The Chemistry And Pharmacology Of Taxol And Its Derivatives

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The Chemistry and Pharmacology of Taxol® and its Derivatives

Author : H. Timmerman
Publisher : Elsevier
ISBN 13 : 9780080544991
Total Pages : 338 pages
Book Rating : 4.5/5 (449 download)

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Book Synopsis The Chemistry and Pharmacology of Taxol® and its Derivatives by : H. Timmerman

Download or read book The Chemistry and Pharmacology of Taxol® and its Derivatives written by H. Timmerman and published by Elsevier. This book was released on 1995-06-16 with total page 338 pages. Available in PDF, EPUB and Kindle. Book excerpt: Taxol®, a naturally occurring diterpenoid is one of the most exciting antitumor drugs available today. Its current indications (refractory ovarian and metastatic breast cancer) may soon be expanded since the drug is showing activity against lung and head-and-neck cancers. The book opens with a review of the naturally occurring taxoids, a chapter which is not a comprehensive list of all taxoids isolated to date, but attempts a systematic approact to describing the different classes of taxoids, with particular reference to all skeletal types and the various functionality patterns. Biosynthetic studies are also discussed, as well as some of the basic chemistry and common functionalities of taxoidic skeleton. Structural identification of taxoids, mostly by spectroscopic means; the formulation of taxanes; the metabolism and pharmacokinetics of Taxol® are also discussed, as are the chemistry of taxanes in relation to SAR studies; SAR aspects of the phenylisoserine side chain; and the mode of action of the taxanes and the mechanisms of resistance. The book is therefore written for medical chemists, in order to stimulate further research in this area and to provide the reader with the necessary background information to start a research program in the area.

The Chemistry and Pharmacology of Taxol and Its Derivatives

Author : Vittorio Farina
Publisher : Elsevier Science & Technology
ISBN 13 : 9780444817716
Total Pages : 339 pages
Book Rating : 4.8/5 (177 download)

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Book Synopsis The Chemistry and Pharmacology of Taxol and Its Derivatives by : Vittorio Farina

Download or read book The Chemistry and Pharmacology of Taxol and Its Derivatives written by Vittorio Farina and published by Elsevier Science & Technology. This book was released on 1995-01-01 with total page 339 pages. Available in PDF, EPUB and Kindle. Book excerpt: Taxol®, a naturally occurring diterpenoid is one of the most exciting antitumor drugs available today. Its current indications (refractory ovarian and metastatic breast cancer) may soon be expanded since the drug is showing activity against lung and head-and-neck cancers. The book opens with a review of the naturally occurring taxoids, a chapter which is not a comprehensive list of all taxoids isolated to date, but attempts a systematic approact to describing the different classes of taxoids, with particular reference to all skeletal types and the various functionality patterns. Biosynthetic studies are also discussed, as well as some of the basic chemistry and common functionalities of taxoidic skeleton. Structural identification of taxoids, mostly by spectroscopic means; the formulation of taxanes; the metabolism and pharmacokinetics of Taxol® are also discussed, as are the chemistry of taxanes in relation to SAR studies; SAR aspects of the phenylisoserine side chain; and the mode of action of the taxanes and the mechanisms of resistance. The book is therefore written for medical chemists, in order to stimulate further research in this area and to provide the reader with the necessary background information to start a research program in the area.

Taxol

Author : Matthew Suffness
Publisher : CRC Press
ISBN 13 : 0429612427
Total Pages : 437 pages
Book Rating : 4.4/5 (296 download)

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Book Synopsis Taxol by : Matthew Suffness

Download or read book Taxol written by Matthew Suffness and published by CRC Press. This book was released on 2021-12-17 with total page 437 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume brings together all aspects of TAXOL® research, development, and clinical use. It provides comprehensive knowledge of the compound and a perspective of the complex interrelationships needed for its development and production. Each chapter is written by an authority in the field. Chapters are carefully coordinated to maximize information on key topics while avoiding overlap and duplication. Previously unpublished material is presented along with thorough reviews of each topic.

Paclitaxel

Author : Mallappa Kumara Swamy
Publisher : Academic Press
ISBN 13 : 0323909523
Total Pages : 356 pages
Book Rating : 4.3/5 (239 download)

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Book Synopsis Paclitaxel by : Mallappa Kumara Swamy

Download or read book Paclitaxel written by Mallappa Kumara Swamy and published by Academic Press. This book was released on 2021-10-08 with total page 356 pages. Available in PDF, EPUB and Kindle. Book excerpt: Paclitaxel: Sources, Chemistry, Anticancer Actions, and Current Biotechnology provides a comprehensive survey of Paclitaxel and its derivatives chemistry, biosynthesis and anticancer activities. In addition, biotechnological methods, including cell cultures, the use of bioreactors and metabolic engineering strategies to improve Paclitaxel production are also discussed. The book discusses topics such as mechanisms of action against cancer, novel forms of Paclitaxel for an effective cancer treatment, strategies for enhancing its bioavailability, and the application of nanocarriers for its delivery and chemotherapy of cancer. This is a valuable resource for cancer researchers, biotechnologists and members of biomedical field who are interested in the promising anticancer qualities of this antineoplastic drug and how to enhance them for better treatments. - Presents detailed information about Paclitaxel research, from its discovery to clinical uses and biotechnological routes of commercial production - Focuses on Paclitaxel development as an effective chemotherapeutic drug, along with its application in different types of cancers - Encompasses descriptive illustrations and workflows to help the reader fully understand the content and easily apply it to their research

Transgenesis and Secondary Metabolism /.

Author : Sumita Jha
Publisher :
ISBN 13 : 9783319274904
Total Pages : pages
Book Rating : 4.2/5 (749 download)

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Book Synopsis Transgenesis and Secondary Metabolism /. by : Sumita Jha

Download or read book Transgenesis and Secondary Metabolism /. written by Sumita Jha and published by . This book was released on with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:

Anticancer Agents from Natural Products

Author : Gordon M. Cragg
Publisher : CRC Press
ISBN 13 : 1420039652
Total Pages : 610 pages
Book Rating : 4.4/5 (2 download)

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Book Synopsis Anticancer Agents from Natural Products by : Gordon M. Cragg

Download or read book Anticancer Agents from Natural Products written by Gordon M. Cragg and published by CRC Press. This book was released on 2005-06-13 with total page 610 pages. Available in PDF, EPUB and Kindle. Book excerpt: Plants, marine organisms, and microorganisms have evolved complex chemical defense and signaling systems that are designed to protect them from predators and provide other biological benefits. These organisms thus produce substances containing novel chemotypes that may have beneficial effects for humans. As collection methods improve and new screen

Chemistry for Pharmacy Students

Author : Professor Satyajit D. Sarker
Publisher : John Wiley & Sons
ISBN 13 : 1118687531
Total Pages : 397 pages
Book Rating : 4.1/5 (186 download)

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Book Synopsis Chemistry for Pharmacy Students by : Professor Satyajit D. Sarker

Download or read book Chemistry for Pharmacy Students written by Professor Satyajit D. Sarker and published by John Wiley & Sons. This book was released on 2013-05-28 with total page 397 pages. Available in PDF, EPUB and Kindle. Book excerpt: "This book has succeeded in covering the basic chemistry essentials required by the pharmaceutical science student... the undergraduate reader, be they chemist, biologist or pharmacist will find this an interesting and valuable read." –Journal of Chemical Biology, May 2009 Chemistry for Pharmacy Students is a student-friendly introduction to the key areas of chemistry required by all pharmacy and pharmaceutical science students. The book provides a comprehensive overview of the various areas of general, organic and natural products chemistry (in relation to drug molecules). Clearly structured to enhance student understanding, the book is divided into six clear sections. The book opens with an overview of general aspects of chemistry and their importance to modern life, with particular emphasis on medicinal applications. The text then moves on to a discussion of the concepts of atomic structure and bonding and the fundamentals of stereochemistry and their significance to pharmacy- in relation to drug action and toxicity. Various aspects of aliphatic, aromatic and heterocyclic chemistry and their pharmaceutical importance are then covered with final chapters looking at organic reactions and their applications to drug discovery and development and natural products chemistry. accessible introduction to the key areas of chemistry required for all pharmacy degree courses student-friendly and written at a level suitable for non-chemistry students includes learning objectives at the beginning of each chapter focuses on the physical properties and actions of drug molecules

Progress in the Chemistry of Organic Natural Products / Fortschritte der Chemie organischer Naturstoffe

Author : M. Glasenapp-Breiling
Publisher : Springer Science & Business Media
ISBN 13 : 3709161606
Total Pages : 261 pages
Book Rating : 4.7/5 (91 download)

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Book Synopsis Progress in the Chemistry of Organic Natural Products / Fortschritte der Chemie organischer Naturstoffe by : M. Glasenapp-Breiling

Download or read book Progress in the Chemistry of Organic Natural Products / Fortschritte der Chemie organischer Naturstoffe written by M. Glasenapp-Breiling and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 261 pages. Available in PDF, EPUB and Kindle. Book excerpt: The first contribution of this book gives an overview on naturally occuring cycling tetrapyrroles. The article describes the four classic tetrapyrrolic structures with their porphyrin, chlorin, bacteriochlorin and corrin skeletons and also novel, interesting structures with unusual biological activities. This review mainly focuses on the occurrence, structure and biological function as well as biosynthesis and aspects of synthesis. The second article deals with the anticancer compound taxol and its semisynthetic analog docetaxel (Taxotere). Taxol was originally isolated in the late 1960 ́s on the basis of its cytotoxity and antileukemic activity, its structure was published in 1971 in a paper that has been cited 1000 times since this publication. The review focuses primarily on the interesting and novel chemistry of taxol that has been discovered over the last eight years.

Discovery and Development of Anti-Breast Cancer Agents from Natural Products

Author : Goutam Brahmachari
Publisher : Elsevier
ISBN 13 : 0128212780
Total Pages : 386 pages
Book Rating : 4.1/5 (282 download)

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Book Synopsis Discovery and Development of Anti-Breast Cancer Agents from Natural Products by : Goutam Brahmachari

Download or read book Discovery and Development of Anti-Breast Cancer Agents from Natural Products written by Goutam Brahmachari and published by Elsevier. This book was released on 2021-06-24 with total page 386 pages. Available in PDF, EPUB and Kindle. Book excerpt: Discovery and Development of Anti-Breast Cancer Agents from Natural Products presents cutting-edge research advances in the field of bioactive natural products and natural drug formulations. This volume in the Natural Products Drug Discovery series focuses on molecules of natural origin and their synthetic analogs that show promising potential to act as anti-breast cancer and chemotherapeutic agents. Combining foundational background information on cancer mechanisms with details of medicinal structures from natural products, this volume compiles the latest developments from across interdisciplinary fields.Discovery and Development of Anti-Breast Cancer Agents from Natural Products will serve as a valuable resource for researchers working to discover promising leads for the development of novel pharmaceuticals for breast cancer, highlighting a number of key structures from natural products and exploring possible future developments in the area. - Highlights active agents from natural sources for development as novel anti-cancer agents - Features contributions from active researchers and leading experts working in the field - Includes foundational background information on both breast cancer mechanisms and natural product structures to support researchers from different disciplines

Anticancer plants: Properties and Application

Author : Mohd Sayeed Akhtar
Publisher : Springer
ISBN 13 : 981108548X
Total Pages : 582 pages
Book Rating : 4.8/5 (11 download)

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Book Synopsis Anticancer plants: Properties and Application by : Mohd Sayeed Akhtar

Download or read book Anticancer plants: Properties and Application written by Mohd Sayeed Akhtar and published by Springer. This book was released on 2018-06-29 with total page 582 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cancer is one of the leading death cause of human population increasingly seen in recent times. Plants have been used for medicinal purposes since immemorial times. Though, several synthetic medicines are useful in treating cancer, they are inefficient and unsafe. However, plants have proved to be useful in cancer cure. Moreover, natural compounds from plants and their derivatives are safe and effective in treatment and management of several cancer types. The anticancer plants such as Catharanthus roseus, Podophyllum peltatum, Taxus brevifolia, Camptotheca acuminate, Andrographis paniculata, Crateva nurvala, Croton tonkinensis, Oplopanax horridus etc., are important source of chemotherapeutic compounds. These plants have proven their significance in the treatment of cancer and various other infectious diseases. Nowadays, several well-known anticancer compounds such as taxol, podophyllotoxins, camptothecin, vinblastine, vincristine, homoharringtonine etc. have been isolated and purified from these medicinal plants. Many of them are used effectively to combat cancer and other related diseases. The herbal medicine and their products are the most suitable and safe to be used as an alternative medicine. Based on their traditional uses and experimental evidences, the anticancer products or compounds are isolated or extracted from the medicinally important plants. Many of these anticancer plants have become endangered due to ruthless harvesting in nature. Hence, there is a need to conserve these species and to propagate them in large scale using plant tissue culture. Alternatively, plant cell tissue and organ culture biotechnology can be adopted to produce these anticancer compounds without cultivation. The proper knowledge and exploration of these isolated molecules or products could provide an alternative source to reduce cancer risk, anti-tumorigenic properties, and suppression of carcinogen activities. Anticancer plants: Volume 1, Properties and Application is a very timely effort in this direction. Discussing the various types of anticancer plants as a source of curative agent, their pharmacological and neutraceutical properties, cryo-preservations and recent trends to understand the basic cause and consequences involved in the diseases diagnosis. We acknowledge the publisher, Springer for their continuous inspiration and valuable suggestions to improvise the content of this book. We further extend our heartfelt gratitude to all our book contributors for their support, and assistance to complete this assignment. I am sure that these books will benefit the scientific communities including academics, pharmaceuticals, nutraceuticals and medical practitioners.

Evolutionary Diversity as a Source for Anticancer Molecules

Author : Akhileshwar Kumar Srivastava
Publisher : Academic Press
ISBN 13 : 0128216980
Total Pages : 392 pages
Book Rating : 4.1/5 (282 download)

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Book Synopsis Evolutionary Diversity as a Source for Anticancer Molecules by : Akhileshwar Kumar Srivastava

Download or read book Evolutionary Diversity as a Source for Anticancer Molecules written by Akhileshwar Kumar Srivastava and published by Academic Press. This book was released on 2020-09-21 with total page 392 pages. Available in PDF, EPUB and Kindle. Book excerpt: Evolutionary Diversity as a Source for Anticancer Molecules discusses evolutionary diversity as source for anticancer agents derived from bacteria, algae, bryophytes, pteridophytes, and gymnosperms. The book goes over the isolation of anticancer agents and the technologyenabled screening process used to develop anticancer drugs. The book also includes discussion of the nutraceuticals and natural productsderived from invertebrates that can be used as part of cancer treatment. Evolutionary Diversity as a Source for Anticancer Molecules also deals with some of the current challenges in the prevention of cancer as well as the side effects of conventional drugs used for cancer patients.This book is a valuable resource for cancer researchers, oncologists, biotechnologists, pharmacologists, and any member of the biomedicalfield interested in understanding more about natural products with anticancer potential. - Discusses the application of natural products in place of conventional drugs to minimize the side effects in cancer treatment - Explains the relation between evolutionary mechanisms and climate change for production of secondary metabolites

The Alkaloids: Chemistry and Pharmacology

Author :
Publisher : Academic Press
ISBN 13 : 0080865631
Total Pages : 377 pages
Book Rating : 4.0/5 (88 download)

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Book Synopsis The Alkaloids: Chemistry and Pharmacology by :

Download or read book The Alkaloids: Chemistry and Pharmacology written by and published by Academic Press. This book was released on 1991-01-10 with total page 377 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Alkaloids: Chemistry and Pharmacology

The Story of Taxol

Author : Jordan Goodman
Publisher : Cambridge University Press
ISBN 13 : 9780521561235
Total Pages : 302 pages
Book Rating : 4.5/5 (612 download)

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Book Synopsis The Story of Taxol by : Jordan Goodman

Download or read book The Story of Taxol written by Jordan Goodman and published by Cambridge University Press. This book was released on 2001-03-05 with total page 302 pages. Available in PDF, EPUB and Kindle. Book excerpt: Taxol is arguably the most celebrated, talked-about and controversial natural product in recent years. It is celebrated because of its efficacy as an anti-cancer drug and because its discovery has provided powerful support for policies concerned with biodiversity; talked about because in the late 1980s and early 1990s the American public was bombarded with news reports and special programmes about the molecule and its host, the Pacific yew; and controversial because during the early 1990s the drug and the tree became embroiled in a number of very sensitive political issues with wide implications for the conduct of public policy. The Story of Taxol tells this story.

Process Chemistry in the Pharmaceutical Industry, Volume 2

Author : Kumar Gadamasetti
Publisher : CRC Press
ISBN 13 : 1420008358
Total Pages : 534 pages
Book Rating : 4.4/5 (2 download)

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Book Synopsis Process Chemistry in the Pharmaceutical Industry, Volume 2 by : Kumar Gadamasetti

Download or read book Process Chemistry in the Pharmaceutical Industry, Volume 2 written by Kumar Gadamasetti and published by CRC Press. This book was released on 2007-12-10 with total page 534 pages. Available in PDF, EPUB and Kindle. Book excerpt: As pharmaceutical companies strive to develop safer medicines at a lower cost, they must keep pace with the rapid growth of technology and research methodologies. Defying the misconception of process chemistry as mere scale-up work, Process Chemistry in the Pharmaceutical Industry, Vol. 2: Challenges in an Ever Changing Climate explor

Natural Products in Medicinal Chemistry

Author : Stephen Hanessian
Publisher : John Wiley & Sons
ISBN 13 : 3527676554
Total Pages : 652 pages
Book Rating : 4.5/5 (276 download)

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Book Synopsis Natural Products in Medicinal Chemistry by : Stephen Hanessian

Download or read book Natural Products in Medicinal Chemistry written by Stephen Hanessian and published by John Wiley & Sons. This book was released on 2013-12-18 with total page 652 pages. Available in PDF, EPUB and Kindle. Book excerpt: The inspiration provided by biologically active natural products to conceive of hybrids, congeners, analogs and unnatural variants is discussed by experts in the field in 16 highly informative chapters. Using well-documented studies over the past decade, this timely monograph demonstrates the current importance and future potential of natural products as starting points for the development of new drugs with improved properties over their progenitors. The examples are chosen so as to represent a wide range of natural products with therapeutic relevance among others, as anticancer agents, antimicrobials, antifungals, antisense nucleosides, antidiabetics, and analgesics. From the content: * Part I: Natural Products as Sources of Potential Drugs and Systematic Compound Collections * Part II: From Marketed Drugs to Designed Analogs and Clinical Candidates * Part III: Natural Products as an Incentive for Enabling Technologies * Part IV: Natural Products as Pharmacological Tools * Part V: Nature: The Provider, the Enticer, and the Healer

Synthesis of Best-Seller Drugs

Author : Ruben Vardanyan
Publisher : Academic Press
ISBN 13 : 0124115241
Total Pages : 870 pages
Book Rating : 4.1/5 (241 download)

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Book Synopsis Synthesis of Best-Seller Drugs by : Ruben Vardanyan

Download or read book Synthesis of Best-Seller Drugs written by Ruben Vardanyan and published by Academic Press. This book was released on 2016-01-07 with total page 870 pages. Available in PDF, EPUB and Kindle. Book excerpt: Synthesis of Best-Seller Drugs is a key reference guide for all those involved with the design, development, and use of the best-selling drugs. Designed for ease of use, this book provides detailed information on the most popular drugs, using a practical layout arranged according to drug type. Each chapter reviews the main drugs in each of nearly 40 key therapeutic areas, also examining their classification, novel structural features, models of action, and synthesis. Of high interest to all those who work in the captivating areas of biologically active compounds and medicinal drug synthesis, in particular medicinal chemists, biochemists, and pharmacologists, the book aims to support current research efforts, while also encouraging future developments in this important field. - Describes methods of synthesis, bioactivity and related drugs in key therapeutic areas - Reviews the main drugs in each of nearly 40 key therapeutic areas, also examining their classification, novel structural features, models of action, and more - Presents a practical layout designed for use as a quick reference tool by those working in drug design, development and implementation

Natural Products

Author : Lixin Zhang
Publisher : Springer Science & Business Media
ISBN 13 : 1592599761
Total Pages : 380 pages
Book Rating : 4.5/5 (925 download)

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Book Synopsis Natural Products by : Lixin Zhang

Download or read book Natural Products written by Lixin Zhang and published by Springer Science & Business Media. This book was released on 2007-11-17 with total page 380 pages. Available in PDF, EPUB and Kindle. Book excerpt: A fresh examination of the past successes of natural products as medicines and their new future from both conventional and new technologies. High-performance liquid chromatography profiling, combinatorial synthesis, genomics, proteomics, DNA shuffling, bioinformatics, and genetic manipulation all now make it possible to rapidly evaluate the activities of extracts as well as purified components derived from microbes, plants, and marine organisms. The authors apply these methods to new natural product drug discoveries, to microbial diversity, to specific groups of products (Chinese herbal drugs, antitumor drugs from microbes and plants, terpenoids, and arsenic compounds), and to specific sources (the sea, rainforest, and endophytes). These new opportunities show how research and development trends in the pharmaceutical industry can advance to include both synthetic compounds and natural products, and how this paradigm shift can be more productive and efficacious.