The Coming Of Age Of Insulin Signalling In Insects

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The Coming of Age of Insulin-Signalling in Insects

Author : Colin G.H. Steel
Publisher : Frontiers E-books
ISBN 13 : 2889193144
Total Pages : 139 pages
Book Rating : 4.8/5 (891 download)

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Book Synopsis The Coming of Age of Insulin-Signalling in Insects by : Colin G.H. Steel

Download or read book The Coming of Age of Insulin-Signalling in Insects written by Colin G.H. Steel and published by Frontiers E-books. This book was released on 2015-01-28 with total page 139 pages. Available in PDF, EPUB and Kindle. Book excerpt: The new millennium has seen a major paradigm shift in insect endocrinology. Great advancements are being made which establish that nutrition and growth play a central role in diverse cellular and physiological phenomena during insect development and reproduction. Nutrition affects rates of growth and is mainly regulated by the function of the pathway of insulin/insulin-like growth factor signalling. This pathway is highly conserved across species and ultimately regulates rates of cell growth and proliferation in growing organs. Insulin and insulin-like peptides (ILPs) are some of the best studied hormones in the animal kingdom and all share a common structural motif and initiate a wide range of closely similar physiological processes in higher organisms. In insects, nutrition, via circulating sugar, promotes release of ILPs from brain neurosecretory cells into the haemolymph, which act on peripheral tissues and stimulate protein synthesis and cell growth. Therefore, insect ILPs are common mediators between nutrition and growth in insects and are functionally analogous to mammalian insulin. The 1980s and 1990s witnessed great progress in elucidation of the physiological and molecular mechanism of action of numerous insect hormones involved in regulation of growth, development, reproduction and metabolism. But the signals for the initiation or termination of controlled events remained largely unknown. ILPs were first identified from the silkmoth Bombyx mori and were named bombyxins, but related peptides were soon found in numerous species and their functions elucidated. The insulin signalling pathway is now recognized as a central factor in the timing of cell proliferation, growth, longevity, reproduction, and reproductive diapause, as well as social behaviour. Recent work has revealed that the insulin signalling pathway is closely integrated with that of various other hormones, including ecdysteroids, the juvenile hormones and neuropeptide(s) such a prothoracicotropic hormone. In addition, the pathway is also linked with both circadian (daily) and photoperiodic (seasonal) clocks potentially providing a basis for its timing function. This Research Topic aims to provide the only current collection of recent advances on insect ILPs. We encouraged submissions on all areas related to identification, characterization, regulation and physiological functions of insect ILPs. We welcomed both full and short reviews and original research articles.

Physiological Systems in Insects

Author : Marc J. Klowden
Publisher : Academic Press
ISBN 13 : 0124159702
Total Pages : 697 pages
Book Rating : 4.1/5 (241 download)

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Book Synopsis Physiological Systems in Insects by : Marc J. Klowden

Download or read book Physiological Systems in Insects written by Marc J. Klowden and published by Academic Press. This book was released on 2013-05-15 with total page 697 pages. Available in PDF, EPUB and Kindle. Book excerpt: Physiological Systems in Insects discusses the roles of molecular biology, neuroendocrinology, biochemistry, and genetics in our understanding of insects. All chapters in the new edition are updated, with major revisions to those covering swiftly evolving areas like endocrine, developmental, behavioral, and nervous systems. The new edition includes the latest details from the literature on hormone receptors, behavioral genetics, insect genomics, neural integration, and much more. Organized according to insect physiological functions, this book is fully updated with the latest and foundational research that has influenced understanding of the patterns and processes of insects and is a valuable addition to the collection of any researcher or student working with insects. There are about 10 quintillion insects in the world divided into more than one million known species, and some scientists believe there may be more than 30 million species. As the largest living group on earth, insects can provide us with insight into adaptation, evolution, and survival. The internationally respected third edition of Marc Klowden's standard reference for entomologists and researchers and textbook for insect physiology courses provides the most comprehensive analysis of the systems that make insects important contributors to our environment. - Third edition has been updated with new information in almost every chapter and new figures - Includes an extensive up-to-date bibliography in each chapter - Provides a glossary of common entomological and physiological terms

Hormones, Brain and Behavior

Author :
Publisher : Academic Press
ISBN 13 : 0128036087
Total Pages : 2494 pages
Book Rating : 4.1/5 (28 download)

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Book Synopsis Hormones, Brain and Behavior by :

Download or read book Hormones, Brain and Behavior written by and published by Academic Press. This book was released on 2016-11-09 with total page 2494 pages. Available in PDF, EPUB and Kindle. Book excerpt: Hormones, Brain and Behavior, Third Edition offers a state-of-the-art overview of hormonally-mediated behaviors, including an extensive discussion of the effects of hormones on insects, fish, amphibians, birds, rodents, and humans. Entries have been carefully designed to provide a valuable source of information for students and researchers in neuroendocrinology and those working in related areas, such as biology, psychology, psychiatry, and neurology. This third edition has been substantially restructured to include both foundational information and recent developments in the field. Continuing the emphasis on interdisciplinary research and practical applications, the book includes articles aligned in five main subject sections, with new chapters included on genetic and genomic techniques and clinical investigations. This reference provides unique treatment of all major vertebrate and invertebrate model systems with excellent opportunities for relating behavior to molecular genetics. The topics cover an unusual breadth (from molecules to ecophysiology), ranging from basic science to clinical research, making this reference of interest to a broad range of scientists in a variety of fields. Comprehensive and updated coverage of a rapidly growing field of research Unique treatment of all major vertebrate and invertebrate model systems with excellent opportunities for relating behavior to molecular genetics Covers an unusual breadth of topics and subject fields, ranging from molecules to ecophysiology, and from basic science to clinical research Ideal resource for interdisciplinary learning and understanding in the fields of hormones and behavior

Insect Microbiome: From Diversity To Applications

Author : George Tsiamis
Publisher : Frontiers Media SA
ISBN 13 : 2889769798
Total Pages : 465 pages
Book Rating : 4.8/5 (897 download)

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Book Synopsis Insect Microbiome: From Diversity To Applications by : George Tsiamis

Download or read book Insect Microbiome: From Diversity To Applications written by George Tsiamis and published by Frontiers Media SA. This book was released on 2023-03-21 with total page 465 pages. Available in PDF, EPUB and Kindle. Book excerpt: Insects are by far the most diverse and abundant animal group with respect to the number of species globally, in ecological habitats and in biomass. The ecological and evolutionary success of insects depends in part on their countless relationships with beneficial microorganisms, which are known to influence all aspects of their physiology, ecology, and evolution. These symbiotic associations are known to: (a) enhance nutrient-poor diets, (b) aid digestion of recalcitrant food components, (c) protect from predators, parasites, and pathogens, (d) contribute to inter- and intraspecific communication, (e) affect efficiency as disease vectors and (f) govern mating and reproductive systems. Characterization, exploitation, and management of the insect-bacterial symbiotic associations can contribute significantly to the control of agricultural pests and disease vectors. Insects that depend exclusively on nutritionally restricted diets such as plant sap, vertebrate blood, and woody material, commonly possess obligate mutualistic endosymbionts involved in the provision of essential nutrients or in the degradation of food materials. These intracellular mutualists commonly have the following biological features: (a) they localize inside bacteriocytes, (b) are essential for fitness, (c) are maternally transmitted, and (d) display strict host-symbiont co-evolutionary patterns. In addition to obligate endosymbionts, many insects harbor bacteria that are not essential for their survival or fecundity and are typically maintained with a patchy distribution in host populations. Such symbionts can induce reproductive phenotypes in insect hosts, including male-killing, feminization, parthenogenesis or cytoplasmic incompatibility. Because these bacteria manipulate their host’s reproductive biology, they also likely accelerate host processes. As for essentially all animals, microbial communities are particularly prominent in the digestive tract, where they may be key mediators of the varied lifestyles of insect hosts. The contribution of microorganisms, particularly gut microorganisms, to insect function is highly relevant from several perspectives, linking to applications in medicine, agriculture, and ecology. Gut-associated microorganisms can include protists, fungi, archaea, and bacteria, but it is generally accepted that bacterial species dominate the microbial community in the guts of most insects. Gut-associated bacteria can influence: (a) vectoring efficiency, (b) developmental time, (c) decomposition of plant biomass and carbon cycle, (d) nitrogen fixation and nitrogen cycle, (e) mating incompatibilities, and (f) detoxification of pesticides leading to the acquisition of insecticide resistance.

Insect Diapause

Author : David L. Denlinger
Publisher : Cambridge University Press
ISBN 13 : 1108755186
Total Pages : 465 pages
Book Rating : 4.1/5 (87 download)

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Book Synopsis Insect Diapause by : David L. Denlinger

Download or read book Insect Diapause written by David L. Denlinger and published by Cambridge University Press. This book was released on 2022-02-03 with total page 465 pages. Available in PDF, EPUB and Kindle. Book excerpt: Our highly seasonal world restricts insect activity to brief portions of the year. This feature necessitates a sophisticated interpretation of seasonal changes and enactment of mechanisms for bringing development to a halt and then reinitiating it when the inimical season is past. The dormant state of diapause serves to bridge the unfavourable seasons, and its timing provides a powerful mechanism for synchronizing insect development. This book explores how seasonal signals are monitored and used by insects to enact specific molecular pathways that generate the diapause phenotype. The broad perspective offered here scales from the ecological to the molecular and thus provides a comprehensive view of this exciting and vibrant research field, offering insights on topics ranging from pest management, evolution, speciation, climate change and disease transmission, to human health, as well as analogies with other forms of invertebrate dormancy and mammalian hibernation.

Neuropeptide GPCRs in neuroendocrinology

Author : Jae Young Seong
Publisher : Frontiers E-books
ISBN 13 : 2889192679
Total Pages : 826 pages
Book Rating : 4.8/5 (891 download)

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Book Synopsis Neuropeptide GPCRs in neuroendocrinology by : Jae Young Seong

Download or read book Neuropeptide GPCRs in neuroendocrinology written by Jae Young Seong and published by Frontiers E-books. This book was released on 2014-11-07 with total page 826 pages. Available in PDF, EPUB and Kindle. Book excerpt: The human genome encompasses ˜ 860 G protein-coupled receptors (GPCRs) including 374 non-chemosensory GPCRs. Half of these latter GPCRs recognize (neuro)peptides as natural ligands. GPCRs thus play a pivotal role in neuroendocrine communication. In particular, GPCRs are involved in the neuroendocrine control of feeding behavior, reproduction, growth, hydromineral homeostasis and stress response. GPCRs are also major drug targets and hence possess a strong potential for the development of innovative pharmaceuticals. The aim of this Research Topic was to assemble a series of review articles and original research papers on neuropeptide GPCRs and their ligands that would illustrate the different facets of the studies currently conducted in this domain.

Neurobiology of Chemical Communication

Author : Carla Mucignat-Caretta
Publisher : CRC Press
ISBN 13 : 1466553413
Total Pages : 614 pages
Book Rating : 4.4/5 (665 download)

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Book Synopsis Neurobiology of Chemical Communication by : Carla Mucignat-Caretta

Download or read book Neurobiology of Chemical Communication written by Carla Mucignat-Caretta and published by CRC Press. This book was released on 2014-02-14 with total page 614 pages. Available in PDF, EPUB and Kindle. Book excerpt: Intraspecific communication involves the activation of chemoreceptors and subsequent activation of different central areas that coordinate the responses of the entire organism—ranging from behavioral modification to modulation of hormones release. Animals emit intraspecific chemical signals, often referred to as pheromones, to advertise their presence to members of the same species and to regulate interactions aimed at establishing and regulating social and reproductive bonds. In the last two decades, scientists have developed a greater understanding of the neural processing of these chemical signals. Neurobiology of Chemical Communication explores the role of the chemical senses in mediating intraspecific communication. Providing an up-to-date outline of the most recent advances in the field, it presents data from laboratory and wild species, ranging from invertebrates to vertebrates, from insects to humans. The book examines the structure, anatomy, electrophysiology, and molecular biology of pheromones. It discusses how chemical signals work on different mammalian and non-mammalian species and includes chapters on insects, Drosophila, honey bees, amphibians, mice, tigers, and cattle. It also explores the controversial topic of human pheromones. An essential reference for students and researchers in the field of pheromones, this is also an ideal resource for those working on behavioral phenotyping of animal models and persons interested in the biology/ecology of wild and domestic species.

Index Medicus

Author :
Publisher :
ISBN 13 :
Total Pages : 1810 pages
Book Rating : 4.:/5 (319 download)

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Book Synopsis Index Medicus by :

Download or read book Index Medicus written by and published by . This book was released on 2004 with total page 1810 pages. Available in PDF, EPUB and Kindle. Book excerpt: Vols. for 1963- include as pt. 2 of the Jan. issue: Medical subject headings.

CephsInAction: Towards Future Challenges for Cephalopod Science

Author : Lindy Holden-Dye
Publisher : Frontiers Media SA
ISBN 13 : 288963437X
Total Pages : 185 pages
Book Rating : 4.8/5 (896 download)

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Book Synopsis CephsInAction: Towards Future Challenges for Cephalopod Science by : Lindy Holden-Dye

Download or read book CephsInAction: Towards Future Challenges for Cephalopod Science written by Lindy Holden-Dye and published by Frontiers Media SA. This book was released on 2020-02-12 with total page 185 pages. Available in PDF, EPUB and Kindle. Book excerpt: The last five years have been extremely challenging, but also very innovative for cephalopod science, and the outstanding tradition of biological contribution with cephalopod molluscs as key players in science and human activities and interests has continued. This Research Topic is one of several dedicated to cephalopod molluscs (e.g., Hanke and Osorio, 2018; Ponte et al., 2018) hosted by Frontiers over the last few years, not to mention other papers published separately. Highlighting of cephalopod science is important because it has much to offer not only the life science community, but also more broadly the public perception of science and its understanding and relationship with scientific endeavour and cephalopods as living organisms and part of our everyday life (at least for most of us). This contribution illustrates the key needs that need to be overcome by the cephalopod research community, i.e. rapid and effective mechanisms for exchange of knowledge and resources, sharing of laboratory protocols, videos, tissues, samples and data-sets, innovative approaches and initiatives in public engagement. The cuttlefish comic included is an excellent example of a type of media that can be used to expand scientific knowledge to the public and human relationship with live animals. There are strategic challenges in convincing globally distributed policy makers and funders of the relevance of cephalopods in scientific advances, and also in the regulatory aspects, since cephalopods are the only invertebrates whose use is regulated in Europe in a research context and this increases the need for integrated oversight and direction in terms of ethics and animal welfare (e.g., Jacquet et al., 2019a; 2019b; Ponte et al., 2019). This Research Topic also aligns with the interests of the cephalopod community in stimulating public interest in cephalopods extending to a broader audience that could include chefs and gourmets, and fishers and scientists aiming to develop sustainable food resources. “CephsInAction: Towards Future Challenges for Cephalopod Science” Research Topic includes 14 papers from about 40 authors representing ten different countries, thus overlapping with the original parties that contributed to the COST FA1301 that, together with CephRes, promoted and supported this editorial initiative.

Principles and Practice of Endocrinology and Metabolism

Author : Kenneth L. Becker
Publisher : Lippincott Williams & Wilkins
ISBN 13 : 9780781717502
Total Pages : 2500 pages
Book Rating : 4.7/5 (175 download)

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Book Synopsis Principles and Practice of Endocrinology and Metabolism by : Kenneth L. Becker

Download or read book Principles and Practice of Endocrinology and Metabolism written by Kenneth L. Becker and published by Lippincott Williams & Wilkins. This book was released on 2001 with total page 2500 pages. Available in PDF, EPUB and Kindle. Book excerpt: Established as the foremost text in the field, Principles and Practice of Endocrinology and Metabolism is now in its thoroughly revised, updated Third Edition. This practical, clinically relevant, and comprehensive text covers the entire field of endocrinology and metabolism, including the diffuse endocrine system; morphology and physiology; diagnosis and treatment of endocrine diseases; endocrinology of the female; hormones and cancer; and much more. The Third Edition contains new chapters reflecting the latest advances and features expanded coverage of genetics and the endocrinology of sepsis. More than 1,400 illustrations complement the text. A drug formulary appears at the back of the book.

Cumulated Index Medicus

Author :
Publisher :
ISBN 13 :
Total Pages : 1216 pages
Book Rating : 4.3/5 (243 download)

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Book Synopsis Cumulated Index Medicus by :

Download or read book Cumulated Index Medicus written by and published by . This book was released on 1986 with total page 1216 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Ecdysone: Structures and Functions

Author : Guy Smagghe
Publisher : Springer Science & Business Media
ISBN 13 : 1402091125
Total Pages : 583 pages
Book Rating : 4.4/5 (2 download)

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Book Synopsis Ecdysone: Structures and Functions by : Guy Smagghe

Download or read book Ecdysone: Structures and Functions written by Guy Smagghe and published by Springer Science & Business Media. This book was released on 2009-03-06 with total page 583 pages. Available in PDF, EPUB and Kindle. Book excerpt: Ecdysone is the steroidal prohormone of the major insect moulting hormone 20-hydroxyecdysone. It groups with its homologues the steroidal molting hormones in arthropods, but they also occur in other phyla where they can play different roles. Besides ecdysteroids appear in many plants mostly as protection agents (toxins or antifeedants) against herbivorous insects. The important developments and achievements in modern ecdysone science since the first edition in 1989 by J. Koolman have led to this new revised, expanded and retitled reference work. New chapters in this edition include RNA interference, the ecdysone receptor crystal structures and structure activity relationships, etc. Each article may also be read independently, as a review of that particular subject. Complete up-to-date coverage of many important topics - the book is divisible into five conceptual areas: (1) Distribution and diversity of ecdysteroids in the two kingdoms is still basis, (2) In the post-genomic era, ecdysteroid genetic hierarchies in insect growth and reproduction, (3) Role of cross talk of genes and growth factors in ecdysteroid titers and signaling, (4) Ecdysteroids function through nuclear and membrane receptors, and (5) Ecdysteroids in modern agriculture, medicine, doping and ecotoxicology. Each of the 23 chapters is written by scientists active in the reviewed research area and a truly distinguished international team of contributors has been chosen. Ecdysone, Structures and Functions will be of immense use and contains essential information for scientists, students, and professionals alike in entomology, endocrinology, physiology, chemistry, and agricultural, plant, biomedicine and environmental sciences.

Insect Endocrinology

Author : Lawrence I. Gilbert
Publisher : Academic Press
ISBN 13 : 0123848512
Total Pages : 589 pages
Book Rating : 4.1/5 (238 download)

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Book Synopsis Insect Endocrinology by : Lawrence I. Gilbert

Download or read book Insect Endocrinology written by Lawrence I. Gilbert and published by Academic Press. This book was released on 2011-07-26 with total page 589 pages. Available in PDF, EPUB and Kindle. Book excerpt: The publication of the extensive seven-volume work Comprehensive Molecular Insect Science provided a complete reference encompassing important developments and achievements in modern insect science. One of the most swiftly moving areas in entomological and comparative research is endocrinology, and this volume, Insect Endocrinology, is designed for those who desire a comprehensive yet concise work on important aspects of this topic. Because this area has moved quickly since the original publication, articles in this new volume are revised, highlighting developments in the related area since its original publication. Insect Endocrinology covers the mechanism of action of insect hormones during growth and metamorphosis as well as the role of insect hormones in reproduction, diapause and the regulation of metabolism. Contents include articles on the juvenile hormones, circadian organization of the endocrine system, ecdysteroid chemistry and biochemistry, as well as new chapters on insulin-like peptides and the peptide hormone Bursicon. This volume will be of great value to senior investigators, graduate students, post-doctoral fellows and advanced undergraduate research students. It can also be used as a reference for graduate courses and seminars on the topic. Chapters will also be valuable to the applied biologist or entomologist, providing the requisite understanding necessary for probing the more applied research areas. - Articles selected by the known and respected editor-in-chief of the original major reference work, Comprehensive Molecular Insect Science - Newly revised contributions bring together the latest research in the quickly moving field of insect endocrinology - Review of the literature of the past five years is now included, as well as full use of data arising from the application of molecular technologies wherever appropriate

Neuropeptide Systems as Targets for Parasite and Pest Control

Author : Timothy G. Geary
Publisher : Springer Science & Business Media
ISBN 13 : 1441969020
Total Pages : 246 pages
Book Rating : 4.4/5 (419 download)

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Book Synopsis Neuropeptide Systems as Targets for Parasite and Pest Control by : Timothy G. Geary

Download or read book Neuropeptide Systems as Targets for Parasite and Pest Control written by Timothy G. Geary and published by Springer Science & Business Media. This book was released on 2011-01-13 with total page 246 pages. Available in PDF, EPUB and Kindle. Book excerpt: The need to continually discover new agents for the control or treatment of invertebrate pests and pathogens is undeniable. Agriculture, both animal and plant, succeeds only to the extent that arthropod and helminth consumers, vectors and pathogens can be kept at bay. Humans and their companion animals are also plagued by invertebrate parasites. The deployment of chemical agents for these purposes inevitably elicits the selection of resistant populations of the targets of control, necessitating a regular introduction of new kinds of molecules. Experience in other areas of chemotherapy has shown that a thorough understanding of the biology of disease is an essential platform upon which to build a discovery program. Unfortunately, investment of research resources into understanding the basic physiology of invertebrates as a strategy to illuminate new molecular targets for pesticide and parasiticide discovery has been scarce, and the pace of introduction of new molecules for these indications has been slowed as a result. An exciting and so far unexploited area to explore in this regard is invertebrate neuropeptide physiology. This book was assembled to focus attention on this promising field by compiling a comprehensive review of recent research on neuropeptides in arthropods and helminths, with contributions from many of the leading laboratories working on these systems.

Pheromones and Animal Behavior

Author : Tristram D. Wyatt
Publisher : Cambridge University Press
ISBN 13 : 0521112907
Total Pages : 425 pages
Book Rating : 4.5/5 (211 download)

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Book Synopsis Pheromones and Animal Behavior by : Tristram D. Wyatt

Download or read book Pheromones and Animal Behavior written by Tristram D. Wyatt and published by Cambridge University Press. This book was released on 2014-01-23 with total page 425 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book explains how animals use chemical communication, emphasising the evolutionary context and covering fields from ecology to neuroscience and chemistry.

Honeybee Neurobiology and Behavior

Author : C. Giovanni Galizia
Publisher : Springer Science & Business Media
ISBN 13 : 9400720998
Total Pages : 500 pages
Book Rating : 4.4/5 (7 download)

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Book Synopsis Honeybee Neurobiology and Behavior by : C. Giovanni Galizia

Download or read book Honeybee Neurobiology and Behavior written by C. Giovanni Galizia and published by Springer Science & Business Media. This book was released on 2011-11-25 with total page 500 pages. Available in PDF, EPUB and Kindle. Book excerpt: The book is a sequel of a similar book, edited by Randolf Menzel and Alison Mercer, “Neurobiology and Behavior of Honeybees”, published in 1987. It is a “Festschrift” for the 70th birthday of Randolf Menzel, who devoted his life to the topic of the book. The book will include an open commentary for each section written by Randolf Menzel, and discussed with the authors. The written contributions take their inspiration from a symposium on the topic, with all the authors, that was held in Berlin in summer 2010

The Domestic and International Impacts of the 2009-H1N1 Influenza A Pandemic

Author : Institute of Medicine
Publisher : National Academies Press
ISBN 13 : 0309146771
Total Pages : 440 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis The Domestic and International Impacts of the 2009-H1N1 Influenza A Pandemic by : Institute of Medicine

Download or read book The Domestic and International Impacts of the 2009-H1N1 Influenza A Pandemic written by Institute of Medicine and published by National Academies Press. This book was released on 2010-07-04 with total page 440 pages. Available in PDF, EPUB and Kindle. Book excerpt: In March and early April 2009, a new, swine-origin 2009-H1N1 influenza A virus emerged in Mexico and the United States. During the first few weeks of surveillance, the virus spread by human-to-human transmission worldwide to over 30 countries. On June 11, 2009, the World Health Organization (WHO) raised the worldwide pandemic alert level to Phase 6 in response to the ongoing global spread of the novel influenza A (H1N1) virus. By October 30, 2009, the H1N1 influenza A had spread to 191 countries and resulted in 5,700 fatalities. A national emergency was declared in the United States and the swine flu joined SARS and the avian flu as pandemics of the 21st century. Vaccination is currently available, but in limited supply, and with a 60 percent effectiveness rate against the virus. The story of how this new influenza virus spread out of Mexico to other parts of North America and then on to Europe, the Far East, and now Australia and the Pacific Rim countries has its origins in the global interconnectedness of travel, trade, and tourism. Given the rapid spread of the virus, the international scientific, public health, security, and policy communities had to mobilize quickly to characterize this unique virus and address its potential effects. The World Health Organization and Centers for Disease Control have played critical roles in the surveillance, detection and responses to the H1N1 virus. The Domestic and International Impacts of the 2009-H1N1 Influenza A Pandemic: Global Challenges, Global Solutions aimed to examine the evolutionary origins of the H1N1 virus and evaluate its potential public health and socioeconomic consequences, while monitoring and mitigating the impact of a fast-moving pandemic. The rapporteurs for this workshop reported on the need for increased and geographically robust global influenza vaccine production capacities; enhanced and sustained interpandemic demand for seasonal influenza vaccines; clear "triggers" for pandemic alert levels; and accelerated research collaboration on new vaccine manufacturing techniques. This book will be an essential guide for healthcare professionals, policymakers, drug manufacturers and investigators.