Read Books Online and Download eBooks, EPub, PDF, Mobi, Kindle, Text Full Free.
The Drosophila Model In Cancer
Download The Drosophila Model In Cancer full books in PDF, epub, and Kindle. Read online The Drosophila Model In Cancer ebook anywhere anytime directly on your device. Fast Download speed and no annoying ads. We cannot guarantee that every ebooks is available!
Book Synopsis The Drosophila Model in Cancer by : Wu-Min Deng
Download or read book The Drosophila Model in Cancer written by Wu-Min Deng and published by Springer Nature. This book was released on 2019-09-13 with total page 251 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume provides a series of review articles that capture the advances in using the fruit fly, Drosophila melanogaster, model system to address a wide range of cancer-related topics. Articles in this book provide case studies that shed light on the intricate cellular and molecular mechanisms underlying tumor formation and progression. Readers will discover the beauty of the fly model’s genetic simplicity and the vast arsenal of powerful genetic tools enabling its efficient and adaptable use. This model organism has provided a unique opportunity to address questions regarding cancer initiation and development that would be extremely challenging in other model systems. This book provides a useful resource for a researcher who wishes to learn about and apply the Drosophila model to tackle fundamental questions in cancer biology, and to find new ways to fight against this devastating disease.
Book Synopsis Drosophila melanogaster by : Farzana Khan Perveen
Download or read book Drosophila melanogaster written by Farzana Khan Perveen and published by BoD – Books on Demand. This book was released on 2018-02-28 with total page 270 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book contains 12 chapters divided into two sections. Section 1 is "Drosophila - Model for Genetics." It covers introduction, chromosomal polymorphism, polytene chromosomes, chromosomal inversion, chromosomal evolution, cell cycle regulators in meiosis and nongenetic transgenerational inheritance in Drosophila. It also includes ecological genetics, wild-type strains, morphometric analysis, cytostatics, frequencies of early and late embryonic lethals (EEL and LEL) and mosaic imaginal discs of Drosophila for genetic analysis in biomedical research. Section 2 is "Drosophila - Model for Therapeutics." It explains Drosophila as model for human diseases, neurodegeneration, heart-kidney metabolic disorders, cancer, pathophysiology of Parkinson's disease, dopamine, neuroprotective therapeutics, mitochondrial dysfunction and translational research. It also covers Drosophila role in ubiquitin-carboxyl-terminal hydrolase-L1 (UCH-L1) protein, eye development, anti-dUCH antibody, neuropathy target esterase (NTE), organophosphorous compound-induced delayed neuropathy (OPIDN) and hereditary spastic paraplegia (HSP). It also includes substrate specificities, kinetic parameters of recombinant glutathione S-transferases E6 and E7 (DmGSTE6 and DmGSTE7), detoxification and insecticidal resistance and antiviral immunity in Drosophila.
Book Synopsis Drosophila Models for Human Diseases by : Masamitsu Yamaguchi
Download or read book Drosophila Models for Human Diseases written by Masamitsu Yamaguchi and published by Springer. This book was released on 2018-06-27 with total page 314 pages. Available in PDF, EPUB and Kindle. Book excerpt: Most biological pathways, physical and neurological properties are highly conserved between humans and Drosophila and nearly 75% of human disease-causing genes have a functional homologue in Drosophila. This volume provides recent advances in Drosophila models for various human diseases, with each chapter providing a review of studies involving Drosophila models, as well as detailed protocols commonly used in laboratories. Starting with a review of Drosophila’s value as a highly tractable model organism for studying human diseases, subsequent chapters present Drosophila models for specific human diseases. The book provides a useful resource for all scientists who are starting to use the Drosophila model in their studies, and for researchers working in the pharmaceutical industry and using new screening models to develop new medicines for various diseases.
Book Synopsis The Drosophila Model of Cancer by : Takeshi Shimizu
Download or read book The Drosophila Model of Cancer written by Takeshi Shimizu and published by . This book was released on 2006 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Life Extension by : Alexander M. Vaiserman
Download or read book Life Extension written by Alexander M. Vaiserman and published by Springer. This book was released on 2015-06-09 with total page 351 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book looks at aging through research on Drosophila, the fruit fly that is one of the most widely used model organisms in bio gerontology. Work in model organisms can expand the theoretical knowledge of aging: it yields valuable insight into the molecular and cellular processes that underlie aging process, and it can perhaps provide new therapeutic targets for the treatment of age-related disorders in humans. Drosophila models have been developed for a large variety of aging-related processes and diseases, and this book provides readers with an overview of current research on the use of the Drosophila model to understand the genetic, molecular and physiological mechanisms that underlie the aging process. Themes of health span, life extension and longevity-associated genes emerge in this collation of international research on Drosophila that is of relevance to geriatrics and gerontology, animal genetics and genomics, and biomedicine. This fascinating, illustrated book will be of interest to a wide audience, ranging from academic researchers to the general reader.
Book Synopsis Transgenic Drosophila as a Drugscreening Tool in Multiple Cancers by : John Rozehnal
Download or read book Transgenic Drosophila as a Drugscreening Tool in Multiple Cancers written by John Rozehnal and published by . This book was released on 2017 with total page 42 pages. Available in PDF, EPUB and Kindle. Book excerpt: Introduction: The selection of appropriate anticancer drugs in patients is a great challenge in cancer treatment. As medicine seeks to understand the difference between the “average” tumor and a tumor in an individual patient, there is great uncertainty regarding the effect of particular genes and drugs that target them. Transgenic Drosophila melanogaster has been proposed as a rapid and efficient system in which to generate a reliable model of an individual tumor and phenotypic screen for effective drugs. Such screens can potentially lead to the identification of a molecule that modifies a cancer phenotype by acting on a previously undescribed target or by acting simultaneously on more than one target.Methods: 97 Patients were assessed for genomic and clinical data. 12 patients had tumor genetics analyzed and models created that comprised driver mutations. 3 models were attempted in Drosophila and tested against 19 anticancer drugs.Results: 1 of 3 models was technically successful and advanced to drug screening. 5 drugs (gemcitabine, trametinib, crizotinib, doxorubicin, docetaxel) were predicted by the model to be effective against that particular cancer. However, neither of the two drugs used in the corresponding patient were predicted to be successful.Conclusions: While this project was unable to concretely validate the Drosophila modeling approach by accurately predicting treatment outcomes. I was able to develop and advance methods to predict the effects of a gene within a tumor and to develop one complete Drosophila model that responded to anticancer drugs in a dose-dependent manner. Further research is needed to assess the predictive value of these models.
Book Synopsis Model organisms in inflammation and cancer by : Yiorgos Apidianakis
Download or read book Model organisms in inflammation and cancer written by Yiorgos Apidianakis and published by Frontiers E-books. This book was released on 2014-12-17 with total page 84 pages. Available in PDF, EPUB and Kindle. Book excerpt: A link between inflammation and cancer was initially made by Rudolf Virchow back in the 19th century. Nowadays many cancers are considered dependent on inflammatory responses to microbial and damaged-self stimuli and both arms of immunity, innate and adaptive, are playing a role in promoting cancer. Moreover, besides environmental factors, opportunistic pathogens contribute to inflammation and cancer. Nevertheless, microbial influence on chronic disease is sometimes difficult to discern, especially in the context of polymicrobial communities, such as those found in the digestive tract. In this light, model organisms provide important insights into immune and growth signals that promote cancer, and suggest therapies that will selectively target potentially harmful microbes or modulate host responses. A number of review and opinion articles in this series address novel aspects and paradigms of the interactions between the microbiota and the host in relation to inflammation and cancer.
Book Synopsis Genes, Development and Cancer by : Howard D. Lipshitz
Download or read book Genes, Development and Cancer written by Howard D. Lipshitz and published by Springer Science & Business Media. This book was released on 2007-12-08 with total page 564 pages. Available in PDF, EPUB and Kindle. Book excerpt: This second edition collects Nobel Prize winner Edward B. Lewis’s key publications in the fields of genetics, developmental biology, radiation and cancer. Editor Howard Lipshitz, a close colleague during the last 20 years of Lewis's life, places the papers in their scientific and historical context and provides insight into Lewis's approach to science and the motivations that drove his choice of subject matter.
Book Synopsis Holland-Frei Cancer Medicine by : Robert C. Bast, Jr.
Download or read book Holland-Frei Cancer Medicine written by Robert C. Bast, Jr. and published by John Wiley & Sons. This book was released on 2017-03-10 with total page 2004 pages. Available in PDF, EPUB and Kindle. Book excerpt: Holland-Frei Cancer Medicine, Ninth Edition, offers a balanced view of the most current knowledge of cancer science and clinical oncology practice. This all-new edition is the consummate reference source for medical oncologists, radiation oncologists, internists, surgical oncologists, and others who treat cancer patients. A translational perspective throughout, integrating cancer biology with cancer management providing an in depth understanding of the disease An emphasis on multidisciplinary, research-driven patient care to improve outcomes and optimal use of all appropriate therapies Cutting-edge coverage of personalized cancer care, including molecular diagnostics and therapeutics Concise, readable, clinically relevant text with algorithms, guidelines and insight into the use of both conventional and novel drugs Includes free access to the Wiley Digital Edition providing search across the book, the full reference list with web links, illustrations and photographs, and post-publication updates
Book Synopsis Assessing a Drosophila Metastasis Model in Mouse and Human Breast Cancer by :
Download or read book Assessing a Drosophila Metastasis Model in Mouse and Human Breast Cancer written by and published by . This book was released on 2008 with total page 8 pages. Available in PDF, EPUB and Kindle. Book excerpt: We propose to combine our expertise to target a process that is critical to breast cancer metastasis that is likely conserved in flies, mice and humans. The advantages of addressing the question of metastasis through the combined expertise of the Cagan and Weilbaecher labs is that we will use the powerful genetic tools provided by Drosophila that will identify key genetic pathways critical to tumor cell migration and metastasis that can be rapidly and rigorously tested. This a real time, in vivo dynamic screen that occurs in a whole organism. Tumors develop in the epithelial layer of the wing and the genetics of tumor cell invasion and migration throughout the organism can be modeled in real time, and genetically manipulated in large scale genetic screens. Dr. Weilbaecher's laboratory will take advantage of the genetic knowledge gained from the Drosophila metastasis models in the development of an improved breast cancer metastasis mouse model. Dr. Cagan's laboratory will be provided with mammalian human and murine breast cancers to validate their genetic and pharmacologic anti-metastasis strategies. Jointly, Drs. Cagan and Weilbaecher propose to develop novel therapeutics targeted to the metastatic process. In year one, we have identified 6 compounds that decrease metastasis in Drosophila metastasis model and decrease viability of mammalian breast cancer cells in vitro. We have validated the compound Cyclopamine, a hedgehog inhibitor, to block lung metastases in murine breast cancer xenograft and will use this as a template for testing other candidate therapeutic compounds from fly to mouse. Finally, we have uncovered a previously unknown and important connection between Src and Hedgehog signaling in mediating metastasis.
Book Synopsis The Characterisation of a Novel Larval Drosophila Melanogaster Model of Cancer Cachexia by : Joseph Alexander Hodgson
Download or read book The Characterisation of a Novel Larval Drosophila Melanogaster Model of Cancer Cachexia written by Joseph Alexander Hodgson and published by . This book was released on 2017 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis The Hypoxia-Inducible Factor-1α in Angiogenesis and Cancer: Insights from the Drosophila Model by : Vasilia Tamamouna
Download or read book The Hypoxia-Inducible Factor-1α in Angiogenesis and Cancer: Insights from the Drosophila Model written by Vasilia Tamamouna and published by . This book was released on 2018 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis The Drosophila Retina as a Model for Human Cancer by : Renee Delozier Read
Download or read book The Drosophila Retina as a Model for Human Cancer written by Renee Delozier Read and published by . This book was released on 2003 with total page 470 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Effects of Acetyl Salicyclic Acid on Drosophila Models of Cancer Inflammation by :
Download or read book Effects of Acetyl Salicyclic Acid on Drosophila Models of Cancer Inflammation written by and published by . This book was released on 2015 with total page 44 pages. Available in PDF, EPUB and Kindle. Book excerpt: Chronic inflammation is a fundamental condition underlying many human disease pathologies including diabetes, cancer, and neurodegeneration. Indeed, one of the most commonly-used anti-inflammatory drugs, aspirin, has been shown to be effective in the treatment of many cancers. To understand the mechanistic linkages between inflammation and cancer, we used Drosophila models in which hyperactive immune signaling causes overproliferation of the hematopoietic system leading to the production of inflammatory blood tumors. In mutant animals, hematopoietic cells divide uncontrollably and exhibit pre-mature differentiation giving rise to large sticky cells. Some mutant cells infiltrate and adhere to cells of the fat body. The fat body is a large organ in fly larvae and akin to the mammalian liver. In wild type larvae, hematopoietic cells exhibit limited rounds of division, and circulating cells in the hemolymph do not stick to fat body. Our hypothesis was that if the biochemistry and genetic circuitry underlying inflammation biology in flies is conserved, then aspirin administration should have the same therapeutic effects on tumor growth and infiltration in fly mutants as it does in humans. Here we show that sublethal levels of systemically-administered aspirin improve viability of mutants and reduce the size and abundance of blood tumors. The accompanying infiltration of blood cells on larval fat body cells of mutants is also reduced. These results support our hypothesis and suggest that the mechanisms underlying aspirin’s effects in flies may be similar with those in mammals. These studies underscore the value of the Drosophila model system and present exciting possibilities for uncovering shared mechanisms.
Book Synopsis Study of Tumor Development Using Drosophila Melanogaster Models by : Kirti Snigdha
Download or read book Study of Tumor Development Using Drosophila Melanogaster Models written by Kirti Snigdha and published by . This book was released on 2020 with total page 128 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Drosophila melanogaster - Model for Recent Advances in Genetics and Therapeutics by : Farzana Khan Perveen
Download or read book Drosophila melanogaster - Model for Recent Advances in Genetics and Therapeutics written by Farzana Khan Perveen and published by . This book was released on 2018 with total page 268 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book contains 12 chapters divided into two sections. Section 1 is ""Drosophila - Model for Genetics."" It covers introduction, chromosomal polymorphism, polytene chromosomes, chromosomal inversion, chromosomal evolution, cell cycle regulators in meiosis and nongenetic transgenerational inheritance in Drosophila. It also includes ecological genetics, wild-type strains, morphometric analysis, cytostatics, frequencies of early and late embryonic lethals (EEL and LEL) and mosaic imaginal discs of Drosophila for genetic analysis in biomedical research. Section 2 is ""Drosophila - Model for Therapeutics."" It explains Drosophila as model for human diseases, neurodegeneration, heart-kidney metabolic disorders, cancer, pathophysiology of Parkinson's disease, dopamine, neuroprotective therapeutics, mitochondrial dysfunction and translational research. It also covers Drosophila role in ubiquitin-carboxyl-terminal hydrolase-L1 (UCH-L1) protein, eye development, anti-dUCH antibody, neuropathy target esterase (NTE), organophosphorous compound-induced delayed neuropathy (OPIDN) and hereditary spastic paraplegia (HSP). It also includes substrate specificities, kinetic parameters of recombinant glutathione S-transferases E6 and E7 (DmGSTE6 and DmGSTE7), detoxification and insecticidal resistance and antiviral immunity in Drosophila.
Book Synopsis Drosophila Models of Human Cancers Associated with Modulation of DCC/frazzled Signaling by : Joseph Sarro
Download or read book Drosophila Models of Human Cancers Associated with Modulation of DCC/frazzled Signaling written by Joseph Sarro and published by . This book was released on 2014 with total page 124 pages. Available in PDF, EPUB and Kindle. Book excerpt:
