Read Books Online and Download eBooks, EPub, PDF, Mobi, Kindle, Text Full Free.
Synthesis Of 123 Triazole Ligands Their Metal Complexes And Applications In Catalysis Gold I Catalyzed 1n Enyne Ester Cycloisomerization Reactions
Download Synthesis Of 123 Triazole Ligands Their Metal Complexes And Applications In Catalysis Gold I Catalyzed 1n Enyne Ester Cycloisomerization Reactions full books in PDF, epub, and Kindle. Read online Synthesis Of 123 Triazole Ligands Their Metal Complexes And Applications In Catalysis Gold I Catalyzed 1n Enyne Ester Cycloisomerization Reactions ebook anywhere anytime directly on your device. Fast Download speed and no annoying ads. We cannot guarantee that every ebooks is available!
Book Synopsis Synthesis of 1,2,3-triazole Ligands, Their Metal Complexes, and Applications in Catalysis; Gold (i) Catalyzed 1,n-enyne Ester Cycloisomerization Reactions by : Sravan Kumar Thummanapelli
Download or read book Synthesis of 1,2,3-triazole Ligands, Their Metal Complexes, and Applications in Catalysis; Gold (i) Catalyzed 1,n-enyne Ester Cycloisomerization Reactions written by Sravan Kumar Thummanapelli and published by . This book was released on 2016 with total page 414 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Gold(I)-catalyzed Cycloisomerization Reactions of Allenes by : Rachel Motove Zeldin
Download or read book Gold(I)-catalyzed Cycloisomerization Reactions of Allenes written by Rachel Motove Zeldin and published by . This book was released on 2011 with total page 532 pages. Available in PDF, EPUB and Kindle. Book excerpt: The modern era of synthetic chemistry can be characterized by increased understanding, development and application of transition metal complexes to traditionally organic transformations. While the field has focused largely on the chemistry of group 4-8 metals (and in particular, rhodium and palladium), there has been growing interest in the past decade in using so-called "coinage metals"--Gold, silver and copper--as catalysts for organic reactions. Gold(I) metal complexes have been shown to effect a range of organic transformations that proceed through [pi]-activation mechanisms, often with greater selectivity than other transition metal complexes. Additionally, in contrast to more established transition metal reactions, gold(I) processes can be conducted at low temperature and in the presence of water and air. Because of their mild conditions and high degree of control, gold(I) reactions are ideal for application to total synthesis. In the first chapter of this text, we discuss the current state of the art of gold(I)-catalysis in the context of complex molecule synthesis. The reactivity exhibited by gold(I) complexes is highly controlled by choice of catalyst ligand. In the second chapter, we discuss the development of ligand-controlled intramolecular reaction of dienes and allenes to afford selectively either [4+2]- or [4+3] cycloadducts. The purpose of this discussion is two-fold: first, to demonstrate the effect that stabilization of reactive intermediates has on the course of gold(I) reactions, and second, to develop methodologies aimed at constructing novel, complex ring structures. In the third chapter of this text, we take one of the reactions discovered in the course of our work in diene-allene cycloadditions and apply it to the total synthesis of antimalarial bisindole alkaloids flinderoles B and C. The key step, a gold(I)-catalyzed hydroarylation of an allene using a C2-indole nucleophile, simulatenously installs three of four unique structural motifs of this natural product.
Book Synopsis Advances in Triazole Chemistry by : Tahir Farooq
Download or read book Advances in Triazole Chemistry written by Tahir Farooq and published by Elsevier. This book was released on 2020-11-28 with total page 266 pages. Available in PDF, EPUB and Kindle. Book excerpt: Advances in Triazole Chemistry reviews the ever-widening scope of triazole chemistry. Triazole is an exceptional structural motif with a range of applications across scientific disciplines, including materials science, organocatalysis, agrochemicals, and medicinal chemistry. These many applications of different classes of triazoles have promoted the development of a range of synthetic strategies over the past few years, which are presented here along with recent and ecofriendly methods for the synthesis of all types of triazoles. The book also reviews the recent notable applications in chemical ligation, peptidomimetics, carbohydrate chemistry, nanotechnology, and polymer and materials science. This comprehensive resource is ideal for researchers using triazoles in various disciplines, as well as chemists working in the pharmaceutical, polymer, and agrochemical industries. Includes coverage of the role triazoles play in DNA synthesis Features comprehensive information on 1,2,3-triazoles and 1,2,4-triazoles and their subclasses, synthesis, and applications Serves as an ideal reference for researchers and chemists interested in using triazole chemistry for functionalization, modification, and development of target products
Book Synopsis Designing Novel 1,2,3- and 1,2,4-triazoles for Coordination Complexes and Frameworks by : Brianna Celiese Hughes
Download or read book Designing Novel 1,2,3- and 1,2,4-triazoles for Coordination Complexes and Frameworks written by Brianna Celiese Hughes and published by . This book was released on 2015 with total page 136 pages. Available in PDF, EPUB and Kindle. Book excerpt: Triazoles are versatile ligands that form a variety of compounds and extended materials within the field of coordination chemistry. The reactions of triazoles with metals lead to the synthesis of homoleptic complexes, coordination polymers and metal-organic frameworks (MOFs). These triazole compounds and materials have been employed for a variety of applications in chemistry ranging from nanomaterials to anion recognition. The synthesis of tris(1,2,3-triazolyl)borate completed and complemented the initial research began by Trofimenko in 1966. This ligand was used in metal reactions and found to form both homoleptic complexes and coordination polymers. The connectivity of the tris(1,2,3-triazolyl)borate varied dependent on the transition metal employed. The success of incorporating a triazole onto a borate ligand led to further work utilizing novel triazole derivatives. By combining a borane with a 1,2,3-triazole, a borate-nitrenium that has an overall neutral charge was synthesized. Nitrenium ligands are the nitrogen analog of Arduengo's N-heterocyclic carbene and have only recently been explored. Although initial attempts to synthesize a metal complex with the monodentate neutral nitrenium ligands were unsuccessful, these potential complexes could influence our understanding of transition metal bonds. Metal-organic frameworks were initially synthesized with carboxylates as the organic linkers connected to the metal centers of the scaffold. Recently, triazoles and tetrazoles have been utilized as an alternative for the formation of porous MOFs. The gate-opening effect of some breathing MOFs has been successfully shown with the inclusion of a bis-triazole linker with a rotating central moiety. By extending the central moiety from a phenyl ring to a biphenyl unit on the bis-triazole linker, we were able to demonstrate three separate states of rotation (open/open, open/closed, closed/closed) within three separate MOFs. These separate states were observed through single crystal X-ray diffraction and were the first example of an isostructurally designed family of gate-based breathing MOFs. Spin-crossover has been shown in iron MOFs by incorporating triazoles and tetrazoles within the organic linker. A family of mixed triazole/tetrazole as well as bis-tetrazole ligands were synthesized and tested with metal salts. A coordination polymer was synthesized with these ligands.
Book Synopsis Artificial Metalloenzymes and MetalloDNAzymes in Catalysis by : Montserrat Diéguez
Download or read book Artificial Metalloenzymes and MetalloDNAzymes in Catalysis written by Montserrat Diéguez and published by John Wiley & Sons. This book was released on 2018-02-21 with total page 431 pages. Available in PDF, EPUB and Kindle. Book excerpt: An important reference for researchers in the field of metal-enzyme hybrid catalysis Artificial Metalloenzymes and MetalloDNAzymes in Catalysis offers a comprehensive review of the most current strategies, developed over recent decades, for the design, synthesis, and optimization of these hybrid catalysts as well as material about their application. The contributors—noted experts in the field—present information on the preparation, characterization, and optimization of artificial metalloenzymes in a timely and authoritative manner. The authors present a thorough examination of this interesting new platform for catalysis that combines the excellent selective recognition/binding properties of enzymes with transition metal catalysts. The text includes information on the various applications of metal-enzyme hybrid catalysts for novel reactions, offers insights into the latest advances in the field, and contains an informative perspective on the future: Explores the development of artificial metalloenzymes, the modern and strongly evolving research field on the verge of industrial application Contains a comprehensive reference to the research area of metal-enzyme hybrid catalysis that has experienced tremendous growth in recent years Includes contributions from leading researchers in the field Shows how this new catalysis combines the selective recognition/binding properties of enzymes with transition metal catalysts Written for catalytic chemists, bioinorganic chemists, biochemists, and organic chemists, Artificial Metalloenzymes and MetalloDNAzymes in Catalysis offers a unique reference to the fundamentals, concepts, applications, and the most recent developments for more efficient and sustainable synthesis.
Book Synopsis Homogeneous Gold Catalysis by : LeGrande M. Slaughter
Download or read book Homogeneous Gold Catalysis written by LeGrande M. Slaughter and published by Springer. This book was released on 2015-03-30 with total page 292 pages. Available in PDF, EPUB and Kindle. Book excerpt: The series Topics in Current Chemistry presents critical reviews of the present and future trends in modern chemical research. The scope of coverage is all areas of chemical science including the interfaces with related disciplines such as biology, medicine and materials science. The goal of each thematic volume is to give the non-specialist reader, whether in academia or industry, a comprehensive insight into an area where new research is emerging which is of interest to a larger scientific audience. Each review within the volume critically surveys one aspect of that topic and places it within the context of the volume as a whole. The most significant developments of the last 5 to 10 years are presented using selected examples to illustrate the principles discussed. The coverage is not intended to be an exhaustive summary of the field or include large quantities of data, but should rather be conceptual, concentrating on the methodological thinking that will allow the non-specialist reader to understand the information presented. Contributions also offer an outlook on potential future developments in the field. Review articles for the individual volumes are invited by the volume editors. Readership: research chemists at universities or in industry, graduate students.
Book Synopsis Synthesis of Triazole Carboxylic Acid Derivatives as Ligands for Metal Binding by : Cassandra Schoborg
Download or read book Synthesis of Triazole Carboxylic Acid Derivatives as Ligands for Metal Binding written by Cassandra Schoborg and published by . This book was released on 2017 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis New Pathways for Organic Synthesis by : H.M. Colquhoun
Download or read book New Pathways for Organic Synthesis written by H.M. Colquhoun and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 459 pages. Available in PDF, EPUB and Kindle. Book excerpt: The continually growing contribution of transition metal chemistry to synthetic organic chemistry is, of course, widely recognized. Equally well known is the difficulty in keeping up-to-date with the multifarious reactions and procedures that seem to be spawned at an ever-increasing rate. These can certainly be summarized on the basis of reviews under the headings of the individual transition metals. More useful to the bench organic chemist, however, would be the opposite type of concordance based on the structural type of the desired synthetic product. This is the approach taken in the present monograph, which presents for each structural entity a conspectus of the transition metal-mediated processes that can be employed in its production. The resulting comparative survey should be a great help in devising the optimum synthetic approach for a particular goal. It is presented from an essentially practical viewpoint, with detailed direc tions interspersed in the Houben-Weyl style. The wide scope of the volume should certainly encourage synthetic organic chemists to utilize fully the range and versatility of these transition metal-mediated processes. This will certainly be a well-thumbed reference book! R. A. RAPHAEL Cambridge University v Preface In recent years an enormous amount of work has been done on the catalysis of organic reactions by various transition metal species and on the organic reactivity of organo-transition-metal compounds.
Book Synopsis 1,2,3-(NH)-triazoles by : Sujata Sengupta
Download or read book 1,2,3-(NH)-triazoles written by Sujata Sengupta and published by . This book was released on 2010 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Synthesis of Functional 1,2,3-triazoles and Its Applications in Transition Metal Catalysis by : Wuming Yan
Download or read book Synthesis of Functional 1,2,3-triazoles and Its Applications in Transition Metal Catalysis written by Wuming Yan and published by . This book was released on 2012 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Catalytic Asymmetric Synthesis by : Takahiko Akiyama
Download or read book Catalytic Asymmetric Synthesis written by Takahiko Akiyama and published by John Wiley & Sons. This book was released on 2022-05-27 with total page 798 pages. Available in PDF, EPUB and Kindle. Book excerpt: Catalytic Asymmetric Synthesis Seminal text presenting detailed accounts of the most important catalytic asymmetric reactions known today This book covers the preparation of enantiomerically pure or enriched chemical compounds by use of chiral catalyst molecules. While reviewing the most important catalytic methods for asymmetric organic synthesis, this book highlights the most important and recent developments in catalytic asymmetric synthesis. Edited by two well-qualified experts, sample topics covered in the work include: Metal catalysis, organocatalysis, photoredox catalysis, enzyme catalysis C–H bond functionalization reactions Carbon–carbon bond formation reactions, carbon–halogen bond formation reactions, hydrogenations, polymerizations, flow reactions Axially chiral compounds Retaining the best of its predecessors but now thoroughly up to date with the important and recent developments in catalytic asymmetric synthesis, the 4th edition of Catalytic Asymmetric Synthesis serves as an excellent desktop reference and text for researchers and students, from upper-level undergraduates all the way to experienced professionals in industry or academia.
Book Synopsis Metal Complexes of 1,2,3-triazoles and 1,2,3-triazole Derived Abnormal Carbenes and Their Applications in Catalysis by :
Download or read book Metal Complexes of 1,2,3-triazoles and 1,2,3-triazole Derived Abnormal Carbenes and Their Applications in Catalysis written by and published by . This book was released on 2014 with total page 344 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Metallocenes in Regio- and Stereoselective Synthesis by : Marko Hapke
Download or read book Metallocenes in Regio- and Stereoselective Synthesis written by Marko Hapke and published by Springer. This book was released on 2024-06-20 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book presents the latest synthetic protocols for the assembly of functionalized Cp ligands and their transition metal complexes. Cyclopentadienyl (Cp) complexes of transition metals belong to the most important classes of transition metal complexes with tightly bound ligands in the coordination sphere since their discovery in the middle of the last century. Even though they have been known for a long time, this field constantly evolves to deliver novel modified Cp ligands and complexes and to blossom into new fields of application. Beside the synthesis of ligands and metal complexes this book concentrates on novel and prospering fields of their application in organic synthesis. In this respect the Cp complexes have been applied to induce and catalyze various significant chemical transformations such as new C-C bond formation involving unsaturated substrates (e.g. cyclotrimerizations, cycloadditions, carbometallations, etc.), C-H bond and C-C bond activations followed by subsequent reactions (e.g. arylation, alkenylations, annulations, etc.), as well as many other processes. This volume also covers the recent development and application of chiral Cp complexes in enantioselective synthesis.
Book Synopsis The Development and Application of Gold(I)-Catalyzed Cyclization Cascades by : Steven Gregory Sethofer
Download or read book The Development and Application of Gold(I)-Catalyzed Cyclization Cascades written by Steven Gregory Sethofer and published by . This book was released on 2011 with total page 460 pages. Available in PDF, EPUB and Kindle. Book excerpt: The formation of saturated carbon-carbon bonds in a precise and controlled manner is arguably the principal objective of organic synthesis. Carbocyclic ring systems comprise the underlying structure for the preponderance of natural products and pharmaceutical agents. Therefore, synthetic methods capable of selectively initiating polycyclization processes in the presence of spectating functionality are of significant value, particularly so when multiple stereocenters are formed enantioselectively. The emergence of phosphine gold(I) catalysis over the past decade has opened up new avenues to carbocycle formation via pi activation of alkynes occurring under exceedingly mild conditions and with excellent chemoselectivity. The research described herein describes the use of homogenous gold(I) complexes to initiate electrophilic cyclization cascades. Through rational substrate design, carbocationic centers may be generated in a predictable manner and employed in subsequent intramolecular cyclization processes. Chapter 1 introduces the unique reactivity observed in complexes of gold imparted by its relativistically accelerated valence electrons. One consequence of this perturbation is the linear geometry maintained by gold(I) complexes, minimizing the influence of ligand-based chirality on reactions occurring at coordinated alkynes. In spite of this challenge, moderate levels of enantioselectivity were achieved in the desymmetrization of dienynes by cycloisomerization using chiral bisphosphite gold(I) catalysts. Ultimately, we were able to achieve selectivities up to 98% ee using hindered chiral bisphosphine gold(I) catalysts during the evaluation of another enyne cycloisomerization reaction, described in chapter 2. In this process, an initial regioselective cyclization was used to generate a carbocationic species poised to undergo intramolecular trapping. Consistently high enantioselectivity was maintained using various pendant oxygen, carbon and nitrogen nucleophiles. The diastereomerically pure bi- and tricyclization products obtained provided support for a concerted polyene cyclization mechanism as predicted by the Stork- Eschenmoser postulate. Chapter 3 describes another tandem process exploiting the transient cationic species arising from gold(I)-promoted enyne cycloisomerization. In this case, a gold(I)-initiated tandem cyclopentannulation reaction was employed in the total synthesis of the novel triquinane ventricosene. A cyclopropanol unit embedded in the enyne substrate underwent a semipinacol rearrangement in response to the carbocation, leading cleanly to bicyclo[3.2.0]heptan-6-one products. For cyclopentenyl substrates, the hindered all-carbon quaternary center and all of the ring fusions of the angular triquinane ring system were formed at once. The choice of a hydrocarbon target highlighted the utility of gold(I) catalysts as selective activators of carbon unsaturation; throughout the synthesis only a single heteroatom was present. This work concludes by extending the scope gold(I)-catalyzed carbocyclization reactions which generate useful cationic intermediates. The gold(I)-catalyzed Rautenstrauch rearrangement forms a cyclopentene-based cationic species which was shown to undergo efficient trapping by pendant arenes to give a saturated 5,6-ring fusion comprising a chiral benzylic quaternary center. The chirality transfer observed in the parent process was found to be conserved in the tandem process. Interestingly, cyclization of racemic substrates by chiral bisphosphine digold catalysts was found to proceed with moderate enantioselectivity, suggesting a competing mechanism is in effect which proceeds through an achiral intermediate.
Book Synopsis Solvents as Reagents in Organic Synthesis by : Xiao-Feng Wu
Download or read book Solvents as Reagents in Organic Synthesis written by Xiao-Feng Wu and published by John Wiley & Sons. This book was released on 2018-01-03 with total page 552 pages. Available in PDF, EPUB and Kindle. Book excerpt: Written by highly renowned and experienced authors, this is the only reference on the application of solvents as reagents. Clearly structured, the text describes various methods for the activation and reaction of these small molecules, highlighting the synthetic opportunities as well as process-oriented advantages. To this end, all relevant types of solvents are covered separately and emphasized with numerous synthetic examples, while taking care to explain applications so as to avoid undesired side reactions. The result is a unique resource for every synthetic chemist and reaction engineer in industry and academia working on the methodical optimization of synthetic transformations.
Book Synopsis Design of New Monodentate Ligands for Regioselectivity and Enantioselectivity Tuning in Late Transition Metal Catalysis by : Aaron A. Ruch
Download or read book Design of New Monodentate Ligands for Regioselectivity and Enantioselectivity Tuning in Late Transition Metal Catalysis written by Aaron A. Ruch and published by . This book was released on 2016 with total page 247 pages. Available in PDF, EPUB and Kindle. Book excerpt: The ability of gold(I) to activate many types of unsaturated bonds toward nucleophilic attack was not widely recognized until the early 2000s. One major challenge in gold catalysis is the control over regioselectivity when there are two or more possible products as a result of complicated mechanistic pathways. It is well know that the choice of ligand can have dramatic effects on which pathway is being followed but very rarely are the reasons for this selectivity understood. The synthesis of new acyclic diaminocarbenes was developed and a study of the ligand effects on the regioselectivity of a gold-catalyzed domino enyne cyclization hydroarylation reaction and a Nazarov cyclization was undertaken. New chiral acyclic diaminocarbenes were also developed and tested along side new C3-symmetric phosphite ligands in an asymmetric intramolecular hydroamination of allenes. Structure activity correlations were developed for the potential use in further rational ligand design. The synthesis of 6a,7-dihydro-5-amino-dibenzo[c,g]chromene derivatives via a gold-catalyzed domino reaction of alkynylbenzaldehydes in the presence of secondary amines was developed. These were sent to be screened for biological activity.
Book Synopsis Multicomponent One-pot One-step Synthesis of 1,2,3-Triazoles Via Cu/Pd Catalysis by : Jung Yun Kim
Download or read book Multicomponent One-pot One-step Synthesis of 1,2,3-Triazoles Via Cu/Pd Catalysis written by Jung Yun Kim and published by . This book was released on 2014 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: In modern synthetic chemistry, the formation of multiple C-C bonds in a limited number of steps to access both diversity and complexity has become an important challenge. In recent years, significant research has been devoted to the synthesis of 1,2,3-triazole containing compounds in a multimetal-catalyzed domino sequence due to the remarkable biological activity and pharmaceutical potency of these compounds. Considering the increasing significance of 1,2,3-triazoles in synthetic chemistry, mixing all of the starting components in a one-pot, one-step process to create the final triazole product will be highly efficient with respect to time, cost and simplicity of performance. A number of published papers illustrated the diverse applications of 1,2,3-triazoles (e.g., palladium-mediated couplings and direct C-H bond functionalization). Similarly, this work demonstrates the development of a highly efficient and practical approach to the synthesis of these versatile triazole-containing motifs via a one-pot, one-step cascade process that involves Sonogashira, Heck and carbopalladation/annulation reactions.
