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Targeted Therapeutics In Melanoma
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Book Synopsis Targeted Therapeutics in Melanoma by : Thomas F. Gajewski
Download or read book Targeted Therapeutics in Melanoma written by Thomas F. Gajewski and published by Springer Science & Business Media. This book was released on 2011-12-15 with total page 377 pages. Available in PDF, EPUB and Kindle. Book excerpt: Melanoma is an increasingly important public health problem. Although the cause of most malignant melanomas – over-exposure to ultraviolet light – is well known, effective treatment has remained challenging. The past several years have been marked by extraordinary developments in melanoma treatment in the arena of targeted therapeutics. This book describes these ground-breaking discoveries and their implications for clinical use. As melanoma biology is increasingly understood, so the development of targeted therapies for this disease is spurred ahead. This book covers both established signal transduction inhibitors and the fascinating emerging realm of molecularly-guided immunotherapies. This benchmark book provides the most up-to-date information on the new breed of melanoma therapies. Composed of the works of major researchers and clinicians, this book offers new insights, novel approaches, and promising data for effective treatment planning. Illuminating the latest advances in the field, it is a solid resource for clinical oncologists, translational scientists, and basic cancer researchers.
Download or read book Melanoma written by Ernest C. Borden and published by Springer Science & Business Media. This book was released on 2002-04-03 with total page 407 pages. Available in PDF, EPUB and Kindle. Book excerpt: Strategies of treatment involving therapeutic proteins, irnrnune immune cells, or cel lular protein targets are those of greatest potential for further reducing mortality from melanoma. Therapeutic proteins or cells may inhibit melanoma cell growth either by augmentation of immune cell function or by inhibition of angiogenesis. Cytokines and melanoma antigens may be used either in vivo as a vaccine to stimulate irnrnune immune cell cell function or ex vivo to stimulate or proliferate cells for infusion. Alternatively, alteration in melanoma cell growth can occur through inhibition of protein signal transduction pathways within melanoma cells or in the endothelial cells constituting the necessary angiogenic support for tumor growth. The great promise of these therapies and their cellular targets constitutes the basis for Melanoma: Biologically Targeted Therapeutics. THE CLINlCAL PROBLEM More than four million people will be diagnosed with melanoma in the first decade of the 21st century. Half of those who will die will be individuals who would otherwise have had a life expectancy of another 25 years or more. These individuals will die of systemic systernic metastases, which are present at the time of primary surgery. Despite use of sunscreens, incidence continues to increase in developed countries worldwide. To reduce mortality, there must continue to be a focus on prevention and earlier detection through public education. Early interventions are always preferable to treatment of disseminated metastatic disease.
Download or read book Cutaneous Melanoma written by and published by . This book was released on with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Melanoma by : William H. Sharfman, MD
Download or read book Melanoma written by William H. Sharfman, MD and published by Demos Medical Publishing. This book was released on 2012-12-17 with total page 238 pages. Available in PDF, EPUB and Kindle. Book excerpt: Emerging Cancer Therapeutics is a trinary hard cover periodical that is designed to provide an up-to-date evidence-based review of a dedicated emerging cancer therapy topic of interest to clinicians and scientists involved in the care of patients receiving cancer treatment. It will serve as both a reference and instructional tool for students, housestaff, fellows, practicing clinical oncologists, radiation oncologists, surgical oncologists, cancer biologists, and interdisciplinary colleagues throughout the oncology spectrum. With contributions from nationally recognized experts representing the fields of dermatology, dermatologic surgery, surgical oncology, dermatopathology, and medical oncology, Melanoma includes chapters on prevention, changes in melanoma staging, the evolving role of established surgical therapies, single-agent specific V600E mutant inhibitors, target therapy for patients without BRAF mutations, new treatments for metastatic melanoma-including ipilimumab and vemurafenib-and more.
Book Synopsis Advances in Molecular and Pharmacological Mechanisms of Novel Targeted Therapies for Melanoma by : Luana Mota Ferreira
Download or read book Advances in Molecular and Pharmacological Mechanisms of Novel Targeted Therapies for Melanoma written by Luana Mota Ferreira and published by Frontiers Media SA. This book was released on 2024-04-15 with total page 129 pages. Available in PDF, EPUB and Kindle. Book excerpt: Malignant melanoma is the most aggressive type of skin cancer with invasive growth patterns. Recent advances in melanoma management have focused on cell growth, proliferation, migration, and survival biomarkers. Numerous FDA-approved molecular-targeted therapies, such as tyrosine kinase inhibitors (TKIs), have been developed targeting genetic biomarkers that play a critical role in tumorigenesis when overexpressed. The use of targeted therapies as an alternative or adjuvant to immunotherapy has revolutionized the management of metastatic melanoma. Although this treatment strategy is more efficacious and less toxic than traditional therapies, targeted therapies are less effective after prolonged treatment due to acquired resistance given the mutations and activation of resistant mechanisms in melanoma tumors. In this sense, identifying novel target therapies and repositioned drugs that could modulate the disease progression, the potential molecular and pharmacological mechanisms of therapies are of utmost interest.
Download or read book Melanoma written by Howard L. Kaufman and published by Springer. This book was released on 2015-11-24 with total page 413 pages. Available in PDF, EPUB and Kindle. Book excerpt: Melanoma is one of the most types of cancer. When melanoma is detected at an early stage, treatment is highly successful, but outcomes can be poor when the disease is advanced. There has been significant progress in our understanding of the molecular biology, genetics, and immunology of melanoma over the past decade. This has been accompanied by rapid advances in therapeutic strategies for patients with melanoma. This book provides the clinician and the researcher with a broad understanding of the molecular and cellular pathogenesis of melanoma, explores the clinical characteristics and criteria for clinical and pathological staging of the disease, and provides an overview of current and evolving treatment strategies in the adjuvant, metastatic, and preventive settings. The treatment of special populations and rare variants of melanoma that often present particular clinical challenges is also covered. Authored by international experts in melanoma biology and clinical management, this volume concisely explains how to diagnose, treat, and prevent melanoma while reviewing advances in basic science and providing an overview of innovative approaches still under development.
Book Synopsis BRAF Targets in Melanoma by : Ryan J. Sullivan
Download or read book BRAF Targets in Melanoma written by Ryan J. Sullivan and published by Springer. This book was released on 2014-11-24 with total page 206 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume contains a collection of writings from the leaders in the fields of Molecular Biology and Melanoma Research which will begin to tell the ever-expanding story of the most recent findings, discoveries, and potential of BRAF-directed targets in melanoma. Recent research has shown that BRAF inhibitors are effective for a short period of time, but there is little hope that this drugs as single agents will lead to durable benefit in a majority of patients. Among scientists and researchers who work in drug discovery, there is a lot of interest in the development of molecularly targeted cancer agents. Namely, the identification of a molecular target, the selection of molecules which effectively inhibit this target. What is starkly different about the development of this class of compounds, however, is that the mechanism of action of these agents are not as straightforward as was once previously assumed and the mechanisms of resistance that tumor cells employ to evade complete destruction are unlike any that have been described before. These discoveries in addition to utilization of modern molecular biology techniques have led to a series of hypotheses regarding which other types of molecules could be used in combination with BRAF-inhibitors in hopes of revolutionizing the potential of therapeutics in melanoma.
Book Synopsis Exploring Novel Strategies to Sensitize Melanoma to Immunotherapy and Targeted Therapies by : Fan Huang
Download or read book Exploring Novel Strategies to Sensitize Melanoma to Immunotherapy and Targeted Therapies written by Fan Huang and published by . This book was released on 2022 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: "Melanoma is the deadliest form of skin cancer. Current treatments for patients with metastatic melanoma include checkpoint blockade immunotherapies and MAPK pathway-targeted therapies. However, innate and acquired resistance are common, presenting a major clinical challenge. Melanomas exhibit high intratumoral heterogeneity and cancer cell plasticity. The ability to switch between different cell states, a process known as phenotype switching, confers an advantage for melanoma cells to metastasize and acquire therapy resistance. Understanding the molecular and genetic determinants of melanoma plasticity is therefore critical for the development of improved and novel treatment regimens. In this thesis, I aimed to explore novel strategies to target melanoma plasticity and sensitize melanoma to therapy. We first investigated the role of the MNK1/2-eIF4E axis, an essential regulator of mRNA translation initiation, in melanoma phenotype switching and immune evasion. We demonstrated that blocking the MNK1/2-eIF4E axis inhibited melanoma switching from a proliferative to an invasive state and sensitized melanoma to anti-PD-1 immunotherapy. Phospho-eIF4E-deficient melanomas were characterized as expressing high levels of melanocytic antigens, producing less inflammatory cytokines, and being more infiltrated with CD8+ T cells. Mechanistically, we identified phospho-eIF4E-mediated translational control of NGFR, a critical effector of phenotype switching. In addition, genetic and pharmacological ablation of tumor cell-extrinsic phospho-eIF4E decreased PD-L1 expression on DCs and MDSCs, thus permitting a more "immune-hot" tumor microenvironment. Finally, dual blockade of the MNK1/2-eIF4E axis and the PD-1/PD-L1 checkpoint demonstrated efficacy in multiple pre-clinical mouse models of melanoma. Using MNK1/2 inhibitors to repress phospho-eIF4E thus offers a new strategy to inhibit melanoma plasticity and improve the efficacy of anti-PD-1 immunotherapy. Next, we investigated how reprogramming lipid metabolism mediates the response of melanoma cell states to MAPK-targeted therapies. We demonstrated that a subset of CD36+ melanoma persister cells tolerate MAPK inhibition through a unique mechanism in which peroxisomes and UGCG collaboratively mediate metabolic rewiring. Genetic inhibition of the peroxin PEX3 reduced peroxisome numbers and augmented MAPK inhibitor (MAPKi)-induced apoptosis in melanoma cells. Using lipidomic analysis, we showed that peroxisome deficiency sensitized melanomas to MAPKi through reprogrammed lipid metabolism, resulting in an increased reliance on UGCG-mediated ceramide metabolism for survival. Re-analysis of a single cell RNA-seq dataset revealed that, while MAPK inhibitors decreased the overall metabolic activity of patient-derived xenografts, a CD36+ cell subpopulation remained metabolically active during minimal residual disease and was characterized by the expression of UGCG and peroxisomal genes. Dual blockade of PEX3 and UGCG selectively eliminated CD36+ persister cells, thereby sensitizing melanoma to MAPKi and delaying resistance. Moreover, therapy-resistant melanomas were re-sensitized to MAPK-targeted therapy when PEX3 and UGCG were simultaneously inhibited. Finally, we combined a small molecule inhibitor that blocks PEX3-PEX19 interaction with a UGCG inhibitor, which led to reduced CD36+ persister cells and sensitized melanomas to MAPK inhibition. Together, our study supports a novel approach to potentiate melanoma response to MAPK-targeted therapies and overcome acquired resistance by disrupting peroxisome and UGCG-mediated lipid metabolism.In conclusion, our data highlight the growing appreciation of targeting translational control and metabolic reprogramming to modulate melanoma plasticity and therapeutic response. Inhibitors of mRNA translation and inhibitors of lipid metabolism, therefore, represent two promising therapeutic approaches to improve responses to standard of care therapies in melanoma"--
Book Synopsis Treatment of Metastatic Melanoma by : Rachael Morton
Download or read book Treatment of Metastatic Melanoma written by Rachael Morton and published by BoD – Books on Demand. This book was released on 2011-10-05 with total page 364 pages. Available in PDF, EPUB and Kindle. Book excerpt: Surgery continues to be the mainstay treatment for melanoma localized to the primary tumor and/or lymph nodes. Results from randomized controlled trials indicate that sentinel node biopsy for the treatment of cutaneous melanoma of intermediate thickness has a beneficial effect on recurrence rates, and adjuvant radiotherapy to regional lymph node fields following surgical resection reduces loco-regional recurrence in patients at high risk of relapse. Isolated limb perfusion, electrochemotherapy, and photodynamic therapy continue to be evaluated for treatment of stage IV disease. However, the greatest excitement in new treatment has been with targeted therapies for genetic mutations. In particular, the promising results of partial and complete tumor response in stage IV disease from early phase trials of the B-RAF kinase inhibitors. This book provides a contemporary insight into the therapeutic treatment options for patients with metastatic melanoma and is relevant to clinicians and researchers worldwide. In addition, an update on current clinical trials for melanoma treatment has been included, and two chapters have been reserved to discuss the treatment of oral and uveal melanoma.
Book Synopsis Melanoma, An Issue of Hematology/Oncology Clinics of North America by : F. Stephen Hodi
Download or read book Melanoma, An Issue of Hematology/Oncology Clinics of North America written by F. Stephen Hodi and published by Elsevier Health Sciences. This book was released on 2020-11-25 with total page 169 pages. Available in PDF, EPUB and Kindle. Book excerpt: This issue of Hematology/Oncology Clinics, Guest Edited by F. Stephen Hodi, is devoted to Melanoma. This issue is one of six selected each year by our series Consulting Editors, George P. Canellos and Edward J. Benz. Topics discussed in this important issue include: State of Melanoma, Biology of Melanoma, Epidemiology of Melanoma, Surgical Management of Melanoma, Melanoma Adjuvant Therapy, Targeted Therapies for Melanoma, Non-cutaneous Melanomas, Immune Checkpoint Therapies for Melanoma, Resistance Mechanisms to Current Therapies, Cellular Therapy and Cytokine Treatments for Melanoma, Combinatorial Approaches to the Treatment of Melanoma, and Melanoma Future Directions.
Book Synopsis Central Nervous System Metastases by : Manmeet Ahluwalia
Download or read book Central Nervous System Metastases written by Manmeet Ahluwalia and published by Springer Nature. This book was released on 2019-11-05 with total page 421 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides a comprehensive overview of brain metastases, from the molecular biology aspects to therapeutic management and perspectives. Due to the increasing incidence of these tumors and the urgent need to effectively control brain metastatic diseases in these patients, new therapeutic strategies have emerged in recent years. The volume discusses all these innovative approaches combined with new surgical techniques (fluorescence, functional mapping, integrated navigation), novel radiation therapy techniques (stereotactic radiosurgery) and new systemic treatment approaches such as targeted- and immunotherapy. These combination strategies represent a new therapeutic model in brain metastatic patients in which each medical practitioner (neurosurgeon, neurologist, medical oncologist, radiation oncologist) plays a pivotal role in defining the optimal treatment in a multidisciplinary approach. Written by recognized experts in the field, this book is a valuable tool for neurosurgeons, neuro-oncologists, neuroradiologists, medical oncologists, radiation oncologists, cognitive therapists, basic scientists and students working in the area of brain tumors.
Book Synopsis Melanoma, An Issue of Hematology/Oncology Clinics by : F. Stephen Hodi
Download or read book Melanoma, An Issue of Hematology/Oncology Clinics written by F. Stephen Hodi and published by Elsevier Health Sciences. This book was released on 2014-06-28 with total page 225 pages. Available in PDF, EPUB and Kindle. Book excerpt: This issue of Hematology/Oncology Clinics, guest edited by Dr. F. Stephen Hodi, is devoted to Melanoma. Articles in this issue include: The current state of Melanoma; Understanding the Biology of Melanoma Development and Therapeutic Implications; Surgical Management of Melanoma; Targeted Therapies for Cutaneous Melanoma; Treatments for Non-cutaneous Melanoma; Resistant Mechanisms and Therapeutic Implications; The Role of the Immune System in Melanoma Development and Treatment; Vaccines and Melanoma; IL-2, Interferon, and Cytokines; Immune Checkpoint Blockade; Adjuvant Treatments, Chance for Cure in Melanoma; and Combinatorial Approach to Treatment of Melanoma.
Book Synopsis Management of Advanced Melanoma by : Larry Nathanson
Download or read book Management of Advanced Melanoma written by Larry Nathanson and published by . This book was released on 1986 with total page 296 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Melanoma in Clinical Practice by : Rhoda M. Alani
Download or read book Melanoma in Clinical Practice written by Rhoda M. Alani and published by Springer Nature. This book was released on 2021-11-26 with total page 354 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides a concise practical guide to melanoma enabling the reader to develop a thorough understanding of the etiology, pathogenesis, diagnosis, treatment and prevention of melanoma. It features easy to digest instructional text that describes a variety of techniques for detecting and staging melanoma including total body photography. Surgical, radiation and systemic therapy treatment options as well as prevention strategies are also covered. Melanoma in Clinical Practice represents a thorough guide on how to diagnose treat and prevent melanoma, and provides a valuable resource for the trainee and experienced clinical dermatologists who are seeking a reference guide to use in their clinical practice.
Book Synopsis Uveal Melanoma by : Eric H. Bernicker
Download or read book Uveal Melanoma written by Eric H. Bernicker and published by Springer Nature. This book was released on 2021-08-03 with total page 229 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides a comprehensive examination of uveal melanoma, a rare neoplasm that carries a very high mortality and whose natural history makes it fairly unique among adult tumors. Split into three sections, this book explores the basic science behind the disease and inherited genetic syndromes that predispose some patients, as well as the pathology and use of gene expression profiling to determine risk of recurrence. It also focuses on the management of the primary tumor in the eye, including surgical intervention and lesion imaging. Elucidating treatment options for metastatic disease, the book reviews chemotherapy agents and immunotherapy approaches, as well as liver-directed therapies, cellular therapies, and various treatments after primary treatment but before the development of metastases. Uveal Melanoma: Biology and Management is the most up-to-date and comprehensive text devoted solely to this disease and will be useful to medical oncologists, ophthalmologists, radiation therapists, interventional radiologists, pathologists, molecular biologists and immunology researchers, as well as trainees in those fields.
Book Synopsis Current Applications for Overcoming Resistance to Targeted Therapies by : Myron R. Szewczuk
Download or read book Current Applications for Overcoming Resistance to Targeted Therapies written by Myron R. Szewczuk and published by Springer. This book was released on 2019-07-15 with total page 320 pages. Available in PDF, EPUB and Kindle. Book excerpt: Targeted therapies were initially developed to exploit the upregulation and dependence on key oncogenic pathways critical to cancer progression. Additionally, they also presented as a method to overcome chemoresistance by supplementing conventional therapeutic regimens with targeted therapies. However, the development of resistance to these combinatorial approaches has led to the reassessment of currently available therapeutic options to overcome resistance to targeted therapy. This book aims to provide an update on the advancements in the therapeutic arms race between cancer, clinicians and scientists alike to overcome resistance to targeted therapies. Subject experts provide a comprehensive overview of the challenges and solutions to resistance to several conventional targeted therapies in addition to providing a discussion on broad topics including targeting components of the tumor microenvironment, emerging therapeutic options, and novel areas to be explored concerning nanotechnology and the epigenome.
Book Synopsis Targeted Therapies for Lung Cancer by : Ravi Salgia
Download or read book Targeted Therapies for Lung Cancer written by Ravi Salgia and published by Springer. This book was released on 2019-06-26 with total page 238 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book contextualizes translational research and provides an up to date progress report on therapies that are currently being targeted in lung cancer. It is now well established that there is tremendous heterogeneity among cancer cells both at the inter- and intra-tumoral level. Further, a growing body of work highlights the importance of targeted therapies and personalized medicine in treating cancer patients. In contrast to conventional therapies that are typically administered to the average patient regardless of the patient’s genotype, targeted therapies are tailored to patients with specific traits. Nonetheless, such genetic changes can be disease-specific and/or target specific; thus, the book addresses these issues manifested in the somatically acquired genetic changes of the targeted gene. Each chapter is written by a leading medical oncologist who specializes in thoracic oncology and is devoted to a particular target in a specific indication. Contributors provide an in-depth review of the literature covering the mechanisms underlying signaling, potential cross talk between the target and downstream signaling, and potential emergence of drug resistance.
