The Chemical Biology Of Thrombin

Download The Chemical Biology Of Thrombin full books in PDF, epub, and Kindle. Read online The Chemical Biology Of Thrombin ebook anywhere anytime directly on your device. Fast Download speed and no annoying ads. We cannot guarantee that every ebooks is available!

The Chemical Biology of Thrombin

Author : Roger L. Lundblad
Publisher : CRC Press
ISBN 13 : 1351677721
Total Pages : 308 pages
Book Rating : 4.3/5 (516 download)

DOWNLOAD NOW!

Book Synopsis The Chemical Biology of Thrombin by : Roger L. Lundblad

Download or read book The Chemical Biology of Thrombin written by Roger L. Lundblad and published by CRC Press. This book was released on 2022-05-01 with total page 308 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is a comprehensive review of thrombin, especially as regulatory protease. The ready availability of highly purified thrombin has stimulated rapid advances in the cell biology of this important macromolecule. The text focuses on research findings from the discovery of thrombin by Andrew Buchanan in 1842 to the present. A substantial amount of this work was conducted by the author and his colleagues. His work on the purification of thrombin was seminal to much subsequent work on thrombin. This volume provides a framework for future studies now made possible by the discovery of the importance of exosites in the physiology of thrombin function. The current work describes the process of the development of an oral inhibitor of thrombin used in the prevention of thrombosis. Key Features Reviews the history of Thrombin (Fibrin Ferment) Documents the relation of protein engineering and chemical modification in the study of thrombin Summarizes the interaction of thrombin with fibrinogen and fibrin Outlines the role of exosites in thrombin function Describes the development of an oral inhibitor for thrombin

Chemistry and Biology of Thrombin

Author : Roger L. Lundblad
Publisher : Butterworth-Heinemann
ISBN 13 :
Total Pages : 584 pages
Book Rating : 4.3/5 (91 download)

DOWNLOAD NOW!

Book Synopsis Chemistry and Biology of Thrombin by : Roger L. Lundblad

Download or read book Chemistry and Biology of Thrombin written by Roger L. Lundblad and published by Butterworth-Heinemann. This book was released on 1977 with total page 584 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Thrombin

Author : Lawrence J. Berliner
Publisher : Springer Science & Business Media
ISBN 13 : 1461532965
Total Pages : 445 pages
Book Rating : 4.4/5 (615 download)

DOWNLOAD NOW!

Book Synopsis Thrombin by : Lawrence J. Berliner

Download or read book Thrombin written by Lawrence J. Berliner and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 445 pages. Available in PDF, EPUB and Kindle. Book excerpt: Research on thrombin structure and function has progressed significantly over the past three decades. We are continually discovering new functions f()r this enzyme in biology. Yet, until quite recently, a full, detailed, three dimensional picture of its structure was difficult to attain. We believe that this text represents a turning point and, more appropriately, a new start ing point for thrombin studies. Our goal for this text is to present a thorough and rounded-out coverage of thrombin chemistry and biochem istry in order to provide the biochemist and physiologist with an excellent desk reference on almost any thrombin-related problem. This volume is organized into three general thrombin topic areas: Structure, Biochemistry, and Physiology. In Part 1, Structure, we open with the complete three-dimensional x-ray structures of two inhibited human thrombin complexes, one of which is the thrombin-hirudin com plex. These complexes are also addressed in the chapter on structural studies in solution, which include NMR, ESR, and fluorescence. Part 2, Biochemistry, includes chapters on synthetic thrombin inhibitors, protein inhibitors (e.g., antithrombin III, hirudin), and thrombin interactions with factor XIII. Part 3, Physiology, covers such topics as chemotactic activities, interactions with cell surfaces, and the vascular endothelium.

The Design of Synthetic Inhibitors of Thrombin

Author : Goran Claeson
Publisher : Springer Science & Business Media
ISBN 13 : 1489924183
Total Pages : 245 pages
Book Rating : 4.4/5 (899 download)

DOWNLOAD NOW!

Book Synopsis The Design of Synthetic Inhibitors of Thrombin by : Goran Claeson

Download or read book The Design of Synthetic Inhibitors of Thrombin written by Goran Claeson and published by Springer Science & Business Media. This book was released on 2013-06-29 with total page 245 pages. Available in PDF, EPUB and Kindle. Book excerpt: In one generation, the numerous factors involved in blood coagulation have become real protein entities, isolated in pure form, expressed by recombinant DNA techniques, and subjected to structure elucidation by the modem methods of physical chemistry, viz. , X-ray diffraction, and NMR, ESR and fluorescence spectroscopy. The major milestone in this field was the breakthrough achieved by W. Bode, R. Huber and their colleagues in 1989 in of human a-thrombin, inhibited with D-Phe-Pro-Arg determining the crystal structure chioromethyl ketone. The availability of this structure will greatly facilitate the interpretation of experiments designed to gain an understanding of the interatomic interactions between this enzyme and fibrinogen and its other substrates. At the same time, it provides a rational basis for the design and synthesis of inhibitors of thrombin, the subject of this symposium. The symposium was organized in four sessions: (1) Structural features of the interaction of thrombin with substrates and inhibitors, (2) Synthetic inhibitors, (3) Hirudin and its analogues, and (4) Pharmacological and clinical considerations. This book contains summaries of most of the papers presented, and takes its rigbful place among two others that provide a comprehensive picture of our current knowledge about thrombin, viz. the 1977 volume entitled "Chemistry and Biology of Thrombin", edited by R. L. Lundblad, J. W. Fenton II, and K. G. Mann, and the 1992 volume entitled "Thrombin: Structure and Function", edited by L. J. Berliner.

Thrombin

Author : Michael E. Maragoudakis
Publisher : Springer Science & Business Media
ISBN 13 : 038709637X
Total Pages : 272 pages
Book Rating : 4.3/5 (87 download)

DOWNLOAD NOW!

Book Synopsis Thrombin by : Michael E. Maragoudakis

Download or read book Thrombin written by Michael E. Maragoudakis and published by Springer Science & Business Media. This book was released on 2010-04-02 with total page 272 pages. Available in PDF, EPUB and Kindle. Book excerpt: In addition to its central role in blood coagulation, it has become increasingly apparent that thrombin and thrombin receptors are involved in many other physiological processes and can contribute to a variety of disease states such as tumor progression and metastasis, inflammation, neurological disorders and cardiovascular complications. This book is a collection of reviews of up-to-date information on the above topics by leaders in these fields. This book will be of value to researchers and academic professionals both in basic and clinical science who are interested in the fields of biochemistry, biophysics, cell biology, pharmacology, cancer, inflammation, angiogenesis, cardiovascular system and neuronal system. These areas of research are prime target areas for drug development by many pharmaceutical and biotechnology companies.

Thrombin

Author : Michael E. Maragoudakis
Publisher : Springer
ISBN 13 : 9780387096360
Total Pages : 0 pages
Book Rating : 4.0/5 (963 download)

DOWNLOAD NOW!

Book Synopsis Thrombin by : Michael E. Maragoudakis

Download or read book Thrombin written by Michael E. Maragoudakis and published by Springer. This book was released on 2008-12-02 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: In addition to its central role in blood coagulation, it has become increasingly apparent that thrombin and thrombin receptors are involved in many other physiological processes and can contribute to a variety of disease states such as tumor progression and metastasis, inflammation, neurological disorders and cardiovascular complications. This book is a collection of reviews of up-to-date information on the above topics by leaders in these fields. This book will be of value to researchers and academic professionals both in basic and clinical science who are interested in the fields of biochemistry, biophysics, cell biology, pharmacology, cancer, inflammation, angiogenesis, cardiovascular system and neuronal system. These areas of research are prime target areas for drug development by many pharmaceutical and biotechnology companies.

The Physical Chemistry of Prothrombin and Its Transformation to Thrombin

Author : François Lamy
Publisher :
ISBN 13 :
Total Pages : 262 pages
Book Rating : 4.:/5 (314 download)

DOWNLOAD NOW!

Book Synopsis The Physical Chemistry of Prothrombin and Its Transformation to Thrombin by : François Lamy

Download or read book The Physical Chemistry of Prothrombin and Its Transformation to Thrombin written by François Lamy and published by . This book was released on 1955 with total page 262 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Molecular Biology of the Cell

Author :
Publisher :
ISBN 13 : 9780815332183
Total Pages : 0 pages
Book Rating : 4.3/5 (321 download)

DOWNLOAD NOW!

Book Synopsis Molecular Biology of the Cell by :

Download or read book Molecular Biology of the Cell written by and published by . This book was released on 2002 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Chemistry and Biology of Heparin and Heparan Sulfate

Author : Hari G. Garg
Publisher : Elsevier
ISBN 13 : 0080529054
Total Pages : 793 pages
Book Rating : 4.0/5 (85 download)

DOWNLOAD NOW!

Book Synopsis Chemistry and Biology of Heparin and Heparan Sulfate by : Hari G. Garg

Download or read book Chemistry and Biology of Heparin and Heparan Sulfate written by Hari G. Garg and published by Elsevier. This book was released on 2011-10-10 with total page 793 pages. Available in PDF, EPUB and Kindle. Book excerpt: The chemistry, biochemistry and pharmacology of heparin and heparan sulfate have been and continue to be a major scientific undertaking - heparin and its derivative remain important drugs in clinical practice. Chemistry and Biology of Heparin and Heparan Sulfate provides readers with an insight into the chemistry, biology and clinical applications of heparin and heparan sulfate and examines their function in various physiological and pathological conditions. Providing a wealth of useful information, no other tome covers the diversity of topics in the field. Students, doctors, chemists, biochemists, and research scientists will find this book an invaluable source for updating their current knowledge of developments in this area. - Comprehensively reviews all aspects of heparin and heparan sulfate research - Uniquely describes the chemistry, biology and clinical application of heparins and heparan sulfates in one work - Provides an invaluable source of knowledge of current developments for chemists, biochemists, medical doctors, researchers, students and practitioners

Physiology and Biochemistry of Prothrombin Conversion

Author : Eberhard F. Mammen
Publisher :
ISBN 13 :
Total Pages : 360 pages
Book Rating : 4.3/5 (243 download)

DOWNLOAD NOW!

Book Synopsis Physiology and Biochemistry of Prothrombin Conversion by : Eberhard F. Mammen

Download or read book Physiology and Biochemistry of Prothrombin Conversion written by Eberhard F. Mammen and published by . This book was released on 1974 with total page 360 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Structural Biology in Drug Discovery

Author : Jean-Paul Renaud
Publisher : John Wiley & Sons
ISBN 13 : 1118900502
Total Pages : 1367 pages
Book Rating : 4.1/5 (189 download)

DOWNLOAD NOW!

Book Synopsis Structural Biology in Drug Discovery by : Jean-Paul Renaud

Download or read book Structural Biology in Drug Discovery written by Jean-Paul Renaud and published by John Wiley & Sons. This book was released on 2020-01-09 with total page 1367 pages. Available in PDF, EPUB and Kindle. Book excerpt: With the most comprehensive and up-to-date overview of structure-based drug discovery covering both experimental and computational approaches, Structural Biology in Drug Discovery: Methods, Techniques, and Practices describes principles, methods, applications, and emerging paradigms of structural biology as a tool for more efficient drug development. Coverage includes successful examples, academic and industry insights, novel concepts, and advances in a rapidly evolving field. The combined chapters, by authors writing from the frontlines of structural biology and drug discovery, give readers a valuable reference and resource that: Presents the benefits, limitations, and potentiality of major techniques in the field such as X-ray crystallography, NMR, neutron crystallography, cryo-EM, mass spectrometry and other biophysical techniques, and computational structural biology Includes detailed chapters on druggability, allostery, complementary use of thermodynamic and kinetic information, and powerful approaches such as structural chemogenomics and fragment-based drug design Emphasizes the need for the in-depth biophysical characterization of protein targets as well as of therapeutic proteins, and for a thorough quality assessment of experimental structures Illustrates advances in the field of established therapeutic targets like kinases, serine proteinases, GPCRs, and epigenetic proteins, and of more challenging ones like protein-protein interactions and intrinsically disordered proteins

Water in Biological and Chemical Processes

Author : Biman Bagchi
Publisher : Cambridge University Press
ISBN 13 : 1107037298
Total Pages : 383 pages
Book Rating : 4.1/5 (7 download)

DOWNLOAD NOW!

Book Synopsis Water in Biological and Chemical Processes by : Biman Bagchi

Download or read book Water in Biological and Chemical Processes written by Biman Bagchi and published by Cambridge University Press. This book was released on 2013-11-14 with total page 383 pages. Available in PDF, EPUB and Kindle. Book excerpt: A unified overview of the dynamical properties of water and its unique and diverse role in biological and chemical processes.

Thrombin and Singlet Oxygen (1?O2*) Main Factors of Hemostasis

Author : Thomas Stief
Publisher :
ISBN 13 : 9781628084672
Total Pages : 373 pages
Book Rating : 4.0/5 (846 download)

DOWNLOAD NOW!

Book Synopsis Thrombin and Singlet Oxygen (1?O2*) Main Factors of Hemostasis by : Thomas Stief

Download or read book Thrombin and Singlet Oxygen (1?O2*) Main Factors of Hemostasis written by Thomas Stief and published by . This book was released on 2013-01-01 with total page 373 pages. Available in PDF, EPUB and Kindle. Book excerpt: Neutrophil granulocytes (PMN) are our primary defense cells against bacteria, fungi, parasites, or micro-thrombi. Their main weapons and signals are the reactive oxygen species (ROS), H2O2 being mother ROS, radicalic *OH and non-radicalic 1?O2* being the two daughter ROS. 1?O2* is the most important ROS because it is harmful against "non-self" and harmless against "self". 1?O2* is highly reactive against S-H, S-S, or C=C groups and releases photons (h?). The activation of the assembly of their NADPH-oxidase, one main trigger (zymosan A) and one main primer (1?O2*/hv) are of great physiological and pathophysiological importance in inflammation and in hemostasis. There is photonic communication: the neutrophils generate different types of photons and they can "see" them in other cells. The approximate 300-400 nm photons are the main signals and the photons of lowest wave length seem to especially alert them in emergency. The present book examines further research on the respective altered matrix (AM=intrinsic=contact phase) - coagulation and regulation of the neutrophil's ROS generation by important substances, e.g. singlet oxygen (the excited "pro-drug" of photons), or photons. 1?O2* releases a photon by ? dimol emission (634 nm red fluorescence, by collision of two 1?O2* molecules), ? monomol emission (1270 nm near infra-red phosphorescence, spontaneous), ? excited carbonyl (R-C=O*) emission (around 400 nm, after alkene oxidation); this emission is shifted to higher wavelenghts by certain atoms such as fluor or phosphor. PMN are activated by kallikrein, generated in AM-coagulation activation. The best way to quantify intrinsic thrombin generation/blood ROS modulation of xenobiotics (drugs or physiologic substances at unphysiologic concentrations) is to perform a recalcified coagulation activity assay (RECA) or a contact phase assay (CPA) in combination with the blood ROS generation assay (BRGA). (Imprint: Nova Biomedical)

Chemical Biology

Author : Herbert Waldmann
Publisher : Wiley-VCH
ISBN 13 :
Total Pages : 240 pages
Book Rating : 4.3/5 (91 download)

DOWNLOAD NOW!

Book Synopsis Chemical Biology by : Herbert Waldmann

Download or read book Chemical Biology written by Herbert Waldmann and published by Wiley-VCH. This book was released on 2004-08-06 with total page 240 pages. Available in PDF, EPUB and Kindle. Book excerpt: Take your first steps in combinatorial synthesis or synthesize bioactive molecules such as antibiotics. Search for mutations in DNA using chemical probes or perform a proteome analysis in yeast. The present selection of 12 inspiring experiments is tailored for maximum learning effect at minimal expense of time and equipment. Almost all currently used laboratory techniques in synthesis and analysis of bioactive compounds are represented at least once. Abundant practical hints are complemented by a thorough treatment of the underlying theory and mechanisms.

Introduction to Bioorganic Chemistry and Chemical Biology

Author : David Van Vranken
Publisher : Garland Science
ISBN 13 : 1135054827
Total Pages : 504 pages
Book Rating : 4.1/5 (35 download)

DOWNLOAD NOW!

Book Synopsis Introduction to Bioorganic Chemistry and Chemical Biology by : David Van Vranken

Download or read book Introduction to Bioorganic Chemistry and Chemical Biology written by David Van Vranken and published by Garland Science. This book was released on 2018-10-08 with total page 504 pages. Available in PDF, EPUB and Kindle. Book excerpt: Introduction to Bioorganic Chemistry and Chemical Biology is the first textbook to blend modern tools of organic chemistry with concepts of biology, physiology, and medicine. With a focus on human cell biology and a problems-driven approach, the text explains the combinatorial architecture of biooligomers (genes, DNA, RNA, proteins, glycans, lipids, and terpenes) as the molecular engine for life. Accentuated by rich illustrations and mechanistic arrow pushing, organic chemistry is used to illuminate the central dogma of molecular biology. Introduction to Bioorganic Chemistry and Chemical Biology is appropriate for advanced undergraduate and graduate students in chemistry and molecular biology, as well as those going into medicine and pharmaceutical science.

Biological Inorganic Chemistry

Author : Robert R. Crichton
Publisher : Elsevier
ISBN 13 : 0080556221
Total Pages : 383 pages
Book Rating : 4.0/5 (85 download)

DOWNLOAD NOW!

Book Synopsis Biological Inorganic Chemistry by : Robert R. Crichton

Download or read book Biological Inorganic Chemistry written by Robert R. Crichton and published by Elsevier. This book was released on 2007-12-11 with total page 383 pages. Available in PDF, EPUB and Kindle. Book excerpt: The importance of metals in biology, the environment and medicine has become increasingly evident over the last twenty five years. The study of the multiple roles of metal ions in biological systems, the rapidly expanding interface between inorganic chemistry and biology constitutes the subject called Biological Inorganic Chemistry. The present text, written by a biochemist, with a long career experience in the field (particularly iron and copper) presents an introduction to this exciting and dynamic field. The book begins with introductory chapters, which together constitute an overview of the concepts, both chemical and biological, which are required to equip the reader for the detailed analysis which follows. Pathways of metal assimilation, storage and transport, as well as metal homeostasis are dealt with next. Thereafter, individual chapters discuss the roles of sodium and potassium, magnesium, calcium, zinc, iron, copper, nickel and cobalt, manganese, and finally molybdenum, vanadium, tungsten and chromium. The final three chapters provide a tantalising view of the roles of metals in brain function, biomineralization and a brief illustration of their importance in both medicine and the environment.Relaxed and agreeable writing style. The reader will not only fiind the book easy to read, the fascinating anecdotes and footnotes will give him pegs to hang important ideas on.Written by a biochemist. Will enable the reader to more readily grasp the biological and clinical relevance of the subject.Many colour illustrations. Enables easier visualization of molecular mechanismsWritten by a single author. Ensures homgeneity of style and effective cross referencing between chapters

Fluorine in Medicinal Chemistry and Chemical Biology

Author : Iwao Ojima
Publisher : John Wiley & Sons
ISBN 13 : 9780470744086
Total Pages : 640 pages
Book Rating : 4.7/5 (44 download)

DOWNLOAD NOW!

Book Synopsis Fluorine in Medicinal Chemistry and Chemical Biology by : Iwao Ojima

Download or read book Fluorine in Medicinal Chemistry and Chemical Biology written by Iwao Ojima and published by John Wiley & Sons. This book was released on 2009-03-23 with total page 640 pages. Available in PDF, EPUB and Kindle. Book excerpt: The extraordinary potential of fluorine-containing molecules in medicinal chemistry and chemical biology has been recognized by researchers outside of the traditional fluorine chemistry field, and thus a new wave of fluorine chemistry is rapidly expanding its biomedical frontiers. With several of the best selling drugs in the world crucially containing fluorine atoms, the incorporation of fluorine to drug leads has become an essential practice in biomedical research, especially for drug design and discovery as well as development. Focusing on the unique and significant roles that fluorine plays in medicinal chemistry and chemical biology, this book reviews recent advances and future prospects in this rapidly developing field. Topics covered include: Discovery and development of fluorine containing drugs and drug candidates. New and efficient synthetic methods for medicinal chemistry and the optimisation of fluorine-containing drug candidates. Structural and chemical biology of fluorinated amino acids and peptides. Fluorine labels as probes in metabolic study, protein engineering and clinical diagnosis. Applications of 19F NMR spectroscopy in biomedical research. An appendix presents an invaluable index of all fluorine-containing drugs that have been approved by the US Food and Drug Administration, including information on structure and pharmaceutical action. Fluorine in Medicinal Chemistry and Chemical Biology will serve as an excellent reference source for graduate students as well as academic and industrial researchers who want to take advantage of fluorine in biomedical research.