Brain Injury Medicine

Download Brain Injury Medicine PDF Online Free

Author :
Publisher : Elsevier Health Sciences
ISBN 13 : 0323779441
Total Pages : 594 pages
Book Rating : 4.3/5 (237 download)

DOWNLOAD NOW!


Book Synopsis Brain Injury Medicine by : Blessen C. Eapen

Download or read book Brain Injury Medicine written by Blessen C. Eapen and published by Elsevier Health Sciences. This book was released on 2020-07-17 with total page 594 pages. Available in PDF, EPUB and Kindle. Book excerpt: The only review book currently available in this complex field, Brain Injury Medicine: Board Review focuses on the prevention, diagnosis, treatment, and management of individuals with varying severity levels of brain injury. Focused, high-yield content prepares you for success on exams and in practice, with up-to-date coverage of traumatic brain injury (TBI), stroke, CNS neoplasms, anoxic brain injury, and other brain disorders. This unique review tool is ideal for residents, fellows, and practitioners studying or working in the field and preparing to take the brain injury medicine exam. Supports self-assessment and review with 200 board-style questions and explanations. Covers the information you need to know on traumatic brain injury by severity and pattern, neurologic disorders, systemic manifestations, rehabilitation problems and outcomes, and basic science. Includes questions on patient management including patient evaluation and diagnosis, prognosis/risk factors, and applied science. Discusses key topics such as neurodegeneration and dementia; proteomic, genetic, and epigenetic biomarkers in TBI; neuromodulation and neuroprosthetics; and assistive technology. Reviews must-know procedures including acute emergency management and critical care; post-concussion syndrome assessment, management and treatment; diagnostic procedures and electrophysiology; neuroimaging, and brain death criteria. Ensures efficient, effective review with content written by experts in physical medicine and rehabilitation, neurology, and psychiatry and a format that mirrors the board exam outline.

Sports-Related Concussions in Youth

Download Sports-Related Concussions in Youth PDF Online Free

Author :
Publisher : National Academies Press
ISBN 13 : 0309288037
Total Pages : 215 pages
Book Rating : 4.3/5 (92 download)

DOWNLOAD NOW!


Book Synopsis Sports-Related Concussions in Youth by : National Research Council

Download or read book Sports-Related Concussions in Youth written by National Research Council and published by National Academies Press. This book was released on 2014-02-04 with total page 215 pages. Available in PDF, EPUB and Kindle. Book excerpt: In the past decade, few subjects at the intersection of medicine and sports have generated as much public interest as sports-related concussions - especially among youth. Despite growing awareness of sports-related concussions and campaigns to educate athletes, coaches, physicians, and parents of young athletes about concussion recognition and management, confusion and controversy persist in many areas. Currently, diagnosis is based primarily on the symptoms reported by the individual rather than on objective diagnostic markers, and there is little empirical evidence for the optimal degree and duration of physical rest needed to promote recovery or the best timing and approach for returning to full physical activity. Sports-Related Concussions in Youth: Improving the Science, Changing the Culture reviews the science of sports-related concussions in youth from elementary school through young adulthood, as well as in military personnel and their dependents. This report recommends actions that can be taken by a range of audiences - including research funding agencies, legislatures, state and school superintendents and athletic directors, military organizations, and equipment manufacturers, as well as youth who participate in sports and their parents - to improve what is known about concussions and to reduce their occurrence. Sports-Related Concussions in Youth finds that while some studies provide useful information, much remains unknown about the extent of concussions in youth; how to diagnose, manage, and prevent concussions; and the short- and long-term consequences of concussions as well as repetitive head impacts that do not result in concussion symptoms. The culture of sports negatively influences athletes' self-reporting of concussion symptoms and their adherence to return-to-play guidance. Athletes, their teammates, and, in some cases, coaches and parents may not fully appreciate the health threats posed by concussions. Similarly, military recruits are immersed in a culture that includes devotion to duty and service before self, and the critical nature of concussions may often go unheeded. According to Sports-Related Concussions in Youth, if the youth sports community can adopt the belief that concussions are serious injuries and emphasize care for players with concussions until they are fully recovered, then the culture in which these athletes perform and compete will become much safer. Improving understanding of the extent, causes, effects, and prevention of sports-related concussions is vitally important for the health and well-being of youth athletes. The findings and recommendations in this report set a direction for research to reach this goal.

Translational Research in Traumatic Brain Injury

Download Translational Research in Traumatic Brain Injury PDF Online Free

Author :
Publisher : CRC Press
ISBN 13 : 1498766579
Total Pages : 388 pages
Book Rating : 4.4/5 (987 download)

DOWNLOAD NOW!


Book Synopsis Translational Research in Traumatic Brain Injury by : Daniel Laskowitz

Download or read book Translational Research in Traumatic Brain Injury written by Daniel Laskowitz and published by CRC Press. This book was released on 2016-04-21 with total page 388 pages. Available in PDF, EPUB and Kindle. Book excerpt: Traumatic brain injury (TBI) remains a significant source of death and permanent disability, contributing to nearly one-third of all injury related deaths in the United States and exacting a profound personal and economic toll. Despite the increased resources that have recently been brought to bear to improve our understanding of TBI, the developme

Chronic Traumatic Encephalopathy (CTE)

Download Chronic Traumatic Encephalopathy (CTE) PDF Online Free

Author :
Publisher : Springer
ISBN 13 : 3030232883
Total Pages : 61 pages
Book Rating : 4.0/5 (32 download)

DOWNLOAD NOW!


Book Synopsis Chronic Traumatic Encephalopathy (CTE) by : Charles J. Golden

Download or read book Chronic Traumatic Encephalopathy (CTE) written by Charles J. Golden and published by Springer. This book was released on 2019-06-20 with total page 61 pages. Available in PDF, EPUB and Kindle. Book excerpt: The term chronic traumatic encephalopathy (CTE) has recently gained a significant amount of media coverage. However, a large proportion of the information disseminated through the media pertaining to the etiology, neuropathology, and clinical manifestations of CTE are not corroborated by empirical research, and are disputed by prominent researchers who study sports related head injury. This book reviews the existing literature pertaining to these components of CTE and includes unique case studies of several retired NFL players that received a comprehensive neuropsychological battery from a board certified neuropsychologist, among other populations. It investigates the claim that CTE causes depression, violent behavior, and an increased risk for suicide by providing an in depth discussion using empirical data. Highlighting the importance of adhering to post concussion protocol and appreciating the long-term consequences of repeated head trauma, this unique review of the current research on CTE will be useful to students and professionals in psychology and neurology.

Evaluation of the Disability Determination Process for Traumatic Brain Injury in Veterans

Download Evaluation of the Disability Determination Process for Traumatic Brain Injury in Veterans PDF Online Free

Author :
Publisher : National Academies Press
ISBN 13 : 0309486890
Total Pages : 211 pages
Book Rating : 4.3/5 (94 download)

DOWNLOAD NOW!


Book Synopsis Evaluation of the Disability Determination Process for Traumatic Brain Injury in Veterans by : National Academies of Sciences, Engineering, and Medicine

Download or read book Evaluation of the Disability Determination Process for Traumatic Brain Injury in Veterans written by National Academies of Sciences, Engineering, and Medicine and published by National Academies Press. This book was released on 2019-05-20 with total page 211 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Veterans Benefits Administration (VBA) provides disability compensation to veterans with a service-connected injury, and to receive disability compensation from the Department of Veterans Affairs (VA), a veteran must submit a claim or have a claim submitted on his or her behalf. Evaluation of the Disability Determination Process for Traumatic Brain Injury in Veterans reviews the process by which the VA assesses impairments resulting from traumatic brain injury for purposes of awarding disability compensation. This report also provides recommendations for legislative or administrative action for improving the adjudication of veterans' claims seeking entitlement to compensation for all impairments arising from a traumatic brain injury.

Traumatic Brain Injury

Download Traumatic Brain Injury PDF Online Free

Author :
Publisher : Springer Nature
ISBN 13 : 3030224368
Total Pages : 465 pages
Book Rating : 4.0/5 (32 download)

DOWNLOAD NOW!


Book Synopsis Traumatic Brain Injury by : Jack W. Tsao

Download or read book Traumatic Brain Injury written by Jack W. Tsao and published by Springer Nature. This book was released on 2019-11-19 with total page 465 pages. Available in PDF, EPUB and Kindle. Book excerpt: This thoroughly revised and updated work covers numerous advances in traumatic brain injury diagnosis, evaluation, treatment, and pathophysiology. Since publication of the first edition in 2012, there has been greatly increased public awareness of the clinical consequences of even the mildest of head injuries, and the result has been a concerted effort of countries around the world to increase research funding. This second edition continues to focus on mild traumatic brain injury--or concussion--and contains updates to all the original chapters as well as adding new chapters addressing clinical sequelae, including pediatric concussion, visual changes, chronic traumatic encephalopathy, and blast-associated TBI. Traumatic Brain Injury: A Clinician's Guide to Diagnosis, Management, and Rehabilitation, Second Edition, is a comprehensive resource designed for neurologists, primary care clinicians, sports physicians, and other medical providers, including psychologists and neuropsychologists, as well as athletic trainers who may evaluate and care for individuals who have sustained a TBI. The book features summaries of the most pertinent areas of diagnosis and therapy, which can be readily accessed by the busy clinician/professional. In addition, the book's treatment algorithms provide a highly practical reference to cutting edge therapies, and an updated appendix of ICD codes is included. An outstanding contribution to the literature, Traumatic Brain Injury: A Clinician's Guide to Diagnosis, Management, and Rehabilitation, Second Edition, again offers an invaluable resource for all providers who treat patients with TBI.

League of Denial

Download League of Denial PDF Online Free

Author :
Publisher : Crown
ISBN 13 : 0770437567
Total Pages : 457 pages
Book Rating : 4.7/5 (74 download)

DOWNLOAD NOW!


Book Synopsis League of Denial by : Mark Fainaru-Wada

Download or read book League of Denial written by Mark Fainaru-Wada and published by Crown. This book was released on 2014-08-26 with total page 457 pages. Available in PDF, EPUB and Kindle. Book excerpt: NEW YORK TIMES BESTSELLER • The story of how the NFL, over a period of nearly two decades, denied and sought to cover up mounting evidence of the connection between football and brain damage “League of Denial may turn out to be the most influential sports-related book of our time.”—The Boston Globe “Professional football players do not sustain frequent repetitive blows to the brain on a regular basis.” So concluded the National Football League in a December 2005 scientific paper on concussions in America’s most popular sport. That judgment, implausible even to a casual fan, also contradicted the opinion of a growing cadre of neuroscientists who worked in vain to convince the NFL that it was facing a deadly new scourge: a chronic brain disease that was driving an alarming number of players—including some of the all-time greats—to madness. In League of Denial, award-winning ESPN investigative reporters Mark Fainaru-Wada and Steve Fainaru tell the story of a public health crisis that emerged from the playing fields of our twenty-first-century pastime. Everyone knows that football is violent and dangerous. But what the players who built the NFL into a $10 billion industry didn’t know—and what the league sought to shield from them—is that no amount of padding could protect the human brain from the force generated by modern football, that the very essence of the game could be exposing these players to brain damage. In a fast-paced narrative that moves between the NFL trenches, America’s research labs, and the boardrooms where the NFL went to war against science, League of Denial examines how the league used its power and resources to attack independent scientists and elevate its own flawed research—a campaign with echoes of Big Tobacco’s fight to deny the connection between smoking and lung cancer. It chronicles the tragic fates of players like Hall of Fame Pittsburgh Steelers center Mike Webster, who was so disturbed at the time of his death he fantasized about shooting NFL executives, and former San Diego Chargers great Junior Seau, whose diseased brain became the target of an unseemly scientific battle between researchers and the NFL. Based on exclusive interviews, previously undisclosed documents, and private emails, this is the story of what the NFL knew and when it knew it—questions at the heart of a crisis that threatens football, from the highest levels all the way down to Pop Warner.

Neuroimmune Pharmacology

Download Neuroimmune Pharmacology PDF Online Free

Author :
Publisher : Springer
ISBN 13 : 3319440225
Total Pages : 1045 pages
Book Rating : 4.3/5 (194 download)

DOWNLOAD NOW!


Book Synopsis Neuroimmune Pharmacology by : Tsuneya Ikezu

Download or read book Neuroimmune Pharmacology written by Tsuneya Ikezu and published by Springer. This book was released on 2016-12-22 with total page 1045 pages. Available in PDF, EPUB and Kindle. Book excerpt: The second edition of Neuroimmune Pharmacology bridges the disciplines of neuroscience, immunology and pharmacology from the molecular to clinical levels with particular thought made to engage new research directives and clinical modalities. Bringing together the foremost field authorities from around the world, Neuroimmune Pharmacology will serve as an invaluable resource for the basic and applied scientists of the current decade and beyond.

TBI Or CTE

Download TBI Or CTE PDF Online Free

Author :
Publisher :
ISBN 13 : 9781938475900
Total Pages : 0 pages
Book Rating : 4.4/5 (759 download)

DOWNLOAD NOW!


Book Synopsis TBI Or CTE by : Mark Tullius

Download or read book TBI Or CTE written by Mark Tullius and published by . This book was released on 2022-06-14 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: An author with a reckless past set his fiction aside to tackle a critical mission:Help those around him struggling with head trauma and chart a way forward.But a fateful visit to the doctor upended his entire world...Former fighter and Ivy League football player Mark Tullius wanted to support his friends with traumatic brain injuries (TBI) and chronic traumatic encephalopathy (CTE). But when presented with a scan of his own grey matter, his life changed forever. After years of lying to himself and insisting he felt fine, Mark had to face the fact that his time on the field and in the cage had caused potentially irreparable damage inside his skull.Tired of throwing in the towel when things get difficult, Mark committed to make his recovery an adventure in health, happiness, and self-discovery. And now he's sharing his journey, research, and joy with you, hoping that you, too, can recover and walk out of the darkness. A powerful balance of scientific fact and personal triumph, this testament to the strength of the human spirit is impossible to put down.If you want a change of pace from heavy medical tomes about TBI and CTE, Mark's true and incredible saga is a life-changing "must read!""It provides a road map of experience that is unparalleled in health literature, offering both thought-provoking assessments and hope to all ages who either participate in sports or are recovering from head injury. It should be in any health collection, as well as in libraries strong in memoirs containing deep psychological self-assessments." - D. Donovan, Senior Reviewer, Midwest Book Review"A gut-wrenchingly honest look at the ultimate nightmare- the betrayal of one's own body. Mark's confrontations with the repercussions of a combat and contact-sport-driven youth lead to an optimistic and information-laden investigation into the emerging treatments for CTE and TBI and related injuries." Sam Sheridan, author of A Fighter's Heart, The Fighter's Mind and The Disaster Diaries

CTE, Media, and the NFL

Download CTE, Media, and the NFL PDF Online Free

Author :
Publisher : Rowman & Littlefield
ISBN 13 : 1498570577
Total Pages : 183 pages
Book Rating : 4.4/5 (985 download)

DOWNLOAD NOW!


Book Synopsis CTE, Media, and the NFL by : Travis R. Bell

Download or read book CTE, Media, and the NFL written by Travis R. Bell and published by Rowman & Littlefield. This book was released on 2019-06-25 with total page 183 pages. Available in PDF, EPUB and Kindle. Book excerpt: CTE, Media, and the NFL: Framing a Public Health Crisis as a Football Epidemic examines the central role of mediain constructing an entangled relationship between chronic traumatic encephalopathy (CTE) and the National Football League (NFL), challenging a predominately symbiotic sports/media complex. The authors of this book analyze more than a decade of media coverage, along with three prominent films, to unpack how media discourse resurrects CTE, a preventable degenerative brain disease linked to boxing in 1928, and subsequently frames it as a football epidemic dating back to 2005. The authors position CTE as a public health crisis, whereby media coverage of CTE and the NFL’s vigorous reliance on controversial published research by the Mild Traumatic Brain Injury (MTBI) Committee parallels the moral panic of the HIV/AIDS epidemic and Big Tobacco’s manufacturing of doubt through faulty science. This book argues that the continued aspiration and idolization of the NFL, and its lack of accountability for health concerns surrounding brain injuries, highlight the firm grasp of hegemonic masculinity on the ideology of American football - further problematizing media’s glorification of the sport. Scholars of sports media, health communication, and general media studies will find this book particularly useful to discuss longitudinal effects of media framing centered on critical health risks in sport and the challenge of translating accurate scientific knowledge to the public domain.

Brain Neurotrauma

Download Brain Neurotrauma PDF Online Free

Author :
Publisher : CRC Press
ISBN 13 : 1466565993
Total Pages : 718 pages
Book Rating : 4.4/5 (665 download)

DOWNLOAD NOW!


Book Synopsis Brain Neurotrauma by : Firas H. Kobeissy

Download or read book Brain Neurotrauma written by Firas H. Kobeissy and published by CRC Press. This book was released on 2015-02-25 with total page 718 pages. Available in PDF, EPUB and Kindle. Book excerpt: With the contribution from more than one hundred CNS neurotrauma experts, this book provides a comprehensive and up-to-date account on the latest developments in the area of neurotrauma including biomarker studies, experimental models, diagnostic methods, and neurotherapeutic intervention strategies in brain injury research. It discusses neurotrauma mechanisms, biomarker discovery, and neurocognitive and neurobehavioral deficits. Also included are medical interventions and recent neurotherapeutics used in the area of brain injury that have been translated to the area of rehabilitation research. In addition, a section is devoted to models of milder CNS injury, including sports injuries.

Pediatric Head Trauma

Download Pediatric Head Trauma PDF Online Free

Author :
Publisher : Wiley-Blackwell
ISBN 13 :
Total Pages : 312 pages
Book Rating : 4.3/5 (91 download)

DOWNLOAD NOW!


Book Synopsis Pediatric Head Trauma by : Kenneth Shapiro

Download or read book Pediatric Head Trauma written by Kenneth Shapiro and published by Wiley-Blackwell. This book was released on 1983 with total page 312 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Hemingway's Brain

Download Hemingway's Brain PDF Online Free

Author :
Publisher : Univ of South Carolina Press
ISBN 13 : 161117743X
Total Pages : 233 pages
Book Rating : 4.6/5 (111 download)

DOWNLOAD NOW!


Book Synopsis Hemingway's Brain by : Andrew Farah

Download or read book Hemingway's Brain written by Andrew Farah and published by Univ of South Carolina Press. This book was released on 2017-04-18 with total page 233 pages. Available in PDF, EPUB and Kindle. Book excerpt: A forensic psychiatrist’s second opinion on the conditions that led to Ernest Hemingway’s suicide, “mixing biography, literature and medical analysis” (The Washington Post). Hemingway’s Brain is an innovative biography and the first forensic psychiatric examination of Nobel Prize–winning author Ernest Hemingway. After seventeen years researching Hemingway’s life and medical history, Andrew Farah, a forensic psychiatrist, has concluded that the writer’s diagnoses were incorrect. Contrary to the commonly accepted diagnoses of bipolar disorder and alcoholism, he provides a comprehensive explanation of the medical conditions that led to Hemingway’s suicide. Hemingway received state-of-the-art psychiatric treatment at one of the nation’s finest medical institutes, but according to Farah it was for the wrong illness, and his death was not the result of medical mismanagement but medical misunderstanding. Farah argues that despite popular mythology Hemingway was not manic-depressive and his alcohol abuse and characteristic narcissism were simply pieces of a much larger puzzle. Through a thorough examination of biographies, letters, memoirs of friends and family, and even Hemingway’s FBI file, combined with recent insights on the effects of trauma on the brain, Farah pieces together this compelling alternative narrative of Hemingway’s illness, one missing from the scholarship for too long. Though Hemingway’s life has been researched extensively and many biographies written, those authors relied on the original diagnoses and turned to psychoanalysis and conjecture regarding Hemingway’s mental state. Farah has sought to understand why Hemingway’s decline accelerated after two courses of electroconvulsive therapy, and in this volume explains which current options might benefit a similar patient today. Hemingway’s Brain provides a full and accurate accounting of this psychiatric diagnosis by exploring the genetic influences, traumatic brain injuries, and neurological and psychological forces that resulted in what many have described as his tortured final years. It aims to eliminate the confusion and define for all future scholarship the specifics of the mental illnesses that shaped legendary literary works and destroyed the life of a master.

The Neuropsychology of Cortical Dementias

Download The Neuropsychology of Cortical Dementias PDF Online Free

Author :
Publisher : Springer Publishing Company
ISBN 13 : 0826107265
Total Pages : 481 pages
Book Rating : 4.8/5 (261 download)

DOWNLOAD NOW!


Book Synopsis The Neuropsychology of Cortical Dementias by : Chad A. Noggle

Download or read book The Neuropsychology of Cortical Dementias written by Chad A. Noggle and published by Springer Publishing Company. This book was released on 2014-12-16 with total page 481 pages. Available in PDF, EPUB and Kindle. Book excerpt: CourseSmart Only

Manual of Traumatic Brain Injury

Download Manual of Traumatic Brain Injury PDF Online Free

Author :
Publisher : Springer Publishing Company
ISBN 13 : 1617052698
Total Pages : 609 pages
Book Rating : 4.6/5 (17 download)

DOWNLOAD NOW!


Book Synopsis Manual of Traumatic Brain Injury by : Felise S. Zollman, MD

Download or read book Manual of Traumatic Brain Injury written by Felise S. Zollman, MD and published by Springer Publishing Company. This book was released on 2016-05-28 with total page 609 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Manual provides an excellent road map to the many topics relevant in the diagnosis, treatment, and long-term management of individuals with TBI. As such, the book can serve either as a fine introduction for the uninitiated or as a valued reference for seasoned clinicians. I highly recommend [it]... Journal of Head Trauma Rehabilitation This is a stellar quality book that will be beneficial for every member of the multidisciplinary team that is required to treat patients with TBI. It offers a concise but broad and informative view of the disorder, and can serve as an easy-to-read and access primary text. 4 Stars! Doody’s Reviews Now completely revised and updated, Manual of Traumatic Brain Injury:Assessment and Management, Second Edition is a comprehensive evidence-based guide to brain injury diagnosis, treatment, and recovery, delivered in a succinct format designed for targeted access to essential content. This concise text, featuring internationally known contributors drawn from leading TBI programs, is organized into five sections. Part 1 discusses fundamental concepts needed to provide a context for clinical decision-making. Part 2 covers mild TBI, from natural history to sports-related concussion, post-concussion syndrome, and more. Part 3 focuses on moderate to severe TBI and contains chapters on pre-hospital, emergency and ICU care, rehabilitation, community reintegration, management of associated impairments, and post-injury outcomes. Part 4 covers the complications and long-term sequelae that may arise in patients with TBI, including spasticity, movement disorders, posttraumatic seizures, hydrocephalus, behavioral and sleep disturbances, and chronic traumatic encephalopathy (CTE). Part 5 focuses on special considerations and resources, including issues specific to selected populations or injury environments (military, pediatric, workers compensation and older patients), as well as return to work and medico-legal issues in TBI. Comprehensively updated to reflect the current state of the art in this rapidly evolving field, this book is a must-have for neurologists, physiatrists, primary care physicians, mental health professionals, social workers, and other healthcare providers who treat TBI patients. New to the Second Edition: "Key Points" section in each chapter crystallizes important clinical pearls New chapters cover anoxia complicating TBI, screening for emotional distress in TBI patients, management of chronic behavioral disturbances, and assistive technology Every chapter has been updated to reflect current evidence-based practice

Coping with Concussion and Mild Traumatic Brain Injury

Download Coping with Concussion and Mild Traumatic Brain Injury PDF Online Free

Author :
Publisher : Penguin
ISBN 13 : 1101631619
Total Pages : 400 pages
Book Rating : 4.1/5 (16 download)

DOWNLOAD NOW!


Book Synopsis Coping with Concussion and Mild Traumatic Brain Injury by : Diane Roberts Stoler Ed.D.

Download or read book Coping with Concussion and Mild Traumatic Brain Injury written by Diane Roberts Stoler Ed.D. and published by Penguin. This book was released on 2013-11-05 with total page 400 pages. Available in PDF, EPUB and Kindle. Book excerpt: A comprehensive guide for improving memory, focus, and quality of life in the aftermath of a concussion. Often presenting itself after a head trauma, concussion— or mild traumatic brain injury (mTBI)— can cause chronic migraines, depression, memory, and sleep problems that can last for years, referred to as post concussion syndrome (PCS). Neuropsychologist and concussion survivor Dr. Diane Roberts Stoler is the authority on all aspects of the recovery process. Coping with Concussion and Mild Traumatic Brain Injury is a lifeline for patients, parents, and other caregivers.

Tau oligomers

Download Tau oligomers PDF Online Free

Author :
Publisher : Frontiers E-books
ISBN 13 : 288919261X
Total Pages : 114 pages
Book Rating : 4.8/5 (891 download)

DOWNLOAD NOW!


Book Synopsis Tau oligomers by : Jesus Avila

Download or read book Tau oligomers written by Jesus Avila and published by Frontiers E-books. This book was released on 2014-08-18 with total page 114 pages. Available in PDF, EPUB and Kindle. Book excerpt: Neurofibrillary tangles (NFTs) composed of intracellular aggregates of tau protein are a key neuropathological feature of Alzheimer’s Disease (AD) and other neurodegenerative diseases, collectively termed tauopathies. The abundance of NFTs has been reported to correlate positively with the severity of cognitive impairment in AD. However, accumulating evidences derived from studies of experimental models have identified that NFTs themselves may not be neurotoxic. Now, many of tau researchers are seeking a “toxic” form of tau protein. Moreover, it was suggested that a “toxic” tau was capable to seed aggregation of native tau protein and to propagate in a prion-like manner. However, the exact neurotoxic tau species remain unclear. Because mature tangles seem to be non-toxic component, “tau oligomers” as the candidate of “toxic” tau have been investigated for more than one decade. In this topic, we will discuss our consensus of “tau oligomers” because the term of “tau oligomers” [e.g. dimer (disulfide bond-dependent or independent), multimer (more than dimer), granular (definition by EM or AFM) and maybe small filamentous aggregates] has been used by each researchers definition. From a biochemical point of view, tau protein has several unique characteristics such as natively unfolded conformation, thermo-stability, acid-stability, and capability of post-translational modifications. Although tau protein research has been continued for a long time, we are still missing the mechanisms of NFT formation. It is unclear how the conversion is occurred from natively unfolded protein to abnormally mis-folded protein. It remains unknown how tau protein can be formed filaments [e.g. paired helical filament (PHF), straight filament and twisted filament] in cells albeit in vitro studies confirmed tau self-assembly by several inducing factors. Researchers are still debating whether tau oligomerization is primary event rather than tau phosphorylation in the tau pathogenesis. Inhibition of either tau phosphorylation or aggregation has been investigated for the prevention of tauopathies, however, it will make an irrelevant result if we don’t know an exact target of neurotoxicity. It is a time to have a consensus of definition, terminology and methodology for the identification of “tau oligomers”.