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Author : Stephen Francis Lawless
Publisher :
ISBN 13 :
Total Pages : 238 pages
Book Rating : 4.:/5 (789 download)
Download or read book Synthesis of 4-substituted Isoquinolines written by Stephen Francis Lawless and published by . This book was released on 1970 with total page 238 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book The Synthesis of 1-, 3- And 1: 3- Substituted Isoquinolines written by and published by . This book was released on 1972 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Michael Angelo Re
Publisher :
ISBN 13 :
Total Pages : 228 pages
Book Rating : 4.:/5 (167 download)
Download or read book A New Approach to the Synthesis of Substituted Isoquinolines written by Michael Angelo Re and published by . This book was released on 1987 with total page 228 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Stephen Roy Taylor
Publisher :
ISBN 13 :
Total Pages : 702 pages
Book Rating : 4.:/5 (225 download)
Download or read book Synthesis of Biaryl Substituted Isoquinolines Based on the Reticuline Scaffold written by Stephen Roy Taylor and published by . This book was released on 2006 with total page 702 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Surya K. De
Publisher : John Wiley & Sons
ISBN 13 : 3527347852
Total Pages : 856 pages
Book Rating : 4.5/5 (273 download)
Download or read book Applied Organic Chemistry written by Surya K. De and published by John Wiley & Sons. This book was released on 2021-03-08 with total page 856 pages. Available in PDF, EPUB and Kindle. Book excerpt: An indispensable guide for all synthetic chemists who want to learn about the most relevant reactions and reagents employed to synthesize important heterocycles and drugs! The synthesis of natural products, bioactive compounds, pharmaceuticals, and drugs is of fundamental interest in modern organic chemistry. New reagents and reaction methods towards these molecules are being constantly developed. By understanding the mechanisms involved and scope and limitations of each reaction applied, organic chemists can further improve existing reaction protocols and develop novel efficient synthetic routes towards frequently used drugs, such as Aspirin or Penicillin. Applied Organic Chemistry provides a summary of important (name) reactions and reagents applied in modern organic chemistry and drug synthesis. It covers rearrangement, condensation, olefination, metathesis, aromatic electrophilic substitutions, Pd-catalyzed C-C bond forming reactions, multi-component reactions, as well as oxidations and reductions. Each chapter is clearly structured, providing valuable information on reaction details, step-by-step mechanism, experimental procedures, applications, and (patent) references. By providing mechanistic information and representative experimental procedures, this book is an indispensable guide for researchers and professionals in organic chemistry, natural product synthesis, pharmaceutical, and medicinal chemistry, as well as post-graduates preparing themselves for a job in the pharmaceutical industry. Hot Topic: Reviews important classes of organic reactions (incl. name reactions) and reagents in medicinal chemistry. Useful: Provides information on reaction details, common reagents, and functional group transformations used to synthesize natural products, bioactive compounds, drugs, and pharmaceuticals, e.g. Aspirin, Penicillin. Unique: For every reaction the mechanism is explained step by step, and representative experimental procedures are given, unlike most books in this area. User-friendly: Chapters are clearly structured making it easy for the reader to compare different reactions. Applied Organic Chemistry is an indispensable guide for researchers and professionals in organic chemistry, natural product synthesis, pharmaceutical, and medicinal chemistry, as well as post-graduates preparing themselves for a job in the pharmaceutical industry.
Download or read book Transformations of Isocarbostyrils for the Synthesis of Isoquinoline Alkaloids and the Related Analogues written by and published by . This book was released on 2007 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: A practical method for the synthesis of an isoquinoline alkaloid 6,7-dimethoxy-2-methylisoquinoline-1,3,4(2H)-trione and its analogues has been demonstrated. Two new methods for synthesizing substituted phthalonimides from the corresponding isocarbostyrils have been developed. Phthalonimide derivatives were obtained by the oxidation of isocarbostyrils protected with methoxymethyl and â, â, â-trichloroethoxymethyl groups. The direct oxidation of isocarbostyrils under different conditions was also investigated. In addition, six dienes for potential use in the development of a [4+2] cycloaddition approach to galanthan tetracyclic ring system have been synthesized. These precursors and dienophiles are based on and drived from isoquinolines and isocarbostyrils.
Author : John Whittall
Publisher : John Wiley & Sons
ISBN 13 : 111948703X
Total Pages : 560 pages
Book Rating : 4.1/5 (194 download)
Download or read book Applied Biocatalysis written by John Whittall and published by John Wiley & Sons. This book was released on 2020-08-21 with total page 560 pages. Available in PDF, EPUB and Kindle. Book excerpt: Provides clear and comprehensive coverage of recently developed applied biocatalysis for synthetic organic chemists with an emphasis to promote green chemistry in pharmaceutical and process chemistry This book aims to make biocatalysis more accessible to both academic and industrial synthetic organic chemists. It focuses on current topics within the applied industrial biocatalysis field and includes short but detailed experimental methods on timely novel biocatalytic transformations using new enzymes or new methodologies using known enzymes. The book also features reactions that are “expanding and making the enzyme toolbox available to chemists”—providing readers with comprehensive methodology and detailed key sourcing information of a wide range of enzymes. Chapters in Applied Biocatalysis: The Chemist’s Enzyme Toolkit are organized by reaction type and feature a short introductory section describing the current state of the art for each example. Much of the book focuses on processes for which the enzymes are readily available so that organic chemists can synthesize appropriate quantities of chemicals with available materials in a standard chemical laboratory. Advanced methods are included to present examples of new enzymes that might encourage collaboration with suppliers or academic groups and that will educate chemists of rapidly expanding future possibilities. Focuses on current topics within the applied industrial biocatalysis field Offers experimental methods on novel biocatalytic transformations using new enzymes or new methodology using known enzymes Covers the hot topics of enzyme and chemoenzymatic cascades and biocatalysis in flow Edited by noted experts from both academia and industry with years of experience in the field of biocatalysis—particularly, the industrial applications of enzymes Written for synthetic organic chemists working in all industries but especially the pharmaceutical industry and for those in academia with an eye for biocatalysis, Applied Biocatalysis: The Chemist’s Enzyme Toolkit will also benefit academic groups in chemistry and related sciences that are using enzymes for synthetic purposes, as well as those working in the area of enzymology and molecular biology.
Author : Jack Alan Hunter
Publisher :
ISBN 13 :
Total Pages : 178 pages
Book Rating : 4.:/5 (443 download)
Download or read book Synthesis of Isoquinolines by Electrophilic Ring Closure of Iminoalkynes written by Jack Alan Hunter and published by . This book was released on 2000 with total page 178 pages. Available in PDF, EPUB and Kindle. Book excerpt: A variety of substituted isoquinolines have been synthesized in good to excellent yields by the electrophilic ring closure of iminoalkynes in the presence of various external electrophiles. The best results were obtained with an excess of the electrophile, plus 3 equiv of sodium bicarbonate as a base when needed, at room temperature with either acetonitrile or methylene chloride as the solvent. This electrophilic ring closure is highly effective when an aryl- or alkenyl-substituted alkyne is utilized. Other acetylenes fail to undergo this ring closure. Mono-substituted isoquinolines have been prepared in good to excellent yields by the silver-catalyzed cyclization of various iminoalkynes. The best results were obtained using 5 mol % silver nitrate at 50°C in chloroform. Aryl-, vinylic- and alkyl-substituted iminoalkynes undergo this silver-catalyzed cyclization in excellent yields.
Author : Xiao-Feng Wu
Publisher : John Wiley & Sons
ISBN 13 : 3527338888
Total Pages : 596 pages
Book Rating : 4.5/5 (273 download)
Download or read book Transition Metal-Catalyzed Heterocycle Synthesis via C-H Activation written by Xiao-Feng Wu and published by John Wiley & Sons. This book was released on 2016-03-07 with total page 596 pages. Available in PDF, EPUB and Kindle. Book excerpt: Reflecting the tremendous growth of this hot topic in recent years, this book covers C-H activation with a focus on heterocycle synthesis. As such, the text provides general mechanistic aspects and gives a comprehensive overview of catalytic reactions in the presence of palladium, rhodium, ruthenium, copper, iron, cobalt, and iridium. The chapters are organized according to the transition metal used and sub-divided by type of heterocycle formed to enable quick access to the synthetic route needed. Chapters on carbonylative synthesis of heterocycles and the application of C-H activation methodology to the synthesis of natural products are also included. Written by an outstanding team of authors, this is a valuable reference for researchers in academia and industry working in the field of organic synthesis, catalysis, natural product synthesis, pharmaceutical chemistry, and crop protection.
Author : Christophe Wiart
Publisher : Academic Press
ISBN 13 : 0123983711
Total Pages : 430 pages
Book Rating : 4.1/5 (239 download)
Download or read book Lead Compounds from Medicinal Plants for the Treatment of Cancer written by Christophe Wiart and published by Academic Press. This book was released on 2012-10-22 with total page 430 pages. Available in PDF, EPUB and Kindle. Book excerpt: Kelley/DNA Repair in Cancer Therapy, 2012, 978-0-12-384999-1.
Author : Ananya Srivastava
Publisher : Elsevier
ISBN 13 : 012821547X
Total Pages : 506 pages
Book Rating : 4.1/5 (282 download)
Download or read book Copper in N-Heterocyclic Chemistry written by Ananya Srivastava and published by Elsevier. This book was released on 2020-11-13 with total page 506 pages. Available in PDF, EPUB and Kindle. Book excerpt: Copper in N-Heterocyclic Chemistry provides an overview of copper-catalyzed synthesis and functionalization of N-heterocyclic compounds, covering all recent developments in a way that is ideal for researchers and students working in the area of synthetic organic chemistry and medicinal chemistry. The book explores N-heterocyclic compounds as unique structural units in the development of natural products and pharmaceuticals, along with the remarkable progress made in the area of high atom economic strategies, and more recently, copper-catalyzed C-H activation and its applications in organic synthesis. Readers will find troubleshooting protocols, as well as the advantages and limitations of each method discussed. As copper catalysts show versatile chemical reactivity in many aspects, including their oxidation states 0–3 are accessible and their ability to facilitate bond formations due to their ability to serve as Lewis acids, oxidizing agents and catalysts, this book is an ideal resource on the topics explored. Discusses novel synthetic methods developed over the past decade for copper-catalyzed synthesis of N-heterocyclic compounds Covers the most recent methodologies adapted in synthetic chemistry for applications in natural products and pharmaceuticals Includes troubleshooting protocols, as well as the advantages and limitations of each method discussed in detail
Author : Jie Jack Li
Publisher : Springer Science & Business Media
ISBN 13 : 3662048353
Total Pages : 435 pages
Book Rating : 4.6/5 (62 download)
Download or read book Name Reactions written by Jie Jack Li and published by Springer Science & Business Media. This book was released on 2013-11-11 with total page 435 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book differs from others on name reactions in organic chemistry by focusing on their mechanisms. It covers over 300 classical as well as contemporary name reactions. Biographical sketches for the chemists who discovered or developed those name reactions have been included. Each reaction is delineated by its detailed step-by-step, electron-pushing mechanism, supplemented with the original and the latest references, especially review articles. This book contains major improvements over the previous edition and the subject index is significantly expanded.
Author : A. C. Knipe
Publisher : John Wiley & Sons
ISBN 13 : 1118707869
Total Pages : 728 pages
Book Rating : 4.1/5 (187 download)
Download or read book Organic Reaction Mechanisms 2013 written by A. C. Knipe and published by John Wiley & Sons. This book was released on 2016-10-31 with total page 728 pages. Available in PDF, EPUB and Kindle. Book excerpt: Organic Reaction Mechanisms 2013, the 49th annual volume in this highly successful and unique series, surveys research on organic reaction mechanisms described in the available literature dated 2013. The following classes of organic reaction mechanisms are comprehensively reviewed: Reaction of Aldehydes and Ketones and their Derivatives Reactions of Carboxylic, Phosphoric, and Sulfonic Acids and their Derivatives Oxidation and Reduction Carbenes and Nitrenes Nucleophilic Aromatic Substitution Electrophilic Aromatic Substitution Carbocations Nucleophilic Aliphatic Substitution Carbanions and Electrophilic Aliphatic Substitution Elimination Reactions Polar Addition Reactions Cycloaddition Reactions Molecular Rearrangements An experienced team of authors compile these reviews every year, so that the reader can rely on a continuing quality of selection and presentation.
Author : Dipakranjan Mal
Publisher : Elsevier
ISBN 13 : 0128138017
Total Pages : 466 pages
Book Rating : 4.1/5 (281 download)
Download or read book Anionic Annulations in Organic Synthesis written by Dipakranjan Mal and published by Elsevier. This book was released on 2018-10-25 with total page 466 pages. Available in PDF, EPUB and Kindle. Book excerpt: Anionic Annulations in Organic Synthesis: A Versatile and Prolific Class of Ring-Forming Reactions is a comprehensive review of the main annulations for the construction of cyclic structures and their use in the total synthesis of functional molecules. The book explores in detail the Hauser, Robinson, Sammes, and Myers annulations, all of which are beneficial to constructing substrates with complex molecular structures suitable for pharmaceutical purposes. This volume begins with an in-depth introduction on the history and perspectives of annulations. It then covers different categories of annulation in each chapter, examining their application to drug synthesis for a range of different medicinal compounds. Anionic Annulations in Organic Synthesis delivers a thorough analysis of the topic and provides the tools necessary to master anionic organic chemistry. It is a valuable resource for chemists, researchers, and students seeking a complete and detailed understanding of anionic annulations. Serves as a useful tool to both academic and industrial researchers in the field Includes numerous examples of anionic annulations and how to apply them practically in research and industry Features anionic annulations that are particularly effective for the synthesis of polyoxygenated polycyclic compounds
![Download Synthesis of 4,9-dihydropyrazolo-[1,5-b]-isoquinolines PDF Online Free](https://books.google.com/books/content/images/frontcover/hmoNOAAACAAJ?fife=w200-h370)
Author : Weiling Hsueh
Publisher :
ISBN 13 :
Total Pages : 76 pages
Book Rating : 4.:/5 (941 download)
Download or read book Synthesis of 4,9-dihydropyrazolo-[1,5-b]-isoquinolines written by Weiling Hsueh and published by . This book was released on 1982 with total page 76 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : J.D. Phillipson
Publisher : Springer Science & Business Media
ISBN 13 : 3642701280
Total Pages : 315 pages
Book Rating : 4.6/5 (427 download)
Download or read book The Chemistry and Biology of Isoquinoline Alkaloids written by J.D. Phillipson and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 315 pages. Available in PDF, EPUB and Kindle. Book excerpt: Isoquinolines form one of the largest groups of plant alkaloids and they in clude a number of valuable clinical agents such as codeine, morphine, eme tine and tubocurarine. Research into different aspects of isoquinolines con tinues in profusion, attracting the talents of botanists, chemists, bioche mists, analysts, pharmacists and pharmacologists. Many of these aspects are of an interdisciplinary nature, and in April 1984, The Phytochemical Society of Europe arranged a 3-day symposium on The Chemistry and Bi ology of Isoquinoline Alkaloids in order to provide a forum for scientists of differing disciplines who are united by a common interest in this one class of natural product. Each chapter in this volume is based on a lecture given at this symposium. Attempts have been made to make the aims and objectives, experimental findings and conclusions reached, intelligible to scientists of differing backgrounds. The introductory chapter, which is mainly based on a historical discus sion, stresses that plants containing isoquinolines have proved to be both a boon and a curse to mankind. The Opium Poppy, Papaver somniferum, produces the medicinally used alkaloids morphine, codeine, noscapine and papaverine whilst it also continues to provide drugs of abuse, particularly morphine and its readily prepared O,O-diacetyl derivative, heroin. Numer ous other alkaloids have been isolated from other members of the Papaver acea, and a knowledge of their presence and distribution within the various species has proved a useful adjunct to systematic botanical studies.
Author : Majid M. Heravi
Publisher : Elsevier
ISBN 13 : 0128242582
Total Pages : 404 pages
Book Rating : 4.1/5 (282 download)
Download or read book Recent Applications of Selected Name Reactions in the Total Synthesis of Alkaloids written by Majid M. Heravi and published by Elsevier. This book was released on 2021-06-12 with total page 404 pages. Available in PDF, EPUB and Kindle. Book excerpt: Recent Applications of Selected Name Reactions in the Total Synthesis of Alkaloids includes comprehensive coverage of name reactions in the synthesis of alkaloids. This book highlights the synthesis of various alkaloids using special name reactions including the Diels-Alder, Friedel-Crafts, Heck, Mannich, Pauson-Khand, Pictet-Spengler, Sonogashira and Suzuki reactions. In this book, some selected name reactions in the total synthesis of alkaloids are covered, as they can be used as the key step/steps in the synthesis of different alkaloids exhibiting various biological activities. All chapters include an introduction, history and mechanism of the name reaction, and present the origin of the natural product and its known biological activities. The pathway to total synthesis is visually illustrated, and the focus is on the step in which a name reaction is applied. Chemists working in the area of synthetic organic chemistry will find this reference useful, as well as those working to develop novel methodologies for the synthesis of natural products in both academia and industry. This book is also beneficial to biologists, pharmacists and botanists. Includes an introduction of alkaloids, their origins and biological properties Features the applications of special name reactions as the key step in the total synthesis of featured alkaloids Covers the pathway for the synthesis of alkaloids from commercially available or easily accessible starting materials by using at least one name reaction to achieve the desired target products
