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The Dentate Gyrus And Its Role In Seizures
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Book Synopsis Jasper's Basic Mechanisms of the Epilepsies by : Jeffrey Noebels
Download or read book Jasper's Basic Mechanisms of the Epilepsies written by Jeffrey Noebels and published by OUP USA. This book was released on 2012-06-29 with total page 1258 pages. Available in PDF, EPUB and Kindle. Book excerpt: Jasper's Basic Mechanisms, Fourth Edition, is the newest most ambitious and now clinically relevant publishing project to build on the four-decade legacy of the Jasper's series. In keeping with the original goal of searching for "a better understanding of the epilepsies and rational methods of prevention and treatment.", the book represents an encyclopedic compendium neurobiological mechanisms of seizures, epileptogenesis, epilepsy genetics and comordid conditions. Of practical importance to the clinician, and new to this edition are disease mechanisms of genetic epilepsies and therapeutic approaches, ranging from novel antiepileptic drug targets to cell and gene therapies.
Book Synopsis Seizures and Epilepsy by : Jerome Engel Jr
Download or read book Seizures and Epilepsy written by Jerome Engel Jr and published by Oxford University Press. This book was released on 2013-01-31 with total page 737 pages. Available in PDF, EPUB and Kindle. Book excerpt: This second edition of 'Seizures and Epilepsy' is completely revised, due to tremendous advances in the understanding of the fundamental neuronal mechanisms underlying epileptic phenomena, as well as current diagnosis and treatment, which have been heavily influenced over the past several decades by seminal neuroscientific developments, particularly the introduction of molecular neurobiology, genetics, and modern neuroimaging. This resource covers a broad range of both basic and clinical epileptology.
Book Synopsis SIDS Sudden Infant and Early Childhood Death by : Roger W. Byard
Download or read book SIDS Sudden Infant and Early Childhood Death written by Roger W. Byard and published by . This book was released on 2018-04 with total page 844 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume covers aspects of sudden infant and early childhood death, ranging from issues with parental grief, to the most recent theories of brainstem neurotransmitters. It also deals with the changes that have occurred over time with the definitions of SIDS (sudden infant death syndrome), SUDI (sudden unexpected death in infancy) and SUDIC (sudden unexpected death in childhood). The text will be indispensable for SIDS researchers, SIDS organisations, paediatric pathologists, forensic pathologists, paediatricians and families, in addition to residents in training programs that involve paediatrics. It will also be of use to other physicians, lawyers and law enforcement officials who deal with these cases, and should be a useful addition to all medical examiner/forensic, paediatric and pathology departments, hospital and university libraries on a global scale. Given the marked changes that have occurred in the epidemiology and understanding of SIDS and sudden death in the very young over the past decade, a text such as this is very timely and is also urgently needed.
Book Synopsis The CA3 Region of the Hippocampus: How is it? What is it for? How does it do it? by : Enrico Cherubini
Download or read book The CA3 Region of the Hippocampus: How is it? What is it for? How does it do it? written by Enrico Cherubini and published by Frontiers Media SA. This book was released on 2015-08-19 with total page 167 pages. Available in PDF, EPUB and Kindle. Book excerpt: The CA3 hippocampal region receives information from the entorhinal cortex either directly from the perforant path or indirectly from the dentate gyrus via the mossy fibers (MFs). According to their specific targets (principal/mossy cells or interneurons), MFs terminate with large boutons or small filopodial extensions, respectively. MF-CA3 synapses are characterized by a low probability of release and pronounced frequency-dependent facilitation. In addition MF terminals are endowed with mGluRs that regulate their own release. We will describe the intrinsic membrane properties of pyramidal cells, which can sometimes fire in bursts, together with the geometry of their dendritic arborization. The single layer of pyramidal cells is quite distinct from the six-layered neocortical arrangement. The resulting aligned dendrites provides the substrate for laminated excitatory inputs. They also underlie a precise, diversity of inhibitory control which we will also describe in detail. The CA3 region has an especially rich internal connectivity, with recurrent excitatory and inhibitory loops. In recent years both in vivo and in vitro studies have allowed to better understand functional properties of the CA3 auto-associative network and its role in information processing. This circuit is implicated in encoding spatial representations and episodic memories. It generates physiological population synchronies, including gamma, theta and sharp-waves that are presumed to associate firing in selected assemblies of cells in different behavioral conditions. The CA3 region is susceptible to neurodegeneration during aging and after stresses such as infection or injury. Loss of some CA3 neurones has striking effects on mossy fiber inputs and can facilitate the generation of pathologic synchrony within the CA3 micro-circuit. The aim of this special topic is to bring together experts on the cellular and molecular mechanisms regulating the wiring properties of the CA3 hippocampal microcircuit in both physiological and pathological conditions, synaptic plasticity, behavior and cognition.We will particularly emphasize the dual glutamatergic and GABAergic phenotype of MF-CA3 synapses at early developmental stages and the steps that regulate the integration of newly generated neurons into the adult dentate gyrus-CA3 circuit.
Download or read book The Plastic Mind written by Sharon Begley and published by Hachette UK. This book was released on 2012-10-25 with total page 374 pages. Available in PDF, EPUB and Kindle. Book excerpt: For decades, the conventional wisdom of neuroscience held that the hardware of the brain is fixed - that we are stuck with what we were born with. But recent pioneering experiments in neuroplasticity reveal that the brain is capable not only of altering its structure but also of generating new neurons, even into old age. The brain can adapt, heal, renew itself after trauma and compensate for disability. In this groundbreaking book, highly respected science writer Sharon Begley documents how this fundamental paradigm shift is transforming both our understanding of the human mind and our approach to deep-seated emotional, cognitive and behavioural problems. These breakthroughs show that it is possible to reset our happiness meter, regain the use of limbs disabled by stroke, train the mind to break cycles of depression and OCD and reverse age-related changes in the brain.
Book Synopsis Limbic Seizures in Children by : G. Avanzini
Download or read book Limbic Seizures in Children written by G. Avanzini and published by John Libbey Eurotext. This book was released on 2001 with total page 272 pages. Available in PDF, EPUB and Kindle. Book excerpt: The aim of the colloquium from which this multi-author book derives, was to outline the specific expression of epilepsies involving the limbic structures in children and to establish a consensus on the evidence relevant to the clinical management of these epilepsies. The book addresses basic questions such as age-related aetiologic, pathogenetic and prognostic factors relevant to the course of infantile epilepsies with limbic seizures, and enlightens the criteria for their clinical and laboratory assessment. The interaction between basic scientists, neuropaediatricians and neurosurgeons contributes to define suitable strategies aimed at preventing the unfavourable course of these often severe infantile epilepsies and their optimal timing.
Book Synopsis The Causes of Epilepsy by : Simon Shorvon
Download or read book The Causes of Epilepsy written by Simon Shorvon and published by Cambridge University Press. This book was released on 2019-05-02 with total page 1013 pages. Available in PDF, EPUB and Kindle. Book excerpt: Expanded and revised, this unique book provides concise descriptions of the many causes of epilepsy, for use in clinical practice.
Book Synopsis The Dentate Gyrus: A Comprehensive Guide to Structure, Function, and Clinical Implications by : Helen E. Scharfman
Download or read book The Dentate Gyrus: A Comprehensive Guide to Structure, Function, and Clinical Implications written by Helen E. Scharfman and published by Elsevier. This book was released on 2011-09-22 with total page 841 pages. Available in PDF, EPUB and Kindle. Book excerpt: The dentate gyrus is a part of the brain that has been a topic of intense interest since the beginning of neuroscience, and pioneering studies from the distant and recent past attest to this. One of the reasons for such interest is that this structure provides some of the most remarkable examples of plasticity within the nervous system. In addition, it is critical to normal cognitive function, although exactly how and when is still a question that eludes answers. Furthermore, abnormalities within the dentate gyrus appear to play a role in diverse clinical conditions, from depression to epilepsy and traumatic brain injury. The primary goal of this book is to provide a context, or background, upon which the detailed knowledge of the current era can be appreciated. A series of overviews are provided to clarify essentials related to structural organization and development, cellular components, neurotransmitters and neuromodulators, plasticity, and clinical relevance. * Covers the topic comprehensively from anatomy to cellular and systems perspectives* Includes basic research and addresses translational implications, so it will be useful to both researchers in the laboratory and clinicians who conduct experiments in humans* Chapters provide fundamentals, but also details and ample references for further review of the topic
Book Synopsis Cognitive Plasticity in Neurologic Disorders by : Joseph I. Tracy
Download or read book Cognitive Plasticity in Neurologic Disorders written by Joseph I. Tracy and published by Oxford University Press, USA. This book was released on 2014-12-02 with total page 433 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume makes clear that the cognitive and behavioural symptoms of neurologic disorders and syndromes are dynamic and changing. Each chapter describes the neuroplastic processes at work in a particular condition, giving rise to these ongoing cognitive changes.
Book Synopsis Introduction to Epilepsy by : Gonzalo Alarcón
Download or read book Introduction to Epilepsy written by Gonzalo Alarcón and published by Cambridge University Press. This book was released on 2012-04-26 with total page 641 pages. Available in PDF, EPUB and Kindle. Book excerpt: Covers all aspects of epilepsy, from basic mechanisms to diagnosis and management, as well as legal and social considerations.
Book Synopsis The Dentate Gyrus and Its Role in Seizures by : Charles E. Ribak
Download or read book The Dentate Gyrus and Its Role in Seizures written by Charles E. Ribak and published by Elsevier Publishing Company. This book was released on 1992 with total page 344 pages. Available in PDF, EPUB and Kindle. Book excerpt: The chapters of this book are grouped to provide a logical sequence for the reader. The first section, entitled Cell Types and Innervation Patterns brings together six presentations that address different aspects of the detailed anatomy of the dentate gyrus. Particular emphasis is placed on the three major cell types, granule cells, basket cells and the heterogeneous cells of the hilus. In addition, two of the chapters focus on the termination pattern of chemically-identified afferents to this region. The section concludes with a paper that bridges the gap between anatomy and the next section: Cellular Physiology and Functional Plasticity of neurons in the dentate gyrus. The five chapters in the second section are devoted to the electrophysiology of different neuronal types of the dentate gyrus. The middle section, entitled Seizures and the Regulation of Gene Expression and Protein Content, demonstrates some remarkable alterations in the expression of neuropeptides, growth factors and intracellular calcium-regulating proteins in experimental models of epilepsy.
Book Synopsis Computational Neuroscience in Epilepsy by : Ivan Soltesz
Download or read book Computational Neuroscience in Epilepsy written by Ivan Soltesz and published by Academic Press. This book was released on 2011-09-02 with total page 649 pages. Available in PDF, EPUB and Kindle. Book excerpt: Epilepsy is a neurological disorder that affects millions of patients worldwide and arises from the concurrent action of multiple pathophysiological processes. The power of mathematical analysis and computational modeling is increasingly utilized in basic and clinical epilepsy research to better understand the relative importance of the multi-faceted, seizure-related changes taking place in the brain during an epileptic seizure. This groundbreaking book is designed to synthesize the current ideas and future directions of the emerging discipline of computational epilepsy research. Chapters address relevant basic questions (e.g., neuronal gain control) as well as long-standing, critically important clinical challenges (e.g., seizure prediction). Computational Neuroscience in Epilepsy should be of high interest to a wide range of readers, including undergraduate and graduate students, postdoctoral fellows and faculty working in the fields of basic or clinical neuroscience, epilepsy research, computational modeling and bioengineering. - Covers a wide range of topics from molecular to seizure predictions and brain implants to control seizures - Contributors are top experts at the forefront of computational epilepsy research - Chapter contents are highly relevant to both basic and clinical epilepsy researchers
Download or read book The Hippocampus written by Ales Stuchlik and published by BoD – Books on Demand. This book was released on 2018-07-11 with total page 180 pages. Available in PDF, EPUB and Kindle. Book excerpt: The hippocampus is an important brain region, a true central hub for memory of various kinds and other processes. Neuropsychiatric disorders such as Alzheimer's disease, drug addiction, and schizophrenia are characterized by hippocampal alterations. The dentate gyrus of the hippocampus is a site exhibiting adult neurogenesis. This book covers the topic of the hippocampus from various perspectives. It discusses adult neurogenesis, effect of enriched environments on hippocampal plasticity, and long-term potentiation-associated gene expression. The book also addresses multiscale representations of complex environments and strategies in the hippocampus-dependent spatial tasks. Finally, insight into the hippocampus as a link between negative affect and relapse to psychostimulants is provided. The book collects evidence of various hippocampal functions in healthy and disordered brain.
Book Synopsis The Mouse Nervous System by : Charles Watson
Download or read book The Mouse Nervous System written by Charles Watson and published by Academic Press. This book was released on 2011-11-28 with total page 815 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Mouse Nervous System provides a comprehensive account of the central nervous system of the mouse. The book is aimed at molecular biologists who need a book that introduces them to the anatomy of the mouse brain and spinal cord, but also takes them into the relevant details of development and organization of the area they have chosen to study. The Mouse Nervous System offers a wealth of new information for experienced anatomists who work on mice. The book serves as a valuable resource for researchers and graduate students in neuroscience. Systematic consideration of the anatomy and connections of all regions of the brain and spinal cord by the authors of the most cited rodent brain atlases A major section (12 chapters) on functional systems related to motor control, sensation, and behavioral and emotional states A detailed analysis of gene expression during development of the forebrain by Luis Puelles, the leading researcher in this area Full coverage of the role of gene expression during development and the new field of genetic neuroanatomy using site-specific recombinases Examples of the use of mouse models in the study of neurological illness
Book Synopsis Understanding Epilepsy by : Vibhangini S. Wasade
Download or read book Understanding Epilepsy written by Vibhangini S. Wasade and published by Cambridge University Press. This book was released on 2019-11-21 with total page 501 pages. Available in PDF, EPUB and Kindle. Book excerpt: A comprehensive, accessible synthesis of current information on epilepsy for medical trainees and physicians preparing for board certification.
Book Synopsis Practical Differential Diagnosis in Surgical Neuropathology by : Richard A. Prayson
Download or read book Practical Differential Diagnosis in Surgical Neuropathology written by Richard A. Prayson and published by Springer Science & Business Media. This book was released on 2000-07-07 with total page 200 pages. Available in PDF, EPUB and Kindle. Book excerpt: This well-organized guide to many of the more commonly encountered diagnostic problems in surgical neuropathology will serve as a day-to-day guide in most active pathology laboratories. The book focuses on the differential diagnosis of the most common neuropathologic entities encountered by general surgical pathologists. The authors go to great lengths to help readers with important diagnoses on very small amounts of tissue, or decide difficult situations where everything looks the same, or cope with intraoperative consultations when time is short and sample preparations are less than ideal. Richly detailed, Practical Differential Diagnosis in Surgical Neuropathology offers both general and specialist neuropathologists a user-friendly, decision-oriented guide to the major diagnostic problems in surgical neuropathology, one that will greatly facilitate successful day-to-day neuropathologic diagnosis, and thus the optimal care of patients.
Book Synopsis Models of Seizures and Epilepsy by : Asla Pitkänen
Download or read book Models of Seizures and Epilepsy written by Asla Pitkänen and published by Academic Press. This book was released on 2017-06-14 with total page 1180 pages. Available in PDF, EPUB and Kindle. Book excerpt: Models of Seizures and Epilepsy, Second Edition, is a valuable, practical reference for investigators who are searching for the most appropriate laboratory models to address key questions in the field. The book also provides an important background for physicians, fellows, and students, offering insight into the potential for advances in epilepsy research as well as R&D drug development. Contents include the current spectrum of models available to model different epilepsy syndromes, epilepsy in transgenic animals, comorbidities in models of epilepsy, and novel technologies to study seizures and epilepsies in animals. - Provides a comprehensive reference detailing animal models of epilepsy and seizure - Offers insights on the use of novel technologies that can be applied in experimental epilepsy research - Edited by leading experts in the field that provide not only technical reviews of these models but also conceptual critiques - Comments on the strengths and limitations of various models, including their relationship to clinical phenomenology and their value in developing better understanding and treatments
