The Aging Immune System And Health

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The Aging Immune System and Health

Author : Valquiria Bueno
Publisher : Frontiers Media SA
ISBN 13 : 2889633616
Total Pages : 314 pages
Book Rating : 4.8/5 (896 download)

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Book Synopsis The Aging Immune System and Health by : Valquiria Bueno

Download or read book The Aging Immune System and Health written by Valquiria Bueno and published by Frontiers Media SA. This book was released on 2020-01-15 with total page 314 pages. Available in PDF, EPUB and Kindle. Book excerpt: The world population presents an increased percentage of individuals over 65 years old and the fastest growing subgroup is over 85 years old. The increase in life expectancy observed in the last century has not been synonymous with extra years lived in good health (disability-free years). Population studies have shown that as individuals age, they can present a great heterogeneity of ability and health. Therefore, aging has been associated for some individuals with disabilities and hospitalizations. Deaths related to infectious pathogens are increased in the aging population mainly due to pneumonia and influenza whereas Cytomegalovirus, Epstein-Barr virus, among other viruses seem to contribute to the low-grade inflammatory process observed (inflammaging). Aging is a complex and multifactorial process in which functions of the organism are adjusted (remodelled) in order to deal with damaging events during life. One of the most important changes in aging individuals occurs in the immune system (innate and adaptive responses) with consequences such as poor response to new infections and vaccinations; increased susceptibility to cancer development and autoimmune diseases; frailty, and organ dysfunction. In addition, it has been proposed that immunosenescence not only reflects the aging of the organism but also contributes to this process. Bone marrow presents decreased hematopoiesis, the thymus undergoes involution and lymphoid organs (lymph nodes, spleen) also present reduced functionality. Therefore, cells derived, matured, or residing in these tissues decline in number and function. These changes have been identified in experimental models, in vitro conditions, peripheral blood, and biopsies via biomarkers such as cell phenotype, stimulus-induced proliferation, cytokines and antibodies levels. Telomere length and telomerase activity also decline in bone marrow-derived and peripheral blood cells and have been shown to play a role in immunosenescence. More recently, the investigation of short non-coding RNA molecules (microRNAs; miRNAs) pointed to this system as a possible control of aging-related mechanisms. Data obtained on these markers for aging individuals could lead to the generation of a marker panel for pathology prediction, to indicate interventions, and to evaluate the efficacy of interventions. Interventions such as nutrition supplements, exercise, vaccination (different dose, concentration of antigen, adjuvants) have been proposed to circumvent age-related diseases. Considering the heterogeneity in the aging process, further investigation is vital before the indication of interventions for aging individuals. As the extension of life expectancy is a reality, it is a challenge to understand how the aging population copes with the remodelling of the organism and how interventions could provide longevity in good health.

The Ageing Immune System and Health

Author : Valquiria Bueno
Publisher : Springer
ISBN 13 : 3319433652
Total Pages : 189 pages
Book Rating : 4.3/5 (194 download)

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Book Synopsis The Ageing Immune System and Health by : Valquiria Bueno

Download or read book The Ageing Immune System and Health written by Valquiria Bueno and published by Springer. This book was released on 2016-10-03 with total page 189 pages. Available in PDF, EPUB and Kindle. Book excerpt: The present book intends to provide an update on immunosenescence and how deficiencies in the immune system contribute to a higher susceptibility to infections, decline in organ function, reduced vaccination responses, age-related disease and the ageing process itself, negatively affecting longevity. Our focus is on the main changes in immune system cells and their products occurring during the ageing process and the possible consequences for health and disease. This includes: discussion of the modulatory and/or suppressive mechanisms associated with the alterations in T regulatory cells, B regulatory cells and Myeloid Derived Suppressor cells; changes in the immune system observed in chronic neurodegenerative diseases, cancer, lung disease and frailty will also be discussed. Most importantly we provide recent literature information about possible interventions (focusing on physical activity) that could alleviate the negative effects of immunosenescence. The Ageing Immune System and Health is a comprehensive guide on the field intended to all physicians, researchers, professors and students interested on relationship between immune system, ageing and health.

Biochemistry and Cell Biology of Ageing: Part II Clinical Science

Author : J. Robin Harris
Publisher : Springer
ISBN 13 : 9811336814
Total Pages : 499 pages
Book Rating : 4.8/5 (113 download)

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Book Synopsis Biochemistry and Cell Biology of Ageing: Part II Clinical Science by : J. Robin Harris

Download or read book Biochemistry and Cell Biology of Ageing: Part II Clinical Science written by J. Robin Harris and published by Springer. This book was released on 2019-03-19 with total page 499 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume of the subcellular Biochemistry series will attempt to bridge the gap between the subcellular events that are related to aging as they were described in the first volume of this set of two books and the reality of aging as this is seen in clinical practice. All chapters will start from the biochemistry or cell biology, where the data is available and work up towards the understanding that we have of aging in the various areas that are related to the subject. Key focus points for this volume are nutrition, external factors and genetics on aging. There will also be chapters that will focus on various organs or tissues in which aging has been well studied, like the eyes, the muscles, the immune system and the bones. The aim of the book project and the book project that is published in concert with this volume is to bring the subcellular and clinical areas into closer contact.

Advances in Geroscience

Author : Felipe Sierra
Publisher : Springer
ISBN 13 : 3319232460
Total Pages : 637 pages
Book Rating : 4.3/5 (192 download)

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Book Synopsis Advances in Geroscience by : Felipe Sierra

Download or read book Advances in Geroscience written by Felipe Sierra and published by Springer. This book was released on 2015-11-10 with total page 637 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides the first comprehensive overview of a new scientific discipline termed Geroscience. Geroscience examines the molecular and cellular mechanisms that might explain why aging is the main risk factor for most chronic diseases affecting the elderly population. Over the past few decades, researchers have made impressive progress in understanding the genetics, biology and physiology of aging. This book presents vital research that can help readers to better understand how aging is a critical malleable risk factor in most chronic diseases, which, in turn, could lead to interventions that can help increase a healthy lifespan, or ‘healthspan.’ The book begins with an analysis of the Geroscience hypothesis, as well as the epidemiological underpinnings that define aging as a candidate main risk factor for most chronic diseases. Next, each chapter focuses on one particular disease, or group of diseases, with an emphasis on how basic molecular and cellular biology might explain why aging is a major risk factor for it. Coverage in the book includes: cancer, cardiovascular disease, dementias, stroke, Parkinson's and Alzheimer’s diseases, osteoporosis, arthritis, diabetes asthma, emphysema, kidney disease, vision impairment, and AIDS/HIV. It finishes with a chapter on pain in the elderly and an overview of future steps needed to bring the newly acquired knowledge into the clinic and the public at large.

Healthy Longevity and Immune System

Author : Valquiria Bueno
Publisher : Springer
ISBN 13 : 9783030875343
Total Pages : 0 pages
Book Rating : 4.8/5 (753 download)

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Book Synopsis Healthy Longevity and Immune System by : Valquiria Bueno

Download or read book Healthy Longevity and Immune System written by Valquiria Bueno and published by Springer. This book was released on 2022-11-12 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book presents studies of the main conditions that affect health and well-being of old people. Considering the present scenario of COVID-19, the effects of this viral infection on individuals older than 65 years are also discussed. The content enables professionals of health and government for the present and future actions in this important area. Readers go through the changes occurring in organs and tissues that can interfere with susceptibility to infections, low response to vaccines, cancer, and loss of cognition during the aging process. A discussion of the central role played by the immune system in the age-related diseases and how the immunity can be impaired during the ageing process is presented. Possibilities to circumvent these conditions via healthy habits in diet, physical exercise, and new pharmacological interventions are part of the content. This book discusses how human healthy longevity is dependent, at least in part, of a functional immune system. Chapters were written for researchers in the field of aging and is especially suited for those interested in the study of immunosenescence and inflammaging affecting the health of old individuals.

Aging

Author : L. Robert
Publisher : Karger Medical and Scientific Publishers
ISBN 13 : 3318026530
Total Pages : 226 pages
Book Rating : 4.3/5 (18 download)

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Book Synopsis Aging by : L. Robert

Download or read book Aging written by L. Robert and published by Karger Medical and Scientific Publishers. This book was released on 2014-05-16 with total page 226 pages. Available in PDF, EPUB and Kindle. Book excerpt: Aging inspired a large number of theories trying to rationalize the aging process common to all living beings. In this publication the most important environmental and intrinsic mechanisms involved in the aging process and in its pathological consequences are reviewed. Furthermore theoretical and experimental evidence of the most important theoretical elements based on Darwinian evolution, cellular aging, role of cell membranes, free radicals and oxidative processes, receptor-mediated reactions, the extracellular matrix and immune functions as well as the most important environmental and intrinsic mechanisms involved in the aging process and in its pathological consequences are discussed. These presentations of theories and related experimental facts give a global overview of up to date concepts of the biology of the aging process and are of essential reading not only for specialists in this field but also for practitioners of scientific, medical, social and experimental sciences.

Immunology of Aging

Author : Ahmad Massoud
Publisher : Springer Science & Business Media
ISBN 13 : 3642394957
Total Pages : 411 pages
Book Rating : 4.6/5 (423 download)

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Book Synopsis Immunology of Aging by : Ahmad Massoud

Download or read book Immunology of Aging written by Ahmad Massoud and published by Springer Science & Business Media. This book was released on 2013-11-29 with total page 411 pages. Available in PDF, EPUB and Kindle. Book excerpt: The rapidity of scientific progress over the last few years guarantees the utility of this new collection of state-of-the-art reviews on the immunology of aging, which is the result of extensive collaboration of more than sixty of the greatest thinkers and scholars in the field, in cooperation with a number of junior colleagues. The book summarizes current knowledge on the cellular and molecular aspects of the aging immune system and their clinical relevance, providing insights into the effects of the aging process on susceptibilities to those diseases most common among elders. The retrieval strategies used to slow down the decline in the immune system in the elderly are another subject detailed extensively. By providing a broad overview of immunosenescence and its consequences, as well as their potential modulation, this book will fill a gap in a timely manner. It will be of value to all immunologists, whether novice or experienced, as well as geriatricians and epidemiologists.

Vitamin E in Human Health

Author : Peter Weber
Publisher : Springer
ISBN 13 : 3030053156
Total Pages : 467 pages
Book Rating : 4.0/5 (3 download)

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Book Synopsis Vitamin E in Human Health by : Peter Weber

Download or read book Vitamin E in Human Health written by Peter Weber and published by Springer. This book was released on 2019-04-01 with total page 467 pages. Available in PDF, EPUB and Kindle. Book excerpt: Vitamin E is a well described and established fat-soluble essential micronutrient and as such has to be provided to the human body on a regular basis in order to avoid deficiency and maintain a healthy status. This is well established and also reviewed in a number of publications. However, a huge body of evidence has accumulated over the last decade, or so, which provides new insights on the mode of action of vitamin E, and the biological role of the tocopherol isomers, and sheds new light on the role of vitamin E in human health. Both fundamental knowledge gain and new data on the role and challenges of vitamin E as an essential micronutrient, including emerging evidence on clinical benefits, will be addressed to put this essential micronutrient in the appropriate perspective. Given this level of new evidence which has emerged over the recent years, a book on vitamin E will put into perspective the concerns which have been raised on vitamin E and which resulted in a misinformation and confusion of the public regarding the importance of vitamin E for human health. This book will reemphasize that Vitamin E is clearly required for human health and its inadequacy leads to increased risk of a variety of diseases. In addition new data of non-communicable diseases (NCD) dependent on vitamin E status show that a lifetime of low intake increases risks of development, severity and complications of NCDs. This text will put the vitamin E case into an up-to-date, science based, applicable real-life perspective and offer pragmatic solutions for its safe and personalized use beyond the various methodological and statistical controversies. The purpose of this book is also to raise awareness not only in the nutrition and medical community, but also in the public media that there are a number of health conditions where an increased intake of vitamin E can be of potential importance. Further this review should also stimulate funding organizations and agencies to increase their support for vitamin E research in order to facilitate the further exploration of the safe and efficacious use of this essential micronutrient.

Handbook on Immunosenescence

Author : Tamas Fulop
Publisher : Springer Science & Business Media
ISBN 13 : 1402090633
Total Pages : 1693 pages
Book Rating : 4.4/5 (2 download)

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Book Synopsis Handbook on Immunosenescence by : Tamas Fulop

Download or read book Handbook on Immunosenescence written by Tamas Fulop and published by Springer Science & Business Media. This book was released on 2009-02-27 with total page 1693 pages. Available in PDF, EPUB and Kindle. Book excerpt: This authoritative handbook covers all aspects of immunosenescence, with contributions from experts in the research and clinical areas. It examines methods and models for studying immunosenescence; genetics; mechanisms including receptors and signal transduction; clinical relevance in disease states including infections, autoimmunity, cancer, metabolic syndrome, neurodegenerative diseases, frailty and osteoporosis; and much more.

Stress Challenges and Immunity in Space

Author : Alexander Choukèr
Publisher : Springer Nature
ISBN 13 : 3030169960
Total Pages : 756 pages
Book Rating : 4.0/5 (31 download)

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Book Synopsis Stress Challenges and Immunity in Space by : Alexander Choukèr

Download or read book Stress Challenges and Immunity in Space written by Alexander Choukèr and published by Springer Nature. This book was released on 2019-11-27 with total page 756 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book explains how stress – either psychological or physical – can activate and/or paralyse human innate or adaptive immunity. Adequate immunity is crucial for maintaining health, both on Earth and in space. During space flight, human physiology is specifically challenged by complex environmental stressors, which are most pronounced during lunar or interplanetary missions. Adopting an interdisciplinary approach, the book identifies the impact of these stressors – the space exposome – on immunity as a result of (dys-)functions of specific cells, organs and organ networks. These conditions (e.g. gravitation changes, radiation, isolation/confinement) affect immunity, but at the same time provide insights that may help to prevent, diagnose and address immune-related health alterations. Written by experts from academia, space agencies and industry, the book is a valuable resource for professionals, researchers and students in the field of medicine, biology and technology. The chapters “The Impact of Everyday Stressors on the Immune System and Health”, “Stress and Radiation Responsiveness” and “Assessment of Radiosensitivity and Biomonitoring of Exposure to Space adiation” are available open access under a Creative Commons Attribution 4.0 International License via link.springer.com.

Healthy Longevity and Immune System

Author : Valquiria Bueno
Publisher : Springer Nature
ISBN 13 : 3030875326
Total Pages : 208 pages
Book Rating : 4.0/5 (38 download)

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Book Synopsis Healthy Longevity and Immune System by : Valquiria Bueno

Download or read book Healthy Longevity and Immune System written by Valquiria Bueno and published by Springer Nature. This book was released on 2021-11-10 with total page 208 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book presents studies of the main conditions that affect health and well-being of old people. Considering the present scenario of COVID-19, the effects of this viral infection on individuals older than 65 years are also discussed. The content enables professionals of health and government for the present and future actions in this important area. Readers go through the changes occurring in organs and tissues that can interfere with susceptibility to infections, low response to vaccines, cancer, and loss of cognition during the aging process. A discussion of the central role played by the immune system in the age-related diseases and how the immunity can be impaired during the ageing process is presented. Possibilities to circumvent these conditions via healthy habits in diet, physical exercise, and new pharmacological interventions are part of the content. This book discusses how human healthy longevity is dependent, at least in part, of a functional immune system. Chapters were written for researchers in the field of aging and is especially suited for those interested in the study of immunosenescence and inflammaging affecting the health of old individuals.

Foods and Dietary Supplements in the Prevention and Treatment of Disease in Older Adults

Author : Ronald Ross Watson
Publisher : Academic Press
ISBN 13 : 0124186866
Total Pages : 400 pages
Book Rating : 4.1/5 (241 download)

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Book Synopsis Foods and Dietary Supplements in the Prevention and Treatment of Disease in Older Adults by : Ronald Ross Watson

Download or read book Foods and Dietary Supplements in the Prevention and Treatment of Disease in Older Adults written by Ronald Ross Watson and published by Academic Press. This book was released on 2015-01-27 with total page 400 pages. Available in PDF, EPUB and Kindle. Book excerpt: Foods and Dietary Supplements in the Prevention and Treatment of Disease in Older Adults focuses on the ways in which food and dietary supplements affect the major health problems of aging adults. Researchers in nutrition, diet, epidemiology, and aging studies, as well as healthcare providers who work with elderly patients will use this comprehensive resource as a tool in their long-term goal of preventing and treating chronic disease within the elderly. This book brings together a broad range of experts working on the different aspects of foods and dietary supplements (vitamins, herbs, plant extracts, etc.) in health promotion and disease prevention. They have contributed chapters which define a range of ways in which foods, nutriceuticals, and dietary supplements prevent disease and promote health in older adults. They begin by reviewing the medicinal role of foods, herbal, and dietary supplements in health promotion in older adults, as well as some of the most commonly used supplements in elder "self-medication." They review the most recent studies of how foods, herbal, and dietary supplements are effective in the prevention and treatment of cancer, cardiovascular disease, diabetes, and other obesity associated diseases in older adults. Then they consider alcohol, other drugs, and plant based drugs of abuse which can adversely affect the health of older adults. Lastly, they consider foods and dietary supplements in gene regulation in older adults. Investigates the important nutritional requirements of the aging population in health and in relation to various acute and chronic diseases Explores the nutritional effects of botanical extracts and components that can have important health promotion benefits, and risks, to ensure safe consumption Reviews studies of common diseases within the aging population including cancer, cardiovascular, metabolic, and infectious diseases that can alter the intake of foods, supplements, and/or requirements for various nutrients Investigates the mechanisms of action of components of foods and dietary supplements, in particular gene activation and epigenetics

Providing Healthy and Safe Foods As We Age

Author : Institute of Medicine
Publisher : National Academies Press
ISBN 13 : 0309158834
Total Pages : 192 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis Providing Healthy and Safe Foods As We Age by : Institute of Medicine

Download or read book Providing Healthy and Safe Foods As We Age written by Institute of Medicine and published by National Academies Press. This book was released on 2010-11-29 with total page 192 pages. Available in PDF, EPUB and Kindle. Book excerpt: Does a longer life mean a healthier life? The number of adults over 65 in the United States is growing, but many may not be aware that they are at greater risk from foodborne diseases and their nutritional needs change as they age. The IOM's Food Forum held a workshop October 29-30, 2009, to discuss food safety and nutrition concerns for older adults.

Immunity and Inflammation in Health and Disease

Author : Shampa Chatterjee
Publisher : Academic Press
ISBN 13 : 0128054026
Total Pages : 477 pages
Book Rating : 4.1/5 (28 download)

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Book Synopsis Immunity and Inflammation in Health and Disease by : Shampa Chatterjee

Download or read book Immunity and Inflammation in Health and Disease written by Shampa Chatterjee and published by Academic Press. This book was released on 2017-08-31 with total page 477 pages. Available in PDF, EPUB and Kindle. Book excerpt: Immunity and Inflammation in Health and Disease: Emerging Roles of Nutraceuticals and Functional Foods in Immune Support provides a comprehensive description of the various pathways by which the vertebrate immune system works, the signals that trigger immune response and how fnew and novel nutraceuticals and functional foods, can be used to contain inflammation and also to boost immunity and immune health. Inflammation is a tool to fight pathogens and the vertebrate immune system has a very complex network of cells to achieve this. However inflammation that goes awry is also the leding cause of several diseases ranging from cardiovascular diseases to diabetes. This book covers the entire gamut from the various cellular players in the inflammation-immune response to its ramifications in terms of protection against pathogens as well as in onset of metabolic, aging and auto-immune related diseases. Finally, the balancing role of dietary nutrients between host defence and immune support is also showcased. The first three scetions explain the various components of the immune system and their modes of activation. The fourth section deals with the ramifications of a robust and execessive inflammatory response. The fifth section is focused on the association between nutrition and immunity and how deficiencies in certain nutrients may affect immunocompetence. The sixth section chapters represent a vision of paradigm shifts within the field and discusses possible future directions. This bool will be a valuable reference for researchers studying immune health either in academia, or in the nutraceutical or functional food industries. Product developers in nutraceutical, supplement, functional food, and health food companies will also appreciate the information presented here. Conceptualizes the key features in natural products which can boost immune function and immune health Explains the intricate mechanistic aspects and balance behind immune health Presents the pathophysiology of several diseases associated with immune system disruption

Handbook of Human Stress and Immunity

Author : Ronald Glaser
Publisher : Academic Press
ISBN 13 : 1483295125
Total Pages : 436 pages
Book Rating : 4.4/5 (832 download)

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Book Synopsis Handbook of Human Stress and Immunity by : Ronald Glaser

Download or read book Handbook of Human Stress and Immunity written by Ronald Glaser and published by Academic Press. This book was released on 2014-06-28 with total page 436 pages. Available in PDF, EPUB and Kindle. Book excerpt: In 1964, George Solomon coined the term psychoneuroimmunology. In the intervening 30 years, this term has emerged into a dynamic field of study which investigates the unique interactions between the nervous, endocrine, and immune systems. The Handbook of Human Stress and Immunity is a comprehensive reference for this dynamic new field. Focusing on how stressors impact the central nervous system and the resulting changes in immune responses, the Handbook is the first to describehow stress specifically affects human immune systems. It discusses how stress generally makes people more susceptible to infection, how personal support systems can counteract the physiological effects of stress, and how stress, or lack of stress, affects the aging process. Chapters are authored by the leading names in the field and cover such diseases as autoimmune disease, viral pathogenesis, herpes, HIV, and AIDS.

Trained Immunity-based Vaccines

Author : Jose Luis Subiza
Publisher : Frontiers Media SA
ISBN 13 : 2889712311
Total Pages : 195 pages
Book Rating : 4.8/5 (897 download)

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Book Synopsis Trained Immunity-based Vaccines by : Jose Luis Subiza

Download or read book Trained Immunity-based Vaccines written by Jose Luis Subiza and published by Frontiers Media SA. This book was released on 2021-08-25 with total page 195 pages. Available in PDF, EPUB and Kindle. Book excerpt: Dr. Jose Luis Subiza is the founder and CEO of Inmunotek SL. The other Topic Editors declare no competing interests with regard to the Research Topic subject.

Military Strategies for Sustainment of Nutrition and Immune Function in the Field

Author : Institute of Medicine
Publisher : National Academies Press
ISBN 13 : 0309173183
Total Pages : 722 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis Military Strategies for Sustainment of Nutrition and Immune Function in the Field by : Institute of Medicine

Download or read book Military Strategies for Sustainment of Nutrition and Immune Function in the Field written by Institute of Medicine and published by National Academies Press. This book was released on 1999-05-13 with total page 722 pages. Available in PDF, EPUB and Kindle. Book excerpt: Every aspect of immune function and host defense is dependent upon a proper supply and balance of nutrients. Severe malnutrition can cause significant alteration in immune response, but even subclinical deficits may be associated with an impaired immune response, and an increased risk of infection. Infectious diseases have accounted for more off-duty days during major wars than combat wounds or nonbattle injuries. Combined stressors may reduce the normal ability of soldiers to resist pathogens, increase their susceptibility to biological warfare agents, and reduce the effectiveness of vaccines intended to protect them. There is also a concern with the inappropriate use of dietary supplements. This book, one of a series, examines the impact of various types of stressors and the role of specific dietary nutrients in maintaining immune function of military personnel in the field. It reviews the impact of compromised nutrition status on immune function; the interaction of health, exercise, and stress (both physical and psychological) in immune function; and the role of nutritional supplements and newer biotechnology methods reported to enhance immune function. The first part of the book contains the committee's workshop summary and evaluation of ongoing research by Army scientists on immune status in special forces troops, responses to the Army's questions, conclusions, and recommendations. The rest of the book contains papers contributed by workshop speakers, grouped under such broad topics as an introduction to what is known about immune function, the assessment of immune function, the effect of nutrition, and the relation between the many and varied stresses encountered by military personnel and their effect on health.