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Synthesis Derivatization And Characterization Of Rhenium Technetium Mono And Bis6 Arene Complexes For The Application In Medicinal Chemistry
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Book Synopsis Synthesis, Derivatization and Characterization of Rhenium/technetium Mono- and Bis(η6-arene) Complexes for the Application in Medicinal Chemistry by : Giuseppe Meola
Download or read book Synthesis, Derivatization and Characterization of Rhenium/technetium Mono- and Bis(η6-arene) Complexes for the Application in Medicinal Chemistry written by Giuseppe Meola and published by . This book was released on 2019 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Synthesis and Reactivity of Rhenium and Technetium Polyaryl Complexes by : Christopher Alan Morse
Download or read book Synthesis and Reactivity of Rhenium and Technetium Polyaryl Complexes written by Christopher Alan Morse and published by . This book was released on 1998 with total page 334 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Synthesis, Characterization, and Reactivity of Technetium and Rhenium Complexes in Intermediate Oxidation States by : Harvey Stewart Trop
Download or read book Synthesis, Characterization, and Reactivity of Technetium and Rhenium Complexes in Intermediate Oxidation States written by Harvey Stewart Trop and published by . This book was released on 1979 with total page 482 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Rhenium Complexes Based on Triazolyl Derivatives by : Jin-Hui Wang
Download or read book Rhenium Complexes Based on Triazolyl Derivatives written by Jin-Hui Wang and published by . This book was released on 2017 with total page 281 pages. Available in PDF, EPUB and Kindle. Book excerpt: Rhenium complexes play a significant role in nuclear medicine. Rhenium has been widely used as a surrogate of technetium for a long time, and the promising physical features of 186Re and 188Re, make 186/188Re-complexes promising candidates as therapeutic radiopharmaceuticals.Similarly, the interesting photoactive and photoluminescence properties of non-radioactive Re-complexes make them excellent catalysts, luminescent materials and imaging sensors.Thus, in this work, our goal was to (i) develop, using a click chemistry strategy, multidentate ligands for the stabilization of different rhenium cores [Re(CO)3]+ and [ReO]3+ (M = Re or 188Re) as well as the analogous 99mTc-cores in some examples, (ii) assess the potential of the rhenium(technetium) complexes as imaging (natRe or 99mTc) or therapeutic (188Re) agents. To do so, two rhenium(technetium) specific-chelating systems were used: a semi-rigid tripodal system in the second chapter and a pyta moiety in the third chapter, these two chelators being developed previously in our group. Thus, based on a N2O tridentate click ligand, two different studies were carried out in chapter II. In the first one, two synthetic pathways to a range of potentially N3O tetradentate ligands, designed to coordinate rhenium cores as well as their coordination behaviors towards different rhenium cores (oxidation states +I and +V), were investigated. The first radiolabeling results combined with the recent work reported by Dugave and co-workers indicated that this ligand could be a promising 99mTc-chelator for nuclear imaging applications. As perspectives to this work, the extension of the radiolabelling work using the [188ReVO]3+ core should be performed, and the in vitro stability should be tested under physiological conditions in human plasma and by cysteine exchange experiments. The second study was focused on the development of novel hypoxia-selective 99mTc radiopharmaceuticals. Our semi-rigid tripodal click framework was decorated with an appended nitro group (either a nitrobenzyl group or a metronidazole (Mtz) unit). Different positions were considered and at least only two metronidazole (Mtz)-containing ligands and one nitro group-containing ligand as well as their corresponding tricarbonyl rhenium(I) complexes were obtained and characterized, in particular by electrochemistry. The reduction potentials of NO2 group in complexes [Re(CO)3Cl(L2)] and [Re(CO)3(L6)] were similar to those of reported hypoxic imaging agents, prompting us to further investigate other properties of these complexes. Chapter III was focused on the study of AIE (aggregation-induced emission) effect in tricarbonyl Re(I) complexes, the association of this effect with the intrinsic properties of Re(I) complexes being expected to lead to very attractive compounds. To do that, we combined an organic fluorophore (PBO) which exhibits excellent stability and optical properties, with a tricarbonylrhenium(I) complex based on a pyta unit (either a 2-pyridyl-1,2,3-triazole or a 2-pyridyl-1,2,4-triazole ligands). Four compounds were studied. The X-Ray structures revealed spectacular discrepancies between the two first triazole-based complexes ReL8 and ReL9. Moreover, this study being a novel orientation in our group, this work is a great starting point for further investigations. Various organic dyes and/or structural modifications of the organic moiety will soon be considered in order to develop highly emissive rhenium(I) luminescent probes.
Book Synopsis Synthesis and Characterization of Technetium and Rhenium Organohydrazide Complexes by : Melissa Hirsch Kuchma
Download or read book Synthesis and Characterization of Technetium and Rhenium Organohydrazide Complexes written by Melissa Hirsch Kuchma and published by . This book was released on 1997 with total page 392 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Chemistry and Radiochemistry on Rhenium and Technetium for Applications as Potential Radiopharmaceuticals by : Jenny L. Green
Download or read book Chemistry and Radiochemistry on Rhenium and Technetium for Applications as Potential Radiopharmaceuticals written by Jenny L. Green and published by . This book was released on 2004 with total page 120 pages. Available in PDF, EPUB and Kindle. Book excerpt: This thesis investigates the synthesis and characterization of Re(III) and Re(V)oxo Schiff base complexes with tertiary phosphines. The complexes are formed by reacting trans -[Re V O(X)L] + with tertiary phosphine of the type PR 3 . The result of these reactions yielded two different complexes, the mono cis PR 3 or the bis trans PR 3 . It was noticed that the yielded complex was dependent on both the type of ligand and phosphine. When the ligand was acac 2 pn the result was always a complex of the form cis -[Re V O(PR 3)(acac 2 pn)] + . A series of reactions with monodentate nucleophiles was investigated in an attempt to better understand the rearrangement versus reduction phenomenon that was seen with tertiary phosphines. The reactions involved starting with the Re(V)oxo complex and reacting it with either NCS - or CN - It was noticed that regardless of the nucleophile or ligand the rearranged product analogous to the form cis -[Re V O(X)(L)] was yielded. A radiolabeling experiment with technetium was done with the Schiff base ligand acac 2 pn and tertiary phosphines. The results suggest that the complex formed is most likely of the form, trans -[Tc III (PR 3) 2 (acac 2 pn)] + . This is based on comparing the data to the Re(III) and Re(V)oxo phosphine complexes and to trans -[Tc III (PR 3) 2 (acac 2 en)] +.
Book Synopsis Synthesis, Derivatisation and Characterisation of Rhenium Mono- and Bis(η6-benzoic Acid) Complexes as Potential Bioorganometallic Building Blocks by : Carla Gotzmann
Download or read book Synthesis, Derivatisation and Characterisation of Rhenium Mono- and Bis(η6-benzoic Acid) Complexes as Potential Bioorganometallic Building Blocks written by Carla Gotzmann and published by . This book was released on 2019 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Ruthenium Chemistry by : Ajay Kumar Mishra
Download or read book Ruthenium Chemistry written by Ajay Kumar Mishra and published by CRC Press. This book was released on 2018-01-17 with total page 386 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book will describe Ruthenium complexes as chemotherapeutic agent specifically at tumor site. It has been the most challenging task in the area of cancer therapy. Nanoparticles are now emerging as the most effective alternative to traditional chemotherapeutic approach. Nanoparticles have been shown to be useful in this respect. However, in view of organ system complicacies, instead of using nanoparticles as a delivery tool, it will be more appropriate to synthesize a drug of nanoparticle size that can use blood transport mechanism to reach the tumor site and regress cancer. Due to less toxicity and effective bio-distribution, ruthenium (Ru) complexes are of much current interest. Additionally, lumiscent Ru-complexes can be synthesized in nanoparticle size and can be directly traced at tissue level. The book will contain the synthesis, characterization, and applications of various Ruthenium complexes as chemotherapeutic agents. The book will also cover the introduction to chemotherapy, classification of Ru- complexes with respect to their oxidation states and geometry, Ruthenium complexes of nano size: shape and binding- selectivity, binding of ruthenium complexes with DNA, DNA cleavage studies and cytotoxicity. The present book will be more beneficial to researchers, scientists and biomedical. Current book will empower specially to younger generation to create a new world of ruthenium chemistry in material science as well as in medicines. This book will be also beneficial to national/international research laboratories, and academia with interest in the area of coordination chemistry more especially to the Ruthenium compounds and its applications.
Book Synopsis Synthesis and Characterization of Rhenium Oxo and Nitrido Complexes for Potential Therapeutic Applications by : Britt E. Allgood
Download or read book Synthesis and Characterization of Rhenium Oxo and Nitrido Complexes for Potential Therapeutic Applications written by Britt E. Allgood and published by . This book was released on 1992 with total page 110 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Synthesis and Characterization of Rhenium (III & V) Schiff Base Complexes for Nuclear Medicine by : Paul Douglas Benny
Download or read book Synthesis and Characterization of Rhenium (III & V) Schiff Base Complexes for Nuclear Medicine written by Paul Douglas Benny and published by . This book was released on 2001 with total page 588 pages. Available in PDF, EPUB and Kindle. Book excerpt: This dissertation investigates the synthesis and characterization of several rhenium Schiff base complexes as potential radiopharmaceuticals for imaging and therapeutic purposes. A series of acetylacetone derived tetradentate N 2 O 2 Schiff base ligands (i.e., acac 2 en, acac 2 pn, acac 2 dmpn) were reacted with a rhenium (V) starting material (i.e., n-Bu 4 N[ReOCl 4], ReOCl 3 (PPh 3) 2) to yield a series of compounds. In most cases, reaction's involving [n-Bu 4 N][ReOCl 4] with two equivalents of ligand in ethanol yielded monomer complexes of the form trans -[ReO(Ligand)X]. The type of axial substituent, X = Cl -, H 2 O, ReO 4 -, MeO -, found trans to the rhenium oxo group can be adjusted by altering the reaction conditions. A similar reaction utilizing ReOCl 3 (PPh 3) 2, one equivalent of the ligand, and triethylamine yielded [mu]-oxo dimer complexes, trans -[Re 2 O 3 (Ligand) 2]. The conversion of rhenium (V) Schiff base monomer complexes into [mu]-oxo dimer complexes was investigated to gain a better understanding of conditions that yield monomer compounds. Experiments reacting trans -[ReO(acac 2 pn)Cl] with various solution conditions led to the proposal of a dimer formation mechanism that involves two pathways: (1) addition of base(OH - ) and (2) addition of water to generate a trans aquo species and additional water molecules to deprotonate the coordinated water molecule. The rhenium (V) monomer complexes, trans -[ReO(acac 2 en)OH 2]Cl and trans -[ReO(acac 2 pn)Cl], were also reacted with phosphine ligands to potentially generate a bis -phosphine(Schiff base)rhenium(III) cationic complexes, trans -[Re(Ligand)(PR 3) 2] + . The trans -[ReO(acac 2 en)H 2 O]Cl complex yielded the Re (III) complex when reacted with phosphines, while the Schiff base ligand of the [trans -ReO(acac 2 pn)]Cl complex underwent an intramolecular rearrangement to yield an asymmetric complex, [cis -ReO(acac 2 pn)PR 3]X. A mechanism is proposed for the rearrangement of the Schiff base ligand in the complex upon treatment with phosphine ligands. Further experiments with other soft monodentate ligands (i.e., thiocyanate, cyanide) yielded neutral asymmetric complexes. A series of experiments investigated the removal radioactive Tc-99 from solution through precipitation. The study focused on precipitating agents that could be added to a simulated waste stream at a uranium reprocessing plant to remove Tc-99 as a pertechnetate ion pair or a reduced Tc (IV) complex.
Book Synopsis Design, Synthesis and Characterization of Novel Rhenium(V) and Technetium(V) Complexes as Potential Radiopharmaceuticals by : Patrick Simon Hlabela
Download or read book Design, Synthesis and Characterization of Novel Rhenium(V) and Technetium(V) Complexes as Potential Radiopharmaceuticals written by Patrick Simon Hlabela and published by . This book was released on 2000 with total page 322 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Synthesis, Characterization, and Photophysical Investigation of Some New Rhenium(I) Complexes by : David Joseph Anderson
Download or read book Synthesis, Characterization, and Photophysical Investigation of Some New Rhenium(I) Complexes written by David Joseph Anderson and published by . This book was released on 1991 with total page 392 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Technetium and Rhenium by : Kenji Yoshihara
Download or read book Technetium and Rhenium written by Kenji Yoshihara and published by Springer. This book was released on 2014-03-12 with total page 301 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Synthesis, Characterization, and Reactivity of Rhenium Dithiodiolate and Monothiodiolate Complexes by : Pitak Chuawong
Download or read book Synthesis, Characterization, and Reactivity of Rhenium Dithiodiolate and Monothiodiolate Complexes written by Pitak Chuawong and published by . This book was released on 2001 with total page 190 pages. Available in PDF, EPUB and Kindle. Book excerpt: The rhenium dithiodiolate, Hydrido-tris-(3,5-dimethyl- 1 -pyrazol yl) borato(ethane- 1,2-dithiodiolato)(oxo)rheni um(V), and Hydrido-tris-(3,5-dimethyl- 1 -pyrazolyl)borato(phenylethanedithiodiolato)(oxo)rhenium(V), were synthesized by reductive cyclocondensation of alkane-1,2-dithiols with Tp'Re03 in a one pot fashion. The rhemium monothiodiolate, Hydrido-tris-(3,5-dimethyl- 1 -pyrazolyl) borato(ethane- 1,2-monothiodiolato)(oxo)rhenium(V), and Hydrido-tris-(3,5- dimethyl- 1 -pyrazolyl)borato(propanemonothiodiolato)(oxo)rhenium(V), were also synthesized by using the same procedure. The syn and anti isomers of rhenium phenylethanedithiodiolate and rhenium propanemonothiodiolate were characterized by using COSY, nOe, and HSQC experiments. An X-ray crystal structure of the rhenium ethanedithiodiolate was obtained, and an unusually small dihedral angle (S-C-C-S) of about 12° was observed. The solution conformation of these compounds was investigated by using a Karplus relationship between vicinal coupling constants and dihedral angle. The dihedral angle for the ethanedithiodiolate appeared to be 38° indicating a staggered geometry for the ring. All of these complexes failed to cyclorevert to any detectable extent at 120°C after 7 days. This observation reflects the thermal stability of rhenium dithiodiolate and monothiodiolate complexes. Energetics of ethylene addition to tetrathioperrhenate anion (ReS4−) and addition of hydrogen sulfide to the alkene adduct were calculated by DFT calculation using LACVP** basis set with B3LYP functionals. The heat of reaction of ethylene addition to ReS4− was 15.4 kcal/mol, and 111.1 kcal/mol for addition of hydrogen sulfide to the alkene adduct. These results are consistent with the stability of the dithiodiolate complex toward cycloreversion reaction. Reaction of Tp'Re03 and ethylene sulfide led to the rhenium ethanedithiolate complex both with and without acid catalysis. This observation led to a proposed multi step mechanism.
Book Synopsis The Chemistry of Technetium and Rhenium by : Raymond Dixon Peacock
Download or read book The Chemistry of Technetium and Rhenium written by Raymond Dixon Peacock and published by . This book was released on 1966 with total page 156 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Novel Rhenium, Technetium and Nickel Complexes as Radiopharmaceuticals in Nuclear Medicine by : Mohamad Jaber Ibrahim Al-Jeboori
Download or read book Novel Rhenium, Technetium and Nickel Complexes as Radiopharmaceuticals in Nuclear Medicine written by Mohamad Jaber Ibrahim Al-Jeboori and published by . This book was released on 1996 with total page 211 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Coordination Chemistry of Re(I) Carbonyl Complexes as Pharmaceutically Important Compounds and Synthesis, Characterization, and Metalation of Novel Phthalocyanine Analogs by : Wijeendra M. Roshinee Samathika Costa
Download or read book Coordination Chemistry of Re(I) Carbonyl Complexes as Pharmaceutically Important Compounds and Synthesis, Characterization, and Metalation of Novel Phthalocyanine Analogs written by Wijeendra M. Roshinee Samathika Costa and published by . This book was released on 2011 with total page 251 pages. Available in PDF, EPUB and Kindle. Book excerpt: "A significant expansion of the synthesis of technetium and rhenium compounds has resulted from the interest in their diagnostic and therapeutic nuclear medicinal applications. One main goal for future Tc/Re radiopharmaceuticals is to find robust compounds that can withstand harsh biological conditions. Recent work has shown that compounds based on the [Re/Tc(CO)3] core exhibit increased resistance towards decomposition. The radionuclide 99mTc is a [gamma]-emitter with a medically useful energy and half-life which is appropriate for the requirements of preparing and administrating diagnostic imaging agents. The chemistry of rhenium is very similar to that of technetium, and it can be used to model technetium complexes. The first part of this dissertation describes the preparation, characterization and properties of Re(CO)3 complexes for possible medicinal applications using oxime, dithiocarbamate, and pyridylimine-based ligand systems. One important class of phthalocyanine analogs is known as the hemiporphyrazines and was first synthesized by Elvidge and Linstead more than five decades ago. In some of these macrocycles, nitrogen atoms in the core are replaced by one or more carbon atoms, similar to carbaporphyrins. This type of phthalocyanine analog can be obtained by replacing one or two diiminoisoindoline units with other heterocycle rings. A phthalocyanine with a single isoindoline replaced with one benzene ring is known as benziphthalocyanine and a phthalocyanine with two opposite isoindoline rings replaced with benzene rings is known as dicarbahemiporhyrazine. The second part of the dissertation describes the preparation, characterization of similarly structured hemiporphyrazines, by incorporating phenol, resorcinol and cyclohexane, as well as a description of the metalation chemistry of these macrocycles with Ag(I) and Co(II)."--Abstract.
