Targeting C Type Lectin Receptors A High Carbohydrate Diet For Dendritic Cells To Improve Cancer Vaccines

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Nanotherapeutics in Cancer Vaccination and Challenges

Author : Mahfoozur Rahman
Publisher : Academic Press
ISBN 13 : 0128236876
Total Pages : 496 pages
Book Rating : 4.1/5 (282 download)

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Book Synopsis Nanotherapeutics in Cancer Vaccination and Challenges by : Mahfoozur Rahman

Download or read book Nanotherapeutics in Cancer Vaccination and Challenges written by Mahfoozur Rahman and published by Academic Press. This book was released on 2022-03-03 with total page 496 pages. Available in PDF, EPUB and Kindle. Book excerpt: Nanotherapeutics in Cancer Vaccination and Challenges consolidates the current research on cancer nanomedicine and therapeutic cancer vaccination to explore the most effective and promising avenues. The book covers cancer vaccines before exploring nanotherapeutics, DNA and mRNA vaccines in cancer treatment. Finally, it considers regulatory and industrial perspectives on cancer vaccination and nanotherapeutics. This resource will be useful for pharmaceutical scientists and researchers focused on biomedical engineering, chemical engineering, vaccine development, and cancer immunotherapy, along with advanced students in these subjects. Cancer is arguably the most complex and challenging disease known to mankind. Over the last two-decades, significant advancements have been made in new and novel concepts of cancer nanomedicines. Therapeutic cancer vaccines may be utilized to inhibit further growth of advanced cancers and/or relapsed tumors that are refractory to conventional therapies, such as surgery, radiation therapy and chemotherapy. - Presents the progress made in cancer medicines from conventional to targeted therapy - Covers the present state-of-the-art of cancer nanomedicines and upcoming therapeutic cancer vaccination - Contains a focus on advanced nanomaterials that are utilized for encapsulation of nucleic acid, mRNA, DNA, siRNA

Dendritic Cells

Author : Svetlana P. Chapoval
Publisher : BoD – Books on Demand
ISBN 13 : 1789844169
Total Pages : 139 pages
Book Rating : 4.7/5 (898 download)

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Book Synopsis Dendritic Cells by : Svetlana P. Chapoval

Download or read book Dendritic Cells written by Svetlana P. Chapoval and published by BoD – Books on Demand. This book was released on 2018-11-07 with total page 139 pages. Available in PDF, EPUB and Kindle. Book excerpt: Since their discovery in 1973 by Zanvil Cohn and Ralph Steinman (Nobel Prize in Physiology and Medicine, 2011), dendritic cells (DCs) continue to intrigue research scientists as their new markers, subpopulations and properties are being detected and the relevant literature is being doubled each year. This book combines the most comprehensive reviews of several critical aspects of DC biology and function written by a group of international experts in the field. The first section briefly discusses recent advances in DC subtypes, phenotypes, and functions in different diseases. The following sections look closely at DC phenotyping, DC-NK cell interplay, and roles of DC in bone loss and repair and parasitic infections. The final section on DC and cancer includes perspectives on DC vaccination based on modifications and therapeutic applications.

Harnessing the Participation of Dendritic Cells in Immunity and Tolerance

Author : Silvia Beatriz Boscardin
Publisher : Frontiers Media SA
ISBN 13 : 2889662012
Total Pages : 511 pages
Book Rating : 4.8/5 (896 download)

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Book Synopsis Harnessing the Participation of Dendritic Cells in Immunity and Tolerance by : Silvia Beatriz Boscardin

Download or read book Harnessing the Participation of Dendritic Cells in Immunity and Tolerance written by Silvia Beatriz Boscardin and published by Frontiers Media SA. This book was released on 2020-12-10 with total page 511 pages. Available in PDF, EPUB and Kindle. Book excerpt: This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact.

Targeted Antigen Delivery: Bridging Innate and Adaptive Immunity

Author : Bénédicte Manoury
Publisher : Frontiers Media SA
ISBN 13 : 2889458334
Total Pages : 166 pages
Book Rating : 4.8/5 (894 download)

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Book Synopsis Targeted Antigen Delivery: Bridging Innate and Adaptive Immunity by : Bénédicte Manoury

Download or read book Targeted Antigen Delivery: Bridging Innate and Adaptive Immunity written by Bénédicte Manoury and published by Frontiers Media SA. This book was released on 2019-05-15 with total page 166 pages. Available in PDF, EPUB and Kindle. Book excerpt: The most efficient way to mount a sustained immune response is to target antigens to antigen presenting cells that trigger both innate and adaptive immune responses. A comprehensive view of the current approaches to the design of new antigenic formulations will enhance our understanding and perspective of targeted immunotherapy. The aim of this Research Topic is to provide an overview of the currently adopted targeting strategies by a collection of articles on: 1.Novel approaches of antigen targeting for immunotherapeutic strategies against cancer and/or infectious diseases. 2. Diversity and biology of dendritic cell subsets in human and mouse. 3. Combined strategies for the delivery of antigens and adjuvant molecules that stimulate innate immune responses and their influence on the quality of immune responses. 4. Impact of the receptor mediate intracellular trafficking on antigen presentation.

Cancer Vaccines and Immunotherapy

Author : Peter L. Stern
Publisher : Cambridge University Press
ISBN 13 : 9780521622639
Total Pages : 304 pages
Book Rating : 4.6/5 (226 download)

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Book Synopsis Cancer Vaccines and Immunotherapy by : Peter L. Stern

Download or read book Cancer Vaccines and Immunotherapy written by Peter L. Stern and published by Cambridge University Press. This book was released on 2000-08-17 with total page 304 pages. Available in PDF, EPUB and Kindle. Book excerpt: Rapid progress in the definition of tumor antigens, and improved immunization methods, bring effective cancer vaccines within reach. In this wide-ranging survey, leading clinicians and scientists review therapeutic cancer vaccine strategies against a variety of diseases and molecular targets. Intended for an interdisciplinary readership, their contributions cover the rationale, development, and implementation of vaccines in human cancer treatment, with specific reference to cancer of the cervix, breast, colon, bladder, and prostate, and to melanoma and lymphoma. They review target identification, delivery vectors and clinical trial design. The book begins and ends with lucid overviews from the editors, that discuss the most recent developments.

Carbohydrate-based Vaccines

Author : René Roy
Publisher : ACS Symposium
ISBN 13 : 9780841239838
Total Pages : 0 pages
Book Rating : 4.2/5 (398 download)

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Book Synopsis Carbohydrate-based Vaccines by : René Roy

Download or read book Carbohydrate-based Vaccines written by René Roy and published by ACS Symposium. This book was released on 2008 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is the first of its kind entirely dedicated to carbohydrate vaccines written by renowned scientists with expertise in carbohydrate chemistry and immunochemistry. It covers the synthesis of carbohydrate antigens related to bacteria and parasites such as: Heamophilus influenza, Streptococcus pnemoniae, Shigella flexneri, Candida albicans, Mycobacterium tuberculosis, and Chlamydia. The first three chapters are of wide interest as they cover fundamental concerns in new vaccine developments. The first one presents the immune system and how carbohydrate antigens are processed before protective antibodies are produced. It also illustrates antigen presentation in the context of major histocompatibility complexes (MHCs). The second chapter describes regulatory issues when carbohydrate vaccines are involved while the third one discuss several techniques used in conjugation chemistry and the implication of certain chemical linkages that may induce unexpected anti-linker antibodies. This section will be particularly appealing for those involved in drug-conjugate design, pro-drug developments, and drug vectorization. The book concludes with one chapter that illustrates the principle through which peptide antigens can functionally mimic carbohydrate epitopes, thus, unraveling the potential for peptide surrogates as replacement for complex carbohydrate structures. This book is unique in that it covers all aspects related to carbohydrate vaccines including the success story with the first semi-synthetic bacterial polysaccharide vaccine against Heamophilus influenza type b responsible for pneumonia and meningitis, liable for more than 600,000 infant deaths worldwide in developing countries. The book also presents regulatory issues and will thus be vital for government agencies approving candidate vaccines. It widely covers synthetic methodologies for the attachment of carbohydrate antigens to peptides and immunogenic protein carriers. Vaccines against bacterial antigens, cancer, and parasites are also discussed by worldwide experts in this field in details. No other book contains such a wide panel of different expertise. It will also be useful to students and researchers involved with the immunology of forreings antigens and how the under appreciated carbohydrate antigens are processed by the immune system.

Immunopotentiators in Modern Vaccines

Author : Virgil Schijns
Publisher : Elsevier
ISBN 13 : 0080457215
Total Pages : 396 pages
Book Rating : 4.0/5 (84 download)

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Book Synopsis Immunopotentiators in Modern Vaccines by : Virgil Schijns

Download or read book Immunopotentiators in Modern Vaccines written by Virgil Schijns and published by Elsevier. This book was released on 2005-12-19 with total page 396 pages. Available in PDF, EPUB and Kindle. Book excerpt: Immunopotentiators in Modern Vaccines provides an in-depth insight and overview of a number of most promising immunopotentiators in modern vaccines. In contrast to existing books on the subject it provides recent data on the critical mechanisms governing the activity of vaccine adjuvants and delivery systems. Knowledge of immunological pathways and scenarios of the cells and molecules involved is described and depicted in comprehensive illustrations. - Contributions from leading international authorities in the field - Well-illustrated, informative figures present the interactions between immunopotentiators and the host immune system - Each chapter lists advantages and potential hurdles for achieving a practical application for the specific immunopentiator

C-Type Lectin Receptors in Immunity

Author : Sho Yamasaki
Publisher : Springer
ISBN 13 : 4431560157
Total Pages : 213 pages
Book Rating : 4.4/5 (315 download)

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Book Synopsis C-Type Lectin Receptors in Immunity by : Sho Yamasaki

Download or read book C-Type Lectin Receptors in Immunity written by Sho Yamasaki and published by Springer. This book was released on 2016-03-22 with total page 213 pages. Available in PDF, EPUB and Kindle. Book excerpt: The book presents the latest findings on C-type lectin receptors, focusing on individual receptors and their signaling. In recent years there have been great advances in the understanding of the function of these receptors as a newly emerging family of pattern-recognition receptors (PRRs) for pathogen-associated molecular patterns (PAMPs) and damage-associated molecular patterns (DAMPs). Comprising four parts: ITAM-coupled Activating Receptors; HemITAM-bearing Receptors; ITIM-bearing Receptors; and Other Receptors and Related Topics, this comprehensive review covers a broad range of C-type lectin receptors. The updated information on C-type lectin receptors and their ligands provided will appeal to a wide readership, from basic immunologists to physicians and surgeons. In addition, sections on novel drug development make this a valuable resource for pharmaceutical scientists.

Cancer Immunology and Immunotherapy

Author : Glenn Dranoff
Publisher : Springer Science & Business Media
ISBN 13 : 3642141366
Total Pages : 313 pages
Book Rating : 4.6/5 (421 download)

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Book Synopsis Cancer Immunology and Immunotherapy by : Glenn Dranoff

Download or read book Cancer Immunology and Immunotherapy written by Glenn Dranoff and published by Springer Science & Business Media. This book was released on 2011-04-11 with total page 313 pages. Available in PDF, EPUB and Kindle. Book excerpt: The interplay between tumors and their immunologic microenvironment is complex, difficult to decipher, but its understanding is of seminal importance for the development of novel prognostic markers and therapeutic strategies. The present review discusses tumor-immune interactions in several human cancers that illustrate various aspects of this complexity and proposes an integrated scheme of the impact of local immune reactions on clinical outcome. Current active immunotherapy trials have shown durable tumor regressions in a fraction of patients. However, clinical efficacy of current vaccines is limited, possibly because tumors skew the immune system by means of myeloid-derived suppressor cells, inflammatory type 2 T cells and regulatory T cells (Tregs), all of which prevent the generation of effector cells. To improve the clinical efficacy of cancer vaccines in patients with metastatic disease, we need to design novel and improved strategies that can boost adaptive immunity to cancer, help overcome Tregs and allow the breakdown of the immunosuppressive tumor microenvironment.

Molecular Biology of the Cell

Author :
Publisher :
ISBN 13 : 9780815332183
Total Pages : 0 pages
Book Rating : 4.3/5 (321 download)

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Book Synopsis Molecular Biology of the Cell by :

Download or read book Molecular Biology of the Cell written by and published by . This book was released on 2002 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Nanopharmaceuticals: Principles and Applications Vol. 3

Author : Vinod Kumar Yata
Publisher : Springer Nature
ISBN 13 : 3030471209
Total Pages : 352 pages
Book Rating : 4.0/5 (34 download)

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Book Synopsis Nanopharmaceuticals: Principles and Applications Vol. 3 by : Vinod Kumar Yata

Download or read book Nanopharmaceuticals: Principles and Applications Vol. 3 written by Vinod Kumar Yata and published by Springer Nature. This book was released on 2020-08-19 with total page 352 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is the third volume on this subject and focuses on the recent advances of nanopharmaceuticals in cancer, dental, dermal and drug delivery applications and presents their safety, toxicity and therapeutic efficacy. The book also includes the transport phenomenon of nanomaterials and important pathways for drug delivery applications. It goes on to explain the toxicity of nanoparticles to different physiological systems and methods used to assess this for different organ systems using examples of in vivo systems.

Adverse Effects of Vaccines

Author : Institute of Medicine
Publisher : National Academies Press
ISBN 13 : 0309214351
Total Pages : 894 pages
Book Rating : 4.3/5 (92 download)

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Book Synopsis Adverse Effects of Vaccines by : Institute of Medicine

Download or read book Adverse Effects of Vaccines written by Institute of Medicine and published by National Academies Press. This book was released on 2012-04-26 with total page 894 pages. Available in PDF, EPUB and Kindle. Book excerpt: In 1900, for every 1,000 babies born in the United States, 100 would die before their first birthday, often due to infectious diseases. Today, vaccines exist for many viral and bacterial diseases. The National Childhood Vaccine Injury Act, passed in 1986, was intended to bolster vaccine research and development through the federal coordination of vaccine initiatives and to provide relief to vaccine manufacturers facing financial burdens. The legislation also intended to address concerns about the safety of vaccines by instituting a compensation program, setting up a passive surveillance system for vaccine adverse events, and by providing information to consumers. A key component of the legislation required the U.S. Department of Health and Human Services to collaborate with the Institute of Medicine to assess concerns about the safety of vaccines and potential adverse events, especially in children. Adverse Effects of Vaccines reviews the epidemiological, clinical, and biological evidence regarding adverse health events associated with specific vaccines covered by the National Vaccine Injury Compensation Program (VICP), including the varicella zoster vaccine, influenza vaccines, the hepatitis B vaccine, and the human papillomavirus vaccine, among others. For each possible adverse event, the report reviews peer-reviewed primary studies, summarizes their findings, and evaluates the epidemiological, clinical, and biological evidence. It finds that while no vaccine is 100 percent safe, very few adverse events are shown to be caused by vaccines. In addition, the evidence shows that vaccines do not cause several conditions. For example, the MMR vaccine is not associated with autism or childhood diabetes. Also, the DTaP vaccine is not associated with diabetes and the influenza vaccine given as a shot does not exacerbate asthma. Adverse Effects of Vaccines will be of special interest to the National Vaccine Program Office, the VICP, the Centers for Disease Control and Prevention, vaccine safety researchers and manufacturers, parents, caregivers, and health professionals in the private and public sectors.

Innovations for Next-Generation Antibody-Drug Conjugates

Author : Marc Damelin
Publisher : Springer
ISBN 13 : 3319781545
Total Pages : 358 pages
Book Rating : 4.3/5 (197 download)

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Book Synopsis Innovations for Next-Generation Antibody-Drug Conjugates by : Marc Damelin

Download or read book Innovations for Next-Generation Antibody-Drug Conjugates written by Marc Damelin and published by Springer. This book was released on 2018-05-29 with total page 358 pages. Available in PDF, EPUB and Kindle. Book excerpt: Antibody-drug conjugates (ADCs) stand at the verge of a transformation. Scores of clinical programs have yielded only a few regulatory approvals, but a wave of technological innovation now empowers us to overcome past technical challenges. This volume focuses on the next generation of ADCs and the innovations that will enable them. The book inspires the future by integrating the field’s history with novel strategies and cutting-edge technologies. While the book primarily addresses ADCs for solid tumors, the last chapter explores the emerging interest in using ADCs to treat other diseases. The therapeutic rationale of ADCs is strong: to direct small molecules to the desired site of action (and away from normal tissues) by conjugation to antibodies or other targeting moieties. However, the combination of small and large molecules imposes deep complexity to lead optimization, pharmacokinetics, toxicology, analytics and manufacturing. The field has made significant advances in all of these areas by improving target selection, ADC design, manufacturing methods and clinical strategies. These innovations will inspire and educate scientists who are designing next-generation ADCs with the potential to transform the lives of patients.

Glycosylation and Cancer

Author :
Publisher : Academic Press
ISBN 13 : 0128016140
Total Pages : 418 pages
Book Rating : 4.1/5 (28 download)

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Book Synopsis Glycosylation and Cancer by :

Download or read book Glycosylation and Cancer written by and published by Academic Press. This book was released on 2015-02-26 with total page 418 pages. Available in PDF, EPUB and Kindle. Book excerpt: Advances in Cancer Research provides invaluable information on the exciting and fast-moving field of cancer research. Here, once again, outstanding and original reviews are presented on a variety of topics. - Provides information on cancer research - Outstanding and original reviews - Suitable for researchers and students

Carbohydrate Antigens

Author : Per J. Garegg
Publisher :
ISBN 13 :
Total Pages : 244 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis Carbohydrate Antigens by : Per J. Garegg

Download or read book Carbohydrate Antigens written by Per J. Garegg and published by . This book was released on 1993 with total page 244 pages. Available in PDF, EPUB and Kindle. Book excerpt: Developed from a symposium at the Fourth Chemical Congress of North America (202nd National Meeting of the ACS) in New York City, August 1991, chapter-papers present research on topics including how proteins recognize and bind oligosaccharides, synthesis and immunological properties of glycopeptide T-cell determinants, Vibrio cholerae polysaccharide studies, and purification of oligosaccharide antigens by weak affinity chromatography. Annotation copyright by Book News, Inc., Portland, OR

Mucosal Vaccines

Author : Hiroshi Kiyono
Publisher : Elsevier
ISBN 13 : 0080537057
Total Pages : 501 pages
Book Rating : 4.0/5 (85 download)

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Book Synopsis Mucosal Vaccines by : Hiroshi Kiyono

Download or read book Mucosal Vaccines written by Hiroshi Kiyono and published by Elsevier. This book was released on 1996-10-23 with total page 501 pages. Available in PDF, EPUB and Kindle. Book excerpt: This comprehensive, authoritative treatise covers all aspects of mucosal vaccines including their development, mechanisms of action, molecular/cellular aspects, and practical applications. The contributing authors and editors of this one-of-a-kind book are very well known in their respective fields. Mucosal Vaccines is organized in a unique format in which basic, clinical, and practical aspects of the mucosal immune system for vaccine development are described and discussed. This project is endorsed by the Society for Mucosal Immunology. - Provides the latest views on mucosal vaccines - Applies basic principles to the development of new vaccines - Links basic, clinical, and practical aspects of mucosal vaccines to different infectious diseases - Unique and user-friendly organization

Leong's Manual of Diagnostic Antibodies for Immunohistology

Author : Runjan Chetty
Publisher : Cambridge University Press
ISBN 13 : 1316592065
Total Pages : 525 pages
Book Rating : 4.3/5 (165 download)

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Book Synopsis Leong's Manual of Diagnostic Antibodies for Immunohistology by : Runjan Chetty

Download or read book Leong's Manual of Diagnostic Antibodies for Immunohistology written by Runjan Chetty and published by Cambridge University Press. This book was released on 2016-11-28 with total page 525 pages. Available in PDF, EPUB and Kindle. Book excerpt: Providing a unique A-Z guide to antibodies for immunohistology, this is an indispensable source for pathologists to ensure the correct application of immunohistochemistry in daily practice. Each entry includes commercial sources, clones, descriptions of stained proteins/epitopes, the full staining spectrum of normal and tumor tissues, staining pattern and cellular localization, the range of conditions of immunoreactivity, and pitfalls of the antibody's immunoprofile, giving pathologists a truly thorough quick-reference guide to sources, preparation and applications of specific antibodies. Appendices provide useful quick-reference tables of antibody panels for differential diagnoses, as well as summaries of diagnostic applications. Expanded from previous editions with over forty new entries, this handbook for diagnostic, therapeutic, prognostic and research applications of antibodies is an essential desktop book for practicing pathologists as well as researchers, residents and trainees.