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Technical Report On Toxicology And Carcinogenesis Studies Of Bromochloroacetic Acid Cas No 5589 96 8 In F344 N Rats And B6c3f1 Mice Drinking Water Studies
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Book Synopsis Technical Report on Toxicology and Carcinogenesis Studies of Bromochloroacetic Acid (CAS No. 5589-96-8) in F344/N Rats and B6C3F1 Mice (Drinking Water Studies) by : R. L. Melnick
Download or read book Technical Report on Toxicology and Carcinogenesis Studies of Bromochloroacetic Acid (CAS No. 5589-96-8) in F344/N Rats and B6C3F1 Mice (Drinking Water Studies) written by R. L. Melnick and published by DIANE Publishing. This book was released on 2009-09 with total page 302 pages. Available in PDF, EPUB and Kindle. Book excerpt: Bromochloroacetic acid is a water disinfection by-product. Bromochloroacetic acid was nominated for toxicity and carcinogenicity studies in rats and mice because of widespread human exposure and because a related dihaloacetate, dichloroacetate, was found to be carcinogenic to the liver of rats and mice. Drinking water was selected as the route of exposure to mimic human exposure to this chemical. Male and female F344/N rats and B6C3F1 mice were exposed to bromochloroacetic acid (greater than 95% pure) in drinking water for 2 weeks, 3 months, or 2 years. Genetic toxicology studies were conducted in ¿Salmonella typhimurium,¿ ¿Escherichia coli,¿ and peripheral blood erythrocytes of exposed mice. Illustrations.
Book Synopsis Environmental Toxicants by : Morton Lippmann
Download or read book Environmental Toxicants written by Morton Lippmann and published by John Wiley & Sons. This book was released on 2009-03-26 with total page 1189 pages. Available in PDF, EPUB and Kindle. Book excerpt: Provides the most current information and research available for performing risk assessments on exposed individuals and populations, giving guidance to public health authorities, primary care physicians, and industrial managers Reviews current knowledge on human exposure to selected chemical agents and physical factors in the ambient environment Updates and revises the previous edition, in light of current scientific literature and its significance to public health concerns Includes new chapters on: airline cabin exposures, arsenic, endocrine disruptors, and nanoparticles
Book Synopsis Disinfection By-Products and Human Health by : Steve E. Hrudey
Download or read book Disinfection By-Products and Human Health written by Steve E. Hrudey and published by IWA Publishing. This book was released on 2012-04-30 with total page 327 pages. Available in PDF, EPUB and Kindle. Book excerpt: Disinfection By-Products and Human Health is based on contributions from speakers who participated in May 2011 workshops on Disinfection By-Products (DBPs) and Human Health at Ozwater 11 in Adelaide, Australia or at an AWA sponsored workshop at the Curtin Water Quality Research Centre, Perth, Australia. The contributions are prepared to facilitate communication with practitioners, rather than researchers, making use of overview illustrations rather than dense text or data tables. Each chapter concludes with up to 5 key findings that are take-home messages for practitioners. Disinfection By-Products and Human Health is aimed specifically at drinking water professionals (engineers, chemists and public health professionals) working on the front lines of drinking water issues where they must encounter actual day-to-day issues of risk management concerning DBPs in relation to all the other regulatory and water quality issues they must manage. Although a topic this complex is certainly not amenable to simplistic explanations, this book aims to provide drinking water professionals with a pragmatic assessment of the current evidence and emerging issues concerning DBPs and public health. Disinfection By-Products and Human Health is an essential, practical and accessible guide for drinking water professionals, engineers, chemists and public health professionals. Editors: Steve E. Hrudey, Professor Emeritus, Analytical & Environmental Toxicology, University of Alberta, Canada, Jeffrey W.A. Charrois, Director and Associate Professor, Curtin Water Quality Research Centre, Curtin University of Technology, Australia, Steve Hrudey is professor emeritus in analytical and environmental toxicology in the University of Alberta's Faculty of Medicine & Dentistry. He spent 13 years as a cabinet-appointed member of the Alberta Environmental Appeals Board, the last four as chair, and was the first non-lawyer to hold this position. During this period, he served on 36 public hearing panels, 19 as chair of the panel. In addition he has testified before senate committees in Canada and the Legislative Council in Western Australia. Hrudey has served on a number of high-profile expert panels, including the Research Advisory Panel to the Walkerton Inquiry (2000-2002), the Expert Panel on Safe Drinking Water for First Nations (2006), the Technical Advisory Committee to the B.C. Minister of Health on turbidity and microbial risk in drinking water (2007-2008, as chair), the Expert Advisory Panel on Water Quality for Washington, D.C., to the U.S. Army Corps of Engineers (2009-2011) and chair of the Royal Society of Canada Expert Panel on Environmental and Health Impacts of Canada's Oil Sands Industry (2009-2010). He has also co-authored or edited nine books, including the widely acclaimed book inspired by the Walkerton tragedy: Safe Drinking Water - Lessons from Recent Outbreaks in Affluent Nations (IWA Publishing, 2004). He has written 26 book chapters, 19 expert panel reports, 163 refereed journal articles, 15 science discussions, six media op-eds and 73 conference proceeding papers. Hrudey is the 2012 winner of the American Water Works Association A.P. Black Research Award for contributions to water science and water supply. This book is sponsored by Australian Water Association (AWA)
Download or read book Technical Report Series written by and published by . This book was released on 2009 with total page 280 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author :American Water Works Association Publisher :McGraw Hill Professional ISBN 13 :0071630104 Total Pages :1696 pages Book Rating :4.0/5 (716 download)
Book Synopsis Water Quality & Treatment: A Handbook on Drinking Water by : American Water Works Association
Download or read book Water Quality & Treatment: A Handbook on Drinking Water written by American Water Works Association and published by McGraw Hill Professional. This book was released on 2010-12-06 with total page 1696 pages. Available in PDF, EPUB and Kindle. Book excerpt: The definitive water quality and treatment resource--fully revised and updated Comprehensive, current, and written by leading experts, Water Quality & Treatment: A Handbook on Drinking Water, Sixth Edition covers state-of-the-art technologies and methods for water treatment and quality control. Significant revisions and new material in this edition reflect the latest advances and critical topics in water supply and treatment. Presented by the American Water Works Association, this is the leading source of authoritative information on drinking water quality and treatment. NEW CHAPTERS ON: Chemical principles, source water composition, and watershed protection Natural treatment systems Water reuse for drinking water augmentation Ultraviolet light processes Formation and control of disinfection by-products DETAILED COVERAGE OF: Drinking water standards, regulations, goals, and health effects Hydraulic characteristics of water treatment reactors Gas-liquid processes and chemical oxidation Coagulation, flocculation, sedimentation, and flotation Granular media and membrane filtration Ion exchange and adsorption of inorganic contaminants Precipitation, coprecipitation, and precipitative softening Adsorption of organic compounds by activated carbon Chemical disinfection Internal corrosion and deposition control Microbiological quality control in distribution systems Water treatment plant residuals management
Book Synopsis Water Encyclopedia, Domestic, Municipal, and Industrial Water Supply and Waste Disposal by : Jay H. Lehr
Download or read book Water Encyclopedia, Domestic, Municipal, and Industrial Water Supply and Waste Disposal written by Jay H. Lehr and published by Wiley-Interscience. This book was released on 2005-06 with total page 1014 pages. Available in PDF, EPUB and Kindle. Book excerpt: Volume 1 outlines water supply infrastructure. The requirements for supplying water to a home, a city or a factory can be very different. Experts in these fields explain the nuances of the details involved in maintaining adequate quantity and quality for these different consumers. Waste water management can be of even greater concern, yet its management can follow similar paths when compared to sophisticated water supply treatment. Both the physics and chemistry of these fields are fully covered. Volume 2 deals with the big picture of regional water supplies, how they become contaminated, how they can be protected and how they can best serve the surrounding populations and industries. Significant focus is placed upon the natural chemistry of available water supplies and its biological impacts. Case studies from regions around the world offer an excellent picture of the world's water resources.
Book Synopsis National Toxicology Program Annual Report for Fiscal Year ... by : National Toxicology Program (U.S.)
Download or read book National Toxicology Program Annual Report for Fiscal Year ... written by National Toxicology Program (U.S.) and published by . This book was released on 1991 with total page 512 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Adverse Effects of Engineered Nanomaterials by : Bengt Fadeel
Download or read book Adverse Effects of Engineered Nanomaterials written by Bengt Fadeel and published by Academic Press. This book was released on 2012-01-27 with total page 367 pages. Available in PDF, EPUB and Kindle. Book excerpt: An essential reference that discusses occupational exposure and the adverse health effects of engineered nanomaterials and highlights current and future biomedical applications of these nanomaterials in relation to nanosafety.
Book Synopsis Genotoxic Impurities by : Andrew Teasdale
Download or read book Genotoxic Impurities written by Andrew Teasdale and published by John Wiley & Sons. This book was released on 2011-03-29 with total page 455 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book examines genotoxic impurities and their impact on the pharmaceutical industry. Specific sections examine this from both a toxicological and analytical perspective. Within these sections, the book defines appropriate strategies to both assess and ultimately control genotoxic impurities, thus aiding the reader to develop effective control measures. An opening section covers the development of guidelines and the threshold of toxicological concern (TTC) and is followed by a section on safety aspects, including safety tests in vivo and vitro, and data interpretation. The second section addresses the risk posed by genotoxic impurities from outside sources and from mutagens within DNA. In the final section, the book deals with the quality perspective of genotoxic impurities focused on two critical aspects, the first being the analysis and the second how to practically evaluate the impurities.
Book Synopsis Test No. 488: Transgenic Rodent Somatic and Germ Cell Gene Mutation Assays by : OECD
Download or read book Test No. 488: Transgenic Rodent Somatic and Germ Cell Gene Mutation Assays written by OECD and published by OECD Publishing. This book was released on 2011-07-28 with total page 16 pages. Available in PDF, EPUB and Kindle. Book excerpt: This Test Guideline describes an in vivo assay that detects chemicals that may induce gene mutations. In this assay, transgenic rats or mice that contain multiple copies of chromosomally integrated plasmid or phage shuttle vectors are used. The ...
Book Synopsis Chemical Carcinogenesis by : Trevor M. Penning
Download or read book Chemical Carcinogenesis written by Trevor M. Penning and published by Springer Science & Business Media. This book was released on 2011-03-03 with total page 447 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume will provide a contemporary account of advances in chemical carcinogenesis. It will promote the view that it is chemical alteration of the DNA that is a route cause of many cancers. The multi-stage model of chemical carcinogenesis, exposure to major classes of human carcinogens and their mode-of-action will be a focal point. The balance between metabolic activation to form biological reactive intermediates and their detoxification, ensuing DNA-lesions and their repair will be profiled. It will describe the chemical changes that occur in DNA that result from endogenous insults including epigenetic changes that lead to gene silencing. It will describe major mechanisms of mutagenesis, affects on tumor suppressor genes and proto-oncogenes, and how cell-cycle check points can be by-passed by the "stealth-like" properties of chemical carcinogens. Environmental agents that can promote tumor formation will be discussed. The monograph will have wide appeal as a knowledge base for graduate students, post-doctoral fellows and faculty interested in this aspect of cancer causation and research.
Download or read book Formaldehyde written by Victor Turoski and published by . This book was released on 1985 with total page 416 pages. Available in PDF, EPUB and Kindle. Book excerpt: Good,No Highlights,No Markup,all pages are intact, Slight Shelfwear,may have the corners slightly dented, may have slight color changes/slightly damaged spine.
Download or read book EPA 100-R. written by and published by . This book was released on 2008-06 with total page 96 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Atlas of Histology of the Juvenile Rat by : George A Parker
Download or read book Atlas of Histology of the Juvenile Rat written by George A Parker and published by Academic Press. This book was released on 2016-05-04 with total page 464 pages. Available in PDF, EPUB and Kindle. Book excerpt: Atlas of Histology of the Juvenile Rat should be of interest to toxicologic pathologists, toxicologists, and other biological scientists who are interested in the histomorphology of juvenile rats. For several decades the laboratory rat has been used extensively in nonclinical toxicology studies designed to detect potential human toxicity of drugs, agrochemicals, industrial chemicals, and environmental hazards. These studies traditionally have involved young adult rats that are 8-10 weeks of age as studies are started. It is becoming increasingly apparent that children and young animals may have different responses to drug/chemical exposures, therefore, regulatory agencies are emphasizing toxicology studies in juvenile animals. While the histologic features of organs from young adult and aged laboratory rats are well known, less is known about the histologic features of organs from juvenile rats. Final histologic maturity of many organs is achieved postnatally, thus immature histologic features must be distinguished from chemical- or drug-related effects. While this postnatal organ development is known to exist as a general concept, detailed information regarding postnatal histologic development is not readily available. The Atlas includes organs that are typically sampled in nonclinical toxicology studies and presents the histologic features at weekly intervals, starting at birth and extending through postnatal day 42. - Written and edited by highly experienced, board-certified toxicologic pathologists - Includes more than 700 high-resolution microscopic images from organs that are typically examined in safety assessment toxicology studies - Detailed figure legends and chapter narratives present the salient features of each organ at each time interval - Figures are available for further study via Elsevier's Virtual Microscope, which allows viewing of microscopic images at higher magnification - Valuable resource for toxicologic pathologists who are confronted with interpretation of lesions in juvenile rats in situations where age-matched concurrent controls are not available for comparison, e.g., with unscheduled decedents - Figures are available for further study on ScienceDirect with Virtual Microscope, which allows viewing of microscopic images at higher magnification
Book Synopsis Toxicological Profile for Formaldehyde by :
Download or read book Toxicological Profile for Formaldehyde written by and published by . This book was released on 2001-01-01 with total page 450 pages. Available in PDF, EPUB and Kindle. Book excerpt: Tells you about formaldehyde (FMH) & the effects of exposure. FMH has been found in many sites identified by the EPA for long-term federal cleanup activities. The report includes a Public Health Statement which explains FMH's relevant toxicologic properties in a nontechnical, Q&A format, & a review of the general health effects observed following exposure; a description of specific health effects; how the chemical can affect children; & further information on FMH's chemical & physical properties, production, use & disposal, potential for human exposure, analytical methods, & regulations & advisories.
Book Synopsis Technical Report on Toxicology and Carcinogenesis Studies of A-Methylstyrene (CAS No. 98-83-9) in F344/N Rats and B6C3F1 Mice (Inhalation Studies) by : M. E. Wyde
Download or read book Technical Report on Toxicology and Carcinogenesis Studies of A-Methylstyrene (CAS No. 98-83-9) in F344/N Rats and B6C3F1 Mice (Inhalation Studies) written by M. E. Wyde and published by DIANE Publishing. This book was released on 2008-04 with total page 464 pages. Available in PDF, EPUB and Kindle. Book excerpt: a-Methylstyrene is used to make heat-resistant acrylonitrile-butadiene-styrene resins & polymers. This report studies the effects of a-methylstyrene on male & female rats & mice to identify potential toxic or cancer-related hazards. It concludes that exposure to a-methylstyrene in the air caused kidney tumors, & possibly mononuclear cell leukemia, in male rats. It concludes that a-methylstyrene caused liver cancer in female mice, & also possibly in male mice. Charts, tables, graphs & plates.
Book Synopsis Toxicology and Carcinogenesis Studies of Bromodichloromethane No 75-27-4) in Male F344/N Rats and Female B6C3Fi Mice by : R. L. Melnick
Download or read book Toxicology and Carcinogenesis Studies of Bromodichloromethane No 75-27-4) in Male F344/N Rats and Female B6C3Fi Mice written by R. L. Melnick and published by . This book was released on 2006-08 with total page 248 pages. Available in PDF, EPUB and Kindle. Book excerpt: Bromodichloromethane (BR) is a by-product of the chlorination of drinking water. It has been shown to be carcinogenic at multiple sites in rats & in mice after administration by gavage in corn oil. To further characterize its dose-response relationships for eval. of human risk, BR was nominated for toxicity & carcinogenicity studies in rats & mice by drinking water exposure. Male F344/N rats & female B6C3F1 mice were exposed to BR in drinking water for 3 weeks or 2 years. Genetic toxicology studies were conducted in Salmonella typhimurium, L5178Y mouse lymphoma cells, cultured Chinese hamster ovary cells, mouse bone marrow cell, & mouse peripheral blood erythrocytes. None of these studies showed evidence of carcinogenic activity. Illustrations.
