Systems Biology And Machine Learning Analytics For Single Cell Rna Sequencing And Skin Microbiome Data

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Systems Medicine

Author :
Publisher : Academic Press
ISBN 13 : 0128160780
Total Pages : 1571 pages
Book Rating : 4.1/5 (281 download)

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Book Synopsis Systems Medicine by :

Download or read book Systems Medicine written by and published by Academic Press. This book was released on 2020-08-24 with total page 1571 pages. Available in PDF, EPUB and Kindle. Book excerpt: Technological advances in generated molecular and cell biological data are transforming biomedical research. Sequencing, multi-omics and imaging technologies are likely to have deep impact on the future of medical practice. In parallel to technological developments, methodologies to gather, integrate, visualize and analyze heterogeneous and large-scale data sets are needed to develop new approaches for diagnosis, prognosis and therapy. Systems Medicine: Integrative, Qualitative and Computational Approaches is an innovative, interdisciplinary and integrative approach that extends the concept of systems biology and the unprecedented insights that computational methods and mathematical modeling offer of the interactions and network behavior of complex biological systems, to novel clinically relevant applications for the design of more successful prognostic, diagnostic and therapeutic approaches. This 3 volume work features 132 entries from renowned experts in the fields and covers the tools, methods, algorithms and data analysis workflows used for integrating and analyzing multi-dimensional data routinely generated in clinical settings with the aim of providing medical practitioners with robust clinical decision support systems. Importantly the work delves into the applications of systems medicine in areas such as tumor systems biology, metabolic and cardiovascular diseases as well as immunology and infectious diseases amongst others. This is a fundamental resource for biomedical students and researchers as well as medical practitioners who need to need to adopt advances in computational tools and methods into the clinical practice. Encyclopedic coverage: ‘one-stop’ resource for access to information written by world-leading scholars in the field of Systems Biology and Systems Medicine, with easy cross-referencing of related articles to promote understanding and further research Authoritative: the whole work is authored and edited by recognized experts in the field, with a range of different expertise, ensuring a high quality standard Digitally innovative: Hyperlinked references and further readings, cross-references and diagrams/images will allow readers to easily navigate a wealth of information

Microbiome Analysis

Author : Robert G. Beiko
Publisher :
ISBN 13 : 9781493987283
Total Pages : 324 pages
Book Rating : 4.9/5 (872 download)

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Book Synopsis Microbiome Analysis by : Robert G. Beiko

Download or read book Microbiome Analysis written by Robert G. Beiko and published by . This book was released on 2018 with total page 324 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Big Data and Artificial Intelligence for Healthcare Applications

Author : Ankur Saxena
Publisher : CRC Press
ISBN 13 : 1000387313
Total Pages : 287 pages
Book Rating : 4.0/5 (3 download)

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Book Synopsis Big Data and Artificial Intelligence for Healthcare Applications by : Ankur Saxena

Download or read book Big Data and Artificial Intelligence for Healthcare Applications written by Ankur Saxena and published by CRC Press. This book was released on 2021-06-14 with total page 287 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book covers a wide range of topics on the role of Artificial Intelligence, Machine Learning, and Big Data for healthcare applications and deals with the ethical issues and concerns associated with it. This book explores the applications in different areas of healthcare and highlights the current research. "Big Data and Artificial Intelligence for Healthcare Applications" covers healthcare big data analytics, mobile health and personalized medicine, clinical trial data management and presents how Artificial Intelligence can be used for early disease diagnosis prediction and prognosis. It also offers some case studies that describes the application of Artificial Intelligence and Machine Learning in healthcare. Researchers, healthcare professionals, data scientists, systems engineers, students, programmers, clinicians, and policymakers will find this book of interest.

Machine Learning with SVM and Other Kernel Methods

Author : K.P. Soman
Publisher : PHI Learning Pvt. Ltd.
ISBN 13 : 8120334353
Total Pages : 495 pages
Book Rating : 4.1/5 (23 download)

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Book Synopsis Machine Learning with SVM and Other Kernel Methods by : K.P. Soman

Download or read book Machine Learning with SVM and Other Kernel Methods written by K.P. Soman and published by PHI Learning Pvt. Ltd.. This book was released on 2009-02-02 with total page 495 pages. Available in PDF, EPUB and Kindle. Book excerpt: Support vector machines (SVMs) represent a breakthrough in the theory of learning systems. It is a new generation of learning algorithms based on recent advances in statistical learning theory. Designed for the undergraduate students of computer science and engineering, this book provides a comprehensive introduction to the state-of-the-art algorithm and techniques in this field. It covers most of the well known algorithms supplemented with code and data. One Class, Multiclass and hierarchical SVMs are included which will help the students to solve any pattern classification problems with ease and that too in Excel. KEY FEATURES  Extensive coverage of Lagrangian duality and iterative methods for optimization  Separate chapters on kernel based spectral clustering, text mining, and other applications in computational linguistics and speech processing  A chapter on latest sequential minimization algorithms and its modifications to do online learning  Step-by-step method of solving the SVM based classification problem in Excel.  Kernel versions of PCA, CCA and ICA The CD accompanying the book includes animations on solving SVM training problem in Microsoft EXCEL and by using SVMLight software . In addition, Matlab codes are given for all the formulations of SVM along with the data sets mentioned in the exercise section of each chapter.

Advances in methods and tools for multi-omics data analysis

Author : Ornella Cominetti
Publisher : Frontiers Media SA
ISBN 13 : 2832523420
Total Pages : 184 pages
Book Rating : 4.8/5 (325 download)

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Book Synopsis Advances in methods and tools for multi-omics data analysis by : Ornella Cominetti

Download or read book Advances in methods and tools for multi-omics data analysis written by Ornella Cominetti and published by Frontiers Media SA. This book was released on 2023-05-12 with total page 184 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Artificial Intelligence for Information Management: A Healthcare Perspective

Author : K. G. Srinivasa
Publisher : Springer Nature
ISBN 13 : 9811604150
Total Pages : 332 pages
Book Rating : 4.8/5 (116 download)

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Book Synopsis Artificial Intelligence for Information Management: A Healthcare Perspective by : K. G. Srinivasa

Download or read book Artificial Intelligence for Information Management: A Healthcare Perspective written by K. G. Srinivasa and published by Springer Nature. This book was released on 2021-05-20 with total page 332 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book discusses the advancements in artificial intelligent techniques used in the well-being of human healthcare. It details the techniques used in collection, storage and analysis of data and their usage in different healthcare solutions. It also discusses the techniques of predictive analysis in early diagnosis of critical diseases. The edited book is divided into four parts – part A discusses introduction to artificial intelligence and machine learning in healthcare; part B highlights different analytical techniques used in healthcare; part C provides various security and privacy mechanisms used in healthcare; and finally, part D exemplifies different tools used in visualization and data analytics.

Deep Learning in Biology and Medicine

Author : Davide Bacciu
Publisher : World Scientific Publishing Europe Limited
ISBN 13 : 9781800610934
Total Pages : 0 pages
Book Rating : 4.6/5 (19 download)

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Book Synopsis Deep Learning in Biology and Medicine by : Davide Bacciu

Download or read book Deep Learning in Biology and Medicine written by Davide Bacciu and published by World Scientific Publishing Europe Limited. This book was released on 2021 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Biology, medicine and biochemistry have become data-centric fields for which Deep Learning methods are delivering groundbreaking results. Addressing high impact challenges, Deep Learning in Biology and Medicine provides an accessible and organic collection of Deep Learning essays on bioinformatics and medicine. It caters for a wide readership, ranging from machine learning practitioners and data scientists seeking methodological knowledge to address biomedical applications, to life science specialists in search of a gentle reference for advanced data analytics.With contributions from internationally renowned experts, the book covers foundational methodologies in a wide spectrum of life sciences applications, including electronic health record processing, diagnostic imaging, text processing, as well as omics-data processing. This survey of consolidated problems is complemented by a selection of advanced applications, including cheminformatics and biomedical interaction network analysis. A modern and mindful approach to the use of data-driven methodologies in the life sciences also requires careful consideration of the associated societal, ethical, legal and transparency challenges, which are covered in the concluding chapters of this book.

Applications of RNA-Seq in Biology and Medicine

Author : Irina Vlasova-St. Louis
Publisher : BoD – Books on Demand
ISBN 13 : 1839626860
Total Pages : 144 pages
Book Rating : 4.8/5 (396 download)

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Book Synopsis Applications of RNA-Seq in Biology and Medicine by : Irina Vlasova-St. Louis

Download or read book Applications of RNA-Seq in Biology and Medicine written by Irina Vlasova-St. Louis and published by BoD – Books on Demand. This book was released on 2021-10-13 with total page 144 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book evaluates and comprehensively summarizes the scientific findings that have been achieved through RNA-sequencing (RNA-Seq) technology. RNA-Seq transcriptome profiling of healthy and diseased tissues allows FOR understanding the alterations in cellular phenotypes through the expression of differentially spliced RNA isoforms. Assessment of gene expression by RNA-Seq provides new insight into host response to pathogens, drugs, allergens, and other environmental triggers. RNA-Seq allows us to accurately capture all subtypes of RNA molecules, in any sequenced organism or single-cell type, under different experimental conditions. Merging genomics and transcriptomic profiling provides novel information underlying causative DNA mutations. Combining RNA-Seq with immunoprecipitation and cross-linking techniques is a clever multi-omics strategy assessing transcriptional, post-transcriptional and post-translational levels of gene expression regulation.

Handbook of Molecular Biotechnology

Author : Dongyou Liu
Publisher : CRC Press
ISBN 13 : 1040005640
Total Pages : 763 pages
Book Rating : 4.0/5 (4 download)

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Book Synopsis Handbook of Molecular Biotechnology by : Dongyou Liu

Download or read book Handbook of Molecular Biotechnology written by Dongyou Liu and published by CRC Press. This book was released on 2024-09-05 with total page 763 pages. Available in PDF, EPUB and Kindle. Book excerpt: With a history that likely dates back to the dawn of human civilization more than 10,000 years ago, and a record that includes the domestication and selective breeding of plants and animals, the harnessing of fermentation process for bread, cheese, and brewage production, and the development of vaccines against infectious diseases, biotechnology has acquired a molecular focus during the 20th century, particularly following the resolution of DNA double helix in 1953, and the publication of DNA cloning protocol in 1973, and transformed our concepts and practices in disease diagnosis, treatment and prevention, pharmaceutical and industrial manufacturing, animal and plant industry, and food processing. While molecular biotechnology offers unlimited opportunities for improving human health and well-being, animal welfare, agricultural innovation and environmental conservation, a dearth of high quality books that have the clarity of laboratory manuals without distractive procedural details and the thoroughness of well-conversed textbooks appears to dampen the enthusiasm of aspiring students. In attempt to fill this glaring gap, Handbook of Molecular Biotechnology includes four sections, with the first three presenting in-depth coverage on DNA, RNA and protein technologies, and the fourth highlighting their utility in biotechnology. Recognizing the importance of logical reasoning and experimental verification over direct observation and simple description in biotechnological research and development, the Introduction provides pertinent discussions on key strategies (i.e., be first, be better, and be different), effective thinking (lateral, parallel, causal, reverse, and random), and experimental execution, which have proven invaluable in helping advance research projects, evaluate and prepare research reports, and enhance other scientific endeavors. Key features Presents state-of-the-art reviews on DNA, RNA and protein technologies and their biotechnological applications Discusses key strategies, effective thinking, and experimental execution for scientific research and development Fills the gap left by detailed-ridden laboratory manuals and insight-lacking standard textbooks Includes expert contributions from international scientists at the forefront of molecular biotechnology research and development Written by international scientists at the forefront of molecular biotechnology research and development, chapters in this volume cover the histories, principles, and applications of individual techniques/technologies, and constitute stand-alone, yet interlinked lectures that strive to educate as well as to entertain. Besides providing an informative textbook for tertiary students in molecular biotechnology and related fields, this volume serves as an indispensable roadmap for novice scientists in their efforts to acquire innovative skills and establish solid track records in molecular biotechnology, and offers a contemporary reference for scholars, educators, and policymakers wishing to keep in touch with recent developments in molecular biotechnology.

Volatiles and Metabolites of Microbes

Author : Joginder Singh Panwar
Publisher : Academic Press
ISBN 13 : 0323851649
Total Pages : 513 pages
Book Rating : 4.3/5 (238 download)

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Book Synopsis Volatiles and Metabolites of Microbes by : Joginder Singh Panwar

Download or read book Volatiles and Metabolites of Microbes written by Joginder Singh Panwar and published by Academic Press. This book was released on 2021-06-22 with total page 513 pages. Available in PDF, EPUB and Kindle. Book excerpt: Volatiles and Metabolites of Microbes compiles the latest research and advancement in the field of volatiles, metabolites synthesized from the microbial strains such as actinomycetes, bacteria, cyanobacteria, and fungal species and their potential applications in the field of healthcare issue and sustainable agriculture. There is an urgent need to explore new and advanced biological methods for health industries and sustainable agriculture and to protect the environment from environmental pollution or contaminates, global warming, and also control the health of human beings from the side effects of various pharmaceuticals products. Focusing all these factors, Volatiles and Metabolites of Microbes explores new aspects of microorganism in terms of volatiles, enzymes, bioactive compounds synthesized from the microbes and their potential applications in the field of sustainable agriculture and health-related issues - Provides a broad aspect about volatiles, bioactive compounds, and secondary metabolites of microbes compiled in one cover - Gives the latest research and advancement in the field of volatiles, secondary metabolites, and bioactive compounds synthesized from the different microbial strains - Responds to new developments in the detection of the complex compound structures of volatiles - Offers insight to a very broad audience in Biotechnology, Applied Microbiology, Agronomy, and Pathology

The Social Biology of Microbial Communities

Author : Institute of Medicine
Publisher : National Academies Press
ISBN 13 : 0309264324
Total Pages : 633 pages
Book Rating : 4.3/5 (92 download)

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Book Synopsis The Social Biology of Microbial Communities by : Institute of Medicine

Download or read book The Social Biology of Microbial Communities written by Institute of Medicine and published by National Academies Press. This book was released on 2013-01-10 with total page 633 pages. Available in PDF, EPUB and Kindle. Book excerpt: Beginning with the germ theory of disease in the 19th century and extending through most of the 20th century, microbes were believed to live their lives as solitary, unicellular, disease-causing organisms . This perception stemmed from the focus of most investigators on organisms that could be grown in the laboratory as cellular monocultures, often dispersed in liquid, and under ambient conditions of temperature, lighting, and humidity. Most such inquiries were designed to identify microbial pathogens by satisfying Koch's postulates.3 This pathogen-centric approach to the study of microorganisms produced a metaphorical "war" against these microbial invaders waged with antibiotic therapies, while simultaneously obscuring the dynamic relationships that exist among and between host organisms and their associated microorganisms-only a tiny fraction of which act as pathogens. Despite their obvious importance, very little is actually known about the processes and factors that influence the assembly, function, and stability of microbial communities. Gaining this knowledge will require a seismic shift away from the study of individual microbes in isolation to inquiries into the nature of diverse and often complex microbial communities, the forces that shape them, and their relationships with other communities and organisms, including their multicellular hosts. On March 6 and 7, 2012, the Institute of Medicine's (IOM's) Forum on Microbial Threats hosted a public workshop to explore the emerging science of the "social biology" of microbial communities. Workshop presentations and discussions embraced a wide spectrum of topics, experimental systems, and theoretical perspectives representative of the current, multifaceted exploration of the microbial frontier. Participants discussed ecological, evolutionary, and genetic factors contributing to the assembly, function, and stability of microbial communities; how microbial communities adapt and respond to environmental stimuli; theoretical and experimental approaches to advance this nascent field; and potential applications of knowledge gained from the study of microbial communities for the improvement of human, animal, plant, and ecosystem health and toward a deeper understanding of microbial diversity and evolution. The Social Biology of Microbial Communities: Workshop Summary further explains the happenings of the workshop.

The Human Microbiome, Diet, and Health

Author : Food Forum
Publisher : National Academies Press
ISBN 13 : 030926586X
Total Pages : 197 pages
Book Rating : 4.3/5 (92 download)

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Book Synopsis The Human Microbiome, Diet, and Health by : Food Forum

Download or read book The Human Microbiome, Diet, and Health written by Food Forum and published by National Academies Press. This book was released on 2013-02-27 with total page 197 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Food Forum convened a public workshop on February 22-23, 2012, to explore current and emerging knowledge of the human microbiome, its role in human health, its interaction with the diet, and the translation of new research findings into tools and products that improve the nutritional quality of the food supply. The Human Microbiome, Diet, and Health: Workshop Summary summarizes the presentations and discussions that took place during the workshop. Over the two day workshop, several themes covered included: The microbiome is integral to human physiology, health, and disease. The microbiome is arguably the most intimate connection that humans have with their external environment, mostly through diet. Given the emerging nature of research on the microbiome, some important methodology issues might still have to be resolved with respect to undersampling and a lack of causal and mechanistic studies. Dietary interventions intended to have an impact on host biology via their impact on the microbiome are being developed, and the market for these products is seeing tremendous success. However, the current regulatory framework poses challenges to industry interest and investment.

OMICS

Author : Debmalya Barh
Publisher : CRC Press
ISBN 13 : 1466562811
Total Pages : 721 pages
Book Rating : 4.4/5 (665 download)

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Book Synopsis OMICS by : Debmalya Barh

Download or read book OMICS written by Debmalya Barh and published by CRC Press. This book was released on 2013-03-26 with total page 721 pages. Available in PDF, EPUB and Kindle. Book excerpt: With the advent of new technologies and acquired knowledge, the number of fields in omics and their applications in diverse areas are rapidly increasing in the postgenomics era. Such emerging fields—including pharmacogenomics, toxicogenomics, regulomics, spliceomics, metagenomics, and environomics—present budding solutions to combat global challenges in biomedicine, agriculture, and the environment. OMICS: Applications in Biomedical, Agricultural, and Environmental Sciences provides valuable insights into the applications of modern omics technologies to real-world problems in the life sciences. Filling a gap in the literature, it offers a broad, multidisciplinary view of current and emerging applications of omics in a single volume. Written by highly experienced active researchers, each chapter describes a particular area of omics and the associated technologies and applications. Topics covered include: Proteomics, epigenomics, and pharmacogenomics Toxicogenomics and the assessment of environmental pollutants Applications of plant metabolomics Nutrigenomics and its therapeutic applications Microalgal omics and omics approaches in biofuel production Next-generation sequencing and omics technology for transgenic plant analysis Omics approaches in crop improvement Engineering dark-operative chlorophyll synthesis Computational regulomics Omics techniques for the analysis of RNA splicing New fields, including metagenomics, glycomics, and miRNA Breast cancer biomarkers for early detection Environomics strategies for environmental sustainability This timely book explores a wide range of omics application areas in the biomedical, agricultural, and environmental sciences. Throughout, it highlights working solutions as well as open problems and future challenges. Demonstrating the diversity of omics, it introduces readers to state-of-the-art developments and trends in omics-driven research.

Environmental Chemicals, the Human Microbiome, and Health Risk

Author : National Academies of Sciences, Engineering, and Medicine
Publisher : National Academies Press
ISBN 13 : 0309468698
Total Pages : 123 pages
Book Rating : 4.3/5 (94 download)

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Book Synopsis Environmental Chemicals, the Human Microbiome, and Health Risk by : National Academies of Sciences, Engineering, and Medicine

Download or read book Environmental Chemicals, the Human Microbiome, and Health Risk written by National Academies of Sciences, Engineering, and Medicine and published by National Academies Press. This book was released on 2018-03-01 with total page 123 pages. Available in PDF, EPUB and Kindle. Book excerpt: A great number of diverse microorganisms inhabit the human body and are collectively referred to as the human microbiome. Until recently, the role of the human microbiome in maintaining human health was not fully appreciated. Today, however, research is beginning to elucidate associations between perturbations in the human microbiome and human disease and the factors that might be responsible for the perturbations. Studies have indicated that the human microbiome could be affected by environmental chemicals or could modulate exposure to environmental chemicals. Environmental Chemicals, the Human Microbiome, and Health Risk presents a research strategy to improve our understanding of the interactions between environmental chemicals and the human microbiome and the implications of those interactions for human health risk. This report identifies barriers to such research and opportunities for collaboration, highlights key aspects of the human microbiome and its relation to health, describes potential interactions between environmental chemicals and the human microbiome, reviews the risk-assessment framework and reasons for incorporating chemicalâ€"microbiome interactions.

Human Genetics and Genomics

Author : Bruce R. Korf
Publisher : John Wiley & Sons
ISBN 13 : 1118537661
Total Pages : 280 pages
Book Rating : 4.1/5 (185 download)

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Book Synopsis Human Genetics and Genomics by : Bruce R. Korf

Download or read book Human Genetics and Genomics written by Bruce R. Korf and published by John Wiley & Sons. This book was released on 2012-11-19 with total page 280 pages. Available in PDF, EPUB and Kindle. Book excerpt: This fourth edition of the best-selling textbook, Human Genetics and Genomics, clearly explains the key principles needed by medical and health sciences students, from the basis of molecular genetics, to clinical applications used in the treatment of both rare and common conditions. A newly expanded Part 1, Basic Principles of Human Genetics, focuses on introducing the reader to key concepts such as Mendelian principles, DNA replication and gene expression. Part 2, Genetics and Genomics in Medical Practice, uses case scenarios to help you engage with current genetic practice. Now featuring full-color diagrams, Human Genetics and Genomics has been rigorously updated to reflect today’s genetics teaching, and includes updated discussion of genetic risk assessment, “single gene” disorders and therapeutics. Key learning features include: Clinical snapshots to help relate science to practice 'Hot topics' boxes that focus on the latest developments in testing, assessment and treatment 'Ethical issues' boxes to prompt further thought and discussion on the implications of genetic developments 'Sources of information' boxes to assist with the practicalities of clinical research and information provision Self-assessment review questions in each chapter Accompanied by the Wiley E-Text digital edition (included in the price of the book), Human Genetics and Genomics is also fully supported by a suite of online resources at www.korfgenetics.com, including: Factsheets on 100 genetic disorders, ideal for study and exam preparation Interactive Multiple Choice Questions (MCQs) with feedback on all answers Links to online resources for further study Figures from the book available as PowerPoint slides, ideal for teaching purposes The perfect companion to the genetics component of both problem-based learning and integrated medical courses, Human Genetics and Genomics presents the ideal balance between the bio-molecular basis of genetics and clinical cases, and provides an invaluable overview for anyone wishing to engage with this fast-moving discipline.

The New Science of Metagenomics

Author : National Research Council
Publisher : National Academies Press
ISBN 13 : 0309106761
Total Pages : 170 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis The New Science of Metagenomics by : National Research Council

Download or read book The New Science of Metagenomics written by National Research Council and published by National Academies Press. This book was released on 2007-06-24 with total page 170 pages. Available in PDF, EPUB and Kindle. Book excerpt: Although we can't usually see them, microbes are essential for every part of human life-indeed all life on Earth. The emerging field of metagenomics offers a new way of exploring the microbial world that will transform modern microbiology and lead to practical applications in medicine, agriculture, alternative energy, environmental remediation, and many others areas. Metagenomics allows researchers to look at the genomes of all of the microbes in an environment at once, providing a "meta" view of the whole microbial community and the complex interactions within it. It's a quantum leap beyond traditional research techniques that rely on studying-one at a time-the few microbes that can be grown in the laboratory. At the request of the National Science Foundation, five Institutes of the National Institutes of Health, and the Department of Energy, the National Research Council organized a committee to address the current state of metagenomics and identify obstacles current researchers are facing in order to determine how to best support the field and encourage its success. The New Science of Metagenomics recommends the establishment of a "Global Metagenomics Initiative" comprising a small number of large-scale metagenomics projects as well as many medium- and small-scale projects to advance the technology and develop the standard practices needed to advance the field. The report also addresses database needs, methodological challenges, and the importance of interdisciplinary collaboration in supporting this new field.

Biodefense in the Age of Synthetic Biology

Author : National Academies of Sciences, Engineering, and Medicine
Publisher : National Academies Press
ISBN 13 : 0309465184
Total Pages : 189 pages
Book Rating : 4.3/5 (94 download)

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Book Synopsis Biodefense in the Age of Synthetic Biology by : National Academies of Sciences, Engineering, and Medicine

Download or read book Biodefense in the Age of Synthetic Biology written by National Academies of Sciences, Engineering, and Medicine and published by National Academies Press. This book was released on 2019-01-05 with total page 189 pages. Available in PDF, EPUB and Kindle. Book excerpt: Scientific advances over the past several decades have accelerated the ability to engineer existing organisms and to potentially create novel ones not found in nature. Synthetic biology, which collectively refers to concepts, approaches, and tools that enable the modification or creation of biological organisms, is being pursued overwhelmingly for beneficial purposes ranging from reducing the burden of disease to improving agricultural yields to remediating pollution. Although the contributions synthetic biology can make in these and other areas hold great promise, it is also possible to imagine malicious uses that could threaten U.S. citizens and military personnel. Making informed decisions about how to address such concerns requires a realistic assessment of the capabilities that could be misused. Biodefense in the Age of Synthetic Biology explores and envisions potential misuses of synthetic biology. This report develops a framework to guide an assessment of the security concerns related to advances in synthetic biology, assesses the levels of concern warranted for such advances, and identifies options that could help mitigate those concerns.