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The Design Synthesis And Characterization Of Scaffold Assembled Collagen Mimetics And Peptide Dendrimers
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Book Synopsis The Design, Synthesis and Characterization of Scaffold-assembled Collagen Mimetics and Peptide Dendrimers by : Weibo Cai
Download or read book The Design, Synthesis and Characterization of Scaffold-assembled Collagen Mimetics and Peptide Dendrimers written by Weibo Cai and published by . This book was released on 2004 with total page 456 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis The Design, Synthesis and Characterization of Scaffold-assembled and Dendritic Collagen Mimetics by : Garth Alden Kinberger
Download or read book The Design, Synthesis and Characterization of Scaffold-assembled and Dendritic Collagen Mimetics written by Garth Alden Kinberger and published by . This book was released on 2002 with total page 488 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis The Design, Synthesis and Characterization of Novel Triple Helical Collagen Mimetic Structures by : Juliann Mijong Kwak
Download or read book The Design, Synthesis and Characterization of Novel Triple Helical Collagen Mimetic Structures written by Juliann Mijong Kwak and published by . This book was released on 2002 with total page 492 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Molecular Self-assembly by : Matthew S. Lamm
Download or read book Molecular Self-assembly written by Matthew S. Lamm and published by ProQuest. This book was released on 2008 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Conformational Assembly and Biological Properties of Collagen Mimetic Peptides and Their Thermally Responsive Polymer Conjugates by : Ohm Divyam Krishna
Download or read book Conformational Assembly and Biological Properties of Collagen Mimetic Peptides and Their Thermally Responsive Polymer Conjugates written by Ohm Divyam Krishna and published by . This book was released on 2011 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: Collagens are one of the most abundant proteins found in body tissues and organs, endowing structural integrity, mechanical strength, and multiple biological functions. Destabilized collagen inside human body leads to various degenerative diseases (ex. osteoarthritis) and ageing. This has continued to motivate the design of synthetic peptides and bio-synthetic polypeptides to closely mimic the native collagens in terms of triple helix structure and stability, potential for higher order assembly, and biological properties. However, the widespread application of de novo collagens has been limited in part by the need for hydroxylated proline in the formation of stable triple helical structures. To address this continued need, a hydroxyproline-free, thermally stable collagen-mimetic peptide (CLP-Cys) was rationally designed via the incorporation of electrostatically stabilized amino acid triplets. CLP-Cys was synthesized via solid phase peptide synthesis. The formation and stability of the triple helical structure were indicated via circular dichroism (CD) experiments and confirmed via differential scanning calorimetry (DSC) results. CLP-Cys also self-assembled into nano-rods and micro-fibrils, as evidenced via a combination of dynamic light scattering and transmission electron microscopy. Given the high thermal stability and its propensity for higher-order assembly, CLP-Cys was further functionalized at both the ends with a thermally responsive polymer, poly(diethylene glycol methyl ether methacrylate), (PDEGMEMA) to synthesize a biohybrid triblock copolymer. The CD results indicated that the triple helical form is retained, the thermal unfolding is sustained and helix to coil transition is reversible in the triblock hybrid context. The LCST of PDEGMEMA homopolymer (26 °C) is increased (to 35 °C) upon conjugation to the hydrophilic collagen peptide domain. Further, a combination of static light scattering, Cryo-SEM, TEM and confocal microscopy elucidated that the collapse of the thermo-responsive polymer upon heating (to above the LCST) leads to the assembly of these hybrid materials as micrometer sized spheres. At 75 °C a morphological transformation from spheres to fibrils were observed. These studies provided unique perspectives about the impact of stimuli-responsive polymers and the triple-helix forming peptides on each other; and how temperature as a stimulus can be employed to sequentially guide the assembly. The development of self-assembling hybrid materials with multiple sensitivities to temperature would offer useful opportunities in the design of stimuli-responsive nano-materials. The CLP-Cys peptide sequence has been designed to incorporate biologically relevant amino acid triplets (GEKGER) and its positive impact was seen via recruitment of human mesenchymal stem cells (hMSCs) for adhesion, spreading and proliferation on CLP-Cys functionalized glass and hyaluronic acid based hydrogel surfaces. Therefore, the prospects of these materials in biomedical applications including wound healing and tissue engineering are promising.
Book Synopsis Collagen Mimetic Peptides and Their Biophysical Characterization by : Jianxi Xiao
Download or read book Collagen Mimetic Peptides and Their Biophysical Characterization written by Jianxi Xiao and published by Springer. This book was released on 2024-09-21 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book embarks on an enlightening journey through the molecular landscape of collagen mimic peptides, shedding light on their significance and potential. In the intricate realm of biomolecules, collagen's preeminence as the most abundant protein in the human body, forming the foundational scaffolding of tissues and organs, renders it a subject of profound scientific interest. It explores diverse facets related to collagen mimic peptides, spanning aspects such as bioinformatic analysis, synthetic strategies, pathological collagen targeting, and the construction of homotrimeric, heterotrimeric and self-assembled peptide models. Furthermore, it provides an exhaustive investigation into biophysical techniques, encompassing Circular Dichroism (CD), X-ray crystallography, Nuclear Magnetic Resonance (NMR), Fluorescence, and Raman spectroscopy, thereby empowering researchers to unravel the structural intricacies of these peptides. The book unravels the profound implications of collagen mimic peptides across a spectrum of scientific domains, including protein science, biomaterials, bioanalysis, and beyond. Its accessibility and insights cater not only to seasoned researchers but also to undergraduate and graduate students eager to delve into the complexities of this fundamental protein.
Book Synopsis Frameworks for Novel Mechanically Interlocked Molecules by : Natalie Martina Ward
Download or read book Frameworks for Novel Mechanically Interlocked Molecules written by Natalie Martina Ward and published by . This book was released on 2016 with total page 438 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Dissertation Abstracts International by :
Download or read book Dissertation Abstracts International written by and published by . This book was released on 2005 with total page 884 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Synthesis and Characterization of Collagen Methacrylamide Sponges for Use as a Biological Scaffold by : Jonathan Richard Branch
Download or read book Synthesis and Characterization of Collagen Methacrylamide Sponges for Use as a Biological Scaffold written by Jonathan Richard Branch and published by . This book was released on 2012 with total page 106 pages. Available in PDF, EPUB and Kindle. Book excerpt: The goal of this thesis was to develop collagen methacrylamide (CMA) into a functional biological scaffold by enhancing its physical strength. CMA is a biocompatible, functionalized type I collagen moiety whose physical strength can be modulated by UV light exposure. Commercially-available, collagen-based biological devices comprised of decellularized ECM possess excellent mechanical properties, but are limited in their amenability to physical and chemical patterning. Scaffolds manufactured from purified collagens are not suitable for most biomedical applications because of their limited physical strength. In the first study, collagen methacrylamide was processed into sponges by lyophilization. Subsequently, the material was characterized through rheometry and found to be weaker than its corresponding hydrogel. A second study evaluated increasing the concentration of the material to increase its strength. In a third study, EDC crosslinking was employed as an additional method to increase the strength of CMA. Both studies demonstrated an increase in the tensile strength and elastic modulus of CMA sponges. However, further increases in strength will be necessary in order for this device to be feasible as a biological scaffold. Nevertheless, the potential exists for CMA sponges, containing gradients of stiffness or peptide-patterning, to be developed into a superior material for numerous tissue engineering applications.
Book Synopsis Biopolymers for Biomedical and Biotechnological Applications by : Bernd H. A. Rehm
Download or read book Biopolymers for Biomedical and Biotechnological Applications written by Bernd H. A. Rehm and published by John Wiley & Sons. This book was released on 2020-12-01 with total page 400 pages. Available in PDF, EPUB and Kindle. Book excerpt: Provides insight into biopolymers, their physicochemical properties, and their biomedical and biotechnological applications This comprehensive book is a one-stop reference for the production, modifications, and assessment of biopolymers. It highlights the technical and methodological advancements in introducing biopolymers, their study, and promoted applications. "Biopolymers for Biomedical and Biotechnological Applications" begins with a general overview of biopolymers, properties, and biocompatibility. It then provides in-depth information in three dedicated sections: Biopolymers through Bioengineering and Biotechnology Venues; Polymeric Biomaterials with Wide Applications; and Biopolymers for Specific Applications. Chapters cover: advances in biocompatibility; advanced microbial polysaccharides; microbial cell factories for biomanufacturing of polysaccharides; exploitation of exopolysaccharides from lactic acid bacteria; and the new biopolymer for biomedical application called nanocellulose. Advances in mucin biopolymer research are presented, along with those in the synthesis of fibrous proteins and their applications. The book looks at microbial polyhydroxyalkanoates (PHAs), as well as natural and synthetic biopolymers in drug delivery and tissue engineering. It finishes with a chapter on the current state and applications of, and future trends in, biopolymers in regenerative medicine. * Offers a complete and thorough treatment of biopolymers from synthesis strategies and physiochemical properties to applications in industrial and medical biotechnology * Discusses the most attracted biopolymers with wide and specific applications * Takes a systematic approach to the field which allows readers to grasp and implement strategies for biomedical and biotechnological applications "Biopolymers for Biomedical and Biotechnological Applications" appeals to biotechnologists, bioengineers, and polymer chemists, as well as to those working in the biotechnological industry and institutes.
Book Synopsis Structural DNA Nanotechnology by : Nadrian C. Seeman
Download or read book Structural DNA Nanotechnology written by Nadrian C. Seeman and published by Cambridge University Press. This book was released on 2015 with total page 269 pages. Available in PDF, EPUB and Kindle. Book excerpt: Written by the founder of the field, this is a comprehensive and accessible introduction to structural DNA nanotechnology.
Book Synopsis Comprehensive Biomaterials II by : Kevin Healy
Download or read book Comprehensive Biomaterials II written by Kevin Healy and published by Elsevier. This book was released on 2017-05-18 with total page 4865 pages. Available in PDF, EPUB and Kindle. Book excerpt: Comprehensive Biomaterials II, Second Edition, Seven Volume Set brings together the myriad facets of biomaterials into one expertly-written series of edited volumes. Articles address the current status of nearly all biomaterials in the field, their strengths and weaknesses, their future prospects, appropriate analytical methods and testing, device applications and performance, emerging candidate materials as competitors and disruptive technologies, research and development, regulatory management, commercial aspects, and applications, including medical applications. Detailed coverage is given to both new and emerging areas and the latest research in more traditional areas of the field. Particular attention is given to those areas in which major recent developments have taken place. This new edition, with 75% new or updated articles, will provide biomedical scientists in industry, government, academia, and research organizations with an accurate perspective on the field in a manner that is both accessible and thorough. Reviews the current status of nearly all biomaterials in the field by analyzing their strengths and weaknesses, performance, and future prospects Covers all significant emerging technologies in areas such as 3D printing of tissues, organs and scaffolds, cell encapsulation; multimodal delivery, cancer/vaccine - biomaterial applications, neural interface understanding, materials used for in situ imaging, and infection prevention and treatment Effectively describes the many modern aspects of biomaterials from basic science, to clinical applications
Author :Andrzej Mackiewicz Publisher :Springer Science & Business Media ISBN 13 :9780306466564 Total Pages :466 pages Book Rating :4.4/5 (665 download)
Book Synopsis Progress in Basic and Clinical Immunology by : Andrzej Mackiewicz
Download or read book Progress in Basic and Clinical Immunology written by Andrzej Mackiewicz and published by Springer Science & Business Media. This book was released on 2001-12-31 with total page 466 pages. Available in PDF, EPUB and Kindle. Book excerpt: Progress in Basic and Clinical Immunology is a result of the 14th European Immunology Meeting - EFIS 2000, held in Poznan, Poland, on 23-27 September 2000. EFIS 2000 gathered over 1400 immunologists from all over the world. It was an exceptionally memorable meeting for a number of reasons: 1) it was held in the last year of the century and the millennium, thus provoking conclusions of past achievements of immunology and projections for the future; 2) it was held in Poland, a country that is a symbol of struggle for freedom for a large number of scientists originating from the `Eastern Bloc' countries; and 3) EFIS celebrated its 25th anniversary at this occasion. This comprehensive volume contains 62 chapters grouped into 11 sections: T-cells, Immune Receptors, Antigen Presentation/Dendritic Cells, Cytokines, Immunodeficiencies, Autoimmunity, Allergy/Inflammation, Immunotherapy, Vaccines, Tumor Immunology, and Cancer Immunotherapy.
Book Synopsis Peptides and Peptide-based Biomaterials and their Biomedical Applications by : Anwar Sunna
Download or read book Peptides and Peptide-based Biomaterials and their Biomedical Applications written by Anwar Sunna and published by Springer. This book was released on 2017-10-26 with total page 309 pages. Available in PDF, EPUB and Kindle. Book excerpt: Solid-binding peptides have been used increasingly as molecular building blocks in nanobiotechnology as they can direct the assembly and functionalisation of a diverse range of materials and have the ability to regulate the synthesis of nanoparticles and complex nanostructures. Nanostructured materials such as β-sheet fibril-forming peptides and α-helical coiled coil systems have displayed many useful properties including stimulus-responsiveness, modularity and multi-functionality, providing potential technological applications in tissue engineering, antimicrobials, drug delivery and nanoscale electronics. The current situation with respect to self-assembling peptides and bioactive matrices for regenerative medicine are reviewed, as well as peptide-target modeling and an examination of future prospects for peptides in these areas.
Book Synopsis Advanced Healthcare Materials by : Ashutosh Tiwari
Download or read book Advanced Healthcare Materials written by Ashutosh Tiwari and published by John Wiley & Sons. This book was released on 2014-05-09 with total page 421 pages. Available in PDF, EPUB and Kindle. Book excerpt: Offers a comprehensive and interdisciplinary view of cutting-edge research on advanced materials for healthcare technology and applications Advanced healthcare materials are attracting strong interest in fundamental as well as applied medical science and technology. This book summarizes the current state of knowledge in the field of advanced materials for functional therapeutics, point-of-care diagnostics, translational materials, and up-and-coming bioengineering devices. Advanced Healthcare Materials highlights the key features that enable the design of stimuli-responsive smart nanoparticles, novel biomaterials, and nano/micro devices for either diagnosis or therapy, or both, called theranostics. It also presents the latest advancements in healthcare materials and medical technology. The senior researchers from global knowledge centers have written topics including: State-of-the-art of biomaterials for human health Micro- and nanoparticles and their application in biosensors The role of immunoassays Stimuli-responsive smart nanoparticles Diagnosis and treatment of cancer Advanced materials for biomedical application and drug delivery Nanoparticles for diagnosis and/or treatment of Alzheimers disease Hierarchical modelling of elastic behavior of human dental tissue Biodegradable porous hydrogels Hydrogels in tissue engineering, drug delivery, and wound care Modified natural zeolites Supramolecular hydrogels based on cyclodextrin poly(pseudo)rotaxane Polyhydroxyalkanoate-based biomaterials Biomimetic molecularly imprinted polymers
Book Synopsis Orthopedic Biomaterials by : Bingyun Li
Download or read book Orthopedic Biomaterials written by Bingyun Li and published by Springer. This book was released on 2018-03-22 with total page 614 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book covers the latest advances, applications, and challenges in orthopedic biomaterials. Topics covered include materials for orthopedic applications, including nanomaterials, biomimetic materials, calcium phosphates, polymers, biodegradable metals, bone grafts/implants, and biomaterial-mediated drug delivery. Absorbable orthopedic biomaterials and challenges related to orthopedic biomaterials are covered in detail. This is an ideal book for graduate and undergraduate students, researchers, and professionals working with orthopedic biomaterials and tissue engineering. This book also: Describes biodegradable metals for orthopedic applications, such as Zn-based medical implants Thoroughly covers various materials for orthopedic applications, including absorbable orthopedic biomaterials with a focus on polymers Details the state-of-the-art research on orthopedic nanomaterials and nanotechnology
Book Synopsis Cutting-Edge Enabling Technologies for Regenerative Medicine by : Heung Jae Chun
Download or read book Cutting-Edge Enabling Technologies for Regenerative Medicine written by Heung Jae Chun and published by Springer. This book was released on 2018-10-24 with total page 490 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book explores in depth the latest enabling technologies for regenerative medicine. The opening section examines advances in 3D bioprinting and the fabrication of electrospun and electrosprayed scaffolds. The potential applications of intelligent nanocomposites are then considered, covering, for example, graphene-based nanocomposites, intrinsically conductive polymer nanocomposites, and smart diagnostic contact lens systems. The third section is devoted to various drug delivery systems and strategies for regenerative medicine. Finally, a wide range of future enabling technologies are discussed. Examples include temperature-responsive cell culture surfaces, nanopatterned scaffolds for neural tissue engineering, and process system engineering methodologies for application in tissue development. This is one of two books to be based on contributions from leading experts that were delivered at the 2018 Asia University Symposium on Biomedical Engineering in Seoul, Korea – the companion book examines in depth novel biomaterials for regenerative medicine.
