Test Systems In Mutagenicity

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Mutagenicity: Assays and Applications

Author : Ashutosh Kumar
Publisher : Academic Press
ISBN 13 : 0128092602
Total Pages : 350 pages
Book Rating : 4.1/5 (28 download)

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Book Synopsis Mutagenicity: Assays and Applications by : Ashutosh Kumar

Download or read book Mutagenicity: Assays and Applications written by Ashutosh Kumar and published by Academic Press. This book was released on 2017-09-26 with total page 350 pages. Available in PDF, EPUB and Kindle. Book excerpt: Mutagenicity: Assays and Applications presents an extensive examination of the detection, assessment and future of mutagenicity, particularly as it concerns human health and the environment. Chapters focused on specific types of mutagens or testing methods for their detection collectively explore the current state of human and environmental mutagenesis, future perspectives and regulatory needs. The test procedures for measuring mutagenicity, their advantages and limitations are described with practical and procedural detail, along with their presentation and data processing aspects. It is an essential reference covering the breadth and depth of the field of mutagenicity studies and regulation. By providing both important introductory material and practical assays and applications, this book is useful to graduate students, academic and industry researchers and regulators at various stages of their careers, leading to improved risk assessment and regulation. Presents an up-to-date and in-depth review of the current state of mutagenesis research Draws upon the combined experience and expertise of an international group of highly respected editors and chapter authors Provides an introduction to the concept of mutagenesis with particular consideration given to novel chemicals and materials

Test Systems in Mutagenicity

Author : Warren W. Nichols
Publisher :
ISBN 13 : 9780080257051
Total Pages : 10 pages
Book Rating : 4.2/5 (57 download)

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Book Synopsis Test Systems in Mutagenicity by : Warren W. Nichols

Download or read book Test Systems in Mutagenicity written by Warren W. Nichols and published by . This book was released on 1980 with total page 10 pages. Available in PDF, EPUB and Kindle. Book excerpt: Explains the reasons for performing mutagenicity tests and the various methods available as well as test results.

Handbook of Mutagenicity Test Procedures

Author : B.J. Kilbey
Publisher : Elsevier
ISBN 13 : 0444600981
Total Pages : 876 pages
Book Rating : 4.4/5 (446 download)

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Book Synopsis Handbook of Mutagenicity Test Procedures by : B.J. Kilbey

Download or read book Handbook of Mutagenicity Test Procedures written by B.J. Kilbey and published by Elsevier. This book was released on 2012-12-02 with total page 876 pages. Available in PDF, EPUB and Kindle. Book excerpt: The compilation of this book was prompted by the necessity of a bench volume which could provide the necessary background information on materials, experimental design, pitfalls and dificulties, in order to perform a particular test in an acceptable way with a minimal need for additional expert help. This Second Edition updates this information, providing: - a comprehensive bench guide - methods known to be reliable - a broad spectrum of approaches - tips to avoid pitfalls when using unfamiliar techniques - data from population records - safety aspects of mutagens and carcinogens - basic statistical concepts for experiment design This `on the bench' methodological text provides the necessary information for most of the common assays for genetic damage in use. The book includes methods which have been sufficiently used and tested to make their use reliable, but also presents methods which are not widely used at present, but which might prove most useful in screening for mutagenic effects.

Short-Term Test Systems for Detecting Carcinogens

Author : K.H. Norpoth
Publisher : Springer Science & Business Media
ISBN 13 : 3642672027
Total Pages : 424 pages
Book Rating : 4.6/5 (426 download)

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Book Synopsis Short-Term Test Systems for Detecting Carcinogens by : K.H. Norpoth

Download or read book Short-Term Test Systems for Detecting Carcinogens written by K.H. Norpoth and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 424 pages. Available in PDF, EPUB and Kindle. Book excerpt: The varying cancer incidence from country to country and region to region suggests that en vironmental factors play a considerable role in the aetiology of cancer. Whether these factors in the environment moderate the effect of car cinogenic chemicals or whether they might them selves be carcinogenic is not known at the present time. What is known is that there are various chemicals, both naturally occurring and man-made, which can induce cancer in man. In the Western world estimates vary as to how much cancer is occupational in origin; the figures range from 1% to 40%. It is our feeling that probably about 10% of cancer has a direct oc cupational origin. Nevertheless this number is considerable and it behoves us therefore to identify those chemicals which are carcinogenic and to reduce human exposure. Recent work on the mode of action of carcinogenic chemicals suggests that the majority exert their effect through an activation step to give elec trophilic metabolites. Such metabolites have as a common feature the ability to react with cel lular nucleophiles to give covalently bound products. Such reaction will occur after carcino gen treatment of animals with nucleic acids par ticularly in target organs. It is reaction with nucleic acids that provides the basis of a num ber of short-term tests for carcinogens, since the basic composition of DNA is similar in micro-organisms and in human cells.

Test Systems in Mutagenicity

Author : B. E. Matter
Publisher : Pergamon Press
ISBN 13 : 9780080280141
Total Pages : 12 pages
Book Rating : 4.2/5 (81 download)

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Book Synopsis Test Systems in Mutagenicity by : B. E. Matter

Download or read book Test Systems in Mutagenicity written by B. E. Matter and published by Pergamon Press. This book was released on 1981-06-01 with total page 12 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Handbook of Hazardous Materials

Author :
Publisher : Academic Press
ISBN 13 : 0323139558
Total Pages : 791 pages
Book Rating : 4.3/5 (231 download)

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Book Synopsis Handbook of Hazardous Materials by :

Download or read book Handbook of Hazardous Materials written by and published by Academic Press. This book was released on 2012-12-02 with total page 791 pages. Available in PDF, EPUB and Kindle. Book excerpt: Handbook of Hazardous Materials is a one-volume compendium of hazardous materials that discusses the toxic effects of these materials on human health and the global environment. It provides comprehensive coverage of individual toxic elements, covers hazardous material groups, and includes more general articles such as evaluation and testing of carcinogens, transport of pollutants, and inhalation toxicology. The fully referenced articles are presented in alphabetical order. The book features a subject index as well as numerous cross-references. Individual articles are preceded by a topical outline and discuss the origin, prevalence, mechanisms of toxicity and damaging effects of each hazardous material.Comprehensive coverage of individual toxic elements, includingAsbestosAlarLeadMercuryCoverage of hazardous material groups, such asPesticidesFood additivesNitrogen compoundsMore general articles, such asEvaluation and testing of carcinogensTransport of pollutantsInhalation toxicology

New Trends in Genetic Risk Assessment

Author : Georges Jolles
Publisher :
ISBN 13 :
Total Pages : 520 pages
Book Rating : 4.:/5 (45 download)

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Book Synopsis New Trends in Genetic Risk Assessment by : Georges Jolles

Download or read book New Trends in Genetic Risk Assessment written by Georges Jolles and published by . This book was released on 1989 with total page 520 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Statistical Evaluation of Mutagenicity Test Data

Author : David J. Kirkland
Publisher : Cambridge University Press
ISBN 13 : 9780521048149
Total Pages : 316 pages
Book Rating : 4.0/5 (481 download)

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Book Synopsis Statistical Evaluation of Mutagenicity Test Data by : David J. Kirkland

Download or read book Statistical Evaluation of Mutagenicity Test Data written by David J. Kirkland and published by Cambridge University Press. This book was released on 2008-01-03 with total page 316 pages. Available in PDF, EPUB and Kindle. Book excerpt: This rigorous and practical account of the interpretation of mutagenicity test data draws upon the expertise of toxicologists and statisticians. Chemicals, such as drugs, food additives and pesticides, all need careful screening to eliminate potentially mutagenic compounds.

Guidelines for the Testing of Chemicals for Mutagenicity

Author : Great Britain. Committee on Mutagenicity of Chemicals in Food, Consumer Products, and the Environment
Publisher :
ISBN 13 :
Total Pages : 112 pages
Book Rating : 4.F/5 ( download)

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Book Synopsis Guidelines for the Testing of Chemicals for Mutagenicity by : Great Britain. Committee on Mutagenicity of Chemicals in Food, Consumer Products, and the Environment

Download or read book Guidelines for the Testing of Chemicals for Mutagenicity written by Great Britain. Committee on Mutagenicity of Chemicals in Food, Consumer Products, and the Environment and published by . This book was released on 1981 with total page 112 pages. Available in PDF, EPUB and Kindle. Book excerpt: references

Statistical Evaluation of Mutagenicity Test Data

Author : United Kingdom Environmental Mutagen Society. Sub-Committee on Guidelines for Mutagenicity Testing
Publisher : Cambridge University Press
ISBN 13 : 9780521366052
Total Pages : 322 pages
Book Rating : 4.3/5 (66 download)

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Book Synopsis Statistical Evaluation of Mutagenicity Test Data by : United Kingdom Environmental Mutagen Society. Sub-Committee on Guidelines for Mutagenicity Testing

Download or read book Statistical Evaluation of Mutagenicity Test Data written by United Kingdom Environmental Mutagen Society. Sub-Committee on Guidelines for Mutagenicity Testing and published by Cambridge University Press. This book was released on 1989-12-07 with total page 322 pages. Available in PDF, EPUB and Kindle. Book excerpt: This rigorous and practical account of the interpretation of mutagenicity test data draws upon the expertise of toxicologists and statisticians. Chemicals, such as drugs, food additives and pesticides, all need careful screening to eliminate potentially mutagenic compounds.

Genotoxicity and Mutagenicity

Author : Sonia Soloneski
Publisher : BoD – Books on Demand
ISBN 13 : 1838800417
Total Pages : 166 pages
Book Rating : 4.8/5 (388 download)

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Book Synopsis Genotoxicity and Mutagenicity by : Sonia Soloneski

Download or read book Genotoxicity and Mutagenicity written by Sonia Soloneski and published by BoD – Books on Demand. This book was released on 2021 with total page 166 pages. Available in PDF, EPUB and Kindle. Book excerpt: This edited book, "Genotoxicity and Mutagenicity - Mechanisms and Test Methods", aims to present the latest developments from different fields, highlighting the detrimental influence that mutagenic and genotoxic agents inflict on DNA and how antimutagenic and anticarcinogenic modulators are able to reduce the negative impact of such toxic agents on living species.

The Medicinal Chemist's Guide to Solving ADMET Challenges

Author : Patrick Schnider
Publisher : Royal Society of Chemistry
ISBN 13 : 1788012275
Total Pages : 541 pages
Book Rating : 4.7/5 (88 download)

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Book Synopsis The Medicinal Chemist's Guide to Solving ADMET Challenges by : Patrick Schnider

Download or read book The Medicinal Chemist's Guide to Solving ADMET Challenges written by Patrick Schnider and published by Royal Society of Chemistry. This book was released on 2021-08-27 with total page 541 pages. Available in PDF, EPUB and Kindle. Book excerpt: Medicinal chemistry is a complex science that lies at the very heart of drug discovery. Poor solubility, complex metabolism, tissue retention and slow elimination are just some of the properties of investigational compounds that present a challenge to the design and conduct of ADMET studies. Medicinal chemistry experience and knowledge relating to how a lead structure was modified to solve a specific problem is generally very challenging to retrieve. Presented in a visual and accessible style, this book provides rapid solutions to overcome the universal challenges to optimizing ADMET.

Mutagenicity Testing

Author : S. Venitt
Publisher :
ISBN 13 :
Total Pages : 378 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis Mutagenicity Testing by : S. Venitt

Download or read book Mutagenicity Testing written by S. Venitt and published by . This book was released on 1984 with total page 378 pages. Available in PDF, EPUB and Kindle. Book excerpt: LABORATORY MANUAL. GENETIC TOXICOLOGY. BACTERIA. YEAST. FRUIT FLY. CULTURED MAMMALIAN CELLS. CYTOGENETIC TESTING. RODENTS. DOMINANT LETHAL TEST.

Oligonucleotide-Based Drugs and Therapeutics

Author : Nicolay Ferrari
Publisher : John Wiley & Sons
ISBN 13 : 1118537335
Total Pages : 576 pages
Book Rating : 4.1/5 (185 download)

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Book Synopsis Oligonucleotide-Based Drugs and Therapeutics by : Nicolay Ferrari

Download or read book Oligonucleotide-Based Drugs and Therapeutics written by Nicolay Ferrari and published by John Wiley & Sons. This book was released on 2018-07-31 with total page 576 pages. Available in PDF, EPUB and Kindle. Book excerpt: A comprehensive review of contemporary antisense oligonucleotides drugs and therapeutic principles, methods, applications, and research Oligonucleotide-based drugs, in particular antisense oligonucleotides, are part of a growing number of pharmaceutical and biotech programs progressing to treat a wide range of indications including cancer, cardiovascular, neurodegenerative, neuromuscular, and respiratory diseases, as well as other severe and rare diseases. Reviewing fundamentals and offering guidelines for drug discovery and development, this book is a practical guide covering all key aspects of this increasingly popular area of pharmacology and biotech and pharma research, from the basic science behind antisense oligonucleotides chemistry, toxicology, manufacturing, to safety assessments, the design of therapeutic protocols, to clinical experience. Antisense oligonucleotides are single strands of DNA or RNA that are complementary to a chosen sequence. While the idea of antisense oligonucleotides to target single genes dates back to the 1970's, most advances have taken place in recent years. The increasing number of antisense oligonucleotide programs in clinical development is a testament to the progress and understanding of pharmacologic, pharmacokinetic, and toxicologic properties as well as improvement in the delivery of oligonucleotides. This valuable book reviews the fundamentals of oligonucleotides, with a focus on antisense oligonucleotide drugs, and reports on the latest research underway worldwide. • Helps readers understand antisense molecules and their targets, biochemistry, and toxicity mechanisms, roles in disease, and applications for safety and therapeutics • Examines the principles, practices, and tools for scientists in both pre-clinical and clinical settings and how to apply them to antisense oligonucleotides • Provides guidelines for scientists in drug design and discovery to help improve efficiency, assessment, and the success of drug candidates • Includes interdisciplinary perspectives, from academia, industry, regulatory and from the fields of pharmacology, toxicology, biology, and medicinal chemistry Oligonucleotide-Based Drugs and Therapeutics belongs on the reference shelves of chemists, pharmaceutical scientists, chemical biologists, toxicologists and other scientists working in the pharmaceutical and biotechnology industries. It will also be a valuable resource for regulatory specialists and safety assessment professionals and an important reference for academic researchers and post-graduates interested in therapeutics, antisense therapy, and oligonucleotides.

Nitroarenes

Author : Paul C. Howard
Publisher : Springer Science & Business Media
ISBN 13 : 1461538009
Total Pages : 324 pages
Book Rating : 4.4/5 (615 download)

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Book Synopsis Nitroarenes by : Paul C. Howard

Download or read book Nitroarenes written by Paul C. Howard and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 324 pages. Available in PDF, EPUB and Kindle. Book excerpt: Prior to 1979, consideration of the problem of the carcinogenicity of the aromatic amine class of chemicals took place primarily in poster sessions and symposia of annual meetings of the American Association for Cancer Research and analogous international associations. In November 1979 the first meeting concerned with the aromatic amines was held in Rockville, Haryland under primary sponsorship of the National Cancer Institute. The proceedings from this meeting were published as Monograph 58 of the Journal of the National Cancel' Institute in 1981. The second meeting in this series, the Second International Conference on N-Substituted Aryl Compounds, was held in March/April of 1982 in Hot Springs, Arkansas. The National Cancer Institute and The National Center for Toxicological Research were the primary sponsors of this meeting. The proceedings were published as Volume 49 of the journal En-vil'onmental Health Perspectives in 1983. The third meeting in this series was held in April of 1987 at the Dearborn Hyatt in Dearborn, Michigan. The principal sponsor of this meeting was the Heyer L. Pre ntis Comprehensive Cancer Center of Metropolitan Detroit. The proceedings, Carcinogenic and Mutagenic Responses to Aromatic Amines and Nitroal'enes, were published in 1987 by Elsevier Press. The fourth meeting was held in Cleveland, Ohio, on July 15-19, 1989.

OECD Guidelines for the Testing of Chemicals, Section 4 Test No. 471: Bacterial Reverse Mutation Test

Author : OECD
Publisher : OECD Publishing
ISBN 13 : 9264071245
Total Pages : 11 pages
Book Rating : 4.2/5 (64 download)

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Book Synopsis OECD Guidelines for the Testing of Chemicals, Section 4 Test No. 471: Bacterial Reverse Mutation Test by : OECD

Download or read book OECD Guidelines for the Testing of Chemicals, Section 4 Test No. 471: Bacterial Reverse Mutation Test written by OECD and published by OECD Publishing. This book was released on 2020-06-29 with total page 11 pages. Available in PDF, EPUB and Kindle. Book excerpt: The bacterial reverse mutation test uses amino-acid requiring at least five strains of Salmonella typhimurium and Escherichia coli to detect point mutations by base substitutions or frameshifts. The principle of this bacterial reverse mutation test ...

Acute Toxicology Testing

Author : Shayne C. Gad
Publisher : Academic Press
ISBN 13 : 008052592X
Total Pages : 561 pages
Book Rating : 4.0/5 (85 download)

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Book Synopsis Acute Toxicology Testing by : Shayne C. Gad

Download or read book Acute Toxicology Testing written by Shayne C. Gad and published by Academic Press. This book was released on 1997-10-27 with total page 561 pages. Available in PDF, EPUB and Kindle. Book excerpt: Acute toxicology testing provides the first line of defense against potentially dangerous chemicals. This book is a complete and practical guide to conducting and interpreting all regulatory required and commonly used acute toxicity tests. It presents detailed protocols for all of the common test designs and reviews their development and objectives. Acute Toxicology Testing, Second Edition will interest not only workers in the pharmaceutical industry, but also researchers and students in toxicology and public health. Key Features * Over 100 tables summarizing and interpreting results * Complete coverage of all major test designs and their limitations and advantages * Current status of alternative test designs and models