The Clinical Biology Of Sodium

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Dietary Reference Intakes for Sodium and Potassium

Author : National Academies of Sciences, Engineering, and Medicine
Publisher : National Academies Press
ISBN 13 : 0309488346
Total Pages : 595 pages
Book Rating : 4.3/5 (94 download)

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Book Synopsis Dietary Reference Intakes for Sodium and Potassium by : National Academies of Sciences, Engineering, and Medicine

Download or read book Dietary Reference Intakes for Sodium and Potassium written by National Academies of Sciences, Engineering, and Medicine and published by National Academies Press. This book was released on 2019-08-26 with total page 595 pages. Available in PDF, EPUB and Kindle. Book excerpt: As essential nutrients, sodium and potassium contribute to the fundamentals of physiology and pathology of human health and disease. In clinical settings, these are two important blood electrolytes, are frequently measured and influence care decisions. Yet, blood electrolyte concentrations are usually not influenced by dietary intake, as kidney and hormone systems carefully regulate blood values. Over the years, increasing evidence suggests that sodium and potassium intake patterns of children and adults influence long-term population health mostly through complex relationships among dietary intake, blood pressure and cardiovascular health. The public health importance of understanding these relationships, based upon the best available evidence and establishing recommendations to support the development of population clinical practice guidelines and medical care of patients is clear. This report reviews evidence on the relationship between sodium and potassium intakes and indicators of adequacy, toxicity, and chronic disease. It updates the Dietary Reference Intakes (DRIs) using an expanded DRI model that includes consideration of chronic disease endpoints, and outlines research gaps to address the uncertainties identified in the process of deriving the reference values and evaluating public health implications.

The Clinical Biology of Sodium

Author : A. R. Michell
Publisher : Elsevier
ISBN 13 : 1483100820
Total Pages : 389 pages
Book Rating : 4.4/5 (831 download)

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Book Synopsis The Clinical Biology of Sodium by : A. R. Michell

Download or read book The Clinical Biology of Sodium written by A. R. Michell and published by Elsevier. This book was released on 2014-04-08 with total page 389 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Clinical Biology of Sodium: The Physiology and Pathophysiology of Sodium in Mammals presents a comparative view of mammalian sodium regulation and its clinical disturbances. This book covers a wide range of topics, including the physiological basis of fluid therapy, oral rehydration for diarrhea, the pathogenesis of edema, hypovolemia, endocrine regulation and disturbances, and nutritional requirement. Organized into 12 chapters, this book begins with an overview of the distribution and physiological functions of sodium. This text then explores the two processes that provide the basis of most of the non-endocrine functions of the kidneys, namely, glomerular filtration and tubular reabsorption of sodium. Other chapters consider the avoidable human and material costs of hypertension. This book discusses as well the molecular biology of sodium transport. The final chapter deals with the three mechanisms capable of detecting changes in cardiovascular filling. This book is a valuable resource for doctors, nurses, and veterinarians.

Sodium in Health and Disease

Author : Michael Burnier
Publisher : CRC Press
ISBN 13 : 1420020943
Total Pages : 478 pages
Book Rating : 4.4/5 (2 download)

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Book Synopsis Sodium in Health and Disease by : Michael Burnier

Download or read book Sodium in Health and Disease written by Michael Burnier and published by CRC Press. This book was released on 2007-11-16 with total page 478 pages. Available in PDF, EPUB and Kindle. Book excerpt: report on the latest developments in the field with new information in basic as well as in clinical sciences, Sodium in Health Diseases, covers both the physiology of sodium balance and how it relates to disease. Expertly written, its concise text examines ATPase, transport and receptor systems, and sodium balance as it relates to sex hormon

Strategies to Reduce Sodium Intake in the United States

Author : Institute of Medicine
Publisher : National Academies Press
ISBN 13 : 0309148057
Total Pages : 506 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis Strategies to Reduce Sodium Intake in the United States by : Institute of Medicine

Download or read book Strategies to Reduce Sodium Intake in the United States written by Institute of Medicine and published by National Academies Press. This book was released on 2010-11-14 with total page 506 pages. Available in PDF, EPUB and Kindle. Book excerpt: Reducing the intake of sodium is an important public health goal for Americans. Since the 1970s, an array of public health interventions and national dietary guidelines has sought to reduce sodium intake. However, the U.S. population still consumes more sodium than is recommended, placing individuals at risk for diseases related to elevated blood pressure. Strategies to Reduce Sodium Intake in the United States evaluates and makes recommendations about strategies that could be implemented to reduce dietary sodium intake to levels recommended by the Dietary Guidelines for Americans. The book reviews past and ongoing efforts to reduce the sodium content of the food supply and to motivate consumers to change behavior. Based on past lessons learned, the book makes recommendations for future initiatives. It is an excellent resource for federal and state public health officials, the processed food and food service industries, health care professionals, consumer advocacy groups, and academic researchers.

Calcium Entry Channels in Non-Excitable Cells

Author : Juliusz Ashot Kozak
Publisher : CRC Press
ISBN 13 : 149875273X
Total Pages : 343 pages
Book Rating : 4.4/5 (987 download)

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Book Synopsis Calcium Entry Channels in Non-Excitable Cells by : Juliusz Ashot Kozak

Download or read book Calcium Entry Channels in Non-Excitable Cells written by Juliusz Ashot Kozak and published by CRC Press. This book was released on 2017-07-14 with total page 343 pages. Available in PDF, EPUB and Kindle. Book excerpt: Calcium Entry Channels in Non-Excitable Cells focuses on methods of investigating the structure and function of non-voltage gated calcium channels. Each chapter presents important discoveries in calcium entry pathways, specifically dealing with the molecular identification of store-operated calcium channels which were reviewed by earlier volumes in the Methods in Signal Transduction series. Crystallographic and pharmacological approaches to the study of calcium channels of epithelial cells are also discussed. Calcium ion is a messenger in most cell types. Whereas voltage gated calcium channels have been studied extensively, the non-voltage gated calcium entry channel genes have only been identified relatively recently. The book will fill this important niche.

Clinical Biochemistry

Author : William J. Marshall
Publisher : Elsevier Health Sciences
ISBN 13 : 0443101868
Total Pages : 997 pages
Book Rating : 4.4/5 (431 download)

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Book Synopsis Clinical Biochemistry by : William J. Marshall

Download or read book Clinical Biochemistry written by William J. Marshall and published by Elsevier Health Sciences. This book was released on 2008-01-01 with total page 997 pages. Available in PDF, EPUB and Kindle. Book excerpt: Now fully revised and updated, Clinical Biochemistry, third edition is essential reading for specialty trainees, particularly those preparing for postgraduate examinations. It is also an invaluable current reference for all established practitioners, including both medical and scientist clinical biochemists. Building on the success of previous editions, this leading textbook primarily focuses on clinical aspects of the subject, giving detailed coverage of all conditions where clinical biochemistry is used in diagnosis and management - including nutritional disorders, diabetes, inherited metabolic disease, metabolic bone disease, renal calculi and dyslipidaemias. The acquisition and interpretation of clinical biochemical data are also discussed in detail. Expanded sections on haematology and immunology for clinical biochemists provide a thorough understanding of both laboratory and clinical aspects New chapters are included on important evolving areas such as the metabolic response to stress, forensic aspects of clinical biochemistry and data quality management An extended editorial team - including three expert new additions - ensures accuracy of information and relevance to current curricula and clinical practice A superb new accompanying electronic version provides an enhanced learning experience and rapid reference anytime, anywhere! Elsevier ExpertConsult.com Enhanced eBooks for medical professionals Compatible with PC, Mac®, most mobile devices and eReaders, browse, search, and interact with this title - online and offline. Redeem your PIN at expertconsult.com today! Straightforward navigation and search across all Elsevier titles Seamless, real-time integration between devices Adjustable text size and brightness Notes and highlights sharing with other users through social media Interactive content

Dietary Reference Intakes for Water, Potassium, Sodium, Chloride, and Sulfate

Author : Institute of Medicine
Publisher : National Academies Press
ISBN 13 : 0309091586
Total Pages : 639 pages
Book Rating : 4.3/5 (9 download)

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Book Synopsis Dietary Reference Intakes for Water, Potassium, Sodium, Chloride, and Sulfate by : Institute of Medicine

Download or read book Dietary Reference Intakes for Water, Potassium, Sodium, Chloride, and Sulfate written by Institute of Medicine and published by National Academies Press. This book was released on 2005-06-18 with total page 639 pages. Available in PDF, EPUB and Kindle. Book excerpt: Dietary Reference Intakes for Water, Potassium, Sodium, Chloride, and Sulfate The Dietary Reference Intakes (DRIs) are quantitative estimates of nutrient intakes to be used for planning and assessing diets for healthy people. This new report, the sixth in a series of reports presenting dietary reference values for the intakes of nutrients by Americans and Canadians, establishes nutrient recommendations on water, potassium, and salt for health maintenance and the reduction of chronic disease risk. Dietary Reference Intakes for Water, Potassium, Sodium, Chloride, and Sulfate discusses in detail the role of water, potassium, salt, chloride, and sulfate in human physiology and health. The major findings in this book include the establishment of Adequate Intakes for total water (drinking water, beverages, and food), potassium, sodium, and chloride and the establishment of Tolerable Upper Intake levels for sodium and chloride. The book makes research recommendations for information needed to advance the understanding of human requirements for water and electrolytes, as well as adverse effects associated with the intake of excessive amounts of water, sodium, chloride, potassium, and sulfate. This book will be an invaluable reference for nutritionists, nutrition researchers, and food manufacturers.

Voltage Gated Sodium Channels

Author : Peter C. Ruben
Publisher : Springer Science & Business Media
ISBN 13 : 3642415881
Total Pages : 328 pages
Book Rating : 4.6/5 (424 download)

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Book Synopsis Voltage Gated Sodium Channels by : Peter C. Ruben

Download or read book Voltage Gated Sodium Channels written by Peter C. Ruben and published by Springer Science & Business Media. This book was released on 2014-04-15 with total page 328 pages. Available in PDF, EPUB and Kindle. Book excerpt: A number of techniques to study ion channels have been developed since the electrical basis of excitability was first discovered. Ion channel biophysicists have at their disposal a rich and ever-growing array of instruments and reagents to explore the biophysical and structural basis of sodium channel behavior. Armed with these tools, researchers have made increasingly dramatic discoveries about sodium channels, culminating most recently in crystal structures of voltage-gated sodium channels from bacteria. These structures, along with those from other channels, give unprecedented insight into the structural basis of sodium channel function. This volume of the Handbook of Experimental Pharmacology will explore sodium channels from the perspectives of their biophysical behavior, their structure, the drugs and toxins with which they are known to interact, acquired and inherited diseases that affect sodium channels and the techniques with which their biophysical and structural properties are studied.

Pocket Guide to Low Sodium Foods

Author : Bobbie Mostyn
Publisher : Indata Group
ISBN 13 : 9780967396910
Total Pages : 224 pages
Book Rating : 4.3/5 (969 download)

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Book Synopsis Pocket Guide to Low Sodium Foods by : Bobbie Mostyn

Download or read book Pocket Guide to Low Sodium Foods written by Bobbie Mostyn and published by Indata Group. This book was released on 2003 with total page 224 pages. Available in PDF, EPUB and Kindle. Book excerpt: This nutritional counter is an indispensable reference for anyone who is watching his or her salt intake. It is small enough to put in a pocket or purse to enable one to make wise food choices at the grocery store and while dining out. Intended for the estimated 60 million Americans with high blood pressure and severe kidney disease, this guide addresses which supermarket products and fast food items have the lowest sodium counts and simplifies supermarket choices by listing only low sodium products. Each food is analyzed by calories, fat, saturated fat, cholesterol, carbohydrates, fiber, sugar, and sodium. Also included are brief descriptions of each of these nutrients and their effect on blood pressure, explanations of food labeling guidelines, and clarification of nutritional content claims.

Interrelations between Essential Metal Ions and Human Diseases

Author : Astrid Sigel
Publisher : Springer Science & Business Media
ISBN 13 : 9400775008
Total Pages : 603 pages
Book Rating : 4.4/5 (7 download)

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Book Synopsis Interrelations between Essential Metal Ions and Human Diseases by : Astrid Sigel

Download or read book Interrelations between Essential Metal Ions and Human Diseases written by Astrid Sigel and published by Springer Science & Business Media. This book was released on 2014-01-27 with total page 603 pages. Available in PDF, EPUB and Kindle. Book excerpt: MILS-13 provides an up-to-date review on the relationships between essential metals and human diseases, covering 13 metals and 3 metalloids: The bulk metals sodium, potassium, magnesium, and calcium, plus the trace elements manganese, iron, cobalt, copper, zinc, molybdenum, and selenium, all of which are essential for life. Also covered are chromium, vanadium, nickel, silicon, and arsenic, which have been proposed as being essential for humans in the 2nd half of the last century. However, if at all, they are needed only in ultra-trace amounts, and because of their prevalence in the environment, it has been difficult to prove whether or not they are required. In any case, all these elements are toxic in higher concentrations and therefore, transport and cellular concentrations of at least the essential ones, are tightly controlled; hence, their homeostasis and role for life, including deficiency or overload, and their links to illnesses, including cancer and neurological disorders, are thoroughly discussed. Indeed, it is an old wisdom that metals are indispensable for life. Therefore, Volume 13 provides in an authoritative and timely manner in 16 stimulating chapters, written by 29 internationally recognized experts from 7 nations, and supported by more than 2750 references, and over 20 tables and 80 illustrations, many in color, a most up-to-date view on the vibrant research area of the Interrelations between Essential Metal Ions and Human Diseases.

Core Topics in Endocrinology in Anaesthesia and Critical Care

Author : George M. Hall
Publisher : Cambridge University Press
ISBN 13 : 1139486128
Total Pages : 203 pages
Book Rating : 4.1/5 (394 download)

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Book Synopsis Core Topics in Endocrinology in Anaesthesia and Critical Care by : George M. Hall

Download or read book Core Topics in Endocrinology in Anaesthesia and Critical Care written by George M. Hall and published by Cambridge University Press. This book was released on 2010-04-01 with total page 203 pages. Available in PDF, EPUB and Kindle. Book excerpt: Core Topics in Endocrinology in Anesthesia and Critical Care provides a comprehensive, practical overview of the perioperative management of patients with endocrine disorders, giving clear diagnostic advice and management guidelines. This book considers the management of patients with endocrine disorders of the pituitary, thyroid, parathyroid and adrenal glands, including rarer disorders such as MEN syndrome. It then considers all aspects of the perioperative management of diabetic patients, including paediatric, obstetric and ambulatory patients. Finally it discusses endocrine disorders in the critically ill patient, covering such issues as the topical conundrum of glucose control and the management of diabetic metabolic acidosis, thyroid storm and myxoedema coma. Every chapter reviews the relevant anatomy and pathophysiology and the latest developments in defining the genetic causes are also considered where appropriate. Core Topics in Endocrinology in Anesthesia and Critical Care is an invaluable tool for all anaesthetists and intensivists in their daily clinical practice.

Vander's Renal Physiology, 7th Edition

Author : Douglas C. Eaton
Publisher : McGraw Hill Professional
ISBN 13 : 0071613048
Total Pages : 231 pages
Book Rating : 4.0/5 (716 download)

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Book Synopsis Vander's Renal Physiology, 7th Edition by : Douglas C. Eaton

Download or read book Vander's Renal Physiology, 7th Edition written by Douglas C. Eaton and published by McGraw Hill Professional. This book was released on 2009-07-31 with total page 231 pages. Available in PDF, EPUB and Kindle. Book excerpt: The structure, function, and pathologies of the human kidney -- simplified and explained A Doody's Core Title for 2011! 4 STAR DOODY'S REVIEW! "This seventh edition of a concise, well written book on renal physiology continues the legacy of the book as a major contributor in the field....This well written book is an excellent review of renal function and is one of the best concise reviews of the topic."--Doody's Review Service Written in a concise, conversational style, this trusted text reviews the fundamental principles of renal physiology that are essential for an understanding of clinical medicine. Combining the latest research with a fully integrated teaching approach, Vander's Renal Physiology explains how the kidneys affect other body systems and how they in turn are affected by these systems. Filled with the learning tools you need to truly learn key concepts rather than merely memorize facts, Vander's will prove valuable to you at every stage of your studies or practice. Features: New Global case studies New An online physiology learning center that offers additional exam questions, artwork, and graphs Offers the best review of renal physiology available for the USMLE Step 1 Begins with the basics and works up to advanced principles Distills the essence of renal processes and their regulation in a concise, integrated manner that focuses on the logic of renal processes Features learning aids such as flow charts, diagrams, key concepts, clinical examples, learning objectives, and review questions with answers and explanations Explains the relationship between blood pressure and renal function Presents the normal functions of the kidney with clinical correlations to disease states Includes the most current research on the molecular and genetic principles underlying renal physiology

The Salt Fix

Author : Dr. James DiNicolantonio
Publisher : Harmony
ISBN 13 : 0451496973
Total Pages : 274 pages
Book Rating : 4.4/5 (514 download)

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Book Synopsis The Salt Fix by : Dr. James DiNicolantonio

Download or read book The Salt Fix written by Dr. James DiNicolantonio and published by Harmony. This book was released on 2017-06-06 with total page 274 pages. Available in PDF, EPUB and Kindle. Book excerpt: What if everything you know about salt is wrong? A leading cardiovascular research scientist explains how this vital crystal got a negative reputation, and shows how to lower blood pressure and experience weight loss using salt. The Salt Fix is essential reading for everyone on the keto diet! We’ve all heard the recommendation: eat no more than a teaspoon of salt a day for a healthy heart. Health-conscious Americans have hewn to the conventional wisdom that your salt shaker can put you on the fast track to a heart attack, and have suffered through bland but “heart-healthy” dinners as a result. What if the low-salt dogma is wrong? Dr. James DiNicolantonio has reviewed more than five hundred publications to unravel the impact of salt on blood pressure and heart disease. He’s reached a startling conclusion: The vast majority of us don’t need to watch our salt intake. In fact, for most of us, more salt would be advantageous to our nutrition—especially for those of us on the keto diet, as keto depletes this important mineral from our bodies. The Salt Fix tells the remarkable story of how salt became unfairly demonized—a never-before-told drama of competing egos and interests—and took the fall for another white crystal: sugar. According to The Salt Fix, too little salt can: • Make you crave sugar and refined carbs • Send the body into semistarvation mode • Lead to weight gain, insulin resistance, type 2 diabetes, cardiovascular disease, chronic kidney disease, and increased blood pressure and heart rate But eating the salt you desire can improve everything, from your sleep, energy, and mental focus to your fitness, fertility, and sexual performance. It can even stave off common chronic illnesses, including heart disease. The Salt Fix shows the best ways to add salt back into your diet, offering his transformative five-step program for recalibrating your salt thermostat to achieve your unique, ideal salt intake. Science has moved on from the low-salt dogma, and so should you—your life may depend on it.

The No-Salt, Lowest-Sodium Cookbook

Author : Donald A. Gazzaniga
Publisher : Macmillan
ISBN 13 : 1466819103
Total Pages : 436 pages
Book Rating : 4.4/5 (668 download)

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Book Synopsis The No-Salt, Lowest-Sodium Cookbook by : Donald A. Gazzaniga

Download or read book The No-Salt, Lowest-Sodium Cookbook written by Donald A. Gazzaniga and published by Macmillan. This book was released on 2002-07-31 with total page 436 pages. Available in PDF, EPUB and Kindle. Book excerpt: Donald Gazzaniga, diagnosed with congestive heart failure, was headed for a heart transplant - the only effective medical treatment. Urged by his doctor to keep his sodium intake "under 1,500-2000 mg. a day," Don headed for the kitchen and went to work. Aware that cutting out table salt is the barest beginning of a true low-sodium diet, Don devised recipes for delicious low-sodium dishes that added up to less than 500 mg. daily, 70% lower than those in other low-sodium cookbooks. The result? Don's name has been removed from the transplant list and his doctors believe that his diet played a significant role. The No-Salt, Lowest-Sodium Cookbook contains: * Hundreds of good tasting, easy-to-make recipes * An introduction by Dr. Sandra Barbour of the Kaiser Permanente Foundation * Advice on finding low-sodium prepared foods, eating in restaurants, etc. * Accurate sodium content of every ingredient and of the total servings * A twenty-eight-day low-sodium menu planner by Dr. Jeannie Gazzaniga, Ph.D., R.D. This book is for informational purposes only. Readers are advised to consult a physician before making any major change in diet.

Guiding Principles for Developing Dietary Reference Intakes Based on Chronic Disease

Author : National Academies of Sciences, Engineering, and Medicine
Publisher : National Academies Press
ISBN 13 : 0309462568
Total Pages : 335 pages
Book Rating : 4.3/5 (94 download)

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Book Synopsis Guiding Principles for Developing Dietary Reference Intakes Based on Chronic Disease by : National Academies of Sciences, Engineering, and Medicine

Download or read book Guiding Principles for Developing Dietary Reference Intakes Based on Chronic Disease written by National Academies of Sciences, Engineering, and Medicine and published by National Academies Press. This book was released on 2017-12-21 with total page 335 pages. Available in PDF, EPUB and Kindle. Book excerpt: Since 1938 and 1941, nutrient intake recommendations have been issued to the public in Canada and the United States, respectively. Currently defined as the Dietary Reference Intakes (DRIs), these values are a set of standards established by consensus committees under the National Academies of Sciences, Engineering, and Medicine and used for planning and assessing diets of apparently healthy individuals and groups. In 2015, a multidisciplinary working group sponsored by the Canadian and U.S. government DRI steering committees convened to identify key scientific challenges encountered in the use of chronic disease endpoints to establish DRI values. Their report, Options for Basing Dietary Reference Intakes (DRIs) on Chronic Disease: Report from a Joint US-/Canadian-Sponsored Working Group, outlined and proposed ways to address conceptual and methodological challenges related to the work of future DRI Committees. This report assesses the options presented in the previous report and determines guiding principles for including chronic disease endpoints for food substances that will be used by future National Academies committees in establishing DRIs.

Emergency Response Guidebook

Author : U.S. Department of Transportation
Publisher : Simon and Schuster
ISBN 13 : 1626363765
Total Pages : 352 pages
Book Rating : 4.6/5 (263 download)

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Book Synopsis Emergency Response Guidebook by : U.S. Department of Transportation

Download or read book Emergency Response Guidebook written by U.S. Department of Transportation and published by Simon and Schuster. This book was released on 2013-06-03 with total page 352 pages. Available in PDF, EPUB and Kindle. Book excerpt: Does the identification number 60 indicate a toxic substance or a flammable solid, in the molten state at an elevated temperature? Does the identification number 1035 indicate ethane or butane? What is the difference between natural gas transmission pipelines and natural gas distribution pipelines? If you came upon an overturned truck on the highway that was leaking, would you be able to identify if it was hazardous and know what steps to take? Questions like these and more are answered in the Emergency Response Guidebook. Learn how to identify symbols for and vehicles carrying toxic, flammable, explosive, radioactive, or otherwise harmful substances and how to respond once an incident involving those substances has been identified. Always be prepared in situations that are unfamiliar and dangerous and know how to rectify them. Keeping this guide around at all times will ensure that, if you were to come upon a transportation situation involving hazardous substances or dangerous goods, you will be able to help keep others and yourself out of danger. With color-coded pages for quick and easy reference, this is the official manual used by first responders in the United States and Canada for transportation incidents involving dangerous goods or hazardous materials.

Salt

Author : Mark Kurlansky
Publisher : Vintage Canada
ISBN 13 : 030736979X
Total Pages : 490 pages
Book Rating : 4.3/5 (73 download)

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Book Synopsis Salt by : Mark Kurlansky

Download or read book Salt written by Mark Kurlansky and published by Vintage Canada. This book was released on 2011-03-18 with total page 490 pages. Available in PDF, EPUB and Kindle. Book excerpt: From the award-winning and bestselling author of Cod comes the dramatic, human story of a simple substance, an element almost as vital as water, that has created fortunes, provoked revolutions, directed economies and enlivened our recipes. Salt is common, easy to obtain and inexpensive. It is the stuff of kitchens and cooking. Yet trade routes were established, alliances built and empires secured – all for something that filled the oceans, bubbled up from springs, formed crusts in lake beds, and thickly veined a large part of the Earth’s rock fairly close to the surface. From pre-history until just a century ago – when the mysteries of salt were revealed by modern chemistry and geology – no one knew that salt was virtually everywhere. Accordingly, it was one of the most sought-after commodities in human history. Even today, salt is a major industry. Canada, Kurlansky tells us, is the world’s sixth largest salt producer, with salt works in Ontario playing a major role in satisfying the Americans’ insatiable demand. As he did in his highly acclaimed Cod, Mark Kurlansky once again illuminates the big picture by focusing on one seemingly modest detail. In the process, the world is revealed as never before.