The Biochemistry Of Retinoic Acid Receptors I Structure Activation And Function At The Molecular Level

Download The Biochemistry Of Retinoic Acid Receptors I Structure Activation And Function At The Molecular Level full books in PDF, epub, and Kindle. Read online The Biochemistry Of Retinoic Acid Receptors I Structure Activation And Function At The Molecular Level ebook anywhere anytime directly on your device. Fast Download speed and no annoying ads. We cannot guarantee that every ebooks is available!

The Biochemistry of Retinoic Acid Receptors I: Structure, Activation, and Function at the Molecular Level

Author : Mary Ann Asson-Batres
Publisher : Springer
ISBN 13 : 9401790507
Total Pages : 233 pages
Book Rating : 4.4/5 (17 download)

DOWNLOAD NOW!

Book Synopsis The Biochemistry of Retinoic Acid Receptors I: Structure, Activation, and Function at the Molecular Level by : Mary Ann Asson-Batres

Download or read book The Biochemistry of Retinoic Acid Receptors I: Structure, Activation, and Function at the Molecular Level written by Mary Ann Asson-Batres and published by Springer. This book was released on 2014-06-24 with total page 233 pages. Available in PDF, EPUB and Kindle. Book excerpt: A role for vitamin A in living organisms has been known throughout human history. In the last 100 years, the biochemical nature of vitamin A and its active derivative, retinoic acid, its physiological impact on growth processes and the essential details of its mechanism of action have been revealed by investigations carried out by researchers using vertebrate and more recently invertebrate models to study a multiplicity of processes and conditions, encompassing embryogenesis, postnatal development to old age. A wealth of intercellular interactions, intracellular signaling systems and molecular mechanisms have been described and the overall conclusion is that retinoic acid is essential for life. This book series, with chapters authored by experts in every aspect of this complex field, unifies the knowledge base and mechanisms currently known in detailed, engaging, well-illustrated, focused chapters that synthesize information for each specific area. In view of the recent explosion in this field, it is timely to publish a contemporary, comprehensive, book series recapitulating the most exciting developments in the field and covering fundamental research in molecular mechanisms of vitamin A action, its role in physiology, development and continued well-being and the potential of vitamin A derivatives and synthetic mimetics to serve as therapeutic treatments for cancers and other debilitating human diseases. VOLUME I: Here, we present the first volume of a multi-volume series on Retinoic Acid Signaling that will cover all aspects of this broad and diverse field. One aim of Volume I is to present a compilation of topics related to the biochemistry of nuclear retinoic acid receptors, from their architecture when bound to DNA and associated with their coregulators to their ability to regulate target gene transcription. A second aim is to provide insight into recent advances that have been made in identifying novel targets and non-genomic effects of retinoic acid. Volume I is divided into ten chapters contributed by prominent experts in their respective fields. Each chapter starts with the history of the area of research. Then, the key findings that contributed to development of the field are described, followed by a detailed look at key findings and progress that are being made in current, ongoing research. Each chapter is concluded with a discussion of the relevance of the research and a perspective on missing pieces and lingering gaps that the author recommends will be important in defining future directions in vitamin A research.

The Fat-Soluble Vitamins

Author : H. DeLuca
Publisher : Springer Science & Business Media
ISBN 13 : 1461588707
Total Pages : 297 pages
Book Rating : 4.4/5 (615 download)

DOWNLOAD NOW!

Book Synopsis The Fat-Soluble Vitamins by : H. DeLuca

Download or read book The Fat-Soluble Vitamins written by H. DeLuca and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 297 pages. Available in PDF, EPUB and Kindle. Book excerpt: The first demonstration of the existence of a vitamin and the full recognition of this fact are often attributed to the work of McCollum, who found that a sub stance in butterfat and cod-liver oil was necessary for growth and health of ani mals fed purified diets. It became obvious that an organic substance present in microconcentrations was vital to growth and reproduction of animals. Following the coining of the word vitamine by Funk, McCollum named this fat-soluble sub stance vitamin A. We can, therefore, state that vitamin A was certainly one of the first known vitamins, yet its function and the function of the other fat-soluble vitamins had remained largely unknown until recent years. However, there has been an explosion of investigation and new information in this field, which had remained quiescent for at least two or three decades. It is now obvious that the fat-soluble vitamins function quite differently from their water-soluble counter parts. We have learned that vitamin D functions by virtue of its being converted in the kidney to a hormone that functions to regulate calcium and phosphorus metabolism. This new endocrine system is in the process of being elucidated in detail, and in addition, the medical use of these hormonal forms of vitamin D in the treatment of a variety of metabolic bone diseases has excited the medical com munity.

International Review of Cell and Molecular Biology

Author :
Publisher : Academic Press
ISBN 13 : 0128124687
Total Pages : 354 pages
Book Rating : 4.1/5 (281 download)

DOWNLOAD NOW!

Book Synopsis International Review of Cell and Molecular Biology by :

Download or read book International Review of Cell and Molecular Biology written by and published by Academic Press. This book was released on 2017-02-17 with total page 354 pages. Available in PDF, EPUB and Kindle. Book excerpt: International Review of Cell and Molecular Biology (IRCMB), Volume 330 includes comprehensive and detailed reviews on the current advances in cell and molecular biology. The IRCMB series has a world-wide readership, maintaining a high standard by publishing invited articles on important and timely topics authored by prominent cell and molecular biologists. The articles published in IRCMB have a high impact and an average cited half-life of nine years. IRCMB ranks high amongst scientific journals dealing with cell biology. - Includes comprehensive and detailed reviews on the current advances in cell and molecular biology - Publishes only invited review articles on selected topics - Authored by established and active cell and molecular biologists, drawn from international sources - Offers a wide range of perspectives on specific subjects

The Biochemistry of Retinoid Signaling III

Author : Mary Ann Asson-Batres
Publisher : Springer Nature
ISBN 13 : 3030422828
Total Pages : 232 pages
Book Rating : 4.0/5 (34 download)

DOWNLOAD NOW!

Book Synopsis The Biochemistry of Retinoid Signaling III by : Mary Ann Asson-Batres

Download or read book The Biochemistry of Retinoid Signaling III written by Mary Ann Asson-Batres and published by Springer Nature. This book was released on 2020-04-15 with total page 232 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book covers subjects that have major impacts on society, such as the mechanism of maternal-fetal transfer of vitamin A, and the effects of alcohol on retinoic acid signaling and mammalian embryonic development. There has been an awareness of the importance of consuming vitamins throughout human history, but empirical studies of their physiological role and mode of action only began about 150 years ago. Since then, the biochemical nature of vitamin A and its active derivative, retinoic acid, have been identified and researchers around the globe have investigated retinoic acid’s physiological function in growth processes and in maintaining life Written by leading experts, this book discusses the latest findings and advances in retinoic acid research. It addresses topics such as the role of retinoic acid signaling in a multitude of processes, including limb, heart and respiratory system development, as well as its role in maintaining postnatal organ systems. This book is a valuable resource for scientists involved in vitamin A/retinoic acid research and readers interested in developmental biology.

Gene Regulation, Epigenetics and Hormone Signaling

Author : Subhrangsu S. Mandal
Publisher : John Wiley & Sons
ISBN 13 : 3527697241
Total Pages : 688 pages
Book Rating : 4.5/5 (276 download)

DOWNLOAD NOW!

Book Synopsis Gene Regulation, Epigenetics and Hormone Signaling by : Subhrangsu S. Mandal

Download or read book Gene Regulation, Epigenetics and Hormone Signaling written by Subhrangsu S. Mandal and published by John Wiley & Sons. This book was released on 2017-05-09 with total page 688 pages. Available in PDF, EPUB and Kindle. Book excerpt: Das erste Referenzwerk dieser Art mit einer umfassenden und dennoch prägnanten Einführung in die Epigenetik beschäftigt sich mit den unzähligen Interaktionen zwischen Hormonregulation und Epigenetik. Die Inhalte sind gut strukturiert. Es gibt keine Überschneidungen zwischen den Kapiteln und jedes Kapitel beinhaltet Zusatzmaterialien für Präsentationen. Der Schwerpunkt liegt durchgängig auf Erkrankungen. Zielgruppe sind die vielen Physiologen und Entwicklungsbiologen, die zwar mit der Bedeutung und den Mechanismen der Hormonregulation vertraut sind, aber über unzureichendes Hintergrundwissen im Bereich Epigenetik verfügen.

Retinoids in Mammalian Reproduction, with an Initial Scoping Effort to Identify Regulatory Methods

Author : Nilsson, Charlotte
Publisher : Nordic Council of Ministers
ISBN 13 : 9289365307
Total Pages : 116 pages
Book Rating : 4.2/5 (893 download)

DOWNLOAD NOW!

Book Synopsis Retinoids in Mammalian Reproduction, with an Initial Scoping Effort to Identify Regulatory Methods by : Nilsson, Charlotte

Download or read book Retinoids in Mammalian Reproduction, with an Initial Scoping Effort to Identify Regulatory Methods written by Nilsson, Charlotte and published by Nordic Council of Ministers. This book was released on 2020-04-19 with total page 116 pages. Available in PDF, EPUB and Kindle. Book excerpt: Available online: https://pub.norden.org/temanord2020-507/ Abstract [en] This Nordic report builds on ideas brought forward in the OECD Detailed Review Paper (DRP) 178 on screening and testing methods and endpoints for evaluating endocrine disruptors. It was identified that the retinoid system is not presently included in any OECD test guideline, and that it is urgent to cover this knowledge gap. The present TemaNord report is a contribution to an upcoming OECD DRP on retinoids. An overview of retinoid biology in female and male reproduction is presented. The report identifies that, in general, there is a lack of studies investigating effects of chemicals on reproduction, while simultaneously examining effects on retinoid related parameters. This is a major data gap. However, selected in vitro and/or in silico retinoid-related endpoints, presented in this report, could possibly be part of a broader screening test battery aimed at reproductive toxicity.

Stem Cells and Lineage Commitment

Author : Kursad Turksen
Publisher : Springer Nature
ISBN 13 : 1071635379
Total Pages : 228 pages
Book Rating : 4.0/5 (716 download)

DOWNLOAD NOW!

Book Synopsis Stem Cells and Lineage Commitment by : Kursad Turksen

Download or read book Stem Cells and Lineage Commitment written by Kursad Turksen and published by Springer Nature. This book was released on 2023-12-09 with total page 228 pages. Available in PDF, EPUB and Kindle. Book excerpt: This detailed volume explores a variety of techniques used to study lineage commitment in stem cells. Further elucidation of the process that stem cells undergo on their way to becoming more specified cell types is vital for a more complete understanding of cell biology and overall physiology. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step and readily reproducible laboratory protocols, as well as tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Stem Cells and Lineage Commitment: Methods and Protocols serves as an ideal guide for experts and novices in the field of stem cell biology.

Deep Homology?

Author : Lewis I. Held, Jr
Publisher : Cambridge University Press
ISBN 13 : 1316982718
Total Pages : 291 pages
Book Rating : 4.3/5 (169 download)

DOWNLOAD NOW!

Book Synopsis Deep Homology? by : Lewis I. Held, Jr

Download or read book Deep Homology? written by Lewis I. Held, Jr and published by Cambridge University Press. This book was released on 2017-01-28 with total page 291 pages. Available in PDF, EPUB and Kindle. Book excerpt: Humans and flies look nothing alike, yet their genetic circuits are remarkably similar. Here, Lewis I. Held, Jr compares the genetics and development of the two to review the evidence for deep homology, the biggest discovery from the emerging field of evolutionary developmental biology. Remnants of the operating system of our hypothetical common ancestor 600 million years ago are compared in chapters arranged by region of the body, from the nervous system, limbs and heart, to vision, hearing and smell. Concept maps provide a clear understanding of the complex subjects addressed, while encyclopaedic tables offer comprehensive inventories of genetic information. Written in an engaging style with a reference section listing thousands of relevant publications, this is a vital resource for scientific researchers, and graduate and undergraduate students.

Burger's Medicinal Chemistry, Drug Discovery and Development, 8 Volume Set

Author :
Publisher : John Wiley & Sons
ISBN 13 : 111953030X
Total Pages : 6057 pages
Book Rating : 4.1/5 (195 download)

DOWNLOAD NOW!

Book Synopsis Burger's Medicinal Chemistry, Drug Discovery and Development, 8 Volume Set by :

Download or read book Burger's Medicinal Chemistry, Drug Discovery and Development, 8 Volume Set written by and published by John Wiley & Sons. This book was released on 2021-04-20 with total page 6057 pages. Available in PDF, EPUB and Kindle. Book excerpt: Burger’s Medicinal Chemistry, Drug Discovery and Development Explore the freshly updated flagship reference for medicinal chemists and pharmaceutical professionals The newly revised eighth edition of the eight-volume Burger’s Medicinal Chemistry, Drug Discovery and Development is the latest installment in this celebrated series covering the entirety of the drug development and discovery process. With the addition of expert editors in each subject area, this eight-volume set adds 35 chapters to the extensive existing chapters. New additions include analyses of opioid addiction treatments, antibody and gene therapy for cancer, blood-brain barrier, HIV treatments, and industrial-academic collaboration structures. Along with the incorporation of practical material on drug hunting, the set features sections on drug discovery, drug development, cardiovascular diseases, metabolic diseases, immunology, cancer, anti-Infectives, and CNS disorders. The text continues the legacy of previous volumes in the series by providing recognized, renowned, authoritative, and comprehensive information in the area of drug discovery and development while adding cutting-edge new material on issues like the use of artificial intelligence in medicinal chemistry. Included: Volume 1: Methods in Drug Discovery, edited by Kent D. Stewart Volume 2: Discovering Lead Molecules, edited by Kent D. Stewart Volume 3: Drug Development, edited by Ramnarayan S. Randad and Michael Myers Volume 4: Cardiovascular, Endocrine, and Metabolic Diseases, edited by Scott D. Edmondson Volume 5: Pulmonary, Bone, Immunology, Vitamins, and Autocoid Therapeutic Agents, edited by Bryan H. Norman Volume 6: Cancer, edited by Barry Gold and Donna M. Huryn Volume 7: Anti-Infectives, edited by Roland E. Dolle Volume 8: CNS Disorders, edited by Richard A. Glennon Perfect for research departments in the pharmaceutical and biotechnology industries, Burger’s Medicinal Chemistry, Drug Discovery and Development can be used by graduate students seeking a one-stop reference for drug development and discovery and deserves its place in the libraries of biomedical research institutes, medical, pharmaceutical, and veterinary schools.

The Nuclear Receptor FactsBook

Author : Vincent Laudet
Publisher : Gulf Professional Publishing
ISBN 13 : 9780124377356
Total Pages : 486 pages
Book Rating : 4.3/5 (773 download)

DOWNLOAD NOW!

Book Synopsis The Nuclear Receptor FactsBook by : Vincent Laudet

Download or read book The Nuclear Receptor FactsBook written by Vincent Laudet and published by Gulf Professional Publishing. This book was released on 2002 with total page 486 pages. Available in PDF, EPUB and Kindle. Book excerpt: The FactsBook Series has established itself as the best source of easily accessible and accurate facts about protein groups. They use an easy-to-follow format and are researched and compiled by experts in the field. This Factsbook is devoted to nuclear receptors. The first section presents an introduction and describes the mode of action of the receptors in general. The second section of the book contains detailed entries covering each type of receptor. Entries provide information on: Nomenclature and structure, Isolation, DNA binding properties, Ligands, Expression, Target genes, Knockouts, Disease association, Gene structure, promoter and isoforms, Chromosomal location, Amino acid sequences, Key references

Molecular Biology of the Cell

Author :
Publisher :
ISBN 13 : 9780815332183
Total Pages : 0 pages
Book Rating : 4.3/5 (321 download)

DOWNLOAD NOW!

Book Synopsis Molecular Biology of the Cell by :

Download or read book Molecular Biology of the Cell written by and published by . This book was released on 2002 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Gene Regulation, Epigenetics and Hormone Signaling

Author : Subhrangsu S. Mandal
Publisher : John Wiley & Sons
ISBN 13 : 3527322817
Total Pages : 678 pages
Book Rating : 4.5/5 (273 download)

DOWNLOAD NOW!

Book Synopsis Gene Regulation, Epigenetics and Hormone Signaling by : Subhrangsu S. Mandal

Download or read book Gene Regulation, Epigenetics and Hormone Signaling written by Subhrangsu S. Mandal and published by John Wiley & Sons. This book was released on 2017-10-23 with total page 678 pages. Available in PDF, EPUB and Kindle. Book excerpt: The first of its kind, this reference gives a comprehensive but concise introduction to epigenetics before covering the many interactions between hormone regulation and epigenetics at all levels. The contents are very well structured with no overlaps between chapters, and each one features supplementary material for use in presentations. Throughout, major emphasis is placed on pathological conditions, aiming at the many physiologists and developmental biologists who are familiar with the importance and mechanisms of hormone regulation but have a limited background in epigenetics.

Molecular Biology of the Male Reproductive System

Author : David de Kretser
Publisher : Elsevier
ISBN 13 : 008091764X
Total Pages : 502 pages
Book Rating : 4.0/5 (89 download)

DOWNLOAD NOW!

Book Synopsis Molecular Biology of the Male Reproductive System by : David de Kretser

Download or read book Molecular Biology of the Male Reproductive System written by David de Kretser and published by Elsevier. This book was released on 2012-12-02 with total page 502 pages. Available in PDF, EPUB and Kindle. Book excerpt: Written by experts in their respective fields, this book reviews the expanding knowledge concerning the mechanisms regulating male reproduction at the molecular and cellular levels. It covers the development of the testes and regulatory controls for spermatogenesis and steroidogenesis, and it considers aspects of Sertoli cell function. Areas of emphasis include communication between the various cell types involved in reproduction by hormone and growth factors and the mechanisms by which these factors regulate gene expression. A number of mammalian systems, including humans, are covered. The carefully selected authors provide a clear synopsis of the concepts in each area as well as the latest references, enabling the reader to investigate the topic further. This book is of interest to those seeking an understanding of the regulatory mechanisms in male reproduction and is written for the graduate and postgraduate levels. - Provides up-to-date reviews of the molecular and cellular biology of male reproduction - Includes chapters on the developmental biology of the testes - Links conventional hormonal control of testicular function with the evolving role of growth factors and proto-oncogenes

Retinoid Therapy

Author : W.J. Cunliffe
Publisher : Springer Science & Business Media
ISBN 13 : 9401163499
Total Pages : 312 pages
Book Rating : 4.4/5 (11 download)

DOWNLOAD NOW!

Book Synopsis Retinoid Therapy by : W.J. Cunliffe

Download or read book Retinoid Therapy written by W.J. Cunliffe and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 312 pages. Available in PDF, EPUB and Kindle. Book excerpt: The impact of the retinoids in clinical practice has primarily been in dermatology. When Dr Werner Bollag began his basic research and screening programme in the early 1960's, the expectation was that the retinoids would have a major impact on oncology. However, the laboratory and clinical experiences of Bollag and his colleagues in Switzerland, Stuttgen and Orfanos in Germany, led to publications on both etretinates (Tigason) and isotretinoin (Roaccutane) in the years between 1972 and 1976 in the field of dermatology. In fact the first symposium on retinoid research held in Berlin in 1981 was almost entirely dermatological. A year later a retinoid workshop in Iowa was designed to provide a forum for dermatolog ists from the USA involved in specific protocols investigating oral retinoids. In the UK, research into the retinoids began rather later than in Continental Europe or in the USA, although Tigason was first marketed here. It was felt in late 1982 that as many dermatologists had relatively little experience with these compounds it would be appropriate to hold an International Symposium on retinoid therapy in the UK. Thus on 16-18 May 1983 in London, 37 speakers from 11 countries addressed an audience of 300, aminly UK, dermatologists. The scientific organizing committee consisted of but two persons Dr William Cunliffe of Leeds General Infirmary, representing the European Society of Dermatolo gical Research, and myself from Roche Clinical Research. The Symposium was held under the auspices of the ESDR and of Roche Products Limited.

The Retinoids

Author : Michael B. Sporn
Publisher : Academic Press
ISBN 13 : 0323141617
Total Pages : 441 pages
Book Rating : 4.3/5 (231 download)

DOWNLOAD NOW!

Book Synopsis The Retinoids by : Michael B. Sporn

Download or read book The Retinoids written by Michael B. Sporn and published by Academic Press. This book was released on 2012-12-02 with total page 441 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Retinoids, Volume 1 covers the chemistry and biology of retinoids, with an emphasis on the role of retinoids in nutrition and in vision. After briefly discussing the discovery and nomenclature of retinoids, this six-chapter volume describes the chemical and physical properties of natural and synthetic retinoids, as well as the retinoidal benzoic acid derivatives. The book goes on describing various reactions with radioisotopes for the synthesis of retinoids and related compounds. Considerable chapters explain the chemical, physical, and biological methodologies for separating and measuring retinoids. A discussion on the relationships between structure and activity of retinoids is included. The last chapter addresses the role of vitamin A in animal and human nutrition. This volume also discusses the metabolism of vitamin A in normal and disease states, as well as its interaction with hormones, micronutrients, drugs, and alcohol. This volume is an ideal source for nutritionists, clinicians, and researchers who are interested in the progressing field of retinoid research.

Basic Concepts in Biochemistry: A Student's Survival Guide

Author : Hiram F. Gilbert
Publisher : McGraw Hill Professional
ISBN 13 : 9780071356572
Total Pages : 366 pages
Book Rating : 4.3/5 (565 download)

DOWNLOAD NOW!

Book Synopsis Basic Concepts in Biochemistry: A Student's Survival Guide by : Hiram F. Gilbert

Download or read book Basic Concepts in Biochemistry: A Student's Survival Guide written by Hiram F. Gilbert and published by McGraw Hill Professional. This book was released on 2000 with total page 366 pages. Available in PDF, EPUB and Kindle. Book excerpt: "Basic Concepts in Biochemistry has just one goal: to review the toughest concepts in biochemistry in an accessible format so your understanding is through and complete."--BOOK JACKET.

Neuromorphic Olfaction

Author : Krishna C. Persaud
Publisher : CRC Press
ISBN 13 : 1439871728
Total Pages : 237 pages
Book Rating : 4.4/5 (398 download)

DOWNLOAD NOW!

Book Synopsis Neuromorphic Olfaction by : Krishna C. Persaud

Download or read book Neuromorphic Olfaction written by Krishna C. Persaud and published by CRC Press. This book was released on 2016-04-19 with total page 237 pages. Available in PDF, EPUB and Kindle. Book excerpt: Many advances have been made in the last decade in the understanding of the computational principles underlying olfactory system functioning. Neuromorphic Olfaction is a collaboration among European researchers who, through NEUROCHEM (Fp7-Grant Agreement Number 216916)-a challenging and innovative European-funded project-introduce novel computing p