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Download or read book Tau Biology written by Akihiko Takashima and published by Springer Nature. This book was released on 2020-02-24 with total page 416 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book presents essential studies and cutting-edge research results on tau, which is attracting increasing interest as a target for the treatment of Alzheimer's disease. Tau is well known as a microtubule-associated protein that is predominantly localized in the axons of neurons. In various forms of brain disease, neuronal loss occurs, with deposition of hyperphosphorylated tau in the remaining neurons. Important questions remain regarding the way in which tau forms hyperphosphorylated and fibrillar deposits in neurons, and whether tau aggregation represents the toxic pathway leading to neuronal death. With the help of new technologies, researchers are now solving these long-standing questions. In this book, readers will find the latest expert knowledge on all aspects of tau biology, including the structure and role of the tau molecule, tau localization and function, the pathology, drivers, and markers of tauopathies, tau aggregation, and treatments targeting tau. Tau Biology will be an invaluable source of information and fresh ideas for those involved in the development of more effective therapies and for all who seek a better understanding of the biology of the aging brain.
Download or read book Tau Zero written by Poul Anderson and published by Open Road Media. This book was released on 2018-09-18 with total page 192 pages. Available in PDF, EPUB and Kindle. Book excerpt: This Hugo Award finalist, “justifiably regarded as a classic” (SFReviews.net), is the tale of an epic space voyage where time dilation goes horribly wrong. Aboard the spacecraft Leonora Christine, fifty crewmembers, half men and half women, have embarked on a journey of discovery like no other to a planet thirty light-years away. Since their ship is not capable of traveling faster than light, the crew will be subject to the effects of time dilation and relativity. They will age five years on board the ship before reaching their destination, but thirty-three years will pass on Earth. Experienced scientists and researchers, they have come to terms with the time conditions of their space travel. Until . . . the Leonora Christine passes through an uncharted nebula, which damages the engine, making it impossible to decelerate the ship on the second half of their trip. To survive, the crewmembers have no choice but to bypass their destination and continue to accelerate toward the speed of light. But how will they keep hope alive and maintain order as they hurtle deeper into space with time passing more and more rapidly, and their ultimate fate unknown? With its combination of mind-blowing hard science and compelling human drama, Tau Zero is “the ultimate hard science novel” (Mike Resnick).
Book Synopsis Tau Protein: Mechanisms from Health to Degeneration by : Isabel Lastres-Becker
Download or read book Tau Protein: Mechanisms from Health to Degeneration written by Isabel Lastres-Becker and published by Frontiers Media SA. This book was released on 2022-01-03 with total page 299 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Tau oligomers written by Jesus Avila and published by Frontiers E-books. This book was released on 2014-08-18 with total page 114 pages. Available in PDF, EPUB and Kindle. Book excerpt: Neurofibrillary tangles (NFTs) composed of intracellular aggregates of tau protein are a key neuropathological feature of Alzheimer’s Disease (AD) and other neurodegenerative diseases, collectively termed tauopathies. The abundance of NFTs has been reported to correlate positively with the severity of cognitive impairment in AD. However, accumulating evidences derived from studies of experimental models have identified that NFTs themselves may not be neurotoxic. Now, many of tau researchers are seeking a “toxic” form of tau protein. Moreover, it was suggested that a “toxic” tau was capable to seed aggregation of native tau protein and to propagate in a prion-like manner. However, the exact neurotoxic tau species remain unclear. Because mature tangles seem to be non-toxic component, “tau oligomers” as the candidate of “toxic” tau have been investigated for more than one decade. In this topic, we will discuss our consensus of “tau oligomers” because the term of “tau oligomers” [e.g. dimer (disulfide bond-dependent or independent), multimer (more than dimer), granular (definition by EM or AFM) and maybe small filamentous aggregates] has been used by each researchers definition. From a biochemical point of view, tau protein has several unique characteristics such as natively unfolded conformation, thermo-stability, acid-stability, and capability of post-translational modifications. Although tau protein research has been continued for a long time, we are still missing the mechanisms of NFT formation. It is unclear how the conversion is occurred from natively unfolded protein to abnormally mis-folded protein. It remains unknown how tau protein can be formed filaments [e.g. paired helical filament (PHF), straight filament and twisted filament] in cells albeit in vitro studies confirmed tau self-assembly by several inducing factors. Researchers are still debating whether tau oligomerization is primary event rather than tau phosphorylation in the tau pathogenesis. Inhibition of either tau phosphorylation or aggregation has been investigated for the prevention of tauopathies, however, it will make an irrelevant result if we don’t know an exact target of neurotoxicity. It is a time to have a consensus of definition, terminology and methodology for the identification of “tau oligomers”.
Book Synopsis Tau Pathology in Neurological Disorders by : Sonia Do Carmo
Download or read book Tau Pathology in Neurological Disorders written by Sonia Do Carmo and published by Frontiers Media SA. This book was released on 2021-11-12 with total page 268 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis The First Song Book of Delta Tau Delta by : Delta Tau Delta Fraternity
Download or read book The First Song Book of Delta Tau Delta written by Delta Tau Delta Fraternity and published by . This book was released on 1887 with total page 92 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Untangling the Role of Tau in Physiology and Pathology by : Jesus Avila
Download or read book Untangling the Role of Tau in Physiology and Pathology written by Jesus Avila and published by Frontiers Media SA. This book was released on 2020-07-08 with total page 254 pages. Available in PDF, EPUB and Kindle. Book excerpt: This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact.
Download or read book Themis of Zeta Tau Alpha written by and published by . This book was released on 1913 with total page 678 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book The Rainbow of Delta Tau Delta written by and published by . This book was released on 1916 with total page 286 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Zeta Beta Tau Quarterly by : Zeta Beta Tau Fraternity
Download or read book Zeta Beta Tau Quarterly written by Zeta Beta Tau Fraternity and published by . This book was released on 1928 with total page 56 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book The Bent of Tau Beta Pi written by and published by . This book was released on 1912 with total page 442 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Fire Caste written by Peter Fehervari and published by Games Workshop. This book was released on 2013-03-26 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: First Black Library novel starring the mysterious alien race the tau In the jungles of the Dolorosa Coil, a coalition of alien tau and human deserters have waged war upon the Imperium for countless years. Fresh Imperial Guard forces from the Arkhan Confederates are sent in to break the stalemate and annihilate the xenos. But greater forces are at work, and the Confederates soon find themselves broken and scattered. As they fight a desperate guerrilla war, their only hope may lie in the hands of a disgraced commissar, hell-bent on revenge.
Book Synopsis The Lateral Line System of Batrachus Tau by : Cornelia Maria Clapp
Download or read book The Lateral Line System of Batrachus Tau written by Cornelia Maria Clapp and published by . This book was released on 1899 with total page 62 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Crescent written by and published by . This book was released on 1888 with total page 870 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Secrets of the Tau written by Cavan Scott and published by Warhammer Adventures. This book was released on 2019-09-03 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: The third book in the Warped Galaxies series. An exciting new series of sci-fi books for middle-grade reeaders from Black Library. Brave champions and the forces of the Imperium battle alien beasts and mechanical tyrants accross the gulf of space. Journeying to the bustling spaceport of Hinterland after being saved from certain death by a dubious Rogue Trader, Zelia, Talen and Mekki continue their quest to reach the Emperor’s Seat. But much here is not what it seems. Alone in a strange place and surrounded by aliens, who can they really trust and what are the secrets of the Tau?
Book Synopsis Phi Rho Sigma History and Directory by : Phi Rho Sigma
Download or read book Phi Rho Sigma History and Directory written by Phi Rho Sigma and published by . This book was released on 1912 with total page 400 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Fire Warrior written by Simon Spurrier and published by Games Workshop(uk). This book was released on 2003-09 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Ruling over the alien warriors of the Tau empire are the enigmatic Ethereals. When a powerful Ethereal crashes behind Imperial battle lines, it falls to one young Fire Warrior to sacrifice his life for the greater good. Original.
