diseases and disorders. Using an integrative approach, the contributors provide a synopsis of novel mechanisms and signal transduction pathways. To enhance the ease of reading and comprehension the book has further been subdivided into various section including; Section I: Biomolecular Aspects of HSP60; Section II: HSP60 and Cancer; Section III: HSP60 and Inflammatory Diseases and Disorders; Section IV: HSP60 and Cardiovascular Diseases and Disorders; Section V: HSP60 and Neurological and Neurosciences; Section VI: Biomolecular Aspects of HSP60; Section VII: HSP60 and Skeletal Muscle Diseases and Disorders; and Section VIII: HSP60 in Human Health. Key basic and clinical research laboratories from major universities, academic medical hospitals, biotechnology and pharmaceutical laboratories around the world have contributed chapters that review present research activity and importantly project the field into the future. The book is a must read for graduate students. medical students, basic science researchers and postdoctoral scholars in the fields of Translational Medicine, Clinical Research, Human Physiology, Biotechnology, Neurology & Neuroscience, Oncology, Cardiovascular Disease, Skeletal Muscle Diseases and Disorders, Cell & Molecular Medicine, Pharmaceutical Scientists and Researchers involved in Drug Discovery.

The Molecular Basis of Hyperthermophily

Author : National Aeronautics and Space Administration (NASA)
Publisher : Createspace Independent Publishing Platform
ISBN 13 : 9781721515738
Total Pages : 24 pages
Book Rating : 4.5/5 (157 download)

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Book Synopsis The Molecular Basis of Hyperthermophily by : National Aeronautics and Space Administration (NASA)

Download or read book The Molecular Basis of Hyperthermophily written by National Aeronautics and Space Administration (NASA) and published by Createspace Independent Publishing Platform. This book was released on 2018-06-20 with total page 24 pages. Available in PDF, EPUB and Kindle. Book excerpt: In this study, we aim to understand how S. shibatae copes with high temperatures. In particular, we investigated the role of the 60 kDa heat shock protein (HSP60 or chaperonin) with the hypothesis that chaperonin stabilizes the cell membrane under stressful conditions. To prove the hypothesis, this year two questions were addressed: (1) Is the chaperonin localized in the cytoplasm or on the cell membrane? (2) Does the chaperonin show affinity to lipid in vivo? In addition to those, we intensively studied newly discovered chaperonin-related protein, gamma, to understand how it influenced the function of the other components of chaperonin and how their combined activities contributed to hyperthermophily. Kagawa, Hiromi Ames Research Center

Chaperonin Protocols

Author : Christine Schneider
Publisher : Springer Science & Business Media
ISBN 13 : 1592590616
Total Pages : 212 pages
Book Rating : 4.5/5 (925 download)

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Book Synopsis Chaperonin Protocols by : Christine Schneider

Download or read book Chaperonin Protocols written by Christine Schneider and published by Springer Science & Business Media. This book was released on 2008-02-05 with total page 212 pages. Available in PDF, EPUB and Kindle. Book excerpt:

The mitochondrial chaperonin complex Hsp60

Author :
Publisher :
ISBN 13 :
Total Pages : pages
Book Rating : 4.:/5 (929 download)

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Book Synopsis The mitochondrial chaperonin complex Hsp60 by :

Download or read book The mitochondrial chaperonin complex Hsp60 written by and published by . This book was released on with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:

Protein Folding in the Cell

Author :
Publisher : Elsevier
ISBN 13 : 0080522408
Total Pages : 516 pages
Book Rating : 4.0/5 (85 download)

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Book Synopsis Protein Folding in the Cell by :

Download or read book Protein Folding in the Cell written by and published by Elsevier. This book was released on 2002-02-20 with total page 516 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume of Advances in Protein Chemistry provides a broad, yet deep look at the cellular components that assist protein folding in the cell. This area of research is relatively new--10 years ago these components were barely recognized, so this book is a particularly timely compilation of current information. Topics covered include a review of the structure and mechanism of the major chaperone components, prion formation in yeast, and the use of microarrays in studying stress response. Outlines preceding each chapter allow the reader to quickly access the subjects of greatest interest. The information presented in this book should appeal to biochemists, cell biologists, and structural biologists.

Encyclopedia of Signaling Molecules

Author : Sangdun Choi
Publisher : Springer
ISBN 13 : 9781493968008
Total Pages : 6330 pages
Book Rating : 4.9/5 (68 download)

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Book Synopsis Encyclopedia of Signaling Molecules by : Sangdun Choi

Download or read book Encyclopedia of Signaling Molecules written by Sangdun Choi and published by Springer. This book was released on 2017-12-15 with total page 6330 pages. Available in PDF, EPUB and Kindle. Book excerpt: The second edition of this encyclopedia presents over 400 biologically important signaling molecules and the content is built on the core concepts of their functions along with early findings written by some of the world’s foremost experts. The molecules are described by recognized leaders in each molecule. The interactions of these single molecules in signal transduction networks will also be explored. This encyclopedia marks a new era in overview of current cellular signaling molecules for the specialist and the interested non-specialist alike. Currently, there are more than 30,000 genes in human genome. However, not all the proteins encoded by these genes work equally in order to maintain homeostasis. Understanding the important signaling molecules as completely as possible will significantly improve our research-based teaching and scientific capabilities.

Stress-Inducible Cellular Responses

Author : U. Feige
Publisher : Birkhäuser
ISBN 13 : 3034890885
Total Pages : 487 pages
Book Rating : 4.0/5 (348 download)

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Book Synopsis Stress-Inducible Cellular Responses by : U. Feige

Download or read book Stress-Inducible Cellular Responses written by U. Feige and published by Birkhäuser. This book was released on 2013-03-11 with total page 487 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book will deal with heat shock proteins and more generally with stress-related inducible gene expression as a pleiotropic adaptive response to stress. It presents a textbook-like overview of the field not only to heat shock experts, but to physiologists, pharmacologists, physicians, neuropsychologists and others as well. It is intended to be a state-of-the-art and perspective book rather than an up-to-date presentation of recent data. It should provide a basis for new experimetal approaches to fields at the edge of the classical heat shock field. Drugs, UV irradiation and environmental toxics will be considered as important modulators of the stress response. Radical scavengers such as superoxide dismutases and inducible regulatory proteins of metallic ion status such as ferritin as well as immunophilins and protein disulfide isomerases will be considered within the frame of stress proteins. The potential practical applications of heat shock proteins in toxicology and medicine for the diagnosis, prognosis and eventually therapy of clinical conditions associated with an increased oxidative burden will be outlined. The role of heat shock proteins in the modulation of immune responses will also be included. The book considers heat shock from a broad perspective including fields for which heat-shock may become of importance in the very near future such as cellular responses to environmental stresses and complex stress responses under specific conditions. It was also felt timely to incorporate a whole section on medical and technological applications of stress proteins. The book will be invaluable for all those working on stress and is intended for every "stress laboratory" as a source of knowledge and perspectives.

Heat Shock Proteins in Cancer

Author : Stuart K. Calderwood
Publisher : Springer Science & Business Media
ISBN 13 : 1402064012
Total Pages : 399 pages
Book Rating : 4.4/5 (2 download)

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Book Synopsis Heat Shock Proteins in Cancer by : Stuart K. Calderwood

Download or read book Heat Shock Proteins in Cancer written by Stuart K. Calderwood and published by Springer Science & Business Media. This book was released on 2007-09-09 with total page 399 pages. Available in PDF, EPUB and Kindle. Book excerpt: Heat shock proteins are emerging as important molecules in the development of cancer and as key targets in cancer therapy. These proteins enhance the growth of cancer cells and protect tumors from treatments such as drugs or surgery. However, new drugs have recently been developed particularly those targeting heat shock protein 90. As heat shock protein 90 functions to stabilize many of the oncogenes and growth promoting proteins in cancer cells, such drugs have broad specificity in many types of cancer cell and offer the possibility of evading the development of resistance through point mutation or use of compensatory pathways. Heat shock proteins have a further property that makes them tempting targets in cancer immunotherapy. These proteins have the ability to induce an inflammatory response when released in tumors and to carry tumor antigens to antigen presenting cells. They have thus become important components of anticancer vaccines. Overall, heat shock proteins are important new targets in molecular cancer therapy and can be approached in a number of contrasting approaches to therapy.

The Multitasking Molecular Chaperone HSP60

Author : Francesco Cappello
Publisher : Elsevier
ISBN 13 : 0443239975
Total Pages : 0 pages
Book Rating : 4.4/5 (432 download)

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Book Synopsis The Multitasking Molecular Chaperone HSP60 by : Francesco Cappello

Download or read book The Multitasking Molecular Chaperone HSP60 written by Francesco Cappello and published by Elsevier. This book was released on 2024-11-14 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Multitasking Molecular Chaperone HSP60: Structure, Function, and Impact on Health and Disease provides a complete overview of HSP60. It analyzes the molecular structure, localization and functions of HSP60 in normal and pathological cells and tissues in humans. The book then moves on to discuss the role of abnormal HSP60 in disease, considering it across a wide range of skin disorders, heart and blood vessel diseases, respiratory diseases and digestive disorders among others. Genetic chaperonopathies are also covered, and the book moves on to discussion of Hsp60-based therapeutic strategies that can be implemented in the treatment of some diseases. This book is an invaluable reference for researchers and students in molecular biology, biochemistry, biophysics, biomedicine, pharmacology and related life sciences. Discusses therapeutic strategies for diagnosis, patient monitoring, and treatment of disorders in which HSP60 plays a role Considers the fundamental biophysics, genetics, and comparative phylogeny of HSP60 Explores the mechanisms involving HSP60 abnormalities that lead to disease, including carcinogenesis, inflammation, autoimmunity, and neurodegenerative disorders

Prokaryotic Chaperonins

Author : C. M. Santosh Kumar
Publisher : Springer
ISBN 13 : 9811046514
Total Pages : 172 pages
Book Rating : 4.8/5 (11 download)

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Book Synopsis Prokaryotic Chaperonins by : C. M. Santosh Kumar

Download or read book Prokaryotic Chaperonins written by C. M. Santosh Kumar and published by Springer. This book was released on 2017-08-30 with total page 172 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book focuses on a topical and timely aspect of prokaryotic biology - the biology of prokaryotic multiple chaperonins. Chaperonins are a class of molecular chaperones, the proteins that assist folding of other proteins in the cell. The book begins with an introductory chapter on the structural and functional aspects of chaperonins, followed by an outline on different mechanisms of their regulation. Subsequently, the book provides a comprehensive overview on how the multiple-chaperonins have embraced biological requirements in different classes of microbes, discussing their functional diversity, evolutionary paths and the latest advances in the field. It brings together leading experts from across the globe in offering a detailed account of the structural, biochemical, functional and phylogenetic characteristics of microbial chaperonins for students, researchers and teachers working in the area of microbiology/ biophysics/ parasitology – more specifically, in protein folding pathways.

Heat Stress Tolerance in Plants

Author : Shabir H. Wani
Publisher : John Wiley & Sons
ISBN 13 : 1119432367
Total Pages : 315 pages
Book Rating : 4.1/5 (194 download)

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Book Synopsis Heat Stress Tolerance in Plants by : Shabir H. Wani

Download or read book Heat Stress Tolerance in Plants written by Shabir H. Wani and published by John Wiley & Sons. This book was released on 2020-04-06 with total page 315 pages. Available in PDF, EPUB and Kindle. Book excerpt: Demystifies the genetic, biochemical, physiological, and molecular mechanisms underlying heat stress tolerance in plants Heat stress—when high temperatures cause irreversible damage to plant function or development—severely impairs the growth and yield of agriculturally important crops. As the global population mounts and temperatures continue to rise, it is crucial to understand the biochemical, physiological, and molecular mechanisms of thermotolerance to develop ‘climate-smart’ crops. Heat Stress Tolerance in Plants provides a holistic, cross-disciplinary survey of the latest science in this important field. Presenting contributions from an international team of plant scientists and researchers, this text examines heat stress, its impact on crop plants, and various mechanisms to modulate tolerance levels. Topics include recent advances in molecular genetic approaches to increasing heat tolerance, the potential role of biochemical and molecular markers in screening germplasm for thermotolerance, and the use of next-generation sequencing to unravel the novel genes associated with defense and metabolite pathways. This insightful book: Places contemporary research on heat stress in plants within the context of global climate change and population growth Includes diverse analyses from physiological, biochemical, molecular, and genetic perspectives Explores various approaches to increasing heat tolerance in crops of high commercial value, such as cotton Discusses the applications of plant genomics in the development of thermotolerant ‘designer crops’ An important contribution to the field, Heat Stress Tolerance in Plants is an invaluable resource for scientists, academics, students, and researchers working in fields of pulse crop biochemistry, physiology, genetics, breeding, and biotechnology.

Heat Shock Proteins in Human Diseases

Author : Alexzander A. A. Asea
Publisher : Springer Nature
ISBN 13 : 3030622894
Total Pages : 297 pages
Book Rating : 4.0/5 (36 download)

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Book Synopsis Heat Shock Proteins in Human Diseases by : Alexzander A. A. Asea

Download or read book Heat Shock Proteins in Human Diseases written by Alexzander A. A. Asea and published by Springer Nature. This book was released on 2021-03-23 with total page 297 pages. Available in PDF, EPUB and Kindle. Book excerpt: The book Heat Shock Proteins in Cancer Therapeutics provides the most comprehensive review on contemporary knowledge on the role of HSP in various types of cancer therapeutics. Using an integrative approach, the contributors provide a synopsis of the most current updates on the state of HSP in cancer therapeutics. The heat shock response pathway is a highly conserved cellular process. Heat shock factors are a master transcriptional regulator responsible for expression of several important heat shock proteins, which can effectively protect critical client proteins from misfolding and degradation, thus maintaining intracellular integrity under stressed conditions. Recent studies have demonstrated the direct connections between heat shock response players and tumor cell survival, validating heat shock response players as novel molecular targets in anticancer treatment. Although many hurdles in clinical application still need to be effectively addressed, such as undesirable drug toxicity and off target effects; narrow therapeutic window; poor PK/PD profiles, etc. Recent reports on synergistic drug combination, advanced prodrug design, smart nanoparticle packaging, and RNA aptamer selection offer promising solutions to overcome these challenges. Future advancements in this fast-growing area can potentially lead to the next generation of cancer therapeutics. Key basic and clinical research laboratories from major universities, academic medical hospitals, biotechnology and pharmaceutical laboratories around the world have contributed chapters that review present research activity and importantly project the field into the future. The book is a must read for graduate students. medical students, basic science researchers and postdoctoral scholars in the fields of Cancer Biology, Oncology, Translational Medicine, Clinical Research, Biotechnology, Cell & Molecular Medicine, Pharmaceutical Scientists and Researchers involved in Drug Discovery.

Encyclopedia of Cancer

Author : Manfred Schwab
Publisher : Springer Science & Business Media
ISBN 13 : 3540368477
Total Pages : 3307 pages
Book Rating : 4.5/5 (43 download)

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Book Synopsis Encyclopedia of Cancer by : Manfred Schwab

Download or read book Encyclopedia of Cancer written by Manfred Schwab and published by Springer Science & Business Media. This book was released on 2008-09-23 with total page 3307 pages. Available in PDF, EPUB and Kindle. Book excerpt: This comprehensive encyclopedic reference provides rapid access to focused information on topics of cancer research for clinicians, research scientists and advanced students. Given the overwhelming success of the first edition, which appeared in 2001, and fast development in the different fields of cancer research, it has been decided to publish a second fully revised and expanded edition. With an A-Z format of over 7,000 entries, more than 1,000 contributing authors provide a complete reference to cancer. The merging of different basic and clinical scientific disciplines towards the common goal of fighting cancer makes such a comprehensive reference source all the more timely.