Synthesis Of Polylactide Block Polyl Lysine Block Copolymers

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Synthesis of Polylactide-block-poly(l-lysine) Block Copolymers

Author : Liying Wang
Publisher :
ISBN 13 :
Total Pages : 73 pages
Book Rating : 4.:/5 (13 download)

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Book Synopsis Synthesis of Polylactide-block-poly(l-lysine) Block Copolymers by : Liying Wang

Download or read book Synthesis of Polylactide-block-poly(l-lysine) Block Copolymers written by Liying Wang and published by . This book was released on 2018 with total page 73 pages. Available in PDF, EPUB and Kindle. Book excerpt: Polylactide (PLA) is an important biodegradable, biocompatible and renewable material that has been studied for many years for biomedical applications such as tissue scaffolding and surgical sutures. The research project described in this Thesis focused on the synthesis of polylactide-block-polylysine (PLA-b-PLy) amphiphilic block copolymers designed for use in targeted drug delivery systems. Block copolymers with a cleavable, redox-sensitive disulfide bond at the block junction, as well as non-cleavable block copolymers were synthesized for comparison. The molecular weight of the PLA and the PLy blocks in the copolymers was varied, so as to control their hydrophobic/hydrophilic balance, and ultimately their self-assembly behavior. A novel redox-sensitive initiator, tert-butyl (2-((2-hydroxyethyl)disulfanyl)ethyl) carbamate, was used to generate the redox-sensitive copolymers, whereas (3-(Boc-amino)-1-propanol served for the non-cleavable systems. The hydroxyl group of these compounds was activated with the non-metallic catalyst 1,8-diazabicyclo[5.4.0]undec-7-ene/benzoic acid (DBU/BA) to initiate the ring-opening polymerization (ROP) of lactide. After the polymerization of lactide and removal of the Boc protecting group at the end of the PLA chain, the free primary amine functionality was used to initiate the ring-opening polymerization of N6-carbobenzoxy-L-lysine N-carboxyanhydride (Z-protected L-lysine NCA monomer). Sample analysis by size exclusion chromatography (SEC) and proton nuclear magnetic resonance (1H NMR) spectroscopy confirmed that the block copolymers had low polydispersity indices (PDI) and the expected molecular weights. Deprotection of the Z-lysine units of the copolymers was accomplished with HBr, but degradation of the PLA segment could not be avoided under the reaction conditions investigated. It is suggested that future investigations either rely on a different deprotection method for the Z-group, or that a different protecting group be used in the NCA monomer serving to build the PLy block.

Synthesis of Novel Biodegradable Copolymers

Author : Christopher Paul Radano
Publisher :
ISBN 13 :
Total Pages : 270 pages
Book Rating : 4.3/5 (129 download)

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Book Synopsis Synthesis of Novel Biodegradable Copolymers by : Christopher Paul Radano

Download or read book Synthesis of Novel Biodegradable Copolymers written by Christopher Paul Radano and published by . This book was released on 2003 with total page 270 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Colloid and Interface Science in Pharmaceutical Research and Development

Author : Hiroyuki Ohshima
Publisher : Elsevier
ISBN 13 : 0444626085
Total Pages : 533 pages
Book Rating : 4.4/5 (446 download)

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Book Synopsis Colloid and Interface Science in Pharmaceutical Research and Development by : Hiroyuki Ohshima

Download or read book Colloid and Interface Science in Pharmaceutical Research and Development written by Hiroyuki Ohshima and published by Elsevier. This book was released on 2014-07-23 with total page 533 pages. Available in PDF, EPUB and Kindle. Book excerpt: Colloid and Interface Science in Pharmaceutical Research and Development describes the role of colloid and surface chemistry in the pharmaceutical sciences. It gives a detailed account of colloid theory, and explains physicochemical properties of the colloidal-pharmaceutical systems, and the methods for their measurement. The book starts with fundamentals in Part I, covering fundamental aspects of colloid and interface sciences as applied to pharmaceutical sciences and thus should be suitable for teaching. Parts II and III treat applications and measurements, and they explains the application of these properties and their influence and use for the development of new drugs. - Provides a clear description of the fundamentals of colloid and interface science relevant to drug research and development - Explains the physicochemical/colloidal basis of pharmaceutical science - Lists modern experimental characterization techniques, provides analytical equations and explanations on analyzing the experimental data - Describes the most advanced techniques, AFM (Atomic Force Microscopy), SFA (Surface Force Apparatus) in detail

Biodegradable Poly (Lactic Acid)

Author : Jie Ren
Publisher : Springer Science & Business Media
ISBN 13 : 3642175961
Total Pages : 314 pages
Book Rating : 4.6/5 (421 download)

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Book Synopsis Biodegradable Poly (Lactic Acid) by : Jie Ren

Download or read book Biodegradable Poly (Lactic Acid) written by Jie Ren and published by Springer Science & Business Media. This book was released on 2011-04-05 with total page 314 pages. Available in PDF, EPUB and Kindle. Book excerpt: "Biodegradable Poly (Lactic Acid): Synthesis, Modification, Processing and Applications" describes the preparation, modification, processing, and the research and applications of biodegradable poly (lactic acid), which belong to the biomedical and environment-friendly materials. Highly illustrated, the book introduces systematically the synthesis, physical and chemical modifications, and the latest developments of research and applications of poly (lactic acid) in biomedical materials. The book is intended for researchers and graduate students in the fields of materials science and engineering, polymer science and engineering, biomedicine, chemistry, environmental sciences, textile science and engineering, package materials, and so on. Dr. Jie Ren is a professor at the Institute of Nano and Bio-Polymeric Materials, School of Material Science and Engineering, Tongji University, Shanghai, China.

Synthesis, Modification and Characterization of Biocompatible Polymers and Nanoparticles

Author : Filiz Karagöz
Publisher :
ISBN 13 :
Total Pages : 0 pages
Book Rating : 4.:/5 (144 download)

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Book Synopsis Synthesis, Modification and Characterization of Biocompatible Polymers and Nanoparticles by : Filiz Karagöz

Download or read book Synthesis, Modification and Characterization of Biocompatible Polymers and Nanoparticles written by Filiz Karagöz and published by . This book was released on 2022 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Engineered nanoparticle systems based on biocompatible/biodegradable polymers is one of the most promising candidates in the pharmaceutical industry. Therefore, the synthesis of biocompatible and hydrolytically degradable amino-functional polylactide-based copolymers and their nanocarrier formation for drug delivery were studied. AB type poly(L-lactide)-b-poly(L-serine lactone) (PLLA-b-PLSL) copolymers were successfully synthesized via sequential ring-opening polymerization (ROP). Self-assembly of block copolymers in aqueous solutions resulted in formation of micelles which are biocompatible as cell experiments revealed. Further research focused on the formation of enzyme-degradable nanoparticles for cancer therapy. Polymerization of L-lactide by MMP-2 cleavable bifunctional peptide sequences was achieved to yield triblock copolymer nanoparticles via a nonaqueous emulsion. Incubation of the cargo-loaded particles into MMP-2 medium resulted by remarkable cargo release based on the regular peptide sequence. Bioimaging is another emerging topic in pharmaceutical field, thus, fluorescence-modified tools are required for tracking and investigating dynamic behavior of materials. Polypeptides with a fluorescence label was described based on ROP of amino acid NCAs. For tagging the polypeptide by precise number of fluorescent dyes, perylene imides modified with alkylamino group was selected. Further investigations were based on the generation of micelle forming fluorescent amphiphilic block copolymers: PDI-poly(L-lysine)-b-poly(L-leucine) and PDI-poly(L-lysine)-b-poly(L-phenylalanine) were prepared as non-toxic carriers with improved aggregation properties. Finally, the potential of the fluorescent micelles for bioimaging applications was successfully evaluated by CLSM. Finally, the focus is on understanding the hazardous effects of the artificial plastics, which is a critical issue as environmental pollution poses a great threat for all living beings, particularly for the water ecosystem. For such purposes, polycarbonate and polystyrene nanoparticles were prepared and investigated on Fathead Minnow immune system, as they are the most disposed of plastic wastes to nature. Both PS and PC nanoparticles led to higher response, demonstrating the stress on the immune system of the fish species. In conclusion, the established multifunctional polymeric nanoparticles are highly versatile and thus present new opportunities in use for targeted and selective recognition systems which is highly crucial for various applications in the future for the pharmaceutical industry.

Biologically-responsive Hybrid Biomaterials

Author : Esmaiel Jabbari
Publisher : World Scientific
ISBN 13 : 981429568X
Total Pages : 430 pages
Book Rating : 4.8/5 (142 download)

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Book Synopsis Biologically-responsive Hybrid Biomaterials by : Esmaiel Jabbari

Download or read book Biologically-responsive Hybrid Biomaterials written by Esmaiel Jabbari and published by World Scientific. This book was released on 2010 with total page 430 pages. Available in PDF, EPUB and Kindle. Book excerpt: Conjugation of synthetic materials with cell-responsive biologically-active molecules, in addition to providing structural support and release of biomolecules in the regenerating region, can provide the signaling factors required to initiate the cascade of cell migration, adhesion, differentiation, maturation, growth factor modulation, maintenance of matrix integrity, and tissue morphogenesis. Nanoparticles conjugated with ligands that preferentially interact with cell surface receptors in the tumor environment have the potential to drastically improve bioavailability, selectivity and residence time of the chemotherapeutic agent in the tumor microenvironment, while limiting their peripheral toxicity. Multivalent presentation of tumor-associated antigens on a targeted delivery system containing T and B cell epitopes can result in strong, long-lasting, self-adjuvant immunity against cancer and other diseases in vaccination. These examples demonstrate that cell-responsive conjugate biomaterials have profoundly impacted the medical field. This book is divided into three sections. In the first section, synthesis and characterization, conformation, structure-activity, self-assembly, and host response of conjugate hybrid biomaterials are covered. The second section is dedicated to the applications of conjugate biomaterials in drug delivery and vaccination while the last section is devoted to tissue engineering applications including cell adhesion, control of the stem cell niche, cartilage regeneration, neural and vascular tissue engineering, and dynamic cell culture systems for functionalized biomaterials. There is no doubt that biologically-responsive conjugate biomaterials play a key role in the design of biologics and medical devices, and this pioneering reference book provides a comprehensive review on synthesis, characterization, structure-activity, 3D assembly/fabrication, host response and the emerging applications of conjugate hybrid biomaterials.

Synthesis and Characterization of Polymandelide and Lactide/methacrylate Block Copolymers

Author : Tianqi Liu
Publisher :
ISBN 13 :
Total Pages : 416 pages
Book Rating : 4.3/5 (129 download)

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Book Synopsis Synthesis and Characterization of Polymandelide and Lactide/methacrylate Block Copolymers by : Tianqi Liu

Download or read book Synthesis and Characterization of Polymandelide and Lactide/methacrylate Block Copolymers written by Tianqi Liu and published by . This book was released on 2002 with total page 416 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Polymeric Nanomedicines

Author : Marcel Popa
Publisher : Bentham Science Publishers
ISBN 13 : 1608054845
Total Pages : 821 pages
Book Rating : 4.6/5 (8 download)

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Book Synopsis Polymeric Nanomedicines by : Marcel Popa

Download or read book Polymeric Nanomedicines written by Marcel Popa and published by Bentham Science Publishers. This book was released on 2013-05-29 with total page 821 pages. Available in PDF, EPUB and Kindle. Book excerpt: Over the last few decades, numerous nanoparticle platforms have been studied for their use in therapeutic applications. This book deals with the description of the construction of technical systems that combines different functionalities which bring liposomes, polymer-drug conjugates, polymer-protein conjugates, dendrimers, polymeric micelles, polymerosomes and other nanoparticles into the realm of nanotechnology proper, as opposed to traditional pharmacology or supramolecular chemistry. The volume additionally covers topics such as passive and active targeting, the strategies used for drug targeting, and the synthesis and characterization of polymeric nanoparticle platforms. Targeted polymeric nanomedicines have shown exciting results in preclinical studies, demonstrating their potential as therapeutic carriers. Therefore, the development of polymeric nanomedicines as therapeutic agents has generated great enthusiasm both in academia and industry. The book is systematically divided into chapters devoted to a class of polymeric nanomedicines. Each chapter also describes relevant aspects relating to drug design and targeting of polymeric nanomedicines wherever possible. In addition, a series of chapters concerning the contribution of polymeric nanomedicines in the treatment of several categories of diseases including cancer, inflammatory, renal, immunological diseases, and brain disorders is also presented. Key features of this book include: - A comprehensive and cutting-edge overview of polymeric nanomedicines available in a single dedicated volume - Discussions on advances in drug delivery systems for a variety of diseases - more than 2000 references, tables, equations, and drawings Readers, whether beginners or experts, will find in this book, contemporary and relevant information regarding the synthesis, evaluation and applications of polymeric nanomedicines. Supplemented with extensive bibliographic references, tables and figures, this book is an essential and incomparable reference for medicinal chemists, biologists, and medical (oncologic) researchers, as well as for scientists, undergraduate and graduate students in the field of medical bioengineering and polymer nanoscience.

Concise Encyclopedia of Biomedical Polymers and Polymeric Biomaterials

Author : Munmaya Mishra
Publisher : CRC Press
ISBN 13 : 1351653032
Total Pages : 1800 pages
Book Rating : 4.3/5 (516 download)

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Book Synopsis Concise Encyclopedia of Biomedical Polymers and Polymeric Biomaterials by : Munmaya Mishra

Download or read book Concise Encyclopedia of Biomedical Polymers and Polymeric Biomaterials written by Munmaya Mishra and published by CRC Press. This book was released on 2017-08-16 with total page 1800 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Concise Encyclopedia of Biomedical Polymers and Polymeric Biomaterials presents new and selected content from the 11-volume Biomedical Polymers and Polymeric Biomaterials Encyclopedia. The carefully culled content includes groundbreaking work from the earlier published work as well as exclusive online material added since its publication in print. A diverse and global team of renowned scientists provide cutting edge information concerning polymers and polymeric biomaterials. Acknowledging the evolving nature of the field, the encyclopedia also features newly added content in areas such as tissue engineering, tissue repair and reconstruction, and biomimetic materials.

Amino Acids: Insights and Roles in Heterocyclic Chemistry

Author : Zerong Wang
Publisher : CRC Press
ISBN 13 : 1000739007
Total Pages : 423 pages
Book Rating : 4.0/5 (7 download)

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Book Synopsis Amino Acids: Insights and Roles in Heterocyclic Chemistry by : Zerong Wang

Download or read book Amino Acids: Insights and Roles in Heterocyclic Chemistry written by Zerong Wang and published by CRC Press. This book was released on 2023-05-26 with total page 423 pages. Available in PDF, EPUB and Kindle. Book excerpt: This is the third volume of a first-of-its-kind four-volume book set that provides readers with up-to-date information on α-amino acids, the potential challenges in working with α-amino acids, the protecting groups for the carboxyl, amino and side chain groups of the amino acids, and the most popular heterocyclic compounds that are originating from α-amino acids. These heterocyclic compounds include hydantoins, thiohydantoins (including 2-thiohydantoins, 4-thiohydantoins, 2,4-dithiohydantoins), 2,5-diketopiperazines, N-carboxyanhydrides, N-thiocarboxyanhydrides, sydnones, sydnonimines, azlactones, pseudoazlactones, and oxazolidin-5-ones. This is the first resource to comprehensively collect all the heterocycles that can be directly prepared from α-amino acids. In addition, almost all kinds of synthetic methods for a particular type of heterocycles from α-amino acids are included, along with the detailed mechanistic discussions and experimental procedures. Volume 3: N-Carboxyanhydrides, N-Thiocarboxyanhydrides, and Sydnones presents up-to-date detailed information on two types of heterocyclic compounds that originate from alpha-amino acids: NCAs/NTAs and sydnones/sydnonimines. The volume also covers the more than 10 initiating systems for NCA monomers to undergo the ring-opening polymerization, which are very useful for the readers in order to make living polypeptides/polypeptoids. In addition, the method to characterize these prepared polypeptides/polypeptoids is also included. Particularly, two modern mass spectrometric techniques (MALDI-TOF and ESI-TOF) have been explained with detailed examples, where the elucidation of molecular weight of protein based on the ESI-TOF spectra has been given with a practical example as well as the theory that it is based on, a unique feature of the volume. The other volumes in the set are: Volume 1: Protecting Groups Volume 2: Hydantoins, Thiohydantoins, and 2,5-Diketopiperazines Volume 4: Azlactones and Oxazolidin-5-ones All together, this unique 4-volume set thoroughly covers the two types of heterocyclic compounds that are originated from alpha-amino acids, providing carefully compiled updated information with detailed examples. The author has shared many thoughtful insights based on his strong background in physical organic chemistry. The volumes will be highly valuable for graduate students and senior students, as well as for professors and researchers working in the field of medicinal and pharmaceutical chemistry, organic chemistry, organic synthesis, heterocycles, and proteins and peptides.

Synthesis and Solution Self-Assembly of Poly(L-Lactide)-Based Amphiphilic Block Copolymers

Author : Amy Petretic
Publisher :
ISBN 13 :
Total Pages : 196 pages
Book Rating : 4.:/5 (976 download)

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Book Synopsis Synthesis and Solution Self-Assembly of Poly(L-Lactide)-Based Amphiphilic Block Copolymers by : Amy Petretic

Download or read book Synthesis and Solution Self-Assembly of Poly(L-Lactide)-Based Amphiphilic Block Copolymers written by Amy Petretic and published by . This book was released on 2015 with total page 196 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Polymer and Polymer-Hybrid Nanoparticles

Author : Stanislav Rangelov
Publisher : CRC Press
ISBN 13 : 143986909X
Total Pages : 484 pages
Book Rating : 4.4/5 (398 download)

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Book Synopsis Polymer and Polymer-Hybrid Nanoparticles by : Stanislav Rangelov

Download or read book Polymer and Polymer-Hybrid Nanoparticles written by Stanislav Rangelov and published by CRC Press. This book was released on 2013-08-28 with total page 484 pages. Available in PDF, EPUB and Kindle. Book excerpt: Polymeric and hybrid nanoparticles have received increased scientific interest in terms of basic research as well as commercial applications, promising a variety of uses for nanostructures in fields including bionanotechnology and medicine. Condensing the relevant research into a comprehensive reference, Polymer and Polymer-Hybrid Nanoparticles: Fr

Cancer Therapy

Author : Surendra Nimesh
Publisher : Elsevier
ISBN 13 : 0443154023
Total Pages : 552 pages
Book Rating : 4.4/5 (431 download)

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Book Synopsis Cancer Therapy by : Surendra Nimesh

Download or read book Cancer Therapy written by Surendra Nimesh and published by Elsevier. This book was released on 2024-05-30 with total page 552 pages. Available in PDF, EPUB and Kindle. Book excerpt: While there have been a large number of ongoing research projects and publications on the treatment of cancer, there is a limited number of books related to nanotechnology with emphasis on polymeric nanoparticles in cancer therapy. The book, covering all of the recent research work done on this basis, enlightens researchers and students with the benefits of polymeric nanomaterials in cancer. This book provides exhaustive knowledge on polymeric nanoparticles and cancer. - Provides a complete overview of the application of different polymeric nanoparticles in cancer therapeutics: from characterization of nanoparticles to in vitro and in vivo studies. - Contains a detailed description of the delivery of therapeutic molecules with different polymers realized with nanomedicine in cancer therapeutics. - Discusses newly developed promising polymers in cancer. - Describes polymeric nanoparticle and their role in theranostics pertaining to cancer. - Reviews clinical relevance of different polymeric formulations in the field of cancer

Synthesis and Characterization of Poly (L-lactide)-poly (D, L-lactide) Stereo-block Copolymers

Author : Sachit Chopra
Publisher :
ISBN 13 :
Total Pages : 102 pages
Book Rating : 4.:/5 (495 download)

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Book Synopsis Synthesis and Characterization of Poly (L-lactide)-poly (D, L-lactide) Stereo-block Copolymers by : Sachit Chopra

Download or read book Synthesis and Characterization of Poly (L-lactide)-poly (D, L-lactide) Stereo-block Copolymers written by Sachit Chopra and published by . This book was released on 2005 with total page 102 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Crystallization in Multiphase Polymer Systems

Author : Sabu Thomas
Publisher : Elsevier
ISBN 13 : 0128094311
Total Pages : 612 pages
Book Rating : 4.1/5 (28 download)

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Book Synopsis Crystallization in Multiphase Polymer Systems by : Sabu Thomas

Download or read book Crystallization in Multiphase Polymer Systems written by Sabu Thomas and published by Elsevier. This book was released on 2017-09-15 with total page 612 pages. Available in PDF, EPUB and Kindle. Book excerpt: Crystallization in Multiphase Polymer Systems is the first book that explains in depth the crystallization behavior of multiphase polymer systems. Polymeric structures are more complex in nature than other material structures due to their significant structural disorder. Most of the polymers used today are semicrystalline, and the subject of crystallization is still one of the major issues relating to the performance of semicrystalline polymers in the modern polymer industry. The study of the crystallization processes, crystalline morphologies and other phase transitions is of great significance for the understanding the structure-property relationships of these systems. Crystallization in block copolymers, miscible blends, immiscible blends, and polymer composites and nanocomposites is thoroughly discussed and represents the core coverage of this book. The book critically analyzes the kinetics of nucleation and growth process of the crystalline phases in multi-component polymer systems in different length scales, from macro to nanoscale. Various experimental techniques used for the characterization of polymer crystallization process are discussed. Written by experts in the field of polymer crystallization, this book is a unique source and enables professionals and students to understand crystallization behavior in multiphase polymer systems such as block copolymers, polymer blends, composites and nanocomposites. - Covers crystallization of multiphase polymer systems, including copolymers, blends and nanocomposites - Features comprehensive, detailed information about the basic research, practical applications and new developments for these polymeric materials - Analyzes the kinetics of nucleation and growth process of the crystalline phases in multi-component polymer systems in different length scales, from macro to nanoscale

Smart Pharmaceutical Nanocarriers

Author : Vladimir P Torchilin
Publisher : World Scientific
ISBN 13 : 1783267240
Total Pages : 564 pages
Book Rating : 4.7/5 (832 download)

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Book Synopsis Smart Pharmaceutical Nanocarriers by : Vladimir P Torchilin

Download or read book Smart Pharmaceutical Nanocarriers written by Vladimir P Torchilin and published by World Scientific. This book was released on 2015-12-31 with total page 564 pages. Available in PDF, EPUB and Kindle. Book excerpt: Drug delivery systems and pharmaceutical nanocarriers that respond to different types of stimuli, such as internal ones, intrinsic for the pathological area (changes in pH, temperature, redox condition, activity of certain enzymes), or external, artificially applied (magnetic field, ultrasound, various irradiations), represent an important and continuously growing area of research. Smart Phramaceutical Nanocarriers overviews the various stimuli used for drug release and delivery by smart pharmaceutical carriers and presents cutting-edge research and the newest data from the leading laboratories in each area.

Synthesis and Characterization of Polylactide Containing Block Copolymers and Their Potential as Thermoplastic Elastomers and Toughening Agents

Download Synthesis and Characterization of Polylactide Containing Block Copolymers and Their Potential as Thermoplastic Elastomers and Toughening Agents PDF Online Free

Author : Esther Marie Frick
Publisher :
ISBN 13 :
Total Pages : 282 pages
Book Rating : 4.:/5 (626 download)

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Book Synopsis Synthesis and Characterization of Polylactide Containing Block Copolymers and Their Potential as Thermoplastic Elastomers and Toughening Agents by : Esther Marie Frick

Download or read book Synthesis and Characterization of Polylactide Containing Block Copolymers and Their Potential as Thermoplastic Elastomers and Toughening Agents written by Esther Marie Frick and published by . This book was released on 2003 with total page 282 pages. Available in PDF, EPUB and Kindle. Book excerpt: