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Test No 474 Mammalian Erythrocyte Micronucleus Test
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Book Synopsis Test No. 474: Mammalian Erythrocyte Micronucleus Test by : OECD
Download or read book Test No. 474: Mammalian Erythrocyte Micronucleus Test written by OECD and published by OECD Publishing. This book was released on 1997-07-21 with total page 10 pages. Available in PDF, EPUB and Kindle. Book excerpt: The mammalian in vivo micronucleus test is used for the detection of damage induced by the test substance to the chromosomes or the mitotic apparatus of erythroblasts, by analysis of erythrocytes as sampled in bone marrow and/or peripheral blood ...
Book Synopsis OECD Guidelines for the Testing of Chemicals, Section 4 Test No. 474: Mammalian Erythrocyte Micronucleus Test by : OECD
Download or read book OECD Guidelines for the Testing of Chemicals, Section 4 Test No. 474: Mammalian Erythrocyte Micronucleus Test written by OECD and published by OECD Publishing. This book was released on 2016-07-29 with total page 21 pages. Available in PDF, EPUB and Kindle. Book excerpt: The mammalian in vivo micronucleus test is used for the detection of damage induced by the test substance to the chromosomes or the mitotic apparatus of erythroblasts, by analysis of erythrocytes as sampled in bone marrow and/or peripheral blood cells of animals, usually rodents (mice or rats).
Book Synopsis Genotoxicity Assessment by : Alok Dhawan
Download or read book Genotoxicity Assessment written by Alok Dhawan and published by Humana Press. This book was released on 2013-07-30 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Genetic toxicology is recognized by geneticists and researchers concerned with the genetic impact of man-made chemicals. In Genotoxicity Assessment: Methods and Protocols, expert researchers in the field provide comprehensive genetic toxicology protocols. These include in vitro and in vivo protocols on mutation assays, cytogenetic techniques, and primary DNA damage, assays in alternate to animal models, and updated ICH guidelines. Written in the highly successful Methods in Molecular Biology series format, the chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step and readily reproducible laboratory protocols, as well as key tips on troubleshooting and avoiding known pitfalls. Authoritative and cutting-edge, Genotoxicity Assessment: Methods and Protocols seeks to aid research students and scientists working in regulatory toxicology as well as biomedical, biochemical and pharmaceutical sciences.
Book Synopsis Statistical Evaluation of Mutagenicity Test Data by : David J. Kirkland
Download or read book Statistical Evaluation of Mutagenicity Test Data written by David J. Kirkland and published by Cambridge University Press. This book was released on 2008-01-03 with total page 316 pages. Available in PDF, EPUB and Kindle. Book excerpt: This rigorous and practical account of the interpretation of mutagenicity test data draws upon the expertise of toxicologists and statisticians. Chemicals, such as drugs, food additives and pesticides, all need careful screening to eliminate potentially mutagenic compounds.
Book Synopsis The Medicinal Chemist's Guide to Solving ADMET Challenges by : Patrick Schnider
Download or read book The Medicinal Chemist's Guide to Solving ADMET Challenges written by Patrick Schnider and published by Royal Society of Chemistry. This book was released on 2021-08-27 with total page 541 pages. Available in PDF, EPUB and Kindle. Book excerpt: Medicinal chemistry is a complex science that lies at the very heart of drug discovery. Poor solubility, complex metabolism, tissue retention and slow elimination are just some of the properties of investigational compounds that present a challenge to the design and conduct of ADMET studies. Medicinal chemistry experience and knowledge relating to how a lead structure was modified to solve a specific problem is generally very challenging to retrieve. Presented in a visual and accessible style, this book provides rapid solutions to overcome the universal challenges to optimizing ADMET.
Book Synopsis Principles of Food Toxicology, Second Edition by : Tõnu Püssa
Download or read book Principles of Food Toxicology, Second Edition written by Tõnu Püssa and published by CRC Press. This book was released on 2013-08-20 with total page 418 pages. Available in PDF, EPUB and Kindle. Book excerpt: Following in the tradition of the popular first edition, Principles of Food Toxicology, Second Edition integrates the general principles of toxicology with a systematic characterization of the most important food-borne toxicants. Ideal as a textbook in a food toxicology course, and also as a monograph dealing with principles of food toxicology as the whole, and, due to sufficiently increased number of references, a source of elaborated scientific information, the second edition has been significantly revised and updated with new theories, opinions, and methods. It also provides expanded coverage of entry and absorption of foreign substances, carcinogenicity, reproductive and developmental toxicology, multi-organ toxicity, and flavor enhancers. See What’s New in the Second Edition: Role of lymph in transport of xenobiotics Reproductive and developmental toxicity, risk-benefit analysis Trans fatty acids Soybean as a source of possible toxicants Aluminum from cookware Glutamates New chapter on food adulteration Updated and additional references The book introduces the principles of toxicology at the molecular, cellular, and organism level. It provides a moderately rigorous treatment of biochemistry and chemistry with explanations of the mechanisms of toxic effect and medicinal consequences. The book arms toxicologists against new challenges in food safety brought on by long-term and often hard-to-diagnose effects of plant and animal toxicants that have already developed extensively by the time of discovery.
Book Synopsis The Micronucleus Assay in Toxicology by : Michael Fenech
Download or read book The Micronucleus Assay in Toxicology written by Michael Fenech and published by Royal Society of Chemistry. This book was released on 2019-07-26 with total page 684 pages. Available in PDF, EPUB and Kindle. Book excerpt: Concerns about the adverse health effects of chemicals and radiation present in the environment and at workplaces have created the need for better detection systems to assess their potential to cause DNA damage in humans and other organisms across ecosystems. The Micronucleus Assay in Toxicology is the first comprehensive volume concerning the use of micronucleus assays in genetic toxicology. It succinctly explains the mechanisms by which genotoxins cause micronucleus formation and its relation to diseases. Furthermore, it describes the methods which are currently used for the analyses of micronuclei in different types of cells in human in vivo biomonitoring studies, routine in vivo tests with rodents, in vitro studies with human and mammalian cells, environmental monitoring with invertebrates and vertebrates such as molluscs, fish and, also, in plant bioassays. Moreover, this book also focuses on the use of the micronucleus technique in other research areas, including the detection of DNA damage caused by important groups of genotoxic carcinogens (heavy metals, industrial chemicals, cytotoxic drugs, pesticides, ionising radiation, etc.) as well as study designs, statistical analyses, international regulatory guidelines, and the development of automated scoring devices for this assay. This book will serve as both, a reference and a guide to students, and investigators in biomedical, biochemical and pharmaceutical sciences interested in gaining a better understanding of the biology of micronuclei and their application in measuring DNA damage caused by natural or man-made genotoxins.
Book Synopsis Environmental Toxicology by : Luis M. Botana
Download or read book Environmental Toxicology written by Luis M. Botana and published by Walter de Gruyter GmbH & Co KG. This book was released on 2018-05-22 with total page 322 pages. Available in PDF, EPUB and Kindle. Book excerpt: Organic and inorganic chemicals frequently exhibit toxic, mutagenic, carcinogenic, or sensitizing properties when getting in contact with the environment. This comprehensive introduction discusses risk assessment and analysis, environmental fate, transport, and breakdown pathways of chemicals, as well as methods for prevention and procedures for decontamination.
Download or read book Nanotoxicology written by Vineet Kumar and published by CRC Press. This book was released on 2018-03-12 with total page 703 pages. Available in PDF, EPUB and Kindle. Book excerpt: As the application of nanotechnology in the myriad disciplines of science and engineering--from agriculture, pharmaceuticals, material science, and biotechnology to sensors, electronics, and mechanical and electrical engineering--brings benefits it also can produce serious threats to human health and the environment that must be evaluated. The unique properties of nanomaterials make them different from their bulk counterparts. In addition to such unique properties, the nanometric size of nanomaterials can invite some detrimental effects on the health and well-being of living organisms and the environment. Thus, it is important to distinguish nanomaterials with such ill effects from nanomaterials with no or minimum toxicity. Nanotoxicology: Toxicity Evaluation, Risk Assessment and Management covers issues such as the basic principles of nanotoxicity, methods used for nanotoxicity evaluation, risk assessment and its management for nanomaterial toxicity with a focus on current trends, limitations, challenges, and future directions of nanotoxicity evaluation. Various experts from different countries discuss these issues in detail in this book. This will be helpful to researchers, educators, and students who are interested in research opportunities for avoiding the environmental and health hazards of nanomaterials. This book will also be useful for industrial practitioners, policy makers, and other professionals in the fields of toxicology, medicine, pharmacology, food, drugs, and other regulatory sciences.
Book Synopsis Biomedical Applications and Toxicity of Nanomaterials by : P. V. Mohanan
Download or read book Biomedical Applications and Toxicity of Nanomaterials written by P. V. Mohanan and published by Springer Nature. This book was released on 2023-05-08 with total page 771 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book covers the recent trends on the biological applications of nanomaterials, methods for their preparation, and techniques for their characterization. Further, the book examines the fundamentals of nanotoxicity, methods to assess the toxicity of engineered nanomaterials, approaches to reduce toxicity during synthesis. It also provides an overview of the state of the art in the application of Artificial intelligence-based methodologies for evaluation of toxicity of drugs and nanoparticles. The book further discusses nanocarrier design, routes of various nanoparticle administration, nano based drug delivery systems, and the toxicity challenges associated with each drug delivery method. It presents the latest advances in the interaction of nanoparticles with the cellular environment and assess nanotoxicity of these engineered nanoparticles. The book also explores the comparative and mechanistic genotoxicity assessment of the nanomaterials. This book is useful source of information for industrial practitioners, policy makers, and other professionals in the fields of toxicology, medicine, pharmacology, food, and drugs.
Book Synopsis Epigenetic Drug Discovery by : Ho Man Chan
Download or read book Epigenetic Drug Discovery written by Ho Man Chan and published by Royal Society of Chemistry. This book was released on 2024-09-30 with total page 645 pages. Available in PDF, EPUB and Kindle. Book excerpt: Epigenetics is one of the fastest moving fields in drug discovery, with almost every large pharmaceutical company, and a substantial number of biotechnology companies, targeting epigenetic processes to treat diseases ranging from cancer to Huntington’s disease and from inflammation to sickle cell anaemia. This book aims to provide an overview of the key topics adopted in current epigenetic drug discovery programmes with a focus on major developments and new technologies. Importantly, the book incorporates case studies and outlines the key challenges and techniques employed to overcome them. The book is an ideal resource for researchers in both industry and academia with an interest in epigenetic and genetic factors involved in drug discovery, target ID and validation. The book is also an excellent introduction for postgraduates interested in the interface between epigenetics and pharmaceuticals.
Book Synopsis Test No. 487: In Vitro Mammalian Cell Micronucleus Test by : OECD
Download or read book Test No. 487: In Vitro Mammalian Cell Micronucleus Test written by OECD and published by OECD Publishing. This book was released on 2010-07-23 with total page 23 pages. Available in PDF, EPUB and Kindle. Book excerpt: The in vitro micronucleus test is a genotoxicity test for the detection of micronuclei in the cytoplasm of interphase cells. Micronuclei may originate from acentric chromosome fragments (i.e. lacking a centromere), or whole chromosomes that are ...
Book Synopsis Pharmaceutical Toxicology in Practice by : Alberto Lodola
Download or read book Pharmaceutical Toxicology in Practice written by Alberto Lodola and published by John Wiley & Sons. This book was released on 2011-03-31 with total page 280 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book describes, with references to key source materials, the background to, and conduct of, the principal nonclinical studies that are central to drug development. The chapters provide an understanding of the key components of the preclinical phase of drug development with a hands-on description, with core chapters addressing study conduct, types, and reporting. As such, it is a practical guide through toxicology testing and an up-to-date reference on current issues, new developments, and future directions in toxicology. Opening with a practical description of toxicology and its role in the development of pharmaceuticals, the book proceeds to detail international regulations (including the impact of the new REACH standards for chemical safety), interdisciplinary interactions among scientists in drug development, steps in toxicity testing, and risk management. Further, the book covers the methods of genetic toxicology (assays, genomics, in vivo screening) as a complement to “traditional” toxicology in the risk assessment and risk management of pharmaceuticals.
Book Synopsis Handbook of Toxicology by : Michael J. Derelanko
Download or read book Handbook of Toxicology written by Michael J. Derelanko and published by CRC Press. This book was released on 2014-03-07 with total page 1016 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Handbook of Toxicology, Third Edition provides an updated practical reference source for practicing toxicologists in the pharmaceutical and chemical industries, contract laboratories, regulatory agencies, and academia. Written by experts in their specific toxicology fields, the chapters provide both fundamental and applied information. Topics r
Book Synopsis Principles of Tumors by : Leon P. Bignold
Download or read book Principles of Tumors written by Leon P. Bignold and published by Academic Press. This book was released on 2019-11-01 with total page 688 pages. Available in PDF, EPUB and Kindle. Book excerpt: Principles of Tumors: A Translational Approach to Foundations, Second Edition, provides a concise summary of translational/interdisciplinary topics on the various aspects of tumors, especially abnormalities in their cells, their causes and effects on patients. Topics discussed include how genomic abnormalities in tumors may result from the actions of carcinogens and how genomic changes determine the cell biological/morphological abnormalities in tumor cell populations. In addition, the relationships between tumor cell genomics and therapeutic outcomes are described. There are also supporting appendices on general bioscience, including the principles of histology (the cells and tissues of the body), genetics, pathology, radiology and pharmacology. This book gives a thorough, detailed, yet concise account of the main bioscience, clinical and therapeutic aspects of tumors. It emphasizes the translational aspects of research into tumors with extensive discussions of interdisciplinary issues. The content in this book will be invaluable for researchers and clinicians involved in collaborative projects where it is necessary to understand fundamental issues in other branches of biomedicine. - Presents content that has been totally updated with the most recent developments of the field, including new chapters on tumor imaging exams, new surgical techniques, immunotherapy, gene therapy, and several novel therapies using natural and synthetic compounds - Presents translational approaches for every topic to improve conceptual insights for new research projects - Covers a broad range of subjects, making it easier for the reader to understand related fields - Includes diagrams for complex topics to aid in understanding for non-specialists
Book Synopsis In Vitro Toxicology by : Alok Dhawan
Download or read book In Vitro Toxicology written by Alok Dhawan and published by Academic Press. This book was released on 2017-11-13 with total page 250 pages. Available in PDF, EPUB and Kindle. Book excerpt: In Vitro Toxicology details the protocols and methods of in vitro testing, highlighting the usefulness of models, methods and the cost-effectiveness and reproducibility of such methodologies. The current approaches and strategies required to develop an easy, reliable, validated and high throughput system for use in alternative animal models to circumvent in vivo testing are discussed in detail. The book also includes chapters on the principles involved in the general selection and use of models that address safety concerns, regulatory acceptance and the current understandings and strategies for the identification of biomarkers in toxicity testing. Furthermore, principles involved in the general selection and use of models that address the issues of safety concerns and regulatory acceptance of these models are discussed, making the book beneficial to students, scientists, and regulators working in toxicology, as well as those in the field of chemicals and the safety assessment of novel materials. - Discusses new techniques and protocols in a clear and concise manner - includes examinations of nanotoxicity, genotoxicity and carcinogenicity - Explains practical laboratory methods and the theories behind in vitro testing
Book Synopsis Drug Safety Evaluation by : Shayne Cox Gad
Download or read book Drug Safety Evaluation written by Shayne Cox Gad and published by John Wiley & Sons. This book was released on 2016-12-01 with total page 1753 pages. Available in PDF, EPUB and Kindle. Book excerpt: This practical guide presents a road map for safety assessment as an integral part of the development of new drugs and therapeutics. Helps readers solve scientific, technical, and regulatory issues in preclinical safety assessment and early clinical drug development Explains scientific and philosophical bases for evaluation of specific concerns – including local tissue tolerance, target organ toxicity and carcinogenicity, developmental toxicity, immunogenicity, and immunotoxicity Covers the development of new small and large molecules, generics, 505(b)(2) route NDAs, and biosimilars Revises material to reflect new drug products (small synthetic, large proteins and cells, and tissues), harmonized global and national regulations, and new technologies for safety evaluation Adds almost 20% new and thoroughly updates existing content from the last edition
