Author : Young-Min Park
Publisher :
ISBN 13 :
Total Pages : 108 pages
Book Rating : 4.:/5 (752 download)
Book Synopsis The Effects of Beta-hydroxy Âeta-methylbutyrate (HMB) on Skeletal Muscles of Aged Sprague-Dawley Female Rats During 10-week Intensive Resistance Exercise Training by : Young-Min Park
Download or read book The Effects of Beta-hydroxy Âeta-methylbutyrate (HMB) on Skeletal Muscles of Aged Sprague-Dawley Female Rats During 10-week Intensive Resistance Exercise Training written by Young-Min Park and published by . This book was released on 2010 with total page 108 pages. Available in PDF, EPUB and Kindle. Book excerpt: ABSTRACT: HMB intake during Resistance Training (RT) is known to be an effective strategy to improve muscle mass & function and decrease FM. PURPOSE: To determine whether HMB administration during 10-wk RT would facilitate RT-induced improvement in neuromuscular functions, body composition, myofiber dimension and regenerative capacity in aged female rats. METHODS: After four animals were sacrificed for baseline muscle samples, twelve 19-month old female Sprague-Dawley rats (N=16) were randomly divided into two groups, HMB (0.46 g/kg/d, similar to 6 g/d in humans) and non-HMB. Both groups were trained every 3 day for 10 wks on ladder climbing exercise with weights attached to the tail. The MW, GS, inclined plane test were used to measure neuromuscular functions. Body composition was assessed by DXA before and after RT. DTI determined water diffusion in myofibers by calculating FA and eigenvalues. Muscle mRNA expressions of the regulators of myogenesis, mitogenesis, and cell cycle inhibition were analyzed using RT-PCR. The number of satellite cells and myonuclei associated with muscle regeneration capacity were analyzed using Pax7-stained stem-cell immunohistochemistry. RESULTS: There were significant (p0.05) main effects for time for MW (pre vs. post +239%), and normalized MW (pre vs. post +262%). A significant time effect (p