Targeted Cancer Imaging

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Targeted Cancer Imaging

Author : Mehdi Azizi
Publisher : Academic Press
ISBN 13 : 012824514X
Total Pages : 218 pages
Book Rating : 4.1/5 (282 download)

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Book Synopsis Targeted Cancer Imaging by : Mehdi Azizi

Download or read book Targeted Cancer Imaging written by Mehdi Azizi and published by Academic Press. This book was released on 2021-11-24 with total page 218 pages. Available in PDF, EPUB and Kindle. Book excerpt: Targeted Cancer Imaging: Design and Synthesis of Nanoplatforms based on Tumour Biology reviews and categorizes imaging and targeting approaches according to cancer type, highlighting new and safe approaches that involve membrane-coated nanoparticles, tumor cell-derived extracellular vesicles, circulating tumor cells, cell-free DNAs, and cancer stem cells, all with the goal of pointing the way to developing precise targeting and multifunctional nanotechnology-based imaging probes in the future. This book is highly multidisciplinary, bridging the knowledge gap between tumor biology, nanotechnology, and diagnostic imaging, and thus making it suitable for researchers ranging from oncology to bioengineering. Although considerable efforts have been conducted to diagnose, improve and treat cancer in the past few decades, existing therapeutic options are insufficient, as mortality and morbidity rates remain high. One of the best hopes for substantial improvement lies in early detection. Recent advances in nanotechnology are expected to increase our current understanding of tumor biology, allowing nanomaterials to be used for targeting and imaging both in vitro and in vivo experimental models. Gives understanding of cancer biology that is appropriate for students and researchers in engineering and nanotechnology Demonstrates cancer targeting strategies of multifunctional nanotechnology-based imaging probes Shows how to design, synthesize and apply cancer imaging nanostructures

Targeted Radionuclide Therapy

Author : Tod W. Speer
Publisher : Lippincott Williams & Wilkins
ISBN 13 : 1451153260
Total Pages : 564 pages
Book Rating : 4.4/5 (511 download)

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Book Synopsis Targeted Radionuclide Therapy by : Tod W. Speer

Download or read book Targeted Radionuclide Therapy written by Tod W. Speer and published by Lippincott Williams & Wilkins. This book was released on 2012-03-28 with total page 564 pages. Available in PDF, EPUB and Kindle. Book excerpt: Radioimmunotherapy, also known as systemic targeted radiation therapy, uses antibodies, antibody fragments, or compounds as carriers to guide radiation to the targets. It is a topic rapidly increasing in importance and success in treatment of cancer patients. This book represents a comprehensive amalgamation of the radiation physics, chemistry, radiobiology, tumor models, and clinical data for targeted radionuclide therapy. It outlines the current challenges and provides a glimpse at future directions. With significant advances in cell biology and molecular engineering, many targeting constructs are now available that will safely deliver these highly cytotoxic radionuclides in a targeted fashion. A companion website includes the full text and an image bank.

Nuclear Medicine in Oncology

Author : Gang Huang
Publisher : Springer
ISBN 13 : 9811374589
Total Pages : 346 pages
Book Rating : 4.8/5 (113 download)

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Book Synopsis Nuclear Medicine in Oncology by : Gang Huang

Download or read book Nuclear Medicine in Oncology written by Gang Huang and published by Springer. This book was released on 2019-06-11 with total page 346 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book introduces molecular imaging and Target Therapy in various cancers. The first part is the subjects and primary focused on the basics of nuclear physics, radiation dosimetry, nuclear medicine equipment and small animal imaging equipment. The second part is about the radiopharmaceutical and commonly used clinical radiopharmaceuticals, including positron emission imaging agent, single photon emission imaging agent, and radionuclide therapy agents as well as their radioactive preparation, quality control, and a brief clinical application were included. Also, this part introduces a number of new imaging agents which were potential value of clinical applications. In the third part, the clinical application of the conventional imaging agent 18F-FDG in different tumors and neurodegenerative diseases and 18F-Dopa imaging in the nervous system are discussed. Besides the clinical applications of 99mTc labeled radiopharmaceuticals in parathyroid disease, coronary heart disease, myocardial infarction, sentinel lymph node, metastatic bone tumors, liver and gallbladder disease in children are introduced. Finally, the applications of radionuclide 131I on treatments of Graves' disease and differentiated thyroid cancer and metastases are investigated respectively. This book is a useful reference for professionals engaged in nuclear medicine and clinical research, including clinical nuclear medicine physicians, nuclear medicine engineers and nuclear medicine pharmacists.

Targeted Molecular Imaging in Oncology

Author : E. Edmund Kim
Publisher : Springer Science & Business Media
ISBN 13 : 1475735057
Total Pages : 302 pages
Book Rating : 4.4/5 (757 download)

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Book Synopsis Targeted Molecular Imaging in Oncology by : E. Edmund Kim

Download or read book Targeted Molecular Imaging in Oncology written by E. Edmund Kim and published by Springer Science & Business Media. This book was released on 2013-06-29 with total page 302 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume is unique in reporting on strategies for the application of molecular targeted imaging agents such as antibodies, peptides, receptors and contrast agents in the biologic grading of tumors, differential diagnosis of tumors, prediction of therapeutic response and monitoring tumor response to treatment. It also includes updated information on the imaging of tumor angiogenesis, hypoxia, apoptosis and gene delivery as well as expression in the understanding and utility of tumor molecular biology for better cancer management.

Therapy Response Imaging in Oncology

Author : Mizuki Nishino
Publisher : Springer Nature
ISBN 13 : 3030311716
Total Pages : 266 pages
Book Rating : 4.0/5 (33 download)

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Book Synopsis Therapy Response Imaging in Oncology by : Mizuki Nishino

Download or read book Therapy Response Imaging in Oncology written by Mizuki Nishino and published by Springer Nature. This book was released on 2020-01-07 with total page 266 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is a detailed guide to therapy response imaging in cancer patients that fully takes into account the revolutionary progress and paradigm shift in treatment approaches for advanced disease. The opening chapters describe the role of imaging as a “common language” for tumor response evaluation in oncology and address challenges and strategies in the era of precision cancer therapy and cancer immunotherapy. Practical pitfalls are discussed, with emphasis on the importance of approaching cancer as a systemic disease and the need for increased awareness of drug toxicity due to novel therapies. Therapy response imaging in a wide range of cancer types is then comprehensively described and illustrated, using a disease-specific approach. A concluding section focuses on emerging approaches and future directions, including radiomics/radiogenomics, co-clinical imaging, and molecular and functional imaging. Therapy Response Imaging in Oncology will be of high value for radiologists, nuclear medicine physicians, and oncologists. It will also be of interest to cancer care providers and oncology trial investigators.

Early Cancer Detection and Targeted Therapy by Magnetic Resonance Molecular Imaging and Nano Medicine

Author : Zhao Li
Publisher :
ISBN 13 :
Total Pages : 184 pages
Book Rating : 4.:/5 (927 download)

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Book Synopsis Early Cancer Detection and Targeted Therapy by Magnetic Resonance Molecular Imaging and Nano Medicine by : Zhao Li

Download or read book Early Cancer Detection and Targeted Therapy by Magnetic Resonance Molecular Imaging and Nano Medicine written by Zhao Li and published by . This book was released on 2015 with total page 184 pages. Available in PDF, EPUB and Kindle. Book excerpt: The common theme of my 5-year PhD research is to channel progress in spin physics and nano-bio-materials into meaningful improvements in the theoretical studies, methodological developments, and advanced applications of magnetic resonance (MR) to: 1) MR Molecular Imaging: to detect lesions (especially cancers) at early stages through imaging the existence and locations of physiologically important biomarkers; and 2) MR Nano Medicine: to cure diseases (especially cancers) by targeted therapy through nanodrugs and hyperthermia. The research activities had encompassed a balanced approach to develop a rigorous theoretical understanding on sensitively imaging magnetic nanoparticles by active- feedback spin dynamics of selective self-excitation and fixed-point dynamics on one hand and sound methodology with biomedical applicability to early pancreatic cancers and brain tumors detection on the other. Computer simulations, phantom experiments of superparamagnetic nanoparticles, and in vivo experiments of orthotopic pancreatic cancer and brain tumor mouse models had been used to validate the applicability and efficacy of our proposed methods. The major research projects and achievements with my coworkers under the supervision of Prof. Yung-Ya Lin include: 1) Developed original MR method, "Active-Feedback Fixed-Point Imaging", for early cancer detection, with both quantum and classical formulation of the spin dynamics. 2) Demonstrated 3-5 times of enhancement in the contrast-to-noise ratio (CNR) of early pancreatic cancers which were targeted and labeled by CA19-9 conjugated magnetic nanoparticles by our "Spin Avalanche Amplification" method, based on statistics from 7 orthotopic pancreatic cancer mouse models. 3) Demonstrated 4-10 times of enhancement in the CNR of early GBM (glioblastoma multiforme, the most common and aggressive form of brain cancers) by our "Active-Feedback Fixed-Point Imaging" method, based on statistics from 20 orthotopic GBM mouse models. 4) Developed novel multifunctional, theranostic, smart nanoparticles, called "UCS-Gd-Dox" for MR imaging and targeted cancer therapy. By conjugating Gd3+ at the stable core of unibody core-shell polymer (UCS) and encapsulating doxorubicin (Dox) at the shell in a pH-sensitive manner, we achieved a selective drug release (75% difference between pH 7.4 and 5.5) and MR imaging (r1 = 0.9 and 14.5 mM-1s-1 at pH 7.4 and 5.5, respectively). The anti-cancer effect is significantly better than free cancer drugs in tumor-bearing mouse models, presumably due to enhanced permeability and retention effect and pH-triggered release. 5) Formulated more accurate theoretical description to magnetic resonance hyperthermia, including aggregation/disruption of monomers/clusters and nonlinear response under strong external magnetic field.

Molecular Imaging of Tumor Characteristics to Support Targeted Cancer Therapies: a Preclinical Focus on HER2, HER3, C-MET, IGF-1R and VEGF-A Imaging

Download Molecular Imaging of Tumor Characteristics to Support Targeted Cancer Therapies: a Preclinical Focus on HER2, HER3, C-MET, IGF-1R and VEGF-A Imaging PDF Online Free

Author : Antonius Gerhardus Titus Terwisscha Scheltinga
Publisher :
ISBN 13 :
Total Pages : 138 pages
Book Rating : 4.:/5 (839 download)

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Book Synopsis Molecular Imaging of Tumor Characteristics to Support Targeted Cancer Therapies: a Preclinical Focus on HER2, HER3, C-MET, IGF-1R and VEGF-A Imaging by : Antonius Gerhardus Titus Terwisscha Scheltinga

Download or read book Molecular Imaging of Tumor Characteristics to Support Targeted Cancer Therapies: a Preclinical Focus on HER2, HER3, C-MET, IGF-1R and VEGF-A Imaging written by Antonius Gerhardus Titus Terwisscha Scheltinga and published by . This book was released on 2013 with total page 138 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Handbook of Targeted Delivery of Imaging Agents

Author : Vladimir P. Torchilin
Publisher : CRC Press
ISBN 13 : 9780849383083
Total Pages : 762 pages
Book Rating : 4.3/5 (83 download)

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Book Synopsis Handbook of Targeted Delivery of Imaging Agents by : Vladimir P. Torchilin

Download or read book Handbook of Targeted Delivery of Imaging Agents written by Vladimir P. Torchilin and published by CRC Press. This book was released on 1995-08-23 with total page 762 pages. Available in PDF, EPUB and Kindle. Book excerpt: This is the first time detailed and updated information on the targeted delivery of imaging agents has been collected into a single handbook. This comprehensive volume presents the scientific background together with the latest experimental and clinical data in this fast-growing area. The Handbook of Targeted Delivery of Imaging Agents meets the requirements of the broadest audience including researchers, practitioners, and students. The basic principles of targeted delivery of imaging are presented and discussed together with various imaging agents and different imaging modalities such as gamma-imaging, MR-imaging, and CT, PET, and SPECT imaging. The book consists of eight parts and 39 chapters covering all aspects of targeted drug delivery-from the imaging theory and chemistry of imaging agents to their experimental and clinical use for targeted visualization of cancer, including ovarian, prostate, colorectal, and thyroid cancer, cardiovascular (atherosclerosis, myocardial infarction, and thromboses) and neurological diseases, infection, and inflammation sites. A special section discusses the targeted delivery of imaging agents into lymph nodes, which are often sites of metasteses during different malignant diseases. Monoclonal antibody-based targeted imaging agents are considered together with new approaches involving the use of labeled micelles, liposomes, and polymer-coated particles. The book describes the possible application of designer antibodies for the delivery of diagnostic agents, including the preparation, properties, labeling, and experimental use of multifunctional antibodies. The alternative improvement of antibody-directed targeting describes the application of avidin-biotin system for the delivery of imaging agents. Long circulating blood pool imaging agents are considered as a special group of organ-specific pharmaceuticals. The latest trends in the synthesis of immunoscintigraphic, MR, and CT agents are presented. This Handbook of Targeted Delivery of Imaging Agents is a must-have reference for all those who need to stay abreast of the latest developments in this hot field.

Molecular Imaging and Targeted Therapy

Author : Shankar Vallabhajosula
Publisher : Springer Nature
ISBN 13 : 3031232054
Total Pages : 719 pages
Book Rating : 4.0/5 (312 download)

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Book Synopsis Molecular Imaging and Targeted Therapy by : Shankar Vallabhajosula

Download or read book Molecular Imaging and Targeted Therapy written by Shankar Vallabhajosula and published by Springer Nature. This book was released on 2023-03-31 with total page 719 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book, now published in its second edition, covers a wide range of topics relating to the use of radiopharmaceuticals. The basics of nuclear chemistry, radiochemistry, and radiopharmacology are considered in detail, regulatory issues are reviewed, and potential applications in drug development, translational medicine, clinical diagnostics, and targeted therapy are discussed. Compared with the first edition, the chapters on targeted therapy with alpha- and beta-emitting radiopharmaceuticals and theranostics are completely new. Other chapters have been updated and revised as necessary. Radioisotope-based molecular imaging probes (radiopharmaceuticals) provide unprecedented insights into biochemistry and function in both normal and diseased states of living systems, with unbiased in vivo measurements of regional radiotracer activities offering very high specificity and sensitivity. No other molecular imaging technology, including functional magnetic resonance imaging, can provide such high sensitivity and specificity at a tracer level. This book, written by an experienced radiochemist and scientist, offers valuable insights into the full range of applications of this technology.

Magnetic Resonance Imaging Biomarkers For Targeted Cancer Therapies

Author : Renu M. Stephen
Publisher :
ISBN 13 :
Total Pages : 378 pages
Book Rating : 4.:/5 (659 download)

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Book Synopsis Magnetic Resonance Imaging Biomarkers For Targeted Cancer Therapies by : Renu M. Stephen

Download or read book Magnetic Resonance Imaging Biomarkers For Targeted Cancer Therapies written by Renu M. Stephen and published by . This book was released on 2008 with total page 378 pages. Available in PDF, EPUB and Kindle. Book excerpt: In 2007, there will be an estimated 178,480 new cases of breast cancer diagnosed in women in the United States. The elucidation of the vast heterogeneity of individual tumors has led to a paradigm shift from a one-size fits all treatment strategy to more individualized treatment based on the molecular profile of the tumor. Identifying biomarkers that respond to or predict the action of drugs is important in identifying efficacious targets and drugs that will improve clinical outcome. To examine this, we first identified two breast cancer cell lines (ACC-3199 and ACC-3171) from a panel of low passage breast cells lines that were capable of growing serially as tumor xenografts. This was followed by the in vivo molecular characterization of these two cell lines. In ACC-3199 tumors, we identified a gain of pAKT expression compared to cultured cells. Based on this finding, we investigated the role of diffusion-weighted (DW) and dynamic contrast-enhanced (DCE) magnetic resonance imaging (MRI) as potential imaging biomarkers in identifying early response to PX-866, a PI3K inhibitor, in ACC-3199 tumors as represented by changes in tumor cellularity and hemodynamic parameters, respectively. Our results indicated that DW-MRI was able to identify an early response to PX-886 in ACC-3199 tumors as defined by an increase in the apparent diffusion coefficient (ADC) value of the tumors prior to changes in tumor volumes. Using DCE-MRI, we were able to conclude that PX-866 was not an effective anti-angiogenic agent as indicated by an increase in tumor permeability following therapy. Based on the VEGFR2 expression observed in ACC-3171 tumor xenografts, we examined the response of MDA-MB-231/GFP and ACC-3171 tumor xenografts to the anti-angiogenic agent, sunitinib, using the same imaging modalities. DW-MRI was able to detect increases in ADC values as early as 12 h post-treatment in both MDA-MB-231/GFP and ACC-3171 tumors. Thus, it appears that DW-MRI may be a useful clinical test in predicting the early response to PI3K and anti-angiogenic inhibitors. These imaging approaches, in addition to the further molecular characterization of breast tumors may lead to the improvement and development of medical therapies for breast cancer patients.

Harnessing Materials for X-ray Based Cancer Therapy and Imaging

Author : Surender Kumar Sharma
Publisher : Springer Nature
ISBN 13 : 3031040716
Total Pages : 313 pages
Book Rating : 4.0/5 (31 download)

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Book Synopsis Harnessing Materials for X-ray Based Cancer Therapy and Imaging by : Surender Kumar Sharma

Download or read book Harnessing Materials for X-ray Based Cancer Therapy and Imaging written by Surender Kumar Sharma and published by Springer Nature. This book was released on 2022-10-31 with total page 313 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book discusses the efficacy of nanomaterial-based X-rays enhancers against cancer therapy and imaging in both in vitro and in vivo systems. Also, synthesis, mechanism, and the related biological effects are given. Moreover, nanoparticle-based contrast agents to enhance the image quality are compiled. Finally, special nanoparticle-based contrast agents to enhance the contrast for targeted cancer therapy are covered and discussed.

Targeted Cancer Therapy

Author : Razelle Kurzrock
Publisher : Springer Science & Business Media
ISBN 13 : 1603274243
Total Pages : 447 pages
Book Rating : 4.6/5 (32 download)

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Book Synopsis Targeted Cancer Therapy by : Razelle Kurzrock

Download or read book Targeted Cancer Therapy written by Razelle Kurzrock and published by Springer Science & Business Media. This book was released on 2008-03-07 with total page 447 pages. Available in PDF, EPUB and Kindle. Book excerpt: Emerging technologies in target identification, drug discovery, molecular markers, and imaging are rapidly changing the face of cancer. This book provides a foundation of knowledge in targeted cancer therapeutics. The treatment of cancer is increasingly being individualized, based on an understanding of underlying biologic mechanisms. Poised to change the landscape in oncology, this volume provides a state-of-the-art overview. It will be valuable to practicing and academic physicians, fellows, residents and students, as well as basic scientists, interested in the cancer field.

Improving Cancer Diagnosis and Care

Author : National Academies of Sciences, Engineering, and Medicine
Publisher : National Academies Press
ISBN 13 : 0309478286
Total Pages : 93 pages
Book Rating : 4.3/5 (94 download)

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Book Synopsis Improving Cancer Diagnosis and Care by : National Academies of Sciences, Engineering, and Medicine

Download or read book Improving Cancer Diagnosis and Care written by National Academies of Sciences, Engineering, and Medicine and published by National Academies Press. This book was released on 2018-11-25 with total page 93 pages. Available in PDF, EPUB and Kindle. Book excerpt: Rapid advances in cancer research, the development of new and more sophisticated approaches to diagnostic testing, and the growth in targeted cancer therapies are transforming the landscape of cancer diagnosis and care. These innovations have contributed to improved outcomes for patients with cancer, but they have also increased the complexity involved in diagnosis and subsequent care decisions. To examine opportunities to improve cancer diagnosis and care, the National Academies of Sciences, Engineering, and Medicine developed a two-workshop series. The first workshop, held on February 12â€"13, 2018, in Washington, DC, focused on potential strategies to ensure that patients have access to appropriate expertise and technologies in oncologic pathology and imaging to inform their cancer diagnosis and treatment planning, as well as assessment of treatment response and surveillance. This publication chronicles the presentations and discussions at the workshop.

Targeted Therapy in Translational Cancer Research

Author : Apostolia-Maria Tsimberidou
Publisher : John Wiley & Sons
ISBN 13 : 1118468570
Total Pages : 396 pages
Book Rating : 4.1/5 (184 download)

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Book Synopsis Targeted Therapy in Translational Cancer Research by : Apostolia-Maria Tsimberidou

Download or read book Targeted Therapy in Translational Cancer Research written by Apostolia-Maria Tsimberidou and published by John Wiley & Sons. This book was released on 2015-12-21 with total page 396 pages. Available in PDF, EPUB and Kindle. Book excerpt: Targeted Therapy in Translational Cancer Research for the Translational Oncology series provides a comprehensive overview of recent developments in our understanding of tumor biology, elucidates the roles of targets and pathways involved in carcinogenesis, and describes current state-of-the-art anticancer therapy, as well as the most promising areas of translational research and targeted therapy. Introduces cutting-edge ‘bench to bedside and back’ breakthroughs which have transformed the diagnosis, prognosis, and treatment of cancer Covers basic principles of targeted therapy, including immunotherapy and the roles of cancer stem cells, the microenvironment, angiogenesis, epigenetics, microRNAs, and functional imaging in precision medicine Summarises major advances in therapeutic management of hematologic malignancies and solid tumors using conventional therapy, targeted therapy, immunotherapy, or novel treatment modalities

Targeted Cancer Therapy in Biomedical Engineering

Author : Rishabha Malviya
Publisher : Springer Nature
ISBN 13 : 9811997861
Total Pages : 949 pages
Book Rating : 4.8/5 (119 download)

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Book Synopsis Targeted Cancer Therapy in Biomedical Engineering by : Rishabha Malviya

Download or read book Targeted Cancer Therapy in Biomedical Engineering written by Rishabha Malviya and published by Springer Nature. This book was released on 2023-04-11 with total page 949 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book highlights the role of Biomedical Engineering (BME) used in diagnosis (e.g., body scanners) and treatment (radiation therapy and minimal access surgery in order to prevent various diseases). In recent years, an important progress has been made in the expansion of biomedical microdevices which has a major role in diagnosis and therapy of cancer. When fighting cancer, efficacy and speed are of the utmost importance. A recently developed microfluidic chip has enabled a breakthrough in testing the efficacy of specialized cancer drugs. Effective cancer-targeting therapies will require both passive and active targeting strategies and a thorough understanding of physiologic barriers to targeted drug delivery. Targeted cancer treatments in development and the new combinatorial approaches show promise for improving targeted anticancer drug delivery and improving treatment outcomes. This book discusses the advancements and innovations in the field of BME that improve the diagnosis and treatment of cancer. This book is focused on bioengineering approaches to improve targeted delivery for cancer therapeutics, which include particles, targeting moieties, and stimuli-responsive drug release mechanisms. This book is a useful resource for students, researchers, and professionals in BME and medicine.

Targeted Radionuclide Tumor Therapy

Author : Torgny Stigbrand
Publisher : Springer Science & Business Media
ISBN 13 : 1402086962
Total Pages : 407 pages
Book Rating : 4.4/5 (2 download)

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Book Synopsis Targeted Radionuclide Tumor Therapy by : Torgny Stigbrand

Download or read book Targeted Radionuclide Tumor Therapy written by Torgny Stigbrand and published by Springer Science & Business Media. This book was released on 2008-09-01 with total page 407 pages. Available in PDF, EPUB and Kindle. Book excerpt: The last three decades have provided opportunities to explore the potential of treating malignant diseases with antibodies or other targeting molecules labelled with nuclides. While considerable advances have been reported, there is still a signi- cant amount of work left to accomplish before our ambitions can be achieved. It now seems timely to review the accomplishments achieved to date and to clarify the challenges that remain. The choice of radionuclide, the conjugation p- cedure employed, and the selection of suitable targets were early issues that were faced by our field that still persist, however we can now tackle these obstacles with significantly better insight. The expanding array of new targeting molecules (recombinant antibodies, peptides and agents based upon alternate scaffolds) may increase the therapeutic efficacy or even modify the radiation sensitivity of the targeted tumor cell. The title of this book “Targeted Radionuclide Tumour Therapy – Biological Aspects” was selected to reinforce the concept that a major focus of this volume was devoted to understanding the biological effects of targeting and radiation. These important issues have not previously been the primary focus in this context. Furthermore, our rapidly expanding knowledge of different types of cell death and the increasingly likely existence of cancer stem cells suggests to us that even more efficient approaches in targeting might be possible in the future.

Optical Imaging of Cancer

Author : Eben Rosenthal
Publisher : Springer Science & Business Media
ISBN 13 : 0387938745
Total Pages : 278 pages
Book Rating : 4.3/5 (879 download)

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Book Synopsis Optical Imaging of Cancer by : Eben Rosenthal

Download or read book Optical Imaging of Cancer written by Eben Rosenthal and published by Springer Science & Business Media. This book was released on 2009-10-03 with total page 278 pages. Available in PDF, EPUB and Kindle. Book excerpt: To describe principles of optical imaging including chemistry and physics of fluorescence, limitations/advantages of optical imaging compared to metabolic and anatomic imaging. Describe hardware adapted for small animal imaging and for clinical applications: endoscopes and operative microscopes. Outline FDA approved and newer optical imaging probes. Include discussion of chemistry and linkage to other proteins. Review current techniques to image cancer and the development of techniques to specifically image cancer cells. Review use of exploiting differences in tissue autofluorescence to diagnose and treat cancer. Include agents such as 5-aminoleculinic acid. Review mechanisms that require proteolytic processing within the tumor to become active fluorophores. Review use of cancer selective proteins to localize probes to cancer cells: include toxins, antibodies, and minibodies. Introduction of plasmids, viruses or other genetic material may be used to express fluorescent agents in vivo. This chapter will review multiple vectors and delivery mechanisms of optical imaging cassettes.Preclinical investigations into the use of optical contrast agents for the detection of primary tumors in conventional and orthotopic models will be discussed. Preclinical investigations into the use of optical contrast agents for the detection of metastatic tumors in mouse models will be discussed. Use of targeted and non-specific optical contrast agents have been used for the detection of sentinel lymph node detection. These applications and how they differ from other applications will be discussed. Because of the unique difficulty of identifying tumor from normal tissue in brain tissue, a separate chapter would be needed. More clinical data is available for this cancer type than any other. Discussion of potential clinical applications for optical imaging and an assessment of the potential market.