CRC Handbook of Medicinal Spices

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Publisher : CRC Press
ISBN 13 : 1420040480
Total Pages : 360 pages
Book Rating : 4.4/5 (2 download)

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Book Synopsis CRC Handbook of Medicinal Spices by : James A. Duke

Download or read book CRC Handbook of Medicinal Spices written by James A. Duke and published by CRC Press. This book was released on 2002-09-27 with total page 360 pages. Available in PDF, EPUB and Kindle. Book excerpt: "Let food be your medicine, medicine your food."-Hippocrates, 2400 B.C.When the "Father of Medicine" uttered those famous words, spices were as important for medicine, embalming, preserving food, and masking bad odors as they were for more mundane culinary matters. Author James A. Duke predicts that spices such as capsicum, cinnamon, garlic, ginger

Botanical Leads for Drug Discovery

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Publisher : Springer Nature
ISBN 13 : 9811559171
Total Pages : 481 pages
Book Rating : 4.8/5 (115 download)

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Book Synopsis Botanical Leads for Drug Discovery by : Bikarma Singh

Download or read book Botanical Leads for Drug Discovery written by Bikarma Singh and published by Springer Nature. This book was released on 2020-10-05 with total page 481 pages. Available in PDF, EPUB and Kindle. Book excerpt: Active botanical ingredients are a prime requirement for herbal formulations and discovering a drug is all about integration of science disciplines. In recent decades there has been a growing interest in treating wounds and diseases using traditional remedies based on local herbs, combined with chemical advances. Although this has led to the development of new bioactive ingredients from plants, there has been little success in terms of clinical trials and post-marketing studies to comply with FDA guidelines. Plants have been used as a source of medicine throughout history and continue to serve as the basis for many pharmaceuticals used today. However, despite the modern pharmaceutical industry being founded on botanical medicine, synthetic approaches to drug discovery have now become standard. Science-driven translational discovery and botanical development has created a new reality, leading to enormous changes in strategies, technologies and the disciplines involved, which have been embraced by the pharmaceutical and biotech industries. This book gathers scientific expertise and traditional knowledge to promote the discovery and development of new formulations and drugs based on active ingredients and to provide guidance on taking these to clinical trials. It discusses major topics, such as how the phytochemical composition of many plants has changed over time due to factors like cultivation, which can have both positive and negative effects on the levels of bioactive compounds. It also explores the importance of plants as a valuable source of therapeutic compounds as a result of their vast biosynthetic capacity, and classifies them according to their intended use, safety and regulatory status. Further, the book offers insights into the regulatory aspects of botanical products, which is an important issue when considering standardization and quality assessment, and also examines the commercial aspects of plant-derived medications and their proven role in the treatment of chronic diseases such as heart disease, high blood pressure, pain, asthma, and other associated conditions. Given its scope, this book is a valuable tool for botanists, natural product chemists, pharmacologists and microbiologists involved in the study of phytochemicals for drug discovery.

Principles of Bioenergetics

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Publisher : Springer Science & Business Media
ISBN 13 : 364233430X
Total Pages : 435 pages
Book Rating : 4.6/5 (423 download)

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Book Synopsis Principles of Bioenergetics by : Vladimir P. Skulachev

Download or read book Principles of Bioenergetics written by Vladimir P. Skulachev and published by Springer Science & Business Media. This book was released on 2012-12-15 with total page 435 pages. Available in PDF, EPUB and Kindle. Book excerpt: Principles of Bioenergetics summarizes one of the quickly growing branches of modern biochemistry. Bioenergetics concerns energy transductions occurring in living systems and this book pays special attention to molecular mechanisms of these processes. The main subject of the book is the "energy coupling membrane" which refers to inner membranes of intracellular organelles, for example, mitochondria and chloroplasts. Cellular cytoplasmic membranes where respiratory and photosynthetic energy transducers, as well as ion-transporting ATP-synthases (ATPases) are also part of this membrane. Significant attention is paid to the alternative function of mitochondria as generators of reactive oxygen species (ROS) that mediate programmed death of cells (apoptosis and necrosis) and organisms (phenoptosis). The latter process is considered as a key mechanism of aging which may be suppressed by mitochondria-targeted antioxidants.

My Favorite Marquess

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Publisher : Zebra Books
ISBN 13 : 1420100335
Total Pages : 416 pages
Book Rating : 4.4/5 (21 download)

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Book Synopsis My Favorite Marquess by : Alexandra Bassett

Download or read book My Favorite Marquess written by Alexandra Bassett and published by Zebra Books. This book was released on 2006-07 with total page 416 pages. Available in PDF, EPUB and Kindle. Book excerpt: "Ma'am, Let me assure you that I will not be manipulated by any feminine wiles into offering you another penny for such a dilapidated piece of property.--Sebastian Cavanaugh After conventional means fail, Sebastian, Marquess of St. Just, takes reckless measures to secure that crumbling monstrosity known as Trembledown--a haven for local smugglers and moonlighting spies. He plans to scare, not seduce, its owner, but when a midnight encounter leaves them soaked, stranded, and possessing just one blanket for warmth, Sebastian, a.k.a. Robert the Brute, discovers that the widow Violet Treacher is not only willful and unafraid, she is maddeningly desirable ... My Lord, Enclosed find your unsigned contract. Pray do consider your offer as being rejected.--Mrs. Percival Treacher Though the wilds of Cornwall hold no allure, Violet won't give the arrogant Marquess the satisfaction of a sale, so here she shivers, in a wreck of a house, with lips still burning from the passion of a masked smuggler. She knows he's near--for her own bit of real estate is quite the magnet for secrets, danger, even treachery. But how will she recognize the gentleman by day ... with only the memory of his kiss in the dark?."--

A Manual Flora of Egypt

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Publisher :
ISBN 13 :
Total Pages : 692 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis A Manual Flora of Egypt by : Reinhold Conrad Muschler

Download or read book A Manual Flora of Egypt written by Reinhold Conrad Muschler and published by . This book was released on 1912 with total page 692 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Protein Degradation with New Chemical Modalities

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Publisher : Royal Society of Chemistry
ISBN 13 : 1839160772
Total Pages : 382 pages
Book Rating : 4.8/5 (391 download)

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Book Synopsis Protein Degradation with New Chemical Modalities by : Hilmar Weinmann

Download or read book Protein Degradation with New Chemical Modalities written by Hilmar Weinmann and published by Royal Society of Chemistry. This book was released on 2020-10-07 with total page 382 pages. Available in PDF, EPUB and Kindle. Book excerpt: Targeting protein degradation using small molecules is one of the most exciting small-molecule therapeutic strategies in decades and a rapidly growing area of research. In particular, the development of proteolysis targeting chimera (PROTACs) as potential drugs capable of recruiting target proteins to the cellular quality control machinery for elimination has opened new avenues to address traditionally ‘difficult to target’ proteins. This book provides a comprehensive overview from the leading academic and industrial experts on recent developments, scope and limitations in this dynamically growing research area; an ideal reference work for researchers in drug discovery and chemical biology as well as advanced students.

Anti-fibrotic Drug Discovery

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Publisher : Royal Society of Chemistry
ISBN 13 : 1839160519
Total Pages : 364 pages
Book Rating : 4.8/5 (391 download)

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Book Synopsis Anti-fibrotic Drug Discovery by : Jehrod Brenneman

Download or read book Anti-fibrotic Drug Discovery written by Jehrod Brenneman and published by Royal Society of Chemistry. This book was released on 2020-02-17 with total page 364 pages. Available in PDF, EPUB and Kindle. Book excerpt: Fibrosis is a condition with globally high unmet medical need, and as such is a highly active area of academic and pharmaceutical research covering multiple treatment targets, organs, tissues and therapeutic approaches. Anti-fibrotic Drug Discovery is a single source reference for the latest drug-discovery approaches to tackle fibrosis in various tissues, comprehensively covering recent success and future perspectives on emerging therapeutic intervention points. The book highlights significant pre-clinical and clinical drugs currently being developed globally for this disorder. This book is ideal for postgraduate students and researchers with an interest in anti-fibrotic drug discovery as well as clinicians specialising in liver, kidney, heart and lung disease, in which fibrosis plays a key role in pathology.

Medicinal Plants of the Bible

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Publisher :
ISBN 13 :
Total Pages : 246 pages
Book Rating : 4.4/5 (91 download)

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Book Synopsis Medicinal Plants of the Bible by : James A. Duke

Download or read book Medicinal Plants of the Bible written by James A. Duke and published by . This book was released on 1983 with total page 246 pages. Available in PDF, EPUB and Kindle. Book excerpt:

U.S. Spice Trade

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Publisher :
ISBN 13 :
Total Pages : 56 pages
Book Rating : 4.E/5 ( download)

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Book Synopsis U.S. Spice Trade by :

Download or read book U.S. Spice Trade written by and published by . This book was released on 1992 with total page 56 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Successful Drug Discovery, Volume 4

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Publisher : John Wiley & Sons
ISBN 13 : 3527344683
Total Pages : 270 pages
Book Rating : 4.5/5 (273 download)

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Book Synopsis Successful Drug Discovery, Volume 4 by : János Fischer

Download or read book Successful Drug Discovery, Volume 4 written by János Fischer and published by John Wiley & Sons. This book was released on 2019-11-12 with total page 270 pages. Available in PDF, EPUB and Kindle. Book excerpt: Provides unique insider insight into the current drug development process, and what it takes to achieve success In this fourth volume in the series, inventors and primary developers of drugs that made it to the market continue telling the story of the drugs? discovery and development, and discuss the sometimes twisted route from the first drug candidate molecule to the final marketed one. Beginning with a general section addressing overarching topics for drug discovery, the book offers seven chapters that feature selected case studies describing recently introduced drugs or drug classes. These include small molecule drugs as well as biopharmaceuticals and range across different therapeutic fields. Together, they provide a representative cross-section of the present-day drug development effort. Successful Drug Discovery: Volume 4 covers trends in peptide-based drug discovery and the physicochemical properties of recently approved oral drugs. The section on drug class studies looks at antibody-drug conjugates and the discovery, evolution, and therapeutic potential of dopamine partial agonists. Featured case studies examine the discovery of Etelcalcetide for the treatment of secondary hyper-parathyroidism in patients with chronic kidney disease; the development of Lenvatinib Mesylate; the discovery and development of Venetoclax; and more. -Focuses on recently introduced drugs that have not been featured in any textbooks or general references, including Ocrelizumab, a new generation of anti-CD-20 mAb for the treatment of multiple sclerosis, and Venetoclax, a selective antagonist of BCL-2 -Features personal experiences of successful drug developers from industry and academia -Endorsed and supported by the International Union of Pure and Applied Chemistry (IUPAC) Successful Drug Discovery: Volume 4 provides a fascinating and informative look into the process of drug discovery and would be a great reference for those in the pharmaceutical industry, organic and pharmaceutical chemists, and lecturers in pharmacy.

Living Liqueurs

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Publisher :
ISBN 13 : 9780880001434
Total Pages : 110 pages
Book Rating : 4.0/5 (14 download)

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Book Synopsis Living Liqueurs by : James A. Duke

Download or read book Living Liqueurs written by James A. Duke and published by . This book was released on 1987 with total page 110 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Target Discovery and Validation

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Publisher : John Wiley & Sons
ISBN 13 : 3527345299
Total Pages : 396 pages
Book Rating : 4.5/5 (273 download)

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Book Synopsis Target Discovery and Validation by : Alleyn T. Plowright

Download or read book Target Discovery and Validation written by Alleyn T. Plowright and published by John Wiley & Sons. This book was released on 2020-02-18 with total page 396 pages. Available in PDF, EPUB and Kindle. Book excerpt: The modern drug developers? guide for making informed choices among the diverse target identification methods Target Discovery and Validation: Methods and Strategies for Drug Discovery offers a hands-on review of the modern technologies for drug target identification and validation. With contributions from noted industry and academic experts, the book addresses the most recent chemical, biological, and computational methods. Additionally, the book highlights techologies that are applicable to ?difficult? targets and drugs directed at multiple targets, including chemoproteomics, activity-based protein profiling, pathway mapping, genome-wide association studies, and array-based profiling. Throughout, the authors highlight a range of diverse approaches, and target validation studies reveal how these methods can support academic and drug discovery scientists in their target discovery and validation research. This resource: -Offers a guide to identifying and validating targets, a key enabling technology without which no new drug development is possible -Presents the information needed for choosing the appropriate assay method from the ever-growing range of available options -Provides practical examples from recent drug development projects, e. g. in kinase inhibitor profiling Written for medicinal chemists, pharmaceutical professionals, biochemists, biotechnology professionals, and pharmaceutical chemists, Target Discovery and Validation explores the current methods for the identification and validation of drug targets in one comrpehensive volume. It also includes numerous practical examples.

Drug Discovery and Drug Development

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Publisher :
ISBN 13 : 9789811580031
Total Pages : 0 pages
Book Rating : 4.5/5 (8 download)

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Book Synopsis Drug Discovery and Drug Development by : Madhu Dikshit

Download or read book Drug Discovery and Drug Development written by Madhu Dikshit and published by . This book was released on 2021 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Over the years, India has attained a prominent global position in the manufacture of Generic Drugs. This success can be attributed to its synthetic organic chemistry and chemical engineering strengths, nurtured by the timely policies of the Government of India. However, breakthrough successes in New Drug Discovery have remained elusive, despite the brilliant and sustained efforts of many Indian researchers and Pharma establishments. The Indian National Science Academy thought it appropriate to document India's New Drug Discovery Research (NDDR) journey to date. Gathering contributions from prominent researchers in the Indian Pharma Industry and Academia, this book highlights their efforts, achievements, and the status quo of Indian NDDR. .

Piperidine-Based Drug Discovery

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Publisher : Elsevier
ISBN 13 : 0128134283
Total Pages : 359 pages
Book Rating : 4.1/5 (281 download)

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Book Synopsis Piperidine-Based Drug Discovery by : Ruben Vardanyan

Download or read book Piperidine-Based Drug Discovery written by Ruben Vardanyan and published by Elsevier. This book was released on 2017-06-12 with total page 359 pages. Available in PDF, EPUB and Kindle. Book excerpt: Piperidine-Based Drug Discovery outlines the complexities of Piperidine scaffold use in drug discovery, including derivative chemistry, structural properties, methods of synthesis and practical implementations. Piperidine scaffolds are the cornerstones of over 70 commercialized drugs (including multiple blockbusters). Designed as a guide for both experts and students working in this and related areas, it is hoped that this volume will encourage and inspire the continued design and development of novel pharmaceuticals based on Piperidine and its derivatives. Heterocyclic compounds are of central importance to medicinal chemistry, as demonstrated by the high percentage of marketable drugs that feature heterocyclic fragments in their structures. As starting points for drug discovery they offer a broad range of attractive properties, and a detailed understanding of the particular characteristics of each is of great benefit to researchers. The most commonly used heterocycle among US FDA approved pharmaceuticals, Piperidine is an extremely important building block in the synthesis of medicinal agents. This heterocycle and its derivatives exhibit a number of important functionalities and have been employed variously as CNS modulators, antiaggregants, anticoagulants, antihistamines, anti-cancer drugs and analgesics. - Explores this extremely important heterocycle to a high level of detail - Describes synthesis methods for 70 current drugs based on Piperidine scaffolds - Gives drug designers all the key knowledge required to develop new drugs utilizing Piperidine - Provides pharmacologists a solid overview of the chemical background of existing Piperidine-based drugs

Plants for Human Survival and Medicine

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Publisher :
ISBN 13 : 9781032654454
Total Pages : 0 pages
Book Rating : 4.6/5 (544 download)

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Book Synopsis Plants for Human Survival and Medicine by : Bikarma Singh

Download or read book Plants for Human Survival and Medicine written by Bikarma Singh and published by . This book was released on 2023-09-25 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book reports the potential plants for human survival, explored medicinal aspects of the ongoing research and development for ethnic-traditional applications and nutraceutical values of plants. Note: T&F does not sell or distribute the Hardback in India, Pakistan, Nepal, Bhutan, Bangladesh and Sri Lanka.

Drug Discovery Targeting Drug-Resistant Bacteria

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Publisher : Academic Press
ISBN 13 : 0128184809
Total Pages : 432 pages
Book Rating : 4.1/5 (281 download)

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Book Synopsis Drug Discovery Targeting Drug-Resistant Bacteria by : Prashant Kesharwani

Download or read book Drug Discovery Targeting Drug-Resistant Bacteria written by Prashant Kesharwani and published by Academic Press. This book was released on 2020-05-15 with total page 432 pages. Available in PDF, EPUB and Kindle. Book excerpt: Drug Discovery Targeting Drug-Resistant Bacteria explores the status and possible future of developments in fighting drug-resistant bacteria. The book covers the majority of microbial diseases and the drugs targeting them. In addition, it discusses the potential targeting strategies and innovative approaches to address drug resistance. It brings together academic and industrial experts working on discovering and developing drugs targeting drug-resistant (DR) bacterial pathogens. New drugs active against drug-resistant pathogens are discussed, along with new strategies being used to discover molecules acting via new modes of action. In addition, alternative therapies such as peptides and phages are included. Pharmaceutical scientists, microbiologists, medical professionals, pathologists, researchers in the field of drug discovery, infectious diseases and microbial drug discovery both in academia and in industrial settings will find this book helpful.

Quantum Mechanics in Drug Discovery

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Publisher : Humana
ISBN 13 : 9781071602843
Total Pages : 360 pages
Book Rating : 4.6/5 (28 download)

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Book Synopsis Quantum Mechanics in Drug Discovery by : Alexander Heifetz

Download or read book Quantum Mechanics in Drug Discovery written by Alexander Heifetz and published by Humana. This book was released on 2021-02-18 with total page 360 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume looks at applications of quantum mechanical (QM) methods in drug discovery. The chapters in this book describe how QM approaches can be applied to address key drug discovery issues, such as characterizing protein-water-ligand and protein-protein interactions, providing estimates of binding affinities, determining ligand energies and bioactive conformations, refinement of molecular geometries, scoring docked protein–ligand poses, describing molecular similarity, structure–activity-relationship (SAR) analysis, and ADMET prediction. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary software and tools, step-by-step, readily reproducible modeling protocols, and tips on troubleshooting and avoiding known pitfalls. Cutting-edge and unique, Quantum Mechanics in Drug Discovery is a valuable resource for structural and molecular biologists, computational and medicinal chemists, pharmacologists, and drug designers.