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Author : Jennifer Lori Koviach
Publisher :
ISBN 13 :
Total Pages : 280 pages
Book Rating : 4.:/5 (319 download)
Download or read book Synthetic Studies Toward Halichlorine and Pinnaic Acid written by Jennifer Lori Koviach and published by . This book was released on 1999 with total page 280 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : sunghyun Yang
Publisher :
ISBN 13 :
Total Pages : 364 pages
Book Rating : 4.:/5 (156 download)
Download or read book Synthetic Studies Towards the Marine Alkaloids Pinnaic Acid and Halichlorine written by sunghyun Yang and published by . This book was released on 2005 with total page 364 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Louise G. Arini
Publisher :
ISBN 13 :
Total Pages : pages
Book Rating : 4.:/5 (5 download)
Download or read book Studies Towards the Total Synthesis of Halichlorine and Pinnaic Acid written by Louise G. Arini and published by . This book was released on 2004 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Yang Sunghyun
Publisher :
ISBN 13 :
Total Pages : 604 pages
Book Rating : 4.:/5 (45 download)
Download or read book Synthetic Studies Towards Pinnaic Acid and Halichlorine written by Yang Sunghyun and published by . This book was released on 2009 with total page 604 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Eric A. Korf
Publisher :
ISBN 13 :
Total Pages : 574 pages
Book Rating : 4.:/5 (712 download)
Download or read book Studies Toward the Synthesis of Halichlorine and Pinnaic Acid written by Eric A. Korf and published by . This book was released on 2006 with total page 574 pages. Available in PDF, EPUB and Kindle. Book excerpt: Three approaches toward the core of halichlorine and pinnaic acid are described. The first approach entails a racemic transannular nitrone-olefin [3+2] cycloaddition from nitrone 238. Construction of the nitrone 238 began with aldehyde 241. Another key feature in this route involved a ring-closing metathesis for the formation of a 14-membered ring. The route ended upon formation of a key diol 237. The second approach incorporated the C14 methyl group at an early stage to probe its influence upon an intramolecular nitrone-olefin [3+2] cycloaddition. The approach began with dithiane 258. A key feature in the second plan involved asymmetric induction at the C5 carbon through a conjugate addition of an azide to an [alpha, beta]-unsaturated imide to form azide 290 with both excellent yield and stereocontrol for this addition. The route was advanced to oxaziridine 299. Conversion of 299 to the nitrone 300 and ultimately the intramolecular nitrone-olefin [3+2] cycloaddition was unsuccessful. The third and final approach involved using the basic plan of our first successful approach and employing the asymmetric induction of the second approach. This blending of strategies led to an asymmetric intermediate that links up with the first approach. The route began with dithiane 258. Again, the use of an azide addition to a [alpha, beta]-unsaturated imide led to azide 309. Upon formation of the 14-membered lactone, the azide function was first reduced and protected as carbamate 320 which in turn, increased the yield substantially over this same transformation from the first route. Amine 318 now stands ready to complete a formal synthesis of halichlorine and pinnaic acid.
Author : Hamish Saul Christie
Publisher :
ISBN 13 :
Total Pages : 710 pages
Book Rating : 4.:/5 (34 download)
Download or read book Total Synthesis of Halichlorine, Pinnaic Acid and Tauropinnaic Acid written by Hamish Saul Christie and published by . This book was released on 2004 with total page 710 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Lisbet Kværnø
Publisher :
ISBN 13 :
Total Pages : pages
Book Rating : 4.:/5 (474 download)
Download or read book Part A - Studies Towards the Spirocyclic Core of Halichlorine and Pinnaic Acid ;Part B - Synthesis and in Vitro Evaluation of New Cholesterol Absorption Inhibitors written by Lisbet Kværnø and published by . This book was released on 2004 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Camille Gignoux
Publisher :
ISBN 13 :
Total Pages : 440 pages
Book Rating : 4.:/5 (125 download)
Download or read book Studies Towards the Syntheses of Halichlorine and the Pinnaic Acids written by Camille Gignoux and published by . This book was released on 2012 with total page 440 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author :
Publisher :
ISBN 13 :
Total Pages : 902 pages
Book Rating : 4.F/5 ( download)
Download or read book Dissertation Abstracts International written by and published by . This book was released on 2007 with total page 902 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Luis M. Botana
Publisher : John Wiley & Sons
ISBN 13 : 0470276584
Total Pages : 365 pages
Book Rating : 4.4/5 (72 download)
Download or read book Phycotoxins written by Luis M. Botana and published by John Wiley & Sons. This book was released on 2008-02-28 with total page 365 pages. Available in PDF, EPUB and Kindle. Book excerpt: Phycotoxins: Chemistry and Biochemistry presents the most updated information available on phycotoxins. Major emphases are given to chemistry and biochemistry, while minor emphases are given to the aspects of origin, toxicology, or analytical methodology. The book discusses 16 phycotoxins, 7 on those affecting the nervous systems, 4 affecting other body systems; and 4 with undefined targets. An alphabetical listing of toxins presented includes: Azaspiracids; Brevetoxins; Cyanobacterial toxins; Domoic acid; Gambierols; Gymnodimines, prorocentrolides, spirolides, pinnatoxins and cyclic imines in general; Maitotoxin; Okadaic acid and dinophysistoxins; Palytoxins and ostreocins; Pectenotoxins; Polycavernosides; and Yessotoxins. In addition, several mechanistic aspects of newer or emerging toxins are covered such as amphidinols or gymnocine. Information presented and coverage of each toxin follows the following distribution: background and toxicology (10%); chemistry, biochemistry and metabolism (75%); mechanism of action (10%); and analytical methodology (5%). The detailed information on chemistry in Phycotoxins: Chemistry and Biochemistry provides investigators, regulators, food technologists and toxicologists an updated basis on which research in other areas such as toxicology, mechanism of action, analytical methodology and pharmacology can be successfully developed and expanded.
Author : Alan R. Katritzky
Publisher : Academic Press
ISBN 13 : 0123854652
Total Pages : 313 pages
Book Rating : 4.1/5 (238 download)
Download or read book Advances in Heterocyclic Chemistry written by Alan R. Katritzky and published by Academic Press. This book was released on 2011-02-17 with total page 313 pages. Available in PDF, EPUB and Kindle. Book excerpt: Established in 1960, Advances in Heterocyclic Chemistry is the definitive serial in the area—one of great importance to organic chemists, polymer chemists, and many biological scientists. Written by established authorities in the field, the comprehensive reviews combine descriptive chemistry and mechanistic insight and yield an understanding of how the chemistry drives the properties. - Provides up-to-date material on a fast-growing and highly topical subject area - Contains the latest research covering a wide variety of heterocyclic topics - Written by leading authorities and designed as a handbook for students and industry and academic researchers
Author :
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ISBN 13 :
Total Pages : 784 pages
Book Rating : 4.3/5 (91 download)
Download or read book American Doctoral Dissertations written by and published by . This book was released on 1998 with total page 784 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : GOUDEY-PERRIÈRE Françoise
Publisher : Lavoisier
ISBN 13 : 2743019530
Total Pages : 333 pages
Book Rating : 4.7/5 (43 download)
Download or read book Toxines et cancer written by GOUDEY-PERRIÈRE Françoise and published by Lavoisier. This book was released on 2006-11-26 with total page 333 pages. Available in PDF, EPUB and Kindle. Book excerpt: De tout temps, l'homme a eu conscience de l'intérêt thérapeutique des toxines. Certaines toxines végétales depuis longtemps utilisées figurent encore dans la pharmacopée actuelle. Viennent s'y ajouter depuis peu des toxines microbiennes. Cependant le maniement des toxines natives ou à peine modifiées reste délicat tant est faible la marge entre les effets toxiques et l'efficacité thérapeutique. Comment, dans une perspective médicale, canaliser la puissance d'action et l'efficacité d'une toxine ? Connaître sa structure, comprendre son mécanisme d'action n'est pas suffisant : il faut aussi identifier sa cible privilégiée, autrement dit un récepteur cellulaire, faute de quoi l'entreprise apparemment chimérique d'un détournement de sa puissance et de sa spécificité reste aveugle. Ce cap est franchi, depuis un certain nombre d'années, et le développement des recherches sur les toxines axées sur la thérapeutique est devenu foisonnant. Voyez telle ou telle toxine protéique ternaire, avec ses trois domaines, de fixation sur un récepteur membranaire, de translocation qui lui permet de franchir la membrane cellulaire, et d'activité enzymatique qui va alors pouvoir s'exercer dans la cellule. Qu'on parvienne à dissocier chacun de ces trois domaines en leur conservant leurs propriétés, et des possibilités nouvelles d'utilisation thérapeutique vont s'ouvrir, presque à l'infini semble-t-il. Car chacun d'entre eux pourra être couplé à une molécule active bien ciblée, et leur efficacité sera même améliorée pour peu qu'on parvienne à conjuguer leur action. Qu'un récepteur, qu'une molécule, propres au métabolisme ou à la physiologie d'une cellule cancéreuse soient identifiés, et des toxines conjuguées à un ligand de ce récepteur, de cette molécule (ce peut être un anticorps) bloqueront les canaux ioniques ou exerceront leur effet cytolytique sur cette seule cellule, sans nuire aux cellules saines. Nous voilà dégagés de l'utopie, le contenu de cet ouvrage le prouve abondamment. Et même si la concrétisation des promesses reste délicate, le champ d'action est si vaste initialement qu'il ne saurait rester improductif : il ne l'est d'ailleurs déjà plus.
Author : American Chemical Society. Committee on Professional Training
Publisher :
ISBN 13 :
Total Pages : 1932 pages
Book Rating : 4.:/5 (318 download)
Download or read book Directory of Graduate Research written by American Chemical Society. Committee on Professional Training and published by . This book was released on 2005 with total page 1932 pages. Available in PDF, EPUB and Kindle. Book excerpt: Faculties, publications and doctoral theses in departments or divisions of chemistry, chemical engineering, biochemistry and pharmaceutical and/or medicinal chemistry at universities in the United States and Canada.
Author : M. Volkan Kisakürek
Publisher : John Wiley & Sons
ISBN 13 : 9783906390277
Total Pages : 1010 pages
Book Rating : 4.3/5 (92 download)
Download or read book Hominatio written by M. Volkan Kisakürek and published by John Wiley & Sons. This book was released on 2001 with total page 1010 pages. Available in PDF, EPUB and Kindle. Book excerpt: The historical achievements in organic natural product synthesis can be recognized most clearly in the research accomplishments of Albert Eschenmoser. For example, his work on the chemical synthesis of vitamin B12 defined the frontier in organic natural product synthesis and profoundly influenced the science of organic chemistry. In addition to revealing the beautiful reaction pathways leading to compounds of great biochemical significance, Albert Eschenmoser has contributed innovative methods of outstanding utility for organic synthesis. Few individuals have so fundamentally influenced the science of organic chemistry as Albert Eschenmoser has. Over the years, a sizable fraction of Albert Eschenmoser′s work has been published in Helvetica Chimica Acta, hence the decision of the Editor to produce a special issue of the journal on the occasion of Albert Eschenmoser′s 75th birthday, celebrated on August 5, 2000. The highly impressive set of 67 original research papers submitted in response to the Editor′s invitation could not, for obvious technical reasons, be accommodated in a single issue and were thus divided over the August and September issues. The international reaction to this tribute has been so overwhelmingly enthusiastic that the two issues have been combined in this single volume for separate publication.
Author :
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ISBN 13 :
Total Pages : 1832 pages
Book Rating : 4.:/5 (31 download)
Download or read book Cumulated Index Medicus written by and published by . This book was released on 2000 with total page 1832 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : National Academy of Sciences (U.S.).
Publisher :
ISBN 13 :
Total Pages : 1334 pages
Book Rating : 4.:/5 (89 download)
Download or read book Proceedings of the National Academy of Sciences of the United States of America written by National Academy of Sciences (U.S.). and published by . This book was released on 2004 with total page 1334 pages. Available in PDF, EPUB and Kindle. Book excerpt:
