Structural Virology

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Author :
Publisher : Royal Society of Chemistry
ISBN 13 : 184973223X
Total Pages : 389 pages
Book Rating : 4.8/5 (497 download)

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Book Synopsis Structural Virology by : Mavis Agbandje-McKenna

Download or read book Structural Virology written by Mavis Agbandje-McKenna and published by Royal Society of Chemistry. This book was released on 2010-11-11 with total page 389 pages. Available in PDF, EPUB and Kindle. Book excerpt: Over the last ten years, much effort has been devoted to improving the biophysical techniques used in the study of viruses. This has resulted in the visualization of these large macromolecular assemblages at atomic level, thus providing the platform for functional interpretation and therapeutic design. Structural Virology covers a wide range of topics and is split into three sections. The first discusses the vast biophysical methodologies used in structural virology, including sample production and purification, confocal microscopy, mass spectrometry, negative-stain and cryo-electron microscopy, X-ray crystallography and nuclear magnetic resonance spectroscopy. The second discusses the role of virus capsid protein structures in determining the functional roles required for receptor recognition, cellular entry, capsid assembly, genome packaging and mechanisms of host immune system evasion. The last section discusses therapeutic strategies based on virus protein structures, including the design of antiviral drugs and the development of viral capsids as vehicles for foreign gene delivery. Each topic covered will begin with a review of the current literature followed by a more detailed discussion of experimental procedures, a step in the viral life cycle, or strategies for therapeutic development. With contributions from experts in the field of structural biology and virology this exceptional monograph will appeal to biomedical scientists involved in basic and /or applied research on viruses. It also provides up-to-date reference material for students entering the field of structural virology as well as scientists already familiar with the area.

SARS-CoV-2 Spike Protein Convergent Evolution

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Author :
Publisher : Springer Nature
ISBN 13 : 3030873242
Total Pages : 140 pages
Book Rating : 4.0/5 (38 download)

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Book Synopsis SARS-CoV-2 Spike Protein Convergent Evolution by : Daniele Focosi

Download or read book SARS-CoV-2 Spike Protein Convergent Evolution written by Daniele Focosi and published by Springer Nature. This book was released on 2021-10-11 with total page 140 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book reviews the current knowledge of the globally circulating SARS-CoV-2 variants, highlights their distinct genetic characteristics and associated conformational changes in the viral spike protein, and profoundly discusses the mechanisms of convergent evolution that led to the rise of these mutated strains at different geographic regions during the Covid-19 pandemic. Furthermore, the book explores how these variants do and may impact the efficacy of established neutralizing antibody-based (nAb) vaccines and therapeutics by analysing latest in vivo and in vitro clinical data. Finally, the author discusses ways on how nAb Covid-19 treatment derived immune escape of SARS-CoV-2 could be minimized in the future.

A Certain Strain of Peculiar

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Author :
Publisher : Candlewick Press
ISBN 13 : 0763630098
Total Pages : 274 pages
Book Rating : 4.7/5 (636 download)

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Book Synopsis A Certain Strain of Peculiar by : Gigi Amateau

Download or read book A Certain Strain of Peculiar written by Gigi Amateau and published by Candlewick Press. This book was released on 2009 with total page 274 pages. Available in PDF, EPUB and Kindle. Book excerpt: Tired of the miserable life she lives, Mary Harold leaves her mother behind and moves back to Alabama and her grandmother, where she receives support and love and starts to gain confidence in herself and her abilities.

Marijuana As Medicine?

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Publisher : National Academies Press
ISBN 13 : 0309065313
Total Pages : 216 pages
Book Rating : 4.3/5 (9 download)

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Book Synopsis Marijuana As Medicine? by : Institute of Medicine

Download or read book Marijuana As Medicine? written by Institute of Medicine and published by National Academies Press. This book was released on 2000-12-30 with total page 216 pages. Available in PDF, EPUB and Kindle. Book excerpt: Some people suffer from chronic, debilitating disorders for which no conventional treatment brings relief. Can marijuana ease their symptoms? Would it be breaking the law to turn to marijuana as a medication? There are few sources of objective, scientifically sound advice for people in this situation. Most books about marijuana and medicine attempt to promote the views of advocates or opponents. To fill the gap between these extremes, authors Alison Mack and Janet Joy have extracted critical findings from a recent Institute of Medicine study on this important issue, interpreting them for a general audience. Marijuana As Medicine? provides patientsâ€"as well as the people who care for themâ€"with a foundation for making decisions about their own health care. This empowering volume examines several key points, including: Whether marijuana can relieve a variety of symptoms, including pain, muscle spasticity, nausea, and appetite loss. The dangers of smoking marijuana, as well as the effects of its active chemical components on the immune system and on psychological health. The potential use of marijuana-based medications on symptoms of AIDS, cancer, multiple sclerosis, and several other specific disorders, in comparison with existing treatments. Marijuana As Medicine? introduces readers to the active compounds in marijuana. These include the principal ingredient in Marinol, a legal medication. The authors also discuss the prospects for developing other drugs derived from marijuana's active ingredients. In addition to providing an up-to-date review of the science behind the medical marijuana debate, Mack and Joy also answer common questions about the legal status of marijuana, explaining the conflict between state and federal law regarding its medical use. Intended primarily as an aid to patients and caregivers, this book objectively presents critical information so that it can be used to make responsible health care decisions. Marijuana As Medicine? will also be a valuable resource for policymakers, health care providers, patient counselors, medical faculty and studentsâ€"in short, anyone who wants to learn more about this important issue.

The Health Effects of Cannabis and Cannabinoids

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Author :
Publisher : National Academies Press
ISBN 13 : 0309453070
Total Pages : 487 pages
Book Rating : 4.3/5 (94 download)

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Book Synopsis The Health Effects of Cannabis and Cannabinoids by : National Academies of Sciences, Engineering, and Medicine

Download or read book The Health Effects of Cannabis and Cannabinoids written by National Academies of Sciences, Engineering, and Medicine and published by National Academies Press. This book was released on 2017-03-31 with total page 487 pages. Available in PDF, EPUB and Kindle. Book excerpt: Significant changes have taken place in the policy landscape surrounding cannabis legalization, production, and use. During the past 20 years, 25 states and the District of Columbia have legalized cannabis and/or cannabidiol (a component of cannabis) for medical conditions or retail sales at the state level and 4 states have legalized both the medical and recreational use of cannabis. These landmark changes in policy have impacted cannabis use patterns and perceived levels of risk. However, despite this changing landscape, evidence regarding the short- and long-term health effects of cannabis use remains elusive. While a myriad of studies have examined cannabis use in all its various forms, often these research conclusions are not appropriately synthesized, translated for, or communicated to policy makers, health care providers, state health officials, or other stakeholders who have been charged with influencing and enacting policies, procedures, and laws related to cannabis use. Unlike other controlled substances such as alcohol or tobacco, no accepted standards for safe use or appropriate dose are available to help guide individuals as they make choices regarding the issues of if, when, where, and how to use cannabis safely and, in regard to therapeutic uses, effectively. Shifting public sentiment, conflicting and impeded scientific research, and legislative battles have fueled the debate about what, if any, harms or benefits can be attributed to the use of cannabis or its derivatives, and this lack of aggregated knowledge has broad public health implications. The Health Effects of Cannabis and Cannabinoids provides a comprehensive review of scientific evidence related to the health effects and potential therapeutic benefits of cannabis. This report provides a research agendaâ€"outlining gaps in current knowledge and opportunities for providing additional insight into these issuesâ€"that summarizes and prioritizes pressing research needs.

Delta 72

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Author :
Publisher : Diamond Pocket Books Pvt Ltd
ISBN 13 : 935486063X
Total Pages : 97 pages
Book Rating : 4.3/5 (548 download)

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Book Synopsis Delta 72 by : Dr. Biswaroop Roy Chowdhury

Download or read book Delta 72 written by Dr. Biswaroop Roy Chowdhury and published by Diamond Pocket Books Pvt Ltd. This book was released on 2021-08-07 with total page 97 pages. Available in PDF, EPUB and Kindle. Book excerpt: Delta (δ) variant is not a new virus. But a new name, given to an existing virus, definitely with a purpose. This book exposes the horrific purpose through the stories of 72 covid-19 infected patients who were part of the case study at Ahmednagar N.I.C.E centre. You cannot afford to miss reading the book, especially if you know that not knowing the truth may risk you and your child becoming the victim of the conspiracy. And knowing the truth can give you utmost freedom from the fear and panic of much publicised "the 3rd wave".

Delta Wedding

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Author :
Publisher : HMH
ISBN 13 : 0547538685
Total Pages : 339 pages
Book Rating : 4.5/5 (475 download)

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Book Synopsis Delta Wedding by : Eudora Welty

Download or read book Delta Wedding written by Eudora Welty and published by HMH. This book was released on 1979-03-21 with total page 339 pages. Available in PDF, EPUB and Kindle. Book excerpt: This novel of a Mississippi family in the 1920s “presents the essence of the Deep South and does it with infinite finesse” (The Christian Science Monitor). From one of the most treasured American writers, winner of a National Book Award and Pulitzer Prize, comes Delta Wedding, a vivid and charming portrait of Southern life. Set in 1923, the story is centered on the Fairchilds, a big and clamorous family, who live on a plantation in the Mississippi delta. They are in the midst of planning their daughter’s wedding when a nine-year-old relative, Laura McRaven, whose mother has just died, comes to visit. Drama leads to drama, revelation to revelation, in a novel that is “nothing short of wonderful” (The New Yorker). The result is a sometimes-riotous view of a Southern family, and the parentless child who learns to become one of them.

Preventable

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Author :
Publisher : St. Martin's Press
ISBN 13 : 1250770173
Total Pages : 199 pages
Book Rating : 4.2/5 (57 download)

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Book Synopsis Preventable by : Andy Slavitt

Download or read book Preventable written by Andy Slavitt and published by St. Martin's Press. This book was released on 2021-06-15 with total page 199 pages. Available in PDF, EPUB and Kindle. Book excerpt: * NATIONAL BESTSELLER * “Painfully good. The book could have been called, ‘Outrageous.’ The story Andy Slavitt tells is not just about Trump’s monumental failures but also about the deeper ones that started long before, with our health system, our politics, and more.” --Atul Gawande, author of Being Mortal The definitive, behind-the-scenes look at the U.S. Coronavirus crisis from one of the most recognizable and influential voices in healthcare From former Biden Senior Advisor Andy Slavitt, Preventable is the definitive inside account of the United States' failed response to the Coronavirus pandemic. Slavitt chronicles what he saw and how much could have been prevented -- an unflinching investigation of the cultural, political, and economic drivers that led to unnecessary loss of life. With unparalleled access to the key players throughout the government on both sides of the aisle, the principal public figures, as well as the people working on the frontline involved in fighting the virus, Slavitt brings you into the room as fateful decisions are made and focuses on the people at the center of the political system, health care system, patients, and caregivers. The story that emerges is one of a country in which -- despite the heroics of many -- bad leadership, political and cultural fractures, and an unwillingness to sustain sacrifice light a fuse that is difficult to extinguish. Written in the tradition of The Big Short, Preventable continues Andy Slavitt’s important work of addressing the uncomfortable realities that brought America to this place. And, he puts forth the solutions that will prevent us from being here again, ensuring a better, stronger country for everyone.

Colonial Delaware

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Author :
Publisher : Millwood, N.Y. : KTO Press
ISBN 13 :
Total Pages : 320 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis Colonial Delaware by : John Andrew Munroe

Download or read book Colonial Delaware written by John Andrew Munroe and published by Millwood, N.Y. : KTO Press. This book was released on 1978 with total page 320 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Coarse-Grained Deltas

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Author :
Publisher : John Wiley & Sons
ISBN 13 : 1444303864
Total Pages : 368 pages
Book Rating : 4.4/5 (443 download)

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Book Synopsis Coarse-Grained Deltas by : Albina Colella

Download or read book Coarse-Grained Deltas written by Albina Colella and published by John Wiley & Sons. This book was released on 2009-03-30 with total page 368 pages. Available in PDF, EPUB and Kindle. Book excerpt: This Special Publication contains most of the contributions presented at the 1st International Workshop on Fan Deltas (1988) but also contains additional papers which make this particular volume a very well-rounded reference source for the advanced undergraduate/graduate student and the professional earth scientist concerned with sedimentology and petroleum geology. The papers describe the sedimentology and tectonic setting of this important depositional environment. Course-grained deltas, ranging from sand to gravelly, are fully covered and the main focus is on steep-face systems whose steep subaqueous slopes are dominated by high-energy processes. The volume includes case histories from around the world and throughout the book there is emphasis on the subaqueous realm of the delta face, its sedimentary processes and facies associations

Marijuana and Medicine

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Author :
Publisher : National Academies Press
ISBN 13 : 0309071550
Total Pages : 288 pages
Book Rating : 4.3/5 (9 download)

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Book Synopsis Marijuana and Medicine by : Institute of Medicine

Download or read book Marijuana and Medicine written by Institute of Medicine and published by National Academies Press. This book was released on 1999-07-10 with total page 288 pages. Available in PDF, EPUB and Kindle. Book excerpt: The medical use of marijuana is surrounded by a cloud of social, political, and religious controversy, which obscures the facts that should be considered in the debate. This book summarizes what we know about marijuana from evidence-based medicineâ€"the harm it may do and the relief it may bring to patients. The book helps the reader understand not only what science has to say about medical marijuana but also the logic behind the scientific conclusions. Marijuana and Medicine addresses the science base and the therapeutic effects of marijuana use for medical conditions such as glaucoma and multiple sclerosis. It covers marijuana's mechanism of action, acute and chronic effects on health and behavior, potential adverse effects, efficacy of different delivery systems, analysis of the data about marijuana as a gateway drug, and the prospects for developing cannabinoid drugs. The book evaluates how well marijuana meets accepted standards for medicine and considers the conclusions of other blue-ribbon panels. Full of useful facts, this volume will be important to anyone interested in informed debate about the medical use of marijuana: advocates and opponents as well as policymakers, regulators, and health care providers.

Therapeutic Uses of Cannabis

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Author :
Publisher : CRC Press
ISBN 13 : 1000159655
Total Pages : 160 pages
Book Rating : 4.0/5 (1 download)

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Book Synopsis Therapeutic Uses of Cannabis by : British Medical Association

Download or read book Therapeutic Uses of Cannabis written by British Medical Association and published by CRC Press. This book was released on 2020-08-17 with total page 160 pages. Available in PDF, EPUB and Kindle. Book excerpt: At the last Annual Representative Meeting of the British Medical Association a motion was passed that `certain additional cannabinoids should be legalized for wider medicinal use.'' This report supports this landmark statement by reviewing the scientific evidence for the therapeutic use of cannabinoids and sets the agenda for change. It will be welcomed by those who believe that cannabinoids can be used in medical treatment. The report discusses in a clear and readable form the use and adverse effects of the drug for nausea, multiple sclerosis, pain, epilepsy, glaucoma, and asthma.

Uncontrolled Spread

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Author :
Publisher : HarperCollins
ISBN 13 : 0063080028
Total Pages : 550 pages
Book Rating : 4.0/5 (63 download)

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Book Synopsis Uncontrolled Spread by : Scott Gottlieb

Download or read book Uncontrolled Spread written by Scott Gottlieb and published by HarperCollins. This book was released on 2021-09-21 with total page 550 pages. Available in PDF, EPUB and Kindle. Book excerpt: NEW YORK TIMES BESTSELLER “Uncontrolled Spread is everything you’d hope: a smart and insightful account of what happened and, currently, the best guide to what needs to be done to avoid a future pandemic." —Wall Street Journal “Informative and well paced.”—The Guardian “An intense ride through the pandemic with chilling details of what really happened. It is also sprinkled with notes of true wisdom that may help all of us better prepare for the future.”—Sanjay Gupta, MD, chief medical correspondent, CNN Physician and former FDA commissioner Scott Gottlieb asks: Has America’s COVID-19 catastrophe taught us anything? In Uncontrolled Spread, he shows how the coronavirus and its variants were able to trounce America’s pandemic preparations, and he outlines the steps that must be taken to protect against the next outbreak. As the pandemic unfolded, Gottlieb was in regular contact with all the key players in Congress, the Trump administration, and the drug and diagnostic industries. He provides an inside account of how level after level of American government crumbled as the COVID-19 crisis advanced. A system-wide failure across government institutions left the nation blind to the threat, and unable to mount an effective response. We’d prepared for the wrong virus. We failed to identify the contagion early enough and became overly reliant on costly and sometimes divisive tactics that couldn’t fully slow the spread. We never considered asymptomatic transmission and we assumed people would follow public health guidance. Key bureaucracies like the CDC were hidebound and outmatched. Weak political leadership aggravated these woes. We didn’t view a public health disaster as a threat to our national security. Many of the woes sprung from the CDC, which has very little real-time reporting capability to inform us of Covid’s twists and turns or assess our defenses. The agency lacked an operational capacity and mindset to mobilize the kind of national response that was needed. To guard against future pandemic risks, we must remake the CDC and properly equip it to better confront crises. We must also get our intelligence services more engaged in the global public health mission, to gather information and uncover emerging risks before they hit our shores so we can head them off. For this role, our clandestine agencies have tools and capabilities that the CDC lacks. Uncontrolled Spread argues we must fix our systems and prepare for a deadlier coronavirus variant, a flu pandemic, or whatever else nature -- or those wishing us harm -- may threaten us with. Gottlieb outlines policies and investments that are essential to prepare the United States and the world for future threats.

Introduction to Numerical Geodynamic Modelling

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Author :
Publisher : Cambridge University Press
ISBN 13 : 0521887542
Total Pages : 359 pages
Book Rating : 4.5/5 (218 download)

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Book Synopsis Introduction to Numerical Geodynamic Modelling by : Taras Gerya

Download or read book Introduction to Numerical Geodynamic Modelling written by Taras Gerya and published by Cambridge University Press. This book was released on 2010 with total page 359 pages. Available in PDF, EPUB and Kindle. Book excerpt: This user-friendly reference for students and researchers presents the basic mathematical theory, before introducing modelling of key geodynamic processes.

HIV-1 Latency

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Author :
Publisher : Springer
ISBN 13 : 303002816X
Total Pages : 253 pages
Book Rating : 4.0/5 (3 download)

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Book Synopsis HIV-1 Latency by : Guido Silvestri

Download or read book HIV-1 Latency written by Guido Silvestri and published by Springer. This book was released on 2018-10-11 with total page 253 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume summarizes recent advances in understanding the mechanisms of HIV-1 latency, in characterizing residual viral reservoirs, and in developing targeted interventions to reduce HIV-1 persistence during antiretroviral therapy. Specific chapters address the molecular mechanisms that govern and regulate HIV-1 transcription and latency; assays and technical approaches to quantify viral reservoirs in humans and animal models; the complex interchange between viral reservoirs and the host immune system; computational strategies to model viral reservoir dynamics; and the development of therapeutic approaches that target viral reservoir cells. With contributions from an interdisciplinary group of investigators that cover a broad spectrum of subjects, from molecular virology to proof-of-principle clinical trials, this book is a valuable resource for basic scientists, translational investigators, infectious-disease physicians, individuals living with HIV/AIDS and the general public.

Hepatitis Delta Virus

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Author :
Publisher : Springer
ISBN 13 : 9783642067518
Total Pages : 0 pages
Book Rating : 4.0/5 (675 download)

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Book Synopsis Hepatitis Delta Virus by : John L. Casey

Download or read book Hepatitis Delta Virus written by John L. Casey and published by Springer. This book was released on 2010-02-12 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Hepatitis delta virus (HDV), which causes severe acute and chronic liver disease, was discovered nearly 30 years ago following the detection of a novel antigen-antibody system in hepatitis B virus carriers. HDV has continued to surprise and fascinate medical science ever since. This volume reviews recent developments in HDV research, from molecular virology to genetics to experimental investigation of new therapeutic and vaccine candidates.

Delta Green Agent's Handbook

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Author :
Publisher :
ISBN 13 : 9781940410210
Total Pages : pages
Book Rating : 4.4/5 (12 download)

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Book Synopsis Delta Green Agent's Handbook by : Shane Ivey

Download or read book Delta Green Agent's Handbook written by Shane Ivey and published by . This book was released on 2016-03-15 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: