The Effects Of Lymph Node Status On Predicting Outcome In Er Her2 Tamoxifen Treated Breast Cancer Patients Using Gene Signatures

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The Effects of Lymph Node Status on Predicting Outcome in ER+ /HER2- Tamoxifen Treated Breast Cancer Patients Using Gene Signatures

Author : Cali Cali Press
Publisher :
ISBN 13 : 9781542335829
Total Pages : 40 pages
Book Rating : 4.3/5 (358 download)

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Book Synopsis The Effects of Lymph Node Status on Predicting Outcome in ER+ /HER2- Tamoxifen Treated Breast Cancer Patients Using Gene Signatures by : Cali Cali Press

Download or read book The Effects of Lymph Node Status on Predicting Outcome in ER+ /HER2- Tamoxifen Treated Breast Cancer Patients Using Gene Signatures written by Cali Cali Press and published by . This book was released on 2017-01-03 with total page 40 pages. Available in PDF, EPUB and Kindle. Book excerpt: Lymph node (LN) status is the most important prognostic variable used to guide ER positive (+) breast cancer treatment. While a positive nodal status is traditionally associated with a poor prognosis, a subset of these patients respond well to treatment and achieve long-term survival. Several gene signatures have been established as a means of predicting outcome of breast cancer patients, but the development and indication for use of these assays varies. Here we compare the capacity of two approved gene signatures and a third novel signature to predict outcome in distinct LN negative (-) and LN+ populations. We also examine biological differences between tumours associated with LN- and LN+ disease. Proceeds from the sale of this book go to support an elderly disabled person.

Biomarkers in Breast Cancer

Author : Giampietro Gasparini
Publisher : Springer Science & Business Media
ISBN 13 : 159259915X
Total Pages : 335 pages
Book Rating : 4.5/5 (925 download)

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Book Synopsis Biomarkers in Breast Cancer by : Giampietro Gasparini

Download or read book Biomarkers in Breast Cancer written by Giampietro Gasparini and published by Springer Science & Business Media. This book was released on 2008-01-17 with total page 335 pages. Available in PDF, EPUB and Kindle. Book excerpt: Expert laboratory and clinical researchers from around the world review how to design and evaluate studies of tumor markers and examine their use in breast cancer patients. The authors cover both the major advances in sophisticated molecular methods and the state-of-the-art in conventional prognostic and predictive indicators. Among the topics discussed are the relevance of rigorous study design and guidelines for the validation studies of new biomarkers, gene expression profiling by tissue microarrays, adjuvant systemic therapy, and the use of estrogen, progesterone, and epidermal growth factor receptors as both prognostic and predictive indicators. Highlights include the evaluation of HER2 and EGFR family members, of p53, and of UPA/PAI-1; the detection of rare cells in blood and marrow; and the detection and analysis of soluble, circulating markers.

Adjuvant Therapy for Breast Cancer

Author : Monica Castiglione
Publisher : Springer Science & Business Media
ISBN 13 : 0387751157
Total Pages : 483 pages
Book Rating : 4.3/5 (877 download)

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Book Synopsis Adjuvant Therapy for Breast Cancer by : Monica Castiglione

Download or read book Adjuvant Therapy for Breast Cancer written by Monica Castiglione and published by Springer Science & Business Media. This book was released on 2009-07-11 with total page 483 pages. Available in PDF, EPUB and Kindle. Book excerpt: Adjuvant treatment is administered prior to or as follow up to surgical procedures for breast cancer. Proven success in using medical therapies allowing for breast conserving procedures or reducing risk of occurrence. Although there has been much progress towards a cure, including the introduction of new targeted therapies, metastasizing cancer remains highly incurable.

WHO Classification of Tumours of the Breast

Author : Sunil R. Lakhani
Publisher : World Health Organization
ISBN 13 : 9789283224334
Total Pages : 240 pages
Book Rating : 4.2/5 (243 download)

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Book Synopsis WHO Classification of Tumours of the Breast by : Sunil R. Lakhani

Download or read book WHO Classification of Tumours of the Breast written by Sunil R. Lakhani and published by World Health Organization. This book was released on 2012 with total page 240 pages. Available in PDF, EPUB and Kindle. Book excerpt: WHO Classification of Tumours of the Breast is the fourth volume of the WHO series on histological and genetic typing of human tumours. This authoritative, concise reference book provides an international standard for oncologists and pathologists and will serve as an indispensable guide for use in the design of studies monitoring response to therapy and clinical outcome. Diagnostic criteria, pathological features, and associated genetic alterations are described in a strictly disease-oriented manner. Sections on all recognized neoplasms and their variants include new ICD-O codes, epidemiology, clinical features, macroscopy, pathology, genetics, and prognosis and predictive factors. The book, prepared by 90 authors from 24 countries, contains more than 340 colour photographs, tables and figures, and more than 1600 references.

Adverse Effects of Cancer Chemotherapy: Anything New to Improve Tolerance and Reduce Sequelae?

Author : Kulmira Nurgali
Publisher : Frontiers Media SA
ISBN 13 : 2889454827
Total Pages : 245 pages
Book Rating : 4.8/5 (894 download)

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Book Synopsis Adverse Effects of Cancer Chemotherapy: Anything New to Improve Tolerance and Reduce Sequelae? by : Kulmira Nurgali

Download or read book Adverse Effects of Cancer Chemotherapy: Anything New to Improve Tolerance and Reduce Sequelae? written by Kulmira Nurgali and published by Frontiers Media SA. This book was released on 2018-06-12 with total page 245 pages. Available in PDF, EPUB and Kindle. Book excerpt: Advances in anti-cancer chemotherapy over recent years have led to improved efficacy in curing or controlling many cancers. Some chemotherapy-related side-effects are well recognized and include: nausea, vomiting, bone marrow suppression, peripheral neuropathy, cardiac and skeletal muscle dysfunction and renal impairment. However, it is becoming clearer that some chemotherapy-related adverse effects may persist even in long term cancer survivors. Problems such as cognitive, cardiovascular and gastrointestinal dysfunction, and neuropathy may lead to substantial long term morbidity. Despite improvements in treatments to counteract acute chemotherapy-induced adverse effects, they are often incompletely effective. Furthermore, counter-measures for some acute side-effects and many potential longer term sequelae of anti-cancer chemotherapy have not been developed. Thus, new insights into prevalence and mechanisms of cancer chemotherapy-related side effects are needed and new approaches to improving tolerance and reduce sequelae of cancer chemotherapy are urgently needed. The present Research Topic focuses on adverse effects and sequelae of chemotherapy and strategies to counteract them.

Endocrine Therapy in Breast Cancer

Author : William R. Miller
Publisher : CRC Press
ISBN 13 : 0203909836
Total Pages : 395 pages
Book Rating : 4.2/5 (39 download)

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Book Synopsis Endocrine Therapy in Breast Cancer by : William R. Miller

Download or read book Endocrine Therapy in Breast Cancer written by William R. Miller and published by CRC Press. This book was released on 2002-03-08 with total page 395 pages. Available in PDF, EPUB and Kindle. Book excerpt: This reference evaluates and describes the latest strategies for hormone suppression and blockade in the management of early and advanced stage breast cancer and explores the effects of tamoxifen, selective estrogen receptor modulators (SERMs), aromatase inhibitors, and their combination on both breast cancers and normal tissues. Endocrine T

Journal of the National Cancer Institute

Author :
Publisher :
ISBN 13 :
Total Pages : 572 pages
Book Rating : 4.:/5 (319 download)

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Book Synopsis Journal of the National Cancer Institute by :

Download or read book Journal of the National Cancer Institute written by and published by . This book was released on 2012 with total page 572 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Impact of Gene Expression Profiling Tests on Breast Cancer Outcomes

Author : Luigi Marchionni
Publisher : DIANE Publishing
ISBN 13 : 1437911048
Total Pages : 230 pages
Book Rating : 4.4/5 (379 download)

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Book Synopsis Impact of Gene Expression Profiling Tests on Breast Cancer Outcomes by : Luigi Marchionni

Download or read book Impact of Gene Expression Profiling Tests on Breast Cancer Outcomes written by Luigi Marchionni and published by DIANE Publishing. This book was released on 2009-05 with total page 230 pages. Available in PDF, EPUB and Kindle. Book excerpt: Assesses the evidence that three marketed gene expression-based assays improve prognostic accuracy, treatment choice, and health outcomes in women diagnosed with early stage breast cancer. Three gene expression assays were evaluated; Oncotype DX¿, MammaPrint® and the Breast Cancer Profiling (BCP or H/I ratio) test, and for gene expression signatures underlying the assays. They sought evidence on: analytic performance of tests; clinical validity; clinical utility; harms; and impact on clinical decision making and health care costs. Conclusions: Oncotype DX is furthest along the validation pathway, with retrospective evidence that it predicts distant spread and chemotherapy benefit to a clinically relevant extent over standard predictors. Illus.

Molecular Subtypes of Estrogen Receptor Positive Breast Cancers Predict Clinical Behavior

Author : Daniel Alan Kerr
Publisher :
ISBN 13 :
Total Pages : 388 pages
Book Rating : 4.:/5 (682 download)

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Book Synopsis Molecular Subtypes of Estrogen Receptor Positive Breast Cancers Predict Clinical Behavior by : Daniel Alan Kerr

Download or read book Molecular Subtypes of Estrogen Receptor Positive Breast Cancers Predict Clinical Behavior written by Daniel Alan Kerr and published by . This book was released on 2010 with total page 388 pages. Available in PDF, EPUB and Kindle. Book excerpt: Current markers for breast cancer, ER, PR, EGFR and HER-2/neu imperfectly predict prognosis or therapy response. Studies by my mentor revealed distinct molecular subtypes with different clinical characteristics using gene expression profiles from LCM-procured carcinoma cells. Subtypes A and B, although exhibiting ER-positive cancers, had vastly different clinical outcomes. The goal was to derive a clinically relevant subset of genes that predicts breast cancer behavior. Using ERTargetDB and literature review, a ten gene subset of estrogen receptor-associated genes among 100 candidates was validated by qPCR and correlated with biochemical and clinical parameters in primary breast cancer biopsies. These results were combined with expression of genes for conventional biomarkers and assessed for prediction of prognosis in a population of ER-positive, early stage primary breast cancers. All genes except PTGDS exhibited a positive relationship with ER and PR levels. Expression of subtype A genes (BCL2, CAXII, ERBB4, LIV1 and RERG) was significantly decreased in cancers exhibiting increased EGFR protein, although this relationship was not observed for HER-2/neu. Subtype B genes were not altered as a function of EGFR or HER-2/neu levels. Expression of subtype A genes was significantly decreased in cancers with positive lymph nodes, higher grade and larger tumors compared to cancers with subtype B gene expression. Surprisingly, PGR gene expression independently predicted prognosis. Survival analyses of ER+/PR+ cancers revealed multi-gene models classifying risk of recurrence and mortality. LIV1, CD34, EDG1 and NQO1 expression distinguished prognosis differently in node-negative breast cancers compared to the node-positive population. Compared to standard clinical indicators of prognosis using the Adjuvant! Online algorithm, multi-gene models provided superior assessment of risk of recurrence and mortality. Survival analyses of patients with ER+/PR+ breast cancers treated with adjuvant Tamoxifen revealed three multi-gene models significantly predicting recurrence and mortality even after adjusting for age, nodal status, chemotherapy and radiation therapy. Bayesian modeling applied in silico using microarray data identified regulatory networks involving interactions among the ten candidate genes suggesting relationships with cancer differentiation and growth. In summary, a novel subset of 14 ER-associated genes was derived that both predicts risk of recurrence of breast carcinoma and response to Tamoxifen treatment.

AJCC Cancer Staging Manual

Author : Frederick L, Greene
Publisher : Springer Science & Business Media
ISBN 13 : 1475736568
Total Pages : 386 pages
Book Rating : 4.4/5 (757 download)

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Book Synopsis AJCC Cancer Staging Manual by : Frederick L, Greene

Download or read book AJCC Cancer Staging Manual written by Frederick L, Greene and published by Springer Science & Business Media. This book was released on 2013-11-21 with total page 386 pages. Available in PDF, EPUB and Kindle. Book excerpt: The American Joint Committee on Cancer's Cancer Staging Manual is used by physicians throughout the world to diagnose cancer and determine the extent to which cancer has progressed. All of the TNM staging information included in this Sixth Edition is uniform between the AJCC (American Joint Committee on Cancer) and the UICC (International Union Against Cancer). In addition to the information found in the Handbook, the Manual provides standardized data forms for each anatomic site, which can be utilized as permanent patient records, enabling clinicians and cancer research scientists to maintain consistency in evaluating the efficacy of diagnosis and treatment. The CD-ROM packaged with each Manual contains printable copies of each of the book’s 45 Staging Forms.

Clinical Gynecology

Author : Eric J. Bieber
Publisher : Cambridge University Press
ISBN 13 : 1107040396
Total Pages : 1127 pages
Book Rating : 4.1/5 (7 download)

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Book Synopsis Clinical Gynecology by : Eric J. Bieber

Download or read book Clinical Gynecology written by Eric J. Bieber and published by Cambridge University Press. This book was released on 2015-04-23 with total page 1127 pages. Available in PDF, EPUB and Kindle. Book excerpt: Written with the busy practice in mind, this book delivers clinically focused, evidence-based gynecology guidance in a quick-reference format. It explores etiology, screening, tests, diagnosis, and treatment for a full range of gynecologic health issues. The coverage includes the full range of gynecologic malignancies, reproductive endocrinology and infertility, infectious diseases, urogynecologic problems, gynecologic concerns in children and adolescents, and surgical interventions including minimally invasive surgical procedures. Information is easy to find and absorb owing to the extensive use of full-color diagrams, algorithms, and illustrations. The new edition has been expanded to include aspects of gynecology important in international and resource-poor settings.

Abeloff's Clinical Oncology E-Book

Author : Martin D. Abeloff
Publisher : Elsevier Health Sciences
ISBN 13 : 1437720560
Total Pages : 2586 pages
Book Rating : 4.4/5 (377 download)

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Book Synopsis Abeloff's Clinical Oncology E-Book by : Martin D. Abeloff

Download or read book Abeloff's Clinical Oncology E-Book written by Martin D. Abeloff and published by Elsevier Health Sciences. This book was released on 2008-06-30 with total page 2586 pages. Available in PDF, EPUB and Kindle. Book excerpt: Carrying on the tradition established by its founding editor, the late Dr. Martin Abeloff, the 4th Edition of this respected reference synthesizes all of the latest oncology knowledge in one practical, clinically focused, easy-to-use volume. It incorporates basic science, pathology, diagnosis, management, outcomes, rehabilitation, and prevention – all in one convenient resource – equipping you to overcome your toughest clinical challenges. What's more, you can access the complete contents of this Expert Consult title online, and tap into its unparalleled guidance wherever and whenever you need it most! Equips you to select the most appropriate tests and imaging studies for diagnosing and staging each type of cancer, and manage your patients most effectively using all of the latest techniques and approaches. Explores all of the latest scientific discoveries' implications for cancer diagnosis and management. Employs a multidisciplinary approach - with contributions from pathologists, radiation oncologists, medical oncologists, and surgical oncologists - for well-rounded perspectives on the problems you face. Offers a user-friendly layout with a consistent chapter format • summary boxes • a full-color design • and more than 1,445 illustrations (1,200 in full color), to make reference easy and efficient. Offers access to the book's complete contents online – fully searchable – from anyplace with an Internet connection. Presents discussions on cutting-edge new topics including nanotechnology, functional imaging, signal transduction inhibitors, hormone modulators, complications of transplantation, and much more. Includes an expanded color art program that highlights key points, illustrates relevant science and clinical problems, and enhances your understanding of complex concepts.

Molecular Pathology of Breast Cancer

Author : Sunil Badve
Publisher : Springer
ISBN 13 : 3319417614
Total Pages : 427 pages
Book Rating : 4.3/5 (194 download)

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Book Synopsis Molecular Pathology of Breast Cancer by : Sunil Badve

Download or read book Molecular Pathology of Breast Cancer written by Sunil Badve and published by Springer. This book was released on 2016-11-26 with total page 427 pages. Available in PDF, EPUB and Kindle. Book excerpt: The complex landscape of breast cancer requires distinct strategies for the management of various molecular subtypes of this disease. Rapid advances in the field of molecular biology have been bewildering for those involved in its study and management. “Molecular Pathology of Breast Cancer” aims to close this knowledge gap by discussing comprehensively the evolution, biological basis and clinical applications with a focus on the “what, when, and how” of the most significant molecular markers known to date. These markers are evaluated in the context of genomic, transcriptomic and proteomic profiles, which is integral to the practice of precision medicine. The application of next generation sequencing (NGS) has provided new insights in the regulation of genomic and transcriptomic structure and function. Alterations in DNA such as mutations and single nucleotide polymorphisms (SNPs) have been correlated with outcomes and provide for novel therapeutic approaches. These NGS analyses have also revealed the extensive contributions of epigenetic mechanisms such as histone modifications, non-coding RNA and alternative splicing. All of these changes together contribute to alterations in proteome. Newer assays that allow greater stability and analytical consistency are emerging. These alterations in tumor profiles can be also now detected by imaging techniques. The heterogeneity of both tumor and tumor microenvironment, an inevitable reality, is discussed in detail with particular focus on cancer stem cells and immune signaling. A chapter is dedicated to the emerging technology of “liquid biopsy”, which opens a novel approach for “continuous” monitoring of cancer that might be superior to conventional diagnostics, “Molecular Pathology of Breast Cancer” provides a quick and easy, not to mention essential, tour for clinicians, pathologists and scientists who are seeking to understand the integration of molecular biology into the diagnosis, prognosis and management of breast cancer.

Handbook of Metastatic Breast Cancer

Author : Charles Swanton
Publisher : CRC Press
ISBN 13 : 1841848123
Total Pages : 314 pages
Book Rating : 4.8/5 (418 download)

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Book Synopsis Handbook of Metastatic Breast Cancer by : Charles Swanton

Download or read book Handbook of Metastatic Breast Cancer written by Charles Swanton and published by CRC Press. This book was released on 2011-11-14 with total page 314 pages. Available in PDF, EPUB and Kindle. Book excerpt: Recent developments with novel systemic drugs, palliative surgical techniques and diagnostic imaging have given hope for the treatment of patients whose breast cancer has spread beyond its primary tumour. Written by a team from leading cancer centers in Europe, including the UK's Royal Marsden Hospital, the Handbook of Metastatic Breast Cancer, Sec

Bioinformatics Analysis of Omics Data for Biomarker Identification in Clinical Research

Author : Lixin Cheng
Publisher : Frontiers Media SA
ISBN 13 : 2889716635
Total Pages : 574 pages
Book Rating : 4.8/5 (897 download)

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Book Synopsis Bioinformatics Analysis of Omics Data for Biomarker Identification in Clinical Research by : Lixin Cheng

Download or read book Bioinformatics Analysis of Omics Data for Biomarker Identification in Clinical Research written by Lixin Cheng and published by Frontiers Media SA. This book was released on 2022-01-10 with total page 574 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Clinical Oncology

Author : Martin D. Abeloff
Publisher :
ISBN 13 : 9780443075452
Total Pages : 0 pages
Book Rating : 4.0/5 (754 download)

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Book Synopsis Clinical Oncology by : Martin D. Abeloff

Download or read book Clinical Oncology written by Martin D. Abeloff and published by . This book was released on 2000 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: A must-have reference, this new edition provides practical information on treatment guidelines, details of diagnosis and therapy, and personal recommendations on patient management from experts in the field. Consistently formatted chapters allow for a user-friendly presentation for quick access of key information by the practicing clinician. Completely updated, this new edition includes all of the latest developments in treatment strategies of medical, surgical and radiation oncologists.

Diagnostic Histopathology of Tumors

Author : Christopher D. M. Fletcher
Publisher : Elsevier Health Sciences
ISBN 13 : 1455737542
Total Pages : 2294 pages
Book Rating : 4.4/5 (557 download)

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Book Synopsis Diagnostic Histopathology of Tumors by : Christopher D. M. Fletcher

Download or read book Diagnostic Histopathology of Tumors written by Christopher D. M. Fletcher and published by Elsevier Health Sciences. This book was released on 2013-04-02 with total page 2294 pages. Available in PDF, EPUB and Kindle. Book excerpt: Diagnose tumors with confidence with Diagnostic Histopathology of Tumors, 4th Edition. Dr. Christopher Fletcher's renowned reference provides the advanced, expert guidance you need to evaluate and interpret even the most challenging histopathology specimens more quickly and accurately. Consult this title on your favorite e-reader with intuitive search tools and adjustable font sizes. Elsevier eBooks provide instant portable access to your entire library, no matter what device you're using or where you're located. Diagnose efficiently and effectively using diagnostic flow charts, correlations of gross appearances to microscopic findings, and differential diagnosis tables for better recognition and evaluation of similar-looking entities. Employ immunohistochemistry, molecular and genetic diagnostic tests, and other modern techniques as well as the best morphologic diagnostic methods to effectively identify each tumor or tumor-like entity. Utilize new, clinically important molecular genetic data and updated classification schemes to help guide treatment and targeted therapy. Apply the latest techniques and diagnostic criteria with completely rewritten chapters on Small and Large Intestines, Heart, Larynx and Trachea, Ear, and Peritoneum. Find critical information quickly thanks to more tables and bulleted lists throughout.