Systems Medicine

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Publisher : Humana
ISBN 13 : 9781493932825
Total Pages : 0 pages
Book Rating : 4.9/5 (328 download)

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Book Synopsis Systems Medicine by : Ulf Schmitz

Download or read book Systems Medicine written by Ulf Schmitz and published by Humana. This book was released on 2015-12-17 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume guides readers through the field of systems medicine by defining the terminology, and describing how established computational methods form bioinformatics and systems biology can be taken forward to an integrative systems medicine approach. Chapters provide an outlook on the role that systems medicine may or should play in various medical fields, and describe different facets of the systems medicine approach in action. Ultimately it introduces tools, resources and methodologies from bioinformatics and systems biology, and how to apply these in a systems medicine project. Written for the Methods in Molecular Biology series, chapters include introductions to their respective topics, and discuss experimental and computational approaches, methods, and tools that should be considered for a successful systems medicine project. Systems Medicine aims to motivate and provide guidance for collaborations across disciplines to tackle today's challenges related to human health and well-being.

Systems Medicine

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Publisher : Academic Press
ISBN 13 : 0128160780
Total Pages : 1571 pages
Book Rating : 4.1/5 (281 download)

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Book Synopsis Systems Medicine by :

Download or read book Systems Medicine written by and published by Academic Press. This book was released on 2020-08-24 with total page 1571 pages. Available in PDF, EPUB and Kindle. Book excerpt: Technological advances in generated molecular and cell biological data are transforming biomedical research. Sequencing, multi-omics and imaging technologies are likely to have deep impact on the future of medical practice. In parallel to technological developments, methodologies to gather, integrate, visualize and analyze heterogeneous and large-scale data sets are needed to develop new approaches for diagnosis, prognosis and therapy. Systems Medicine: Integrative, Qualitative and Computational Approaches is an innovative, interdisciplinary and integrative approach that extends the concept of systems biology and the unprecedented insights that computational methods and mathematical modeling offer of the interactions and network behavior of complex biological systems, to novel clinically relevant applications for the design of more successful prognostic, diagnostic and therapeutic approaches. This 3 volume work features 132 entries from renowned experts in the fields and covers the tools, methods, algorithms and data analysis workflows used for integrating and analyzing multi-dimensional data routinely generated in clinical settings with the aim of providing medical practitioners with robust clinical decision support systems. Importantly the work delves into the applications of systems medicine in areas such as tumor systems biology, metabolic and cardiovascular diseases as well as immunology and infectious diseases amongst others. This is a fundamental resource for biomedical students and researchers as well as medical practitioners who need to need to adopt advances in computational tools and methods into the clinical practice. Encyclopedic coverage: ‘one-stop’ resource for access to information written by world-leading scholars in the field of Systems Biology and Systems Medicine, with easy cross-referencing of related articles to promote understanding and further research Authoritative: the whole work is authored and edited by recognized experts in the field, with a range of different expertise, ensuring a high quality standard Digitally innovative: Hyperlinked references and further readings, cross-references and diagrams/images will allow readers to easily navigate a wealth of information

Network Medicine

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Publisher : Harvard University Press
ISBN 13 : 0674436539
Total Pages : 449 pages
Book Rating : 4.6/5 (744 download)

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Book Synopsis Network Medicine by : Joseph Loscalzo

Download or read book Network Medicine written by Joseph Loscalzo and published by Harvard University Press. This book was released on 2017-02-01 with total page 449 pages. Available in PDF, EPUB and Kindle. Book excerpt: Big data, genomics, and quantitative approaches to network-based analysis are combining to advance the frontiers of medicine as never before. With contributions from leading experts, Network Medicine introduces this rapidly evolving field of research, which promises to revolutionize the diagnosis and treatment of human diseases.

Systematic

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Publisher : Bloomsbury Publishing USA
ISBN 13 : 1632860317
Total Pages : 289 pages
Book Rating : 4.6/5 (328 download)

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Book Synopsis Systematic by : James R. Valcourt

Download or read book Systematic written by James R. Valcourt and published by Bloomsbury Publishing USA. This book was released on 2017-02-07 with total page 289 pages. Available in PDF, EPUB and Kindle. Book excerpt: A brilliant young scientist introduces us to the fascinating field that is changing our understanding of how the body works and the way we can approach healing. SYSTEMATIC is the first book to introduce general readers to systems biology, which is improving medical treatments and our understanding of living things. In traditional bottom-up biology, a biologist might spend years studying how a single protein works, but systems biology studies how networks of those proteins work together--how they promote health and how to remedy the situation when the system isn't functioning properly. Breakthroughs in systems biology became possible only when powerful computer technology enabled researchers to process massive amounts of data to study complete systems, and has led to progress in the study of gene regulation and inheritance, cancer drugs personalized to an individual's genetically unique tumor, insights into how the brain works, and the discovery that the bacteria and other microbes that live in the gut may drive malnutrition and obesity. Systems biology is allowing us to understand more complex phenomena than ever before. In accessible prose, SYSTEMATIC sheds light not only on how systems within the body work, but also on how research is yielding new kinds of remedies that enhance and harness the body's own defenses.

Temporal Information Systems in Medicine

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Publisher : Springer Science & Business Media
ISBN 13 : 1441965432
Total Pages : 398 pages
Book Rating : 4.4/5 (419 download)

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Book Synopsis Temporal Information Systems in Medicine by : Carlo Combi

Download or read book Temporal Information Systems in Medicine written by Carlo Combi and published by Springer Science & Business Media. This book was released on 2010-05-25 with total page 398 pages. Available in PDF, EPUB and Kindle. Book excerpt: Temporal Information Systems in Medicine introduces the engineering of information systems for medically-related problems and applications. The chapters are organized into four parts; fundamentals, temporal reasoning & maintenance in medicine, time in clinical tasks, and the display of time-oriented clinical information. The chapters are self-contained with pointers to other relevant chapters or sections in this book when necessary. Time is of central importance and is a key component of the engineering process for information systems. This book is designed as a secondary text or reference book for upper -undergraduate level students and graduate level students concentrating on computer science, biomedicine and engineering. Industry professionals and researchers working in health care management, information systems in medicine, medical informatics, database management and AI will also find this book a valuable asset.

Complex Systems in Medicine

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Publisher : Springer Nature
ISBN 13 : 3030245934
Total Pages : 255 pages
Book Rating : 4.0/5 (32 download)

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Book Synopsis Complex Systems in Medicine by : David C. Aron

Download or read book Complex Systems in Medicine written by David C. Aron and published by Springer Nature. This book was released on 2019-08-30 with total page 255 pages. Available in PDF, EPUB and Kindle. Book excerpt: This unique title explores complex systems in clinical medicine and the subsequent implementation of that knowledge into practice. Written conversationally and as a reflection on the journey of learning about complex systems, the book explores how knowledge of these systems can be applied to four key roles in academic medicine: clinical practice, education, research, and administration. Further, this title emphasizes how gaining an understanding of complex systems can greatly help a physician deal with the many challenges found in academic medicine. Unlike other books on complexity in medicine, which tend to focus on only one aspect of the management of patients, Complex Systems in Medicine deals with the multifaceted roles of a physician. The approach in this book is uniquely qualitative rather than mathematical, and is written to make it not only of interest to physicians, trainees, and allied health providers, but also to make it more accessible to a non-medical audience. The inclusion of personal anecdotes by the author provides concrete examples of the application of knowledge of complex systems in academic medicine. A first-of-its-kind contribution to the literature, Complex Systems in Medicine: A Hedgehog’s Tale of Complexity in Clinical Practice, Research, Education, and Management is not only a novel reference for medical professionals, it is an accessible tool for the non-medical audience hoping to learn more about complex systems and their direct relevance to medicine, a field that deals with the infinite variety of humans and their ills. It illustrates the consequences of the interactive elements of patient care that make medicine both a science and an art.

From Systems Biology to Systems Medicine

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Publisher :
ISBN 13 : 9781536179606
Total Pages : 252 pages
Book Rating : 4.1/5 (796 download)

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Book Synopsis From Systems Biology to Systems Medicine by : James A. Marcum

Download or read book From Systems Biology to Systems Medicine written by James A. Marcum and published by . This book was released on 2020-07-09 with total page 252 pages. Available in PDF, EPUB and Kindle. Book excerpt: Throughout most of the twentieth century, the biomedical model dominated healthcare. However, the biomedical model had its critics, who proposed alternative models to replace it. Eventually, biomedicine became fragmented at its foundations with a variety of approaches to its nature and practice. Medicine's current response to this fragmentation is to combine these disparate approaches into a single system--systems medicine. In the present book, I examine the shift, during the postgenomics era, from the biomedical model to systems medicine vis-à-vis systems biology, as well as the challenges facing systems medicine's implementation in the twenty-first century. The main goal of the present book is to provide a disciplinary framework for examining the rise of systems medicine, especially in terms of the incorporation of systems biology into the biomedical model. To realize that goal, the following questions are addressed. What is a disciplinary framework? And, why is this framework important for understanding systems biology and medicine? Briefly, a disciplinary framework represents the relational structure among disparate disciplines that support and ground a discipline and its corpus. For traditional biology and medicine, that framework consists of various disciplines within the biological and biomedical sciences, including physiology, neuroscience, pathology, and epidemiology--to name a few. For the present purpose, systems biology within the last several decades is reshaping the disciplinary framework of the biological and biomedical sciences, which is also responsible for the emergence of systems medicine. In addition, the challenges facing systems medicine, especially its operationalization and implementation with respect to medical education and practice, as well as research, are also explored.

Translational Systems Medicine and Oral Disease

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Publisher : Academic Press
ISBN 13 : 0128137630
Total Pages : 458 pages
Book Rating : 4.1/5 (281 download)

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Book Synopsis Translational Systems Medicine and Oral Disease by : Stephen Sonis

Download or read book Translational Systems Medicine and Oral Disease written by Stephen Sonis and published by Academic Press. This book was released on 2019-09-14 with total page 458 pages. Available in PDF, EPUB and Kindle. Book excerpt: Translational Systems Medicine and Oral Disease bridges the gap between discovery science and clinical oral medicine, providing opportunities for both the scientific and clinical communities to understand how to apply recent findings in cell biology, genomic profiling, and systems medicine to favorably impact the diagnosis, treatment and management of oral diseases. Fully illustrated chapters from leading international contributors explore clinical applications of genomics, proteomics, metabolomics, microbiomics and epigenetics, as well as analytic methods and functional omics in oral medicine. Disease specific chapters detail systems approaches to periodontal disease, salivary gland diseases, oral cancer, bone disease, and autoimmune disease, among others. In addition, the book emphasizes biological synergisms across disciplines and their translational impact for clinicians, researchers and students in the fields of dentistry, dermatology, gastroenterology, otolaryngology, oncology and primary care. Presents the work of leading international researchers and clinicians who speak on the clinical applications of genomics, proteomics, metabolomics, microbiomics, and epigenetics, as well as analytic methods and functional omics in oral medicine Provides full-color, richly illustrated chapters that examine systems approaches to periodontal disease, salivary gland diseases, oral cancer, bone disease and autoimmune diseases Includes clinical case studies that illustrate examples of oral disease diagnostics and management, highlighting points of key importance for the reader Emphasizes biological synergisms across disciplines and their translational impact for clinicians, researchers, and students in the fields of dentistry, dermatology, gastroenterology, otolaryngology, oncology, and primary care

To Err Is Human

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Publisher : National Academies Press
ISBN 13 : 0309068371
Total Pages : 312 pages
Book Rating : 4.3/5 (9 download)

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Book Synopsis To Err Is Human by : Institute of Medicine

Download or read book To Err Is Human written by Institute of Medicine and published by National Academies Press. This book was released on 2000-03-01 with total page 312 pages. Available in PDF, EPUB and Kindle. Book excerpt: Experts estimate that as many as 98,000 people die in any given year from medical errors that occur in hospitals. That's more than die from motor vehicle accidents, breast cancer, or AIDSâ€"three causes that receive far more public attention. Indeed, more people die annually from medication errors than from workplace injuries. Add the financial cost to the human tragedy, and medical error easily rises to the top ranks of urgent, widespread public problems. To Err Is Human breaks the silence that has surrounded medical errors and their consequenceâ€"but not by pointing fingers at caring health care professionals who make honest mistakes. After all, to err is human. Instead, this book sets forth a national agendaâ€"with state and local implicationsâ€"for reducing medical errors and improving patient safety through the design of a safer health system. This volume reveals the often startling statistics of medical error and the disparity between the incidence of error and public perception of it, given many patients' expectations that the medical profession always performs perfectly. A careful examination is made of how the surrounding forces of legislation, regulation, and market activity influence the quality of care provided by health care organizations and then looks at their handling of medical mistakes. Using a detailed case study, the book reviews the current understanding of why these mistakes happen. A key theme is that legitimate liability concerns discourage reporting of errorsâ€"which begs the question, "How can we learn from our mistakes?" Balancing regulatory versus market-based initiatives and public versus private efforts, the Institute of Medicine presents wide-ranging recommendations for improving patient safety, in the areas of leadership, improved data collection and analysis, and development of effective systems at the level of direct patient care. To Err Is Human asserts that the problem is not bad people in health careâ€"it is that good people are working in bad systems that need to be made safer. Comprehensive and straightforward, this book offers a clear prescription for raising the level of patient safety in American health care. It also explains how patients themselves can influence the quality of care that they receive once they check into the hospital. This book will be vitally important to federal, state, and local health policy makers and regulators, health professional licensing officials, hospital administrators, medical educators and students, health caregivers, health journalists, patient advocatesâ€"as well as patients themselves. First in a series of publications from the Quality of Health Care in America, a project initiated by the Institute of Medicine

The Learning Healthcare System

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Publisher : National Academies Press
ISBN 13 : 0309133939
Total Pages : 374 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis The Learning Healthcare System by : Institute of Medicine

Download or read book The Learning Healthcare System written by Institute of Medicine and published by National Academies Press. This book was released on 2007-06-01 with total page 374 pages. Available in PDF, EPUB and Kindle. Book excerpt: As our nation enters a new era of medical science that offers the real prospect of personalized health care, we will be confronted by an increasingly complex array of health care options and decisions. The Learning Healthcare System considers how health care is structured to develop and to apply evidence-from health profession training and infrastructure development to advances in research methodology, patient engagement, payment schemes, and measurement-and highlights opportunities for the creation of a sustainable learning health care system that gets the right care to people when they need it and then captures the results for improvement. This book will be of primary interest to hospital and insurance industry administrators, health care providers, those who train and educate health workers, researchers, and policymakers. The Learning Healthcare System is the first in a series that will focus on issues important to improving the development and application of evidence in health care decision making. The Roundtable on Evidence-Based Medicine serves as a neutral venue for cooperative work among key stakeholders on several dimensions: to help transform the availability and use of the best evidence for the collaborative health care choices of each patient and provider; to drive the process of discovery as a natural outgrowth of patient care; and, ultimately, to ensure innovation, quality, safety, and value in health care.

Practical Predictive Analytics and Decisioning Systems for Medicine

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Publisher : Academic Press
ISBN 13 : 012411640X
Total Pages : 1111 pages
Book Rating : 4.1/5 (241 download)

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Book Synopsis Practical Predictive Analytics and Decisioning Systems for Medicine by : Gary D. Miner

Download or read book Practical Predictive Analytics and Decisioning Systems for Medicine written by Gary D. Miner and published by Academic Press. This book was released on 2014-09-27 with total page 1111 pages. Available in PDF, EPUB and Kindle. Book excerpt: With the advent of electronic medical records years ago and the increasing capabilities of computers, our healthcare systems are sitting on growing mountains of data. Not only does the data grow from patient volume but the type of data we store is also growing exponentially. Practical Predictive Analytics and Decisioning Systems for Medicine provides research tools to analyze these large amounts of data and addresses some of the most pressing issues and challenges where data integrity is compromised: patient safety, patient communication, and patient information. Through the use of predictive analytic models and applications, this book is an invaluable resource to predict more accurate outcomes to help improve quality care in the healthcare and medical industries in the most cost–efficient manner.Practical Predictive Analytics and Decisioning Systems for Medicine provides the basics of predictive analytics for those new to the area and focuses on general philosophy and activities in the healthcare and medical system. It explains why predictive models are important, and how they can be applied to the predictive analysis process in order to solve real industry problems. Researchers need this valuable resource to improve data analysis skills and make more accurate and cost-effective decisions. Includes models and applications of predictive analytics why they are important and how they can be used in healthcare and medical research Provides real world step-by-step tutorials to help beginners understand how the predictive analytic processes works and to successfully do the computations Demonstrates methods to help sort through data to make better observations and allow you to make better predictions

Systems Medicine For Human Spaceflight

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Publisher : World Scientific
ISBN 13 : 9811287708
Total Pages : 369 pages
Book Rating : 4.8/5 (112 download)

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Book Synopsis Systems Medicine For Human Spaceflight by : Mark J Shelhamer

Download or read book Systems Medicine For Human Spaceflight written by Mark J Shelhamer and published by World Scientific. This book was released on 2024-03-19 with total page 369 pages. Available in PDF, EPUB and Kindle. Book excerpt: This edited volume makes the case that a systems approach is needed for long-term spaceflight missions. Due to distance from Earth and the impossibility of resupply or rapid return, these flights will entail unprecedented autonomy on the part of the crew. This autonomy includes the need for local clinical decision support and other assistance with urgent medical concerns. The advantage of a systems approach to medical needs in human spaceflight is that it enables a systematic and repeatable methodology for identifying and developing the individual pieces of the spacecraft systems based on the human system needs that are unique to that problem and environment.The book begins by introducing a systems basis for thinking about humans in space. It describes existing models and paradigms of systems medicine, as well as the tools and analytical approaches involved. A tantalizing peek at preliminary applications of systems medicine in NASA is provided. As systems in human spaceflight continue to evolve for the foreseeable future, it is argued that a systems approach will help to ensure that the evolution of the relevant sub-systems is centered on optimal human-system function across the unique spaceflight needs of the developing customer base. The discussions on balancing the needs of the mission versus the maintenance of crew health, medical risk and liability for commercial spaceflights, and the need to anticipate what the next medical issues might be, will hopefully leave readers cautiously optimistic about this new frontier of applied science.

Applications of Dynamical Systems in Biology and Medicine

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Publisher : Springer
ISBN 13 : 1493927825
Total Pages : 240 pages
Book Rating : 4.4/5 (939 download)

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Book Synopsis Applications of Dynamical Systems in Biology and Medicine by : Trachette Jackson

Download or read book Applications of Dynamical Systems in Biology and Medicine written by Trachette Jackson and published by Springer. This book was released on 2015-07-06 with total page 240 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume highlights problems from a range of biological and medical applications that can be interpreted as questions about system behavior or control. Topics include drug resistance in cancer and malaria, biological fluid dynamics, auto-regulation in the kidney, anti-coagulation therapy, evolutionary diversification and photo-transduction. Mathematical techniques used to describe and investigate these biological and medical problems include ordinary, partial and stochastic differentiation equations, hybrid discrete-continuous approaches, as well as 2 and 3D numerical simulation.

Recommender Systems for Medicine and Music

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Publisher : Springer Nature
ISBN 13 : 3030664503
Total Pages : 236 pages
Book Rating : 4.0/5 (36 download)

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Book Synopsis Recommender Systems for Medicine and Music by : Zbigniew W. Ras

Download or read book Recommender Systems for Medicine and Music written by Zbigniew W. Ras and published by Springer Nature. This book was released on 2021-04-07 with total page 236 pages. Available in PDF, EPUB and Kindle. Book excerpt: Music recommendation systems are becoming more and more popular. The increasing amount of personal data left by users on social media contributes to more accurate inference of the user’s musical preferences and the same to quality of personalized systems. Health recommendation systems have become indispensable tools in decision making processes in the healthcare sector. Their main objective is to ensure the availability of valuable information at the right time by ensuring information quality, trustworthiness, authentication, and privacy concerns. Medical doctors deal with various kinds of diseases in which the music therapy helps to improve symptoms. Listening to music may improve heart rate, respiratory rate, and blood pressure in people with heart disease. Sound healing therapy uses aspects of music to improve physical and emotional health and well-being. The book presents a variety of approaches useful to create recommendation systems in healthcare, music, and in music therapy.

Modeling Methods for Medical Systems Biology

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Publisher :
ISBN 13 : 9783319893556
Total Pages : 258 pages
Book Rating : 4.8/5 (935 download)

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Book Synopsis Modeling Methods for Medical Systems Biology by : María Elena Álvarez-Buylla Roces

Download or read book Modeling Methods for Medical Systems Biology written by María Elena Álvarez-Buylla Roces and published by . This book was released on 2018 with total page 258 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book contributes to better understand how lifestyle modulations can effectively halt the emergence and progression of human diseases. The book will allow the reader to gain a better understanding of the mechanisms by which the environment interferes with the bio-molecular regulatory processes underlying the emergence and progression of complex diseases, such as cancer. Focusing on key and early cellular bio-molecular events giving rise to the emergence of degenerative chronic disease, it builds on previous experience on the development of multi-cellular organisms, to propose a mathematical and computer based framework that allows the reader to analyze the complex interplay between bio-molecular processes and the (micro)-environment from an integrative, mechanistic, quantitative and dynamical perspective. Taking the wealth of empirical evidence that exists it will show how to build and analyze models of core regulatory networks involved in the emergence and progression of chronic degenerative diseases, using a bottom-up approach.

Systems Biology for Traditional Chinese Medicine

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Publisher : John Wiley & Sons
ISBN 13 : 1118313356
Total Pages : 518 pages
Book Rating : 4.1/5 (183 download)

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Book Synopsis Systems Biology for Traditional Chinese Medicine by : Guoan Luo

Download or read book Systems Biology for Traditional Chinese Medicine written by Guoan Luo and published by John Wiley & Sons. This book was released on 2012-05-11 with total page 518 pages. Available in PDF, EPUB and Kindle. Book excerpt: The application of systems biology methods to Traditional Chinese Medicine Emphasizing the harmony of the human body with the environment, Traditional Chinese Medicine (TCM) has evolved over thousands of years. It is a systemic theory derived from clinical experience, the philosophy of holism and systematology, and the belief that man is an integral part of nature. Systems Biology for Traditional Chinese Medicine describes how the latest methods in systems biology can be applied to TCM, providing a comprehensive resource for the modernization and advancement of TCM as well as general drug discovery efforts. It is the first comprehensive work to propose a system-to-system research methodology to study the interaction between TCM and the human body and its applications in drug research and development. Using three popular traditional Chinese medicines—Shuanglongfang, Qingkailing, and Liushenwan—as examples, the authors set forth case examples demonstrating how to find material groups, perform efficacy screenings, and conduct safety evaluations of TCM. The book also: Describes the mechanisms of TCM at the molecular and systems levels using chemomics, genomics, proteomics, metabolomics, and bioinformatics Places modern scientific technologies within the context of TCM, helping drug researchers improve experimental designs and strategies Illustrates how a systems biology approach is compatible with TCM's traditional, holistic therapeutic strategies and treatment modalities Presents topics of current interest, such as integrated global systems biology and the application of chemometrics research to herbal medicines This book not only opens a new pathway for the continued development of TCM, but also for systems biology. In addition, it fosters collaboration and discussion among Eastern and Western scientists by applying systems biology to TCM.

Handbook of Research on Systems Biology Applications in Medicine

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Author :
Publisher : IGI Global
ISBN 13 : 1605660779
Total Pages : 982 pages
Book Rating : 4.6/5 (56 download)

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Book Synopsis Handbook of Research on Systems Biology Applications in Medicine by : Daskalaki, Andriani

Download or read book Handbook of Research on Systems Biology Applications in Medicine written by Daskalaki, Andriani and published by IGI Global. This book was released on 2008-11-30 with total page 982 pages. Available in PDF, EPUB and Kindle. Book excerpt: "This book highlights the use of systems approaches including genomic, cellular, proteomic, metabolomic, bioinformatics, molecular, and biochemical, to address fundamental questions in complex diseases like cancer diabetes but also in ageing"--Provided by publisher.