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Synthetic Studies Towards The Total Synthesis Of Sordaricin
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Book Synopsis Synthetic Studies Towards the Total Synthesis of Sordaricin by : Jacqueline Loiuse Whalley
Download or read book Synthetic Studies Towards the Total Synthesis of Sordaricin written by Jacqueline Loiuse Whalley and published by . This book was released on 1995 with total page 454 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Synthetic Studies Towards the Total Synthesis of Tuberostemonine by : Lilian Ai Cheng Low
Download or read book Synthetic Studies Towards the Total Synthesis of Tuberostemonine written by Lilian Ai Cheng Low and published by . This book was released on 1998 with total page 182 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Synthetic Studies Towards Aruncin B by : Aubert Ribaucourt
Download or read book Synthetic Studies Towards Aruncin B written by Aubert Ribaucourt and published by . This book was released on 2017 with total page 484 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Synthetic Studies Towards the Total Synthesis of Lancifodilactone G. by : Sanil Sreekumar
Download or read book Synthetic Studies Towards the Total Synthesis of Lancifodilactone G. written by Sanil Sreekumar and published by . This book was released on 2011 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: This thesis presents our studies towards the first total synthesis of the novel anti- HIV agent lancifodilactone G, which has a highly unusual aliphatic enol. The first chapter provides a survey of architecturally diverse nortriterpenoids that were isolated from the Schisandraceae family. A proposed biosynthetic pathway for lancifodilactone G and closely related natural products provides a rationale for the formation of the consecutive 7/8/5 fused carbo cycles that are unique to Schisandra nortriterpenoids. Chapter 1 goes on to outline the reported strategies to access the core of lancifodilactone G and concludes with a retrosynthetic analysis proposed by the Evans group, which includes a biosynthetically inspired single-pot polycyclisation reaction. Chapter 2 describes the highly stereocontrolled synthesis of the eastern fragment (F-G rings) using transition metal-mediated Pauson-Khand reaction. This chapter also reviews the metal-mediated diastereoselective Pauson-Khand reaction directed by the stereogenic centre at C2, with the ample illustration to total synthesis. Attempted strategies for the assembly of the bicyclic cyclopentanone motif via a dienyl Pauson-Khand reaction of silicon- and oxygen- tethered diene-enes are presented. The failure of these strategies at different stages of the synthesis resulted in the exploration of a classical Pauson-Khand approach, which successfully furnished the eastern fragment. Finally, a second-generation synthesis is described which provided the fully functionalised eastern fragment with improved efficiency and overall yield. Chapter 3 discusses the successful synthesis of the western fragment (B-C rings) using a diastereoselective [4+3] cycloaddition strategy. Attempted strategies for the synthesis of the key 2,3-disubstituted furan derivative are presented, which was achieved via a hetero Pauson- Khand reaction. This chapter includes a brief account of the classical [4+3] cycloaddition reactions of furans using an in situ generated oxyallyl cation and also employing vinyl carbenoids in the metal-catalysed version. The review also highlights the application of the [4+ 3] cycloaddition reaction in the expeditious assembly of functionalised 7-membered rings that occur in a number of important biologically active natural products. The third chapter goes on to describe the application of these cycloaddition reactions in the synthesis of the fully functionalised western fragment of Lancifodilactone G. Chapter 4 describes a model study aimed at expediting the synthesis of the western fragment using a rhodium-catalysed allylic substitution reaction. A brief mechanistic discussion on unique aspects of the allylic alkylation reaction is illustrated. Chapter 4 concludes by outlining the coupling strategy for eastern and western fragments and the end game studies for the completion of the synthesis of lancifodilactone G.
Book Synopsis Synthetic Studies Towards the Total Synthesis of Norzoanthamine by : Fatima R. Rivas
Download or read book Synthetic Studies Towards the Total Synthesis of Norzoanthamine written by Fatima R. Rivas and published by . This book was released on 2006 with total page 499 pages. Available in PDF, EPUB and Kindle. Book excerpt: The work presented herein is the conclusion of synthetic studies toward the total synthesis of norzoanthamine. This dissertation on the norzoanthamine synthetic studies will be divided into 3 sections: (1) an introduction describing the norzoanthamine family along with their biological significance and previous studies; (2) a stereoselective synthesis of the ABC ring system, and the crucial development of the fully functionalized C ring; (3) a biomimetic approach towards norzoanthamine; which will discuss studies to create the C ring from a polyene system through a Diels-Alder reaction, studies to synthesize the A ring through a sigmatropic rearrangement, studies to generate the BC ring through an intramolecular Diels-Alder reaction from carvone as a chiral pool, development of isocarvone, and studies of 2-acylamino 1,3 dienes as a viable synthon to form the BC ring through a [4+2] cycloaddition reaction.
Book Synopsis Synthetic Studies Towards the Total Synthesis of Phyllanthocin by : Andrew John King
Download or read book Synthetic Studies Towards the Total Synthesis of Phyllanthocin written by Andrew John King and published by . This book was released on 1990 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Synthetic Studies Toward the Total Synthesis of Sirodesmin A by : Daniel James Conatser
Download or read book Synthetic Studies Toward the Total Synthesis of Sirodesmin A written by Daniel James Conatser and published by . This book was released on 1982 with total page 144 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Total Synthesis of Lasionectrin and Synthetic Studies Towards Pestaloxazine A by : Vincent Poral
Download or read book Total Synthesis of Lasionectrin and Synthetic Studies Towards Pestaloxazine A written by Vincent Poral and published by . This book was released on 2016 with total page 267 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Part I. Total Synthesis and Structural Revision of (±)-Tricholomalides A and B. Part II. Synthetic Studies Towards (+)-Cortistatin A by : Zhang Wang
Download or read book Part I. Total Synthesis and Structural Revision of (±)-Tricholomalides A and B. Part II. Synthetic Studies Towards (+)-Cortistatin A written by Zhang Wang and published by . This book was released on 2011 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: The first part describes the total synthesis and structural revision of (±)-tricholomalides A and B. The synthetic strategy started from a homo-Robinson annulation, followed by a ketene-olefin [2+2] cycloaddition to introduce the lactone ring. Then a Grignard-type reaction appended the isopropenyl moiety, and the synthesis of tricholomalides A and B was achieved. During the course of synthesis, the structures of tricholomalides A and B were revised. The second part describes the synthetic studies towards (+)-cortistatin A, especially the A ring functionalization. The C3 nitrogen was introduced by azide displacement, and C2 hydroxyl was built up by Luche reduction. The challenging C1 functionalization was achieved with bromine-induced methoxymethyl deprotection, and some interesting chemistry was found in this system. The synthetic endeavor set a promising stage for the total synthesis of cortistatin A.
Book Synopsis Synthetic Studies Directed Towards the Total Synthesis of Penitrem D. by : Peter V. Zawada
Download or read book Synthetic Studies Directed Towards the Total Synthesis of Penitrem D. written by Peter V. Zawada and published by . This book was released on 2006 with total page 728 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Protecting Group Free Total Synthesis of (-)-palmyrolide A and Synthetic Studies Towards the Syntheses of Taumycin A by : Tara Devi Newar
Download or read book Protecting Group Free Total Synthesis of (-)-palmyrolide A and Synthetic Studies Towards the Syntheses of Taumycin A written by Tara Devi Newar and published by . This book was released on 2016 with total page 244 pages. Available in PDF, EPUB and Kindle. Book excerpt: A full account of our synthetic work toward the first total synthesis of the neuroactive marine macrolide (-)-palmyrolide A is highlighted. Our first-generation approach aimed to unlock the unknown C(5)- C(7) stereochemical relationship via the synthesis of four diastereomers of palmyrolide A aldehyde, a known degradation product. When these efforts provided inconclusive results, recourse to synthesizing all possible stereocombinations of the 15-membered macrolide was undertaken. These studies were critical in confirming the absolute stereochemistry, yielding the first total synthesis of (+)-ent palmyrolide A. Subsequent to this work, the first protecting group-free total synthesis of natural (-)-palmyrolide A is also described. After the successful total synthesis, a small library of synthetic (-)-palmyrolide A diastereomers, analogues, and acyclic precursors have been synthesized and examined with respect to their interaction with voltage-gated sodium channels (VGSCs). A detailed NMR and computational analysis of four diastereomers revealed that none had the same combination of shape and electrostatic potential as exhibited by natural (-)-palmyrolide A. These data indicated that the relative configuration about the tert-butyl and methyl substituents and an intact macrolide is required a prerequisite for biological function. Synthetic work towards the total synthesis of the lipodesipeptides Taumycins A and B was investigated. Enantiomeric isoleucine residues and the unique side chain consisting of a methyl stereocenter imbedded between two trisubstituted E-olefins are key features of this structurally intriguing natural product. By first targeting the taumycin aldehyde, the relative configuration of the macrocycle was identified in 2014 by the Maio laboratory. With the known relative configuration in hand, A total synthesis campaign was initiated, making use of a stereoselective aldol union between a pseudo-symmetrical side chain with orthogonal protecting groups, as a means to access the two possible diastereomeric combinations of the desired natural product. Synthetic studies to synthesize the pseudosymmetric side chain exploring a variety of methods, including an sp3-sp2 Negishi cross coupling reaction, are described.
Book Synopsis Synthetic Studies on Biologically Interesting Molecules by : Jason Daniel Speake
Download or read book Synthetic Studies on Biologically Interesting Molecules written by Jason Daniel Speake and published by . This book was released on 1997 with total page 316 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Studies Towards the Total Synthesis of Samaderine C and Related Analogues by : David Burns
Download or read book Studies Towards the Total Synthesis of Samaderine C and Related Analogues written by David Burns and published by . This book was released on 2013 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Total Synthesis of (-)-Mitrephorone A and Synthetic Studies Towards (+)-Mollanol A, Diastereoselective Cycloisomerization of Cyclopropylidene Acylsilanes by : Matthieu J. R. Richter
Download or read book Total Synthesis of (-)-Mitrephorone A and Synthetic Studies Towards (+)-Mollanol A, Diastereoselective Cycloisomerization of Cyclopropylidene Acylsilanes written by Matthieu J. R. Richter and published by . This book was released on 2020 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Total Synthesis of Epicolactone and Synthetic Studies on Mutanobactins A and C by : Alberto Kravina
Download or read book Total Synthesis of Epicolactone and Synthetic Studies on Mutanobactins A and C written by Alberto Kravina and published by . This book was released on 2018 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Synthetic Studies Towards a Total Synthesis of Roseophilin by : Eddy Michel Elie Viseux
Download or read book Synthetic Studies Towards a Total Synthesis of Roseophilin written by Eddy Michel Elie Viseux and published by . This book was released on 2006 with total page 468 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Studies Towards the Total Synthesis of Merrilactone A by : Jone Iriondo-Alberdi
Download or read book Studies Towards the Total Synthesis of Merrilactone A written by Jone Iriondo-Alberdi and published by . This book was released on 2006 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: