Targeting Functional Centers Of The Ribosome

Download Targeting Functional Centers Of The Ribosome full books in PDF, epub, and Kindle. Read online Targeting Functional Centers Of The Ribosome ebook anywhere anytime directly on your device. Fast Download speed and no annoying ads. We cannot guarantee that every ebooks is available!

Targeting Functional Centers of the Ribosome

Author : Chen Davidovich
Publisher : Springer Science & Business Media
ISBN 13 : 3642169317
Total Pages : 85 pages
Book Rating : 4.6/5 (421 download)

DOWNLOAD NOW!

Book Synopsis Targeting Functional Centers of the Ribosome by : Chen Davidovich

Download or read book Targeting Functional Centers of the Ribosome written by Chen Davidovich and published by Springer Science & Business Media. This book was released on 2011-02-02 with total page 85 pages. Available in PDF, EPUB and Kindle. Book excerpt: This thesis describes research into the mode of function, inhibition, and evolution of the ribosomal catalytic center, the Peptidyl Transferase Center (PTC)--research that has already led to attempts at improving PTC antibiotics. The PhD candidate carried out two parallel studies. One using a combination of X-ray crystallography, biochemistry, molecular biology, and theoretical studies to obtain crystal structures of ribosomal particles with antibiotics that target the PTC, revealing the modes of action, resistance, cross-resistance and discrimination between ribosomes of eubacterial pathogens and eukaryotic hosts. In the second parallel study, the candidate synthesized a ribosomal substructure--one that may represent the minimal entity capable of catalyzing peptide bond formation--shedding light on the origin of the ribosome itself.

DNA and RNA Modification Enzymes

Author : Henri Grosjean
Publisher : CRC Press
ISBN 13 : 1498713157
Total Pages : 682 pages
Book Rating : 4.4/5 (987 download)

DOWNLOAD NOW!

Book Synopsis DNA and RNA Modification Enzymes by : Henri Grosjean

Download or read book DNA and RNA Modification Enzymes written by Henri Grosjean and published by CRC Press. This book was released on 2009-06-11 with total page 682 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume is a timely and comprehensive description of the many facets of DNA and RNA modification-editing processes and to some extent repair mechanisms. Each chapter offers fundamental principles as well as up to date information on recent advances in the field (up to end 2008). They ended by a shortconclusion and future prospect' section and

Molecular Biology of the Cell

Author :
Publisher :
ISBN 13 : 9780815332183
Total Pages : 0 pages
Book Rating : 4.3/5 (321 download)

DOWNLOAD NOW!

Book Synopsis Molecular Biology of the Cell by :

Download or read book Molecular Biology of the Cell written by and published by . This book was released on 2002 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:

The Ribosome

Author : Roger A. Garrett
Publisher : Amer Society for Microbiology
ISBN 13 : 9781555811846
Total Pages : 565 pages
Book Rating : 4.8/5 (118 download)

DOWNLOAD NOW!

Book Synopsis The Ribosome by : Roger A. Garrett

Download or read book The Ribosome written by Roger A. Garrett and published by Amer Society for Microbiology. This book was released on 2000 with total page 565 pages. Available in PDF, EPUB and Kindle. Book excerpt: Complete coverage of the ribosome and mechanisms of protein synthesis. * Examines the structure and function of numerous extra-chromosomal factors. * Offers the first detailed account of crystal structures of the ribosome as well as insights into the mechanisms and action of antibiotics. This title is published by the American Society for Microbiology Press and distributed by Taylor and Francis in rest of world territories.

Comprehensive and Molecular Phytopathology

Author : Yuri Dyakov
Publisher : Elsevier
ISBN 13 : 0080469337
Total Pages : 497 pages
Book Rating : 4.0/5 (84 download)

DOWNLOAD NOW!

Book Synopsis Comprehensive and Molecular Phytopathology by : Yuri Dyakov

Download or read book Comprehensive and Molecular Phytopathology written by Yuri Dyakov and published by Elsevier. This book was released on 2007-01-09 with total page 497 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book offers a collection of information on successive steps of molecular 'dialogue' between plants and pathogens. It additionally presents data that reflects intrinsic logic of plant-parasite interactions. New findings discussed include: host and non-host resistance, specific and nonspecific elicitors, elicitors and suppressors, and plant and animal immunity. This book enables the reader to understand how to promote or prevent disease development, and allows them to systematize their own ideas of plant-pathogen interactions.* Offers a more extensive scope of the problem as compared to other books in the market* Presents data to allow consideration of host-parasite relationships in dynamics and reveals interrelations between pathogenicity and resistance factors* Discusses beneficial plant-microbe interactions and practical aspects of molecular investigations of plant-parasite relationships* Compares historical study of common and specific features of plant immunity with animal immunity

The Eukaryotic Ribosome

Author : Heinz Bielka
Publisher : Walter de Gruyter GmbH & Co KG
ISBN 13 : 3112729757
Total Pages : 340 pages
Book Rating : 4.1/5 (127 download)

DOWNLOAD NOW!

Book Synopsis The Eukaryotic Ribosome by : Heinz Bielka

Download or read book The Eukaryotic Ribosome written by Heinz Bielka and published by Walter de Gruyter GmbH & Co KG. This book was released on 1982-12-31 with total page 340 pages. Available in PDF, EPUB and Kindle. Book excerpt: No detailed description available for "The Eukaryotic Ribosome".

Fine-Tuning of RNA Functions by Modification and Editing

Author : Henri Grosjean
Publisher : Springer
ISBN 13 : 3540314547
Total Pages : 0 pages
Book Rating : 4.5/5 (43 download)

DOWNLOAD NOW!

Book Synopsis Fine-Tuning of RNA Functions by Modification and Editing by : Henri Grosjean

Download or read book Fine-Tuning of RNA Functions by Modification and Editing written by Henri Grosjean and published by Springer. This book was released on 2005-05-11 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Naturally occurring RNA always contains numerous biochemically altered nucleotides. They are formed by enzymatic modification of the primary transcripts during the complex RNA maturation process designated RNA modification. A large number of enzymes catalyzing the formation of these modified nucleosides or converting one canonical base into another at the posttranscriptional level have been studied for many years, but only recently have systematic and comparative studies begun. The functions of individual enzymes and/or the modified/edited nucleosides in RNA, however, have remained largely ignored. This book provides advance information on RNA modification, including the associated editing machinery, while offering the reader some perspective on the significance of such modifications in fine-tuning the structure and functions of mature RNA molecules and hence the ability to influence the efficiency and accuracy of genetic expression. Outstanding scientists who are actively working on RNA modification/editing processes have provided up-to-date information on these intriguing cellular processes that have been generated over the course of millions of years in all living organisms. Each review has been written and illustrated for a large audience of readers, not only specialists in the field, but also for advanced students or researchers who want to learn more about recent progress in RNA modification and editing.

The Nucleolus

Author : Mark O. J. Olson
Publisher : Springer Science & Business Media
ISBN 13 : 1461405149
Total Pages : 434 pages
Book Rating : 4.4/5 (614 download)

DOWNLOAD NOW!

Book Synopsis The Nucleolus by : Mark O. J. Olson

Download or read book The Nucleolus written by Mark O. J. Olson and published by Springer Science & Business Media. This book was released on 2011-09-15 with total page 434 pages. Available in PDF, EPUB and Kindle. Book excerpt: Within the past two decades, extraordinary new functions for the nucleolus have begun to appear, giving the field a new vitality and generating renewed excitement and interest. These new discoveries include both newly-discovered functions and aspects of its conventional role. The Nucleolus is divided into three parts: nucleolar structure and organization, the role of the nucleolus in ribosome biogenesis, and novel functions of the nucleolus.

Macromolecular Protein Complexes II: Structure and Function

Author : J. Robin Harris
Publisher : Springer Nature
ISBN 13 : 3030281515
Total Pages : 657 pages
Book Rating : 4.0/5 (32 download)

DOWNLOAD NOW!

Book Synopsis Macromolecular Protein Complexes II: Structure and Function by : J. Robin Harris

Download or read book Macromolecular Protein Complexes II: Structure and Function written by J. Robin Harris and published by Springer Nature. This book was released on 2020-01-14 with total page 657 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book follows on from Volume 83 in the SCBI series (“Macromolecular Protein Complexes”), and addresses several important topics (such as the Proteasome, Anaphase Promoting Complex, Ribosome and Apoptosome) that were not previously included, together with a number of additional exciting topics in this rapidly expanding field of study. Although the first SCBI Protein Complex book focused on soluble protein complexes, the second (Vol. 87)addressed Membrane Complexes, and the third (Vol. 88) put the spotlight on Viral Protein and Nucleoprotein Complexes, a number of membrane, virus and even fibrillar protein complexes have been be considered for inclusion in the present book. A further book is also under preparation that follows the same pattern, in an attempt to provide a thorough coverage of the subject. Chapter 9 is available open access under a Creative Commons Attribution 4.0 International License via link.springer.com.

Protein Synthesis and Ribosome Structure

Author : Knud H. Nierhaus
Publisher : John Wiley & Sons
ISBN 13 : 9783527306381
Total Pages : 608 pages
Book Rating : 4.3/5 (63 download)

DOWNLOAD NOW!

Book Synopsis Protein Synthesis and Ribosome Structure by : Knud H. Nierhaus

Download or read book Protein Synthesis and Ribosome Structure written by Knud H. Nierhaus and published by John Wiley & Sons. This book was released on 2004-10-15 with total page 608 pages. Available in PDF, EPUB and Kindle. Book excerpt: Knud Nierhaus, who has studied the ribosome for more than 30 years, has assembled here the combined efforts of several scientific disciplines into a uniform picture of the largest enzyme complex found in living cells, finally resolving many decades-old questions in molecular biology. In so doing he considers virtually all aspects of ribosome structure and function -- from the molecular mechanism of different ribosomal ribozyme activities to their selective inhibition by antibiotics, from assembly of the core particle to the regulation of ribosome component synthesis. The result is a premier resource for anyone with an interest in ribosomal protein synthesis, whether in the context of molecular biology, biotechnology, pharmacology or molecular medicine.

The Ribosome

Author :
Publisher : CSHL Press
ISBN 13 : 9780879696207
Total Pages : 660 pages
Book Rating : 4.6/5 (962 download)

DOWNLOAD NOW!

Book Synopsis The Ribosome by :

Download or read book The Ribosome written by and published by CSHL Press. This book was released on 2001 with total page 660 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Ribosomes Structure, Function, and Dynamics

Author : Marina V. Rodnina
Publisher : Springer Science & Business Media
ISBN 13 : 3709102154
Total Pages : 428 pages
Book Rating : 4.7/5 (91 download)

DOWNLOAD NOW!

Book Synopsis Ribosomes Structure, Function, and Dynamics by : Marina V. Rodnina

Download or read book Ribosomes Structure, Function, and Dynamics written by Marina V. Rodnina and published by Springer Science & Business Media. This book was released on 2011-12-10 with total page 428 pages. Available in PDF, EPUB and Kindle. Book excerpt: The ribosome is a macromolecular machine that synthesizes proteins with a high degree of speed and accuracy. Our present understanding of its structure, function and dynamics is the result of six decades of research. This book collects over 40 articles based on the talks presented at the 2010 Ribosome Meeting, held in Orvieto, Italy, covering all facets of the structure and function of the ribosome. New high-resolution crystal structures of functional ribosome complexes and cryo-EM structures of translating ribosomes are presented, while partial reactions of translation are examined in structural and mechanistic detail, featuring translocation as a most dynamic process. Mechanisms of initiation, both in bacterial and eukaryotic systems, translation termination, and novel details of the functions of the respective factors are described. Structure and interactions of the nascent peptide within, and emerging from, the ribosomal peptide exit tunnel are addressed in several articles. Structural and single-molecule studies reveal a picture of the ribosome exhibiting the energy landscape of a processive Brownian machine. The collection provides up-to-date reviews which will serve as a source of essential information for years to come.

The Liver

Author : Irwin M. Arias
Publisher : John Wiley & Sons
ISBN 13 : 1119436826
Total Pages : 1156 pages
Book Rating : 4.1/5 (194 download)

DOWNLOAD NOW!

Book Synopsis The Liver by : Irwin M. Arias

Download or read book The Liver written by Irwin M. Arias and published by John Wiley & Sons. This book was released on 2020-03-09 with total page 1156 pages. Available in PDF, EPUB and Kindle. Book excerpt: Bridging the gap between basic scientific advances and the understanding of liver disease — the extensively revised new edition of the premier text in the field. The latest edition of The Liver: Biology and Pathobiology remains a definitive volume in the field of hepatology, relating advances in biomedical sciences and engineering to understanding of liver structure, function, and disease pathology and treatment. Contributions from leading researchers examine the cell biology of the liver, the pathobiology of liver disease, the liver’s growth, regeneration, metabolic functions, and more. Now in its sixth edition, this classic text has been exhaustively revised to reflect new discoveries in biology and their influence on diagnosing, managing, and preventing liver disease. Seventy new chapters — including substantial original sections on liver cancer and groundbreaking advances that will have significant impact on hepatology — provide comprehensive, fully up-to-date coverage of both the current state and future direction of hepatology. Topics include liver RNA structure and function, gene editing, single-cell and single-molecule genomic analyses, the molecular biology of hepatitis, drug interactions and engineered drug design, and liver disease mechanisms and therapies. Edited by globally-recognized experts in the field, this authoritative volume: Relates molecular physiology to understanding disease pathology and treatment Links the science and pathology of the liver to practical clinical applications Features 16 new “Horizons” chapters that explore new and emerging science and technology Includes plentiful full-color illustrations and figures The Liver: Biology and Pathobiology, Sixth Edition is an indispensable resource for practicing and trainee hepatologists, gastroenterologists, hepatobiliary and liver transplant surgeons, and researchers and scientists in areas including hepatology, cell and molecular biology, virology, and drug metabolism.

The Ribosome

Author : Aleksandr S. Spirin
Publisher : Springer Science & Business Media
ISBN 13 : 3642884466
Total Pages : 173 pages
Book Rating : 4.6/5 (428 download)

DOWNLOAD NOW!

Book Synopsis The Ribosome by : Aleksandr S. Spirin

Download or read book The Ribosome written by Aleksandr S. Spirin and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 173 pages. Available in PDF, EPUB and Kindle. Book excerpt: This monograph is neither a historical outline of the development of the concepts of protein biosynthesis and the structure and functions of the ribosomes, nor an exhaustive survey of the literature on these questions. The monograph is based upon an analysis of the modern trends in this field. The purpose of the monograph was to formulate more or less generalized representations of the structure and" function of the ribosome, as we envision it at the present day. It may be that this attempt is premature for a number of reasons, and the concepts outlined here will very soon be revised. Nonetheless, despite this risk, we believe it to be advisable to undertake this attempt for the following reasons: firstly, the undertaken analysis could aid in the comprehension of the substantial mass of extremely scattered experimental data on the ribosomes presently available; secondly, in any event, even if most of the concepts outlined rapidly become obselete, they can still serve as a stimulus for a whole series of experiments; and thirdly, we hope that some of the concepts outlined will still remain essentially correct and relatively stable. In view of the aforementioned, we should make the following reservations. First of all, we made no attempt to cite all the literature on the problems discussed, but considered it sufficient to illustrate the various premises with one or several sample references.

Regulatory Nascent Polypeptides

Author : Koreaki Ito
Publisher : Springer
ISBN 13 : 4431550526
Total Pages : 313 pages
Book Rating : 4.4/5 (315 download)

DOWNLOAD NOW!

Book Synopsis Regulatory Nascent Polypeptides by : Koreaki Ito

Download or read book Regulatory Nascent Polypeptides written by Koreaki Ito and published by Springer. This book was released on 2014-08-19 with total page 313 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book highlights a new paradigm of translation control by regulatory nascent polypeptides, which is integrated into cellular regulatory systems. Translation lies in the hub of the central dogma of biology, in which the genetic information in the forms of 4-letter sentences is translated into 20-letter sentences: sequences of amino acids that constitute proteins, the functional molecules of life. The process involves a huge number of chemical reactions as well as physical movements of the ribosome along a messenger RNA and takes, on average, tens of seconds in prokaryotes and a few minutes in eukaryotes. Detailed knowledge about the progression of translation, called "elongation", only recently started to accumulate. Newly synthesized and growing polypeptides, called nascent polypeptides, can interact with the intra-ribosomal conduit, called the ribosomal exit tunnel, when they have some specific amino acid sequences, called "an arrest sequence". Such interaction leads to a halt in the elongation reaction. Resulting stalling of the ribosome on messenger RNA can affect the secondary structure and/or localization of the message in the cell, consequently leading to biological outputs such as elevation or reduction of a gene product. This book provides a first collection of knowledge focused on regulatory nascent polypeptides, which have been studied recently using diverse organisms including bacteria, plants, and animals. Readers will be impressed by a new paradigm showing that proteins can function even during the course of their biosynthesis and that the ribosome, the "factory" of protein production, interacts with and inspects its products to adjust the speed of completion of each product. Moreover, regulatory nascent polypeptides can sense or monitor physiological states of the cell and modulate its ability to arrest translation. Living organisms use such intricate control mechanisms of translational speed to regulate gene expression. This book will be a useful addition for established scientists while inspiring students and young scientists to gain deeper insights into the processes of expression of genetic information.

The Molecular Basis of Antibiotic Action

Author : Ernest Frederick Gale
Publisher : John Wiley & Sons
ISBN 13 :
Total Pages : 682 pages
Book Rating : 4.3/5 (91 download)

DOWNLOAD NOW!

Book Synopsis The Molecular Basis of Antibiotic Action by : Ernest Frederick Gale

Download or read book The Molecular Basis of Antibiotic Action written by Ernest Frederick Gale and published by John Wiley & Sons. This book was released on 1981 with total page 682 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Nanotechnology Applied To Pharmaceutical Technology

Author : Mahendra Rai
Publisher : Springer
ISBN 13 : 3319702998
Total Pages : 388 pages
Book Rating : 4.3/5 (197 download)

DOWNLOAD NOW!

Book Synopsis Nanotechnology Applied To Pharmaceutical Technology by : Mahendra Rai

Download or read book Nanotechnology Applied To Pharmaceutical Technology written by Mahendra Rai and published by Springer. This book was released on 2017-11-21 with total page 388 pages. Available in PDF, EPUB and Kindle. Book excerpt: Focusing on the application of nanotechnology in pharmaceutical technology the editors seek to integrate the two in order to obtain innovative products and solutions in pharmacology. Interdisciplinary in content it is of interest to those who are involved in the development of nanoproducts including nanotechnologists, microbiologists, biotechnologists pharmacologists and clinicians. Recent studies are presented that include the biosynthesis of nanoparticles focusing on antimicrobials; nanomaterial-based formulations that treat cancer, infections, skin disorders and wounds;nanomaterials in eye diseases and toxicity and safety issues. It demonstrates the crucial role this plays in tackling multi-drug resistant threats.