The Effects Of Extracellular Matrix Components On Chondrocyte Gene Expression

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Mechanosensitive Ion Channels

Author : Andre Kamkin
Publisher : Springer Science & Business Media
ISBN 13 : 1402064268
Total Pages : 390 pages
Book Rating : 4.4/5 (2 download)

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Book Synopsis Mechanosensitive Ion Channels by : Andre Kamkin

Download or read book Mechanosensitive Ion Channels written by Andre Kamkin and published by Springer Science & Business Media. This book was released on 2007-10-06 with total page 390 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book explores the latest data dealing with mechanosensitive channels research results. It was compiled by a group of internationally recognized scientists leading in the field of mechanosensitive ion channels or mechanically gated channels and signaling cascades research. Key problems of cell mechanobiology are also discussed. As a whole, the volume dwells on the major issues of mechanical stress influencing the ion channels and intracellular signaling pathways.

The Extracellular Matrix Factsbook

Author : Shirley Ayad
Publisher : Academic Press
ISBN 13 : 9780120689118
Total Pages : 301 pages
Book Rating : 4.6/5 (891 download)

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Book Synopsis The Extracellular Matrix Factsbook by : Shirley Ayad

Download or read book The Extracellular Matrix Factsbook written by Shirley Ayad and published by Academic Press. This book was released on 1998 with total page 301 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Second Edition of The Extracellular Matrix FactsBook has been completely revised, updated and expanded by over 50 percent. It contains over 85 entries on the diverse group of macromolecules that assemble toform the extracellular matrix. Entries provide information on molecular structure, isolation, primary structure, structural and functional sites, gene structure, database accession numbers, and key references. Key Features * Compiled by members of one of the foremost centers of matrix biochemistry in the world * Contains over 30 new entries, with all previous entries being revised and updated * Includes new entries on proteinases involved in the deposition of the extracellular matrix * Presents 3D ribbon diagrams in cases where the protein structure is now known

The Growth Plate

Author : Irving M. Shapiro
Publisher : IOS Press
ISBN 13 : 9781586032401
Total Pages : 312 pages
Book Rating : 4.0/5 (324 download)

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Book Synopsis The Growth Plate by : Irving M. Shapiro

Download or read book The Growth Plate written by Irving M. Shapiro and published by IOS Press. This book was released on 2002 with total page 312 pages. Available in PDF, EPUB and Kindle. Book excerpt: Evidence generated by a number of genetic studies indicates that growth is regulated by a number of genes and that interference with their expression can have catastrophic effects on the well being of the whole organism. This work covers skeletal development and growth.

Connective Tissue and Its Heritable Disorders

Author : Peter M. Royce
Publisher : John Wiley & Sons
ISBN 13 : 0471461172
Total Pages : 1201 pages
Book Rating : 4.4/5 (714 download)

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Book Synopsis Connective Tissue and Its Heritable Disorders by : Peter M. Royce

Download or read book Connective Tissue and Its Heritable Disorders written by Peter M. Royce and published by John Wiley & Sons. This book was released on 2003-04-14 with total page 1201 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Second Edition of Connective Tissue and Its Heritable Disorders: Molecular, Genetic, and Medical Aspects is the definitive reference text in its field, with over 40% more pages on the nature, diagnosis, and treatment of disease than its predecessor. Collecting new research on disorders detailed in the first edition as well as on those previously excluded, editors Peter Royce and Beat Steinmann provide the most up-to-date clinical and scientific information for medical specialists treating affected individuals. Features of this revised and updated volume include detailed reviews of the clinical diagnosis, mode of inheritance, risk of recurrence, and prenatal diagnosis of each inherited connective tissue disorder; a thorough description of the morphology of connective tissues; a completely updated and revised section on the biology of the extracellular matrix; and the addition of syndromes such as craniosyntosis, and disorders of sulfate metabolism.

Extracellular Matrix in Development

Author : Douglas W. DeSimone
Publisher : Springer Science & Business Media
ISBN 13 : 3642359353
Total Pages : 260 pages
Book Rating : 4.6/5 (423 download)

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Book Synopsis Extracellular Matrix in Development by : Douglas W. DeSimone

Download or read book Extracellular Matrix in Development written by Douglas W. DeSimone and published by Springer Science & Business Media. This book was released on 2013-03-15 with total page 260 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cells in the developing embryo depend on signals from the extracellular environment to help guide their differentiation. An important mediator in this process is the extracellular matrix – secreted macromolecules that interact to form large protein networks outside the cell. During development, the extracellular matrix serves to separate adjacent cell groups, participates in establishing morphogenic gradients, and, through its ability to interact directly will cell-surface receptors, provides developmental clocks and positional information. This volume discusses how the extracellular matrix influences fundamental developmental processes and how model systems can be used to elucidate ECM function. The topics addressed range from how ECM influences early development as well as repair processes in the adult that recapitulate developmental pathways.

Cartilage Molecular Aspects

Author : Brian K. Hall
Publisher : CRC Press
ISBN 13 : 9780849388170
Total Pages : 280 pages
Book Rating : 4.3/5 (881 download)

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Book Synopsis Cartilage Molecular Aspects by : Brian K. Hall

Download or read book Cartilage Molecular Aspects written by Brian K. Hall and published by CRC Press. This book was released on 1991-06-18 with total page 280 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cartilage plays diverse roles as a definitive supporting tissue in some organs, the basis of low friction surfaces in joints, and a transient morphogenetic template during embryogenesis and repair of the skeleton. The versatility of cartilage is derived from the remarkable material properties of its extracellular matrix, the wide spectrum of regulatory systems that influence the synthesis and degradation of the unique molecular constituents of this matrix, and the development and growth of the cells that produce it. This book touches on each of these areas and provides the first comprehensive reviews of the molecular biology of the genes specifying the collagenous and noncollagenous proteins of the cartilage matrix, as well as the biophysical-chemical properties of the matrix that suits it to the various functions it performs. Up-to-date critical reviews of the mineralization and degradation of cartilage matrix, the roles of polypeptide growth and inducing factors, of ions, in the regulation of cartilage growth and development, and the unique requirements of the energy metabolism of cartilage as a nonvascular tissue, make this volume a useful source for concepts and results for the multiple disciplines that play a part in modern cartilage research.

Molecular Biology of the Cell

Author :
Publisher :
ISBN 13 : 9780815332183
Total Pages : 0 pages
Book Rating : 4.3/5 (321 download)

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Book Synopsis Molecular Biology of the Cell by :

Download or read book Molecular Biology of the Cell written by and published by . This book was released on 2002 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Design of Artificial Human Joints & Organs

Author : Subrata Pal
Publisher : Springer Science & Business Media
ISBN 13 : 146146255X
Total Pages : 429 pages
Book Rating : 4.4/5 (614 download)

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Book Synopsis Design of Artificial Human Joints & Organs by : Subrata Pal

Download or read book Design of Artificial Human Joints & Organs written by Subrata Pal and published by Springer Science & Business Media. This book was released on 2013-08-31 with total page 429 pages. Available in PDF, EPUB and Kindle. Book excerpt: Design of Artificial Human Joints & Organs is intended to present the basics of the normal systems and how, due to aging, diseases or trauma, body parts may need to be replaced with manmade materials. The movement of the body generates forces in various work situations and also internally at various joints, muscles and ligaments. It is essential to figure out the forces, moments, pressure etc to design replacements that manage these stresses without breaking down. The mechanical characterization of the hard and the soft tissues are presented systematically using the principles of solid mechanics. The viscoelastic properties of the tissue will also discussed. This text covers the design science and methodology from concept to blueprint to the final component being replaced. Each chapter will be a brief overview of various joint/organ replacement systems. Engineers working on artificial joints and organs, as well as students of Mechanical Engineering and Biomedical Engineering are the main intended audience, however, the pedagogy is simple enough for those who are learning the subject for the first time.

Relaxin and Related Peptides

Author : Alexander I. Agoulnik
Publisher : Springer Science & Business Media
ISBN 13 : 0387746722
Total Pages : 161 pages
Book Rating : 4.3/5 (877 download)

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Book Synopsis Relaxin and Related Peptides by : Alexander I. Agoulnik

Download or read book Relaxin and Related Peptides written by Alexander I. Agoulnik and published by Springer Science & Business Media. This book was released on 2008-12-19 with total page 161 pages. Available in PDF, EPUB and Kindle. Book excerpt: This comprehensive book contains the latest information on diverse biological functions of relaxin and related peptide found since the recent discovery of relaxin receptors. It also describes the evolution of relaxin family peptides and their receptors, molecular mechanisms of ligand/receptor interaction and the analysis of activated signaling pathways.

Cartilage and Osteoarthritis

Author : Massimo Sabatini
Publisher : Springer Science & Business Media
ISBN 13 : 1592598102
Total Pages : 362 pages
Book Rating : 4.5/5 (925 download)

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Book Synopsis Cartilage and Osteoarthritis by : Massimo Sabatini

Download or read book Cartilage and Osteoarthritis written by Massimo Sabatini and published by Springer Science & Business Media. This book was released on 2008-02-01 with total page 362 pages. Available in PDF, EPUB and Kindle. Book excerpt: Osteoarthritis (OA), the most common form of arthritis, is generally characterized by a slowly progressive degeneration of articular cartilage, particularly in the weight-bearing joints. It has a stronger prevalence in women, and its incidence increases with age. OA is a major and growing health concern in developed countries, owing to steadily increasing life expectancy and the demand for better quality of life. Because of its chronic nature and nonfatal outcome, OA affects the growing population of the elderly over an increasing time span. Moreover, despite its relatively benign character, OA is one of the most disabling diseases; it is responsible for increasing financial and social burdens in terms of medical treatments, forced inactivity, loss of mobility, and dependence. Despite a growing awareness of OA as a medical problem that has yet to reach its maximum impact on society, there is a surprising absence of effective medical treatments beyond pain control and surgery. So far, only symptom-modifying drugs are available, while there remains a major demand for disease-modifying treatments of proven clinical efficacy. This demand will hopefully be met in the future by some of the drugs that have been pressed into development and are now at different stages of clinical investigation. Nevertheless, the current lack of effective treatments reflects a still insufficient knowledge of cartilage with respect to its metabolism, interactions with other joint tissues, and causes and mechanisms (possibly of very different nature) leading to failure of its turnover.

Evolution of Extracellular Matrix

Author : Fred W. Keeley
Publisher : Springer Science & Business Media
ISBN 13 : 3642360025
Total Pages : 297 pages
Book Rating : 4.6/5 (423 download)

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Book Synopsis Evolution of Extracellular Matrix by : Fred W. Keeley

Download or read book Evolution of Extracellular Matrix written by Fred W. Keeley and published by Springer Science & Business Media. This book was released on 2013-03-15 with total page 297 pages. Available in PDF, EPUB and Kindle. Book excerpt: The evolution of single cells into multicellular organisms was mediated, in large part, by the extracellular matrix. The proteins and glycoconjugates that make up the extracellular matrix provide structural support to cellular complexes, facilitate cell adhesion and migration, and impart mechanical properties that are important for tissue function. Each class of ECM macromolecule has evolved to incorporate distinctive properties that are defined by conserved modules that are mixed together to achieve appropriate function. This volume provides a comprehensive analysis of how the major ECM components evolved over time in order to fill their specific roles found in modern organisms. The major focus is on the structural matrix proteins, matricellular proteins, and more complex ECM structures such as basement membranes. Adhesive proteins and their receptors are also discussed.

Mimicking the Extracellular Matrix

Author : Gregory H. Hudalla
Publisher : Royal Society of Chemistry
ISBN 13 : 1849738335
Total Pages : 422 pages
Book Rating : 4.8/5 (497 download)

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Book Synopsis Mimicking the Extracellular Matrix by : Gregory H. Hudalla

Download or read book Mimicking the Extracellular Matrix written by Gregory H. Hudalla and published by Royal Society of Chemistry. This book was released on 2015-11-18 with total page 422 pages. Available in PDF, EPUB and Kindle. Book excerpt: Mimicking the Extracellular Matrix approaches this topic from both basic science and practical engineering perspectives. Suitable for undergraduates, postgraduates, and academics, this text aims to unify the current knowledge of ECM biology and matrix-mimicking biomaterials.

Cartilage

Author : Susanne Grässel
Publisher : Springer
ISBN 13 : 3319458035
Total Pages : 265 pages
Book Rating : 4.3/5 (194 download)

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Book Synopsis Cartilage by : Susanne Grässel

Download or read book Cartilage written by Susanne Grässel and published by Springer. This book was released on 2017-01-25 with total page 265 pages. Available in PDF, EPUB and Kindle. Book excerpt: In three Volumes this mini book series presents current knowledge and new perspectives on cartilage as a specialized yet versatile tissue. This second volume is dedicated to basic pathologies of the two most common osteoarticular diseases affecting large segments of the Western population, osteoarthritis and chondrodysplasias. This book addresses Professors, researchers and PhD students who are interested in musculoskeletal and cartilage biology and pathobiology.

Developmental Biology and Musculoskeletal Tissue Engineering

Author : Martin J. Stoddart
Publisher : Academic Press
ISBN 13 : 0128115386
Total Pages : 272 pages
Book Rating : 4.1/5 (281 download)

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Book Synopsis Developmental Biology and Musculoskeletal Tissue Engineering by : Martin J. Stoddart

Download or read book Developmental Biology and Musculoskeletal Tissue Engineering written by Martin J. Stoddart and published by Academic Press. This book was released on 2018-04-24 with total page 272 pages. Available in PDF, EPUB and Kindle. Book excerpt: Developmental Biology and Musculoskeletal Tissue Engineering: Principles and Applications focuses on the regeneration of orthopedic tissue, drawing upon expertise from developmental biologists specializing in orthopedic tissues and tissue engineers who have used and applied developmental biology approaches. Musculoskeletal tissues have an inherently poor repair capacity, and thus biologically-based treatments that can recapitulate the native tissue properties are desirable. Cell- and tissue-based therapies are gaining ground, but basic principles still need to be addressed to ensure successful development of clinical treatments. Written as a source of information for practitioners and those with a nascent interest, it provides background information and state-of-the-art solutions and technologies. Recent developments in orthopedic tissue engineering have sought to recapitulate developmental processes for tissue repair and regeneration, and such developmental-biology based approaches are also likely to be extremely amenable for use with more primitive stem cells. - Brings the fields of tissue engineering and developmental biology together to explore the potential for regenerative medicine-based research to contribute to enhanced clinical outcomes - Initial chapters provide an outline of the development of the musculoskeletal system in general, and later chapters focus on specific tissues - Addresses the effect of mechanical forces on the musculoskeletal system during development and the relevance of these processes to tissue engineering - Discusses the role of genes in the development of musculoskeletal tissues and their potential use in tissue engineering - Describes how developmental biology is being used to influence and guide tissue engineering approaches for cartilage, bone, disc, and tendon repair

Subcellular Biochemistry

Author : J. Robin Harris
Publisher : Springer Science & Business Media
ISBN 13 : 1461303257
Total Pages : 446 pages
Book Rating : 4.4/5 (613 download)

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Book Synopsis Subcellular Biochemistry by : J. Robin Harris

Download or read book Subcellular Biochemistry written by J. Robin Harris and published by Springer Science & Business Media. This book was released on 2013-11-11 with total page 446 pages. Available in PDF, EPUB and Kindle. Book excerpt: In Volume 25, leading experts present studies on the value of increased ascorbic acid intake and explore its specific contributions to human and animal health.

Cartilage Repair Strategies

Author : Riley J. Williams
Publisher : Springer Science & Business Media
ISBN 13 : 1597453439
Total Pages : 383 pages
Book Rating : 4.5/5 (974 download)

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Book Synopsis Cartilage Repair Strategies by : Riley J. Williams

Download or read book Cartilage Repair Strategies written by Riley J. Williams and published by Springer Science & Business Media. This book was released on 2008-01-23 with total page 383 pages. Available in PDF, EPUB and Kindle. Book excerpt: The focus of this book is to create a comprehensive analysis of cartilage injury and repair strategies. Twenty chapters cover proven and emerging procedures and methodologies. Readers will be able to understand the clinical problem, appropriate diagnosis, and repair strategies relevant to first line and secondary cartilage repair procedures.

The Joints and Synovial Fluid

Author : Leon Sokoloff
Publisher : Academic Press
ISBN 13 : 1483259625
Total Pages : 578 pages
Book Rating : 4.4/5 (832 download)

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Book Synopsis The Joints and Synovial Fluid by : Leon Sokoloff

Download or read book The Joints and Synovial Fluid written by Leon Sokoloff and published by Academic Press. This book was released on 2014-05-10 with total page 578 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Joints and Synovial Fluid II is a collection of papers that deals with the basic aspects of the articular apparatus, including the general pathology of the appendicular and axial structures, the disease processes, and comparative anthology. Some papers discuss in vitro culture of joints and articular tissues, the chemistry of the ground substance of joint cartilage, and the structure of the intervertebral disc in relation to its function and to the aging process. As a humans being ages, the whole nucleus found in the disc will behave more like a sponge than a shock absorber as regards its ability to distribute stress and pressure from the end plates of the disc. Another paper describes load distribution of the knee, ankle joint, the spine, the arms, elbows, fingers. One paper deals with the pathology of the spine covering infectious diseases, metabolic and developmental disease of cartilage and bones, traumatic and degenerative diseases, autoimmune connective tissue diseases (such as ankylosing spondylitis), and miscellaneous diseases (such as tumors). The collection is suitable for researchers, scientists, medical practitioners, and academicians in the fields of biochemistry, bioengineering, anatomical sciences, immunology, organ physiology, cell biology, orthopedics, rheumatology, or rehabilitation medicine.