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Synthesis Characterization And Use Of New Chiral P N Ligands In The Palladium Catalyzed Asymmetric Allylic Alkylation And A New Synthetic Route To The Preparation Of Optically Active Cyclomercurated Ferrocenylimines
Download Synthesis Characterization And Use Of New Chiral P N Ligands In The Palladium Catalyzed Asymmetric Allylic Alkylation And A New Synthetic Route To The Preparation Of Optically Active Cyclomercurated Ferrocenylimines full books in PDF, epub, and Kindle. Read online Synthesis Characterization And Use Of New Chiral P N Ligands In The Palladium Catalyzed Asymmetric Allylic Alkylation And A New Synthetic Route To The Preparation Of Optically Active Cyclomercurated Ferrocenylimines ebook anywhere anytime directly on your device. Fast Download speed and no annoying ads. We cannot guarantee that every ebooks is available!
Book Synopsis Chiral Ligands by : Montserrat Diéguez
Download or read book Chiral Ligands written by Montserrat Diéguez and published by CRC Press. This book was released on 2021-05-12 with total page 338 pages. Available in PDF, EPUB and Kindle. Book excerpt: Many new drugs on the market are chiral compounds, that is, they can exist in two non-superimposable mirror-image forms. Asymmetric catalysis encompasses a large variety of processes for obtaining such compounds. The performance of the catalyst in those processes largely depends on the ligand that makes up the catalyst. This book describes the most relevant ligand libraries for some key processes, including an overview of the state of art and the key mechanistic aspects that favor a high catalytic performance. Key Features: The book presents historical content from the time of discovery for each family of ligands. Provides a description of the synthetic route and the ligand library's application in various catalytic asymmetric reactions Suitable as supplementary reading for courses targeting the design, synthesis and application of chiral catalysts, asymmetric catalysis and sustainable production Edited by a distinguished scientist in the field, the book has a diverse audience including research groups in homogeneous catalysis, particularly asymmetric transformations
Book Synopsis Development and Evaluation of Chiral Catalysts for Asymmetric C-C and C-H Bond forming Reactions by : Christian Ebner
Download or read book Development and Evaluation of Chiral Catalysts for Asymmetric C-C and C-H Bond forming Reactions written by Christian Ebner and published by Cuvillier Verlag. This book was released on 2012-03-05 with total page 263 pages. Available in PDF, EPUB and Kindle. Book excerpt: This work was dedicated to the development and evaluation of new chiral catalysts for asymmetric C-C and C-H bond forming reactions. In the first part of the thesis an ESI-MS screening method is described, which allows the determination of a chiral catalyst´s selectivity in the palladium catalyzed asymmetric allylic alkylation by testing its racemic form. The value of this new method was demonstrated when different new aryl-PHOX-type ligands, which are not easily accessible in their enantiopure form, were evaluated. In the second part new PHOX-type ligands were tested in the iridium-catalyzed asymmetric hydrogenation of different unsaturated compounds. Although low activities and selectivities were found in most cases, one ligand showed promising results in the hydrogenation of allylic alcohols and imines. Furthermore air- and moisture-stable secondary phosphine oxide (SPO) containing bidentate ligands were tested in the palladium-catalyzed asymmetric allylic alkylation reaction. SPO,N-ligands bearing a PHOX type backbone were inactive in this transformation as they tend to form inactive palladium-bis-ligand complexes. SPO,P ligands however, were able to promote the desired reaction in a highly selective fashion although only low activities were found. During this work as well a new organo-catalyst, based on the structure of 2,3-dihydrobenzo[1,4]oxazine, was developed which allows for the asymmetric organo-catalyzed transfer-hydrogenation of α,β-unsaturated aldehydes. This catalyst was able to reduce for the first time β, β-diaryl acrylaldehydes with very good activities and high enantioselectivities. Moreover an ESI-MS based mechanistic study on the tripeptide catalyzed conjugate addition reaction of aldehydes to nitroolefins was carried out. By this all reaction intermediates postulated for an enamine mechanism have been detected. Furthermore the attack of the enamine onto the nitroolefin was found to be the selectivity determining step in this process. The last part of this work aimed for the asymmetric α -allylation of carbonyl compounds by a tandem-catalysis approach. An intensive screening of both the organo-catalyst and the palladium-ligand led to reaction conditions which allowed for the selective mono-allylation of ketones in high yields. The formation of a quaternary center by α -allylation of α -branched aldehydes was also achieved. However, only low enantiomeric excesses were obtained in this transformation for the different catalyst systems tested.
Book Synopsis Development of New Synthetic Routes to Chiral Intermediates and Synthesis, Characterization of Novel Membrane Based Advanced Materials by : Guijun Wang
Download or read book Development of New Synthetic Routes to Chiral Intermediates and Synthesis, Characterization of Novel Membrane Based Advanced Materials written by Guijun Wang and published by . This book was released on 1999 with total page 466 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Chiral Sulfur Ligands by : Hélène Pellissier
Download or read book Chiral Sulfur Ligands written by Hélène Pellissier and published by Royal Society of Chemistry. This book was released on 2009 with total page 403 pages. Available in PDF, EPUB and Kindle. Book excerpt: The goal of this book is to show the high potential of chiral sulfur-containing ligands to promote numerous asymmetric catalytic transformations. These ligands can now be recognised as real competitors to the more usual phosphorus- or nitrogen-containing ligands.
Book Synopsis Chiral Diazaligands for Asymmetric Synthesis by : Marc Lemaire
Download or read book Chiral Diazaligands for Asymmetric Synthesis written by Marc Lemaire and published by Springer. This book was released on 2010-02-12 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: The use of phosphine derivatives has historically induced the tremendous development of catalysis (both non-asymmetric and asymmetric). Although the chemistry of amines is more documented, the use of nitrogen-containing ligands only appeared recently. Nevertheless, during the last ten years, the results describing chiral diamine preparations and their uses in asymmetric catalysis and synthesis are increasing faster than their phosphorus counterparts. The reader will find in this volume the most recent methods for the synthesis of chiral diamines as well as their applications in asymmetric catalysis of CC bond formation. Particular attention will be given to spartein and derivatives of such diamines. Recently, the particular properties and the chemistry of amines allowed to obtain catalysts easy to separate and recycle and new types of ligands such as diaminocarbenes, ureas and thioureas. Finally, the complexing properties of some diamines allowed the formation of complexes with chirality "at the metal " which is of major theoretical interest and presents numerous potential applications.
Book Synopsis Polymeric Chiral Catalyst Design and Chiral Polymer Synthesis by : Shinichi Itsuno
Download or read book Polymeric Chiral Catalyst Design and Chiral Polymer Synthesis written by Shinichi Itsuno and published by John Wiley & Sons. This book was released on 2011-06-28 with total page 674 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book reviews chiral polymer synthesis and its application to asymmetric catalysis. It features the design and use of polymer-immobilized catalysts and methods for their design and synthesis. Chapters cover peptide-catalyzed and enantioselective synthesis, optically-active polymers, and continuous flow processes. It collects recent advances in an important field of polymer and organic chemistry, with leading researchers explaining applications in academic and industry R & D.
Book Synopsis Transition Metal Catalyzed Enantioselective Allylic Substitution in Organic Synthesis by : Uli Kazmaier
Download or read book Transition Metal Catalyzed Enantioselective Allylic Substitution in Organic Synthesis written by Uli Kazmaier and published by Springer Science & Business Media. This book was released on 2011-10-29 with total page 354 pages. Available in PDF, EPUB and Kindle. Book excerpt: Giovanni Poli, Guillaume Prestat, Frédéric Liron, Claire Kammerer-Pentier: Selectivity in Palladium Catalyzed Allylic Substitution.- Jonatan Kleimark and Per-Ola Norrby: Computational Insights into Palladium-mediated Allylic Substitution Reactions.- Ludovic Milhau, Patrick J. Guiry: Palladium-catalyzed enantioselective allylic substitution.- Wen-Bo Liu, Ji-Bao Xia, Shu-Li You: Iridium-Catalyzed Asymmetric Allylic Substitutions.- Christina Moberg: Molybdenum- and Tungsten-Catalyzed Enantioselective Allylic Substitutions.- Jean-Baptiste Langlois, Alexandre Alexakis: Copper-catalyzed enantioselective allylic substitution.- Jeanne-Marie Begouin, Johannes E. M. N. Klein, Daniel Weickmann, B. Plietker: Allylic Substitutions Catalyzed by Miscellaneous Metals.- Barry M. Trost, Matthew L. Crawley: Enantioselective Allylic Substitutions in Natural Product Synthesis.
Book Synopsis Atropisomerism And Axial Chirality by : Jose M Lassaletta
Download or read book Atropisomerism And Axial Chirality written by Jose M Lassaletta and published by World Scientific. This book was released on 2019-05-23 with total page 676 pages. Available in PDF, EPUB and Kindle. Book excerpt: Chapter contribution from Ben Feringa, Nobel Laureate in Chemistry 2016.Atropisomerism and Axial Chirality provides a global survey of the chemistry of axially chiral compounds including biaryls, heterobiaryls, non-biaryl atropisomers, allenes and spyrocyclic derivatives. From the perspective of a synthetic organic chemist, this book provides a unique compilation of the available methodologies for their synthesis, with emphasis on the most efficient and modern strategies, a review of the huge amount of practical applications in the field of asymmetric catalysis, either as transition metal ligands or as organocatalysts, and an overview of their occurrence as bioactive compounds and natural products.The first of its kind, this book serves as a general introduction and a practical reference to advanced chemistry students and researchers, while also offering creative ideas for further developments in the field.
Book Synopsis Asymmetric Synthesis by : James D. Morrison
Download or read book Asymmetric Synthesis written by James D. Morrison and published by Elsevier. This book was released on 2012-12-02 with total page 409 pages. Available in PDF, EPUB and Kindle. Book excerpt: The chapters in this volume have been written by some of the foremost practictioners in the field and should be of interest to both mechanistic and synthetic chemists.
Book Synopsis Chiral Phosphorous Based Ligands in Earth-Abundant Transition Metal Catalysis by : Junliang Zhang
Download or read book Chiral Phosphorous Based Ligands in Earth-Abundant Transition Metal Catalysis written by Junliang Zhang and published by Elsevier. This book was released on 2023-05-27 with total page 322 pages. Available in PDF, EPUB and Kindle. Book excerpt: Chiral Phosphorous Based Ligands in Earth-Abundant Transition Metal Catalysis summarizes the most significant progress in the field of chiral phosphine ligand chemistry and a broad range of earth-abundant transition metal/chiral phosphine ligand-catalyzed enantioselective transformations. The book provides an authoritative and in-depth understanding of important topics about asymmetric catalysis based on earth-abundant transition metals/chiral phosphine ligands, making it ideal for organic chemistry researchers working in the field of asymmetric catalysis, synthetic methodologies and total synthesis.The development of new chiral phosphine ligands to achieve precise stereo control in many earth-abundant transition metal-catalyzed reactions is a very important field in organic synthesis, materials science and medicinal chemistry. The asymmetric synthesis promoted by transition metal/chiral phosphine ligands provides one of the most ideal ways to produce valuable optically active chemicals. - Includes a discussion of state-of-the-art asymmetric organic reactions mediated by earth-abundant transition metals and chiral phosphine ligands - Features the progress and the prospect of chiral phosphine ligands in asymmetric transition metal catalysis - Covers the asymmetric reactivity modes of earth-abundant transition metals and phosphine ligands
Book Synopsis Principles and Applications of Asymmetric Synthesis by : Guo-Qiang Lin
Download or read book Principles and Applications of Asymmetric Synthesis written by Guo-Qiang Lin and published by John Wiley & Sons. This book was released on 2001-02-21 with total page 538 pages. Available in PDF, EPUB and Kindle. Book excerpt: Asymmetric synthesis remains a challenge to practicing scientists as the need for enantiomerically pure or enriched compounds continues to increase. Over the last decade, a large amount of literature has been published in this field. Principles and Applications of Asymmetric Synthesis consolidates and evaluates the most useful methodologies into a one-volume resource for the convenience of practicing scientists and students. Authored by internationally renowned scientists in the field, this reliable reference covers more than 450 reactions and includes important stoichiometric as well as catalytic asymmetric reactions. The first chapter reviews the basic principles, common nomenclature, and analytical methods, and the remainder of the book is organized according to reaction type. The text examines such topics as: Carbon-carbon bond formations involving carbonyls, enamines, imines, and enolates Asymmetric C-O bond formations including epoxidation, dihydroxylation, and aminohydroxylation Asymmetric synthesis using the Diels-Alder reaction and other cyclizations Applications to the total synthesis of natural products Use of enzymes in asymmetric synthesis Practicing chemists in the pharmaceutical, fine chemical, and agricultural professions as well as graduate students will find that Principles and Applications of Asymmetric Synthesis affords comprehensive and current coverage.
Book Synopsis Privileged Chiral Ligands and Catalysts by : Qi-Lin Zhou
Download or read book Privileged Chiral Ligands and Catalysts written by Qi-Lin Zhou and published by John Wiley & Sons. This book was released on 2011-02-10 with total page 670 pages. Available in PDF, EPUB and Kindle. Book excerpt: Catalytic asymmetric synthesis has been one of the most active research areas in chemistry (Nobel Prize in 2001). The development of efficient chiral catalysts plays a crucial role in asymmetric catalysis. Although many chiral ligands/catalysts have been developed in the past decades, the most efficient catalysts are derived from a few core structures, called "privileged chiral catalysts". This ultimate "must have" and long awaited reference for every chemist working in the field of asymmetric catalysis starts with the core structure of the catalysts, explaining why a certain ligand or catalyst is so successful. It describes in detail the history, the basic structural characteristics, and the applications of these "privileged catalysts". This novel presentation provides readers with a much deeper insight into the topic and makes it a must-have for organic chemists, catalytic chemists, chemists working with/on organometallics, chemists in industry, and libraries. From the contents: * BINAP * Bisphosphacycles - From DuPhos and BPE to a Diverse Set of Broadly Applied Ligands * Josiphos Ligands: From Discovery to Technical Applications * Chiral Spiro Ligands * Chiral Bisoxazoline Ligands * PHOX Ligands * Chiral Salen Complexes * BINOL * TADDOLate Ligands * Cinchona Alkaloids * Proline Derivatives
Book Synopsis The Chiral Carbon Pool and Chiral Sulfur, Nitrogen, Phosphorus, and Silicon Centers by : James D. Morrison
Download or read book The Chiral Carbon Pool and Chiral Sulfur, Nitrogen, Phosphorus, and Silicon Centers written by James D. Morrison and published by . This book was released on 1984 with total page 400 pages. Available in PDF, EPUB and Kindle. Book excerpt: Asymmetric Synthesis, Volume 4: The Chiral Carbon Pool and Chiral Sulfur, Nitrogen, Phosphorus, and Silicon Centers describes the practical methods of obtaining chiral fragments. Divided into five chapters, this book specifically examines initial chiral transmission and extension. The opening chapter describes the so-called chiral carbon pool, the readily available chiral carbon fragments used as building blocks in synthesis. This chapter also provides a list of 375 chiral building blocks, along with their commercial sources, approximate prices, and methods of synthesis. Schemes involving almo ...
Book Synopsis Ligand Design in Metal Chemistry by : Mark Stradiotto
Download or read book Ligand Design in Metal Chemistry written by Mark Stradiotto and published by John Wiley & Sons. This book was released on 2016-10-17 with total page 463 pages. Available in PDF, EPUB and Kindle. Book excerpt: The design of ancillary ligands used to modify the structural and reactivity properties of metal complexes has evolved into a rapidly expanding sub-discipline in inorganic and organometallic chemistry. Ancillary ligand design has figured directly in the discovery of new bonding motifs and stoichiometric reactivity, as well as in the development of new catalytic protocols that have had widespread positive impact on chemical synthesis on benchtop and industrial scales. Ligand Design in Metal Chemistry presents a collection of cutting-edge contributions from leaders in the field of ligand design, encompassing a broad spectrum of ancillary ligand classes and reactivity applications. Topics covered include: Key concepts in ligand design Redox non-innocent ligands Ligands for selective alkene metathesis Ligands in cross-coupling Ligand design in polymerization Ligand design in modern lanthanide chemistry Cooperative metal-ligand reactivity P,N Ligands for enantioselective hydrogenation Spiro-cyclic ligands in asymmetric catalysis This book will be a valuable reference for academic researchers and industry practitioners working in the field of ligand design, as well as those who work in the many areas in which the impact of ancillary ligand design has proven significant, for example synthetic organic chemistry, catalysis, medicinal chemistry, polymer science and materials chemistry.
Book Synopsis Chiral Reagents for Asymmetric Synthesis by : Leo A. Paquette
Download or read book Chiral Reagents for Asymmetric Synthesis written by Leo A. Paquette and published by John Wiley & Sons. This book was released on 2003-08-01 with total page 620 pages. Available in PDF, EPUB and Kindle. Book excerpt: Derived from the renowned, Encyclopedia of Reagents for Organic Synthesis (EROS), the related editors have created a new handbook which focuses on chiral reagents used in asymmetric synthesis and is designed for the chemist at the bench. This new handbook follows the same format as the Encyclopedia, including an introduction and an alphabetical arrangement of the reagents. As chiral reagents are the key for the successful asymmetric synthesis, choosing the right reagents is essential, in this handy reference the editors give details on how to prepare, store and use the reagents as well as providing key reactions to demonstrate where reagents have been successfully used. Comprehensive information on 226 reagents Covers 64 reagents which were not included in EROS All information in one easy to use volume – at an affordable price All reagents included will be added to e-EROS – please visit the site where you can gain access to over 50,000 reactions and 3,800 of the most frequently consulted reagents. Visit: www.interscience.wiley.com/eros
Book Synopsis New Ferrocenyl Thio and Ethers Ligands, Preparation, Characterization, and Their Palladium (II) and Platinum (II) Complexes as Catalysts for Selective Hydrogenation by : Chung-Kung Lai
Download or read book New Ferrocenyl Thio and Ethers Ligands, Preparation, Characterization, and Their Palladium (II) and Platinum (II) Complexes as Catalysts for Selective Hydrogenation written by Chung-Kung Lai and published by . This book was released on 1988 with total page 512 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Chiral Auxiliaries and Ligands in Asymmetric Synthesis by : J. Seyden-Penne
Download or read book Chiral Auxiliaries and Ligands in Asymmetric Synthesis written by J. Seyden-Penne and published by Wiley-Interscience. This book was released on 1995-10-23 with total page 744 pages. Available in PDF, EPUB and Kindle. Book excerpt: Table of Contents Preface Abbreviations Introduction 1 1 Enantiomerically Pure Chiral Auxiliaries 43 2 Chiral Reagents 87 3 Chiral Catalysis and Catalysts Bearing Chiral Ligands 117 4 Asymmetric Deprotonations and Protonations 143 5 Alkylations and Related Reactions 157 6 Additions to C=O and C=N Double Bonds 209 7 Additions to Carbon-Carbon Double Bonds 367 8 Additions to Double Bonds Bearing Heteroatoms. Oxidations of Sulfides and Selenides 503 9 Cycloadditions 513 10 Sigmatropic Rearrangements 593 11 Transition Metal Catalyzed Reactions 619 References 637 Index 707.
