Synthesis And Study Of Lanthanide Complexes As Mri Contrast Agents

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The Chemistry of Contrast Agents in Medical Magnetic Resonance Imaging

Author : Andre S. Merbach
Publisher : John Wiley & Sons
ISBN 13 : 1118503678
Total Pages : 514 pages
Book Rating : 4.1/5 (185 download)

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Book Synopsis The Chemistry of Contrast Agents in Medical Magnetic Resonance Imaging by : Andre S. Merbach

Download or read book The Chemistry of Contrast Agents in Medical Magnetic Resonance Imaging written by Andre S. Merbach and published by John Wiley & Sons. This book was released on 2013-02-19 with total page 514 pages. Available in PDF, EPUB and Kindle. Book excerpt: Magnetic Resonance Imaging (MRI) is one of the most important tools in clinical diagnostics and biomedical research. The number of MRI scanners operating around the world is estimated to be approximately 20,000, and the development of contrast agents, currently used in about a third of the 50 million clinical MRI examinations performed every year, has largely contributed to this significant achievement. This completely revised and extended second edition: Includes new chapters on targeted, responsive, PARACEST and nanoparticle MRI contrast agents. Covers the basic chemistries, MR physics and the most important techniques used by chemists in the characterization of MRI agents from every angle from synthesis to safety considerations. Is written for all of those involved in the development and application of contrast agents in MRI. Presented in colour, it provides readers with true representation and easy interpretation of the images. A word from the Authors: Twelve years after the first edition published, we are convinced that the chemistry of MRI agents has a bright future. By assembling all important information on the design principles and functioning of magnetic resonance imaging probes, this book intends to be a useful tool for both experts and newcomers in the field. We hope that it helps inspire further work in order to create more efficient and specific imaging probes that will allow materializing the dream of seeing even deeper and better inside the living organisms. Reviews of the First Edition: "...attempts, for the first time, to review the whole spectrum of involved chemical disciplines in this technique..."—Journal of the American Chemical Society "...well balanced in its scope and attention to detail...a valuable addition to the library of MR scientists..."—NMR in Biomedicine

Molecular and Cellular MR Imaging

Author : Michel M.J. Modo
Publisher : CRC Press
ISBN 13 : 1420004093
Total Pages : 456 pages
Book Rating : 4.4/5 (2 download)

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Book Synopsis Molecular and Cellular MR Imaging by : Michel M.J. Modo

Download or read book Molecular and Cellular MR Imaging written by Michel M.J. Modo and published by CRC Press. This book was released on 2007-03-28 with total page 456 pages. Available in PDF, EPUB and Kindle. Book excerpt: The ability of molecular and cellular imaging to track the survival, migration, and differentiation of cells in vivo as well as monitor particular gene expression in living subjects is rapidly moving from the research laboratory into daily clinical settings. The interdisciplinary nature of the field mandates a constant dialogue among molecular and

Macrocyclic Chemistry

Author : Bernard Dietrich
Publisher :
ISBN 13 :
Total Pages : 414 pages
Book Rating : 4.:/5 (318 download)

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Book Synopsis Macrocyclic Chemistry by : Bernard Dietrich

Download or read book Macrocyclic Chemistry written by Bernard Dietrich and published by . This book was released on 1993 with total page 414 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Multinuclear NMR

Author : J. Mason
Publisher : Springer Science & Business Media
ISBN 13 : 1461317835
Total Pages : 642 pages
Book Rating : 4.4/5 (613 download)

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Book Synopsis Multinuclear NMR by : J. Mason

Download or read book Multinuclear NMR written by J. Mason and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 642 pages. Available in PDF, EPUB and Kindle. Book excerpt: With the power and range of modern pulse spectrometers the compass of NMR spec troscopy is now very large for a single book-but we have undertaken this. Our book covers the Periodic Table as multinuclear spectrometers do, and introductory chapters are devoted to the essentials of the NMR experiment and its products. Primary products are chemical shifts (including anisotropies), spin-spin coupling constants, and relaxation times; the ultimate product is a knowledge of content and constitution, dynamic as well as static. Our province is chemical and biochemical rather than physical or technical; only passing reference is made to metallic solids or unstable species, or to practical NMR spectroscopy. Our aim is depth as well as breadth, to explain the fundamental processes, whether of nuclear magnetic shielding, spin-spin coupling, relaxation, or the multiple pulse sequences that have allowed the development of high-resolution studies of solids, multidimensional NMR spectroscopy, techniques for sensitivity enhancement, and so on. This book therefore combines the functions of advanced textbook and reference book. For reasonably comprehensive coverage in a single volume we have sum marized the information in tables and charts, and included all leading references.

Rare Earth Coordination Chemistry

Author : Chun-Hui Huang
Publisher : John Wiley & Sons
ISBN 13 : 0470824867
Total Pages : 602 pages
Book Rating : 4.4/5 (78 download)

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Book Synopsis Rare Earth Coordination Chemistry by : Chun-Hui Huang

Download or read book Rare Earth Coordination Chemistry written by Chun-Hui Huang and published by John Wiley & Sons. This book was released on 2011-09-23 with total page 602 pages. Available in PDF, EPUB and Kindle. Book excerpt: Edited by a highly regarded scientist and with contributions from sixteen international research groups, spanning Asia and North America, Rare Earth Coordination Chemistry: Fundamentals and Applications provides the first one-stop reference resource for important accomplishments in the area of rare earth. Consisting of two parts, Fundamentals and Applications, readers are armed with the systematic basic aspects of rare earth coordination chemistry and presented with the latest developments in the applications of rare earths. The systematic introduction of basic knowledge, application technology and the latest developments in the field, makes this ideal for readers across both introductory and specialist levels.

Fluorine Magnetic Resonance Imaging

Author : Ulrich Flogel
Publisher : CRC Press
ISBN 13 : 1315340933
Total Pages : 426 pages
Book Rating : 4.3/5 (153 download)

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Book Synopsis Fluorine Magnetic Resonance Imaging by : Ulrich Flogel

Download or read book Fluorine Magnetic Resonance Imaging written by Ulrich Flogel and published by CRC Press. This book was released on 2016-10-26 with total page 426 pages. Available in PDF, EPUB and Kindle. Book excerpt: Over the past decade, fluorine (19F) magnetic resonance imaging (MRI) has garnered significant scientific interest in the biomedical research community owing to the unique properties of fluorinated materials and the 19F nucleus. Fluorine has an intrinsically sensitive nucleus for MRI. There is negligible endogenous 19F in the body and thus there is no background signal. Fluorine-containing compounds are ideal tracer labels for a wide variety of MRI applications. Moreover, the chemical shift and nuclear relaxation rate can be made responsive to physiology via creative molecular design. This book is an interdisciplinary compendium that details cutting-edge science and medical research in the emerging field of 19F MRI. Edited by Ulrich Flögel and Eric Ahrens, two prominent MRI researchers, this book will appeal to investigators involved in MRI, biomedicine, immunology, pharmacology, probe chemistry, and imaging physics.

MRI Contrast Agents

Author : Sophie Laurent
Publisher : Springer
ISBN 13 : 9811025290
Total Pages : 128 pages
Book Rating : 4.8/5 (11 download)

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Book Synopsis MRI Contrast Agents by : Sophie Laurent

Download or read book MRI Contrast Agents written by Sophie Laurent and published by Springer. This book was released on 2016-11-03 with total page 128 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book describes the multiple aspects of (i) preparation of the magnetic core, (ii) the stabilization with different coatings, (iii) the physico-chemical characterization and (iv) the vectorization to obtain specific nanosystems. Several bio-applications are also presented in this book. In the early days of Magnetic Resonance Imaging (MRI), paramagnetic ions were proposed as contrast agents to enhance the diagnostic quality of MR images. Since then, academic and industrial efforts have been devoted to the development of new and more efficient molecular, supramolecular and nanoparticular systems. Old concepts and theories, like paramagnetic relaxation, were revisited and exploited, leading to new scientific tracks. With their high relaxivity payload, the superparamagnetic nanoparticles are very appealing in the context of molecular imaging but challenges are still numerous: absence of toxicity, specificity, ability to cross the biological barriers, etc.

Trends in Contrast Media

Author : Henrik S. Thomsen
Publisher : Springer Science & Business Media
ISBN 13 : 3642598145
Total Pages : 471 pages
Book Rating : 4.6/5 (425 download)

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Book Synopsis Trends in Contrast Media by : Henrik S. Thomsen

Download or read book Trends in Contrast Media written by Henrik S. Thomsen and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 471 pages. Available in PDF, EPUB and Kindle. Book excerpt: A different approach to contrast media, discussed primarily from the point of view of the radiologist. Comprehensive sections are devoted to iodinated contrast media and to the contrast media employed in magnetic resonance imaging and ultrasonography. The latest agents available receive due attention, as do adverse reactions. A final section considers the use of contrast media in nuclear medicine.

Handbook on the Physics and Chemistry of Rare Earths

Author : Jean-Claude G. Bunzli
Publisher : Academic Press
ISBN 13 : 0323986048
Total Pages : 236 pages
Book Rating : 4.3/5 (239 download)

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Book Synopsis Handbook on the Physics and Chemistry of Rare Earths by : Jean-Claude G. Bunzli

Download or read book Handbook on the Physics and Chemistry of Rare Earths written by Jean-Claude G. Bunzli and published by Academic Press. This book was released on 2022-08-09 with total page 236 pages. Available in PDF, EPUB and Kindle. Book excerpt: Handbook on the Physics and Chemistry of Rare Earths: Including Actinides, Volume 61 presents the latest release in this continuous series that covers all aspects of rare earth science, including chemistry, life sciences, materials science and physics. - Presents up-to-date overviews and new developments in the field of rare earths, covering both their physics and chemistry - Contains individual chapters that are comprehensive and broad, along with critical reviews - Provides contributions from highly experienced, invited experts

Supramolecular Chemistry in Biomedical Imaging

Author : Stephen Faulkner
Publisher : Royal Society of Chemistry
ISBN 13 : 183916137X
Total Pages : 310 pages
Book Rating : 4.8/5 (391 download)

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Book Synopsis Supramolecular Chemistry in Biomedical Imaging by : Stephen Faulkner

Download or read book Supramolecular Chemistry in Biomedical Imaging written by Stephen Faulkner and published by Royal Society of Chemistry. This book was released on 2022-04-01 with total page 310 pages. Available in PDF, EPUB and Kindle. Book excerpt: There have been many great advances in the field of biomedical imaging in recent years, with supramolecular chemistry playing a key role in the evolution of modern imaging techniques. Non-covalent supramolecular interactions are fundamental to countless biological processes, from host–guest binding to the stabilisation of complex structures. Supramolecular chemistry techniques can be employed to create probes that can be targeted to either exploit or disrupt these interactions, giving the potential for both diagnostic and therapeutic effects. Furthermore, in techniques such as contrast enhanced MRI, controlling the interactions between solvent molecules and the imaging agent is crucial to the development of the technique. With rapid growth in the synthesis and study of molecular imaging agents, the understanding of their associated techniques has sometimes lagged behind. Supramolecular Chemistry in Biomedical Imaging will fill this gap by clarifying the state of current understanding and the nature of the underlying problems inherent to addressing problems in biology. It will cover both the techniques used in imaging and the molecular and supramolecular systems used to exploit them. This publication targets academics coming to the field from mainstream supramolecular chemistry, research graduates and undergraduates interested in supramolecular chemistry, synthesis or imaging agents and imaging techniques for biomedical applications.

The Chemistry of Imaging Probes

Author : Lorenzo Tei
Publisher : Frontiers Media SA
ISBN 13 : 288945598X
Total Pages : 129 pages
Book Rating : 4.8/5 (894 download)

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Book Synopsis The Chemistry of Imaging Probes by : Lorenzo Tei

Download or read book The Chemistry of Imaging Probes written by Lorenzo Tei and published by Frontiers Media SA. This book was released on 2018-10-19 with total page 129 pages. Available in PDF, EPUB and Kindle. Book excerpt: Over the past decades, the field of molecular imaging has been rapidly growing involving multiple disciplines such as medicine, biology, chemistry, pharmacology and biomedical engineering. Any molecular imaging procedure requires an imaging probe that is an agent used to visualize, characterize and quantify biological processes in living systems. Such a probe typically consists of an agent that usually produces signal for imaging purpose, a targeting moiety, and a linker connecting the targeting moiety and the signaling agent. Many challenging problems of molecular imaging can be addressed by exploiting the great possibilities offered by modern synthetic organic and coordination chemistry and the powerful procedures provided by conjugation chemistry. Thus, chemistry plays a decisive role in the development of this cutting-edge methodology. Currently, the diagnostic imaging modalities include Magnetic Resonance Imaging (MRI), Computed Tomography (CT), Ultrasound (US), Nuclear Imaging (PET, SPECT), Optical Imaging (OI) and Photoacoustic Imaging (PAI). Each of these imaging modalities has its own advantages and disadvantages, and therefore, a multimodal approach combining two techniques is often adopted to generate complementary anatomical and functional information of the disease. The basis for designing imaging probes for a given application is dictated by the chosen imaging modality, which in turn is dependent upon the concentration and localization profile (vascular, extracellular matrix, cell membrane, intracellular, near or at the cell nucleus) of the target molecule. The development of high-affinity ligands and their conjugation to the targeting vector is also one of the key steps for pursuing efficient molecular imaging probes. Other excellent reviews, text and monographs describe the principles of biomedical imaging, focusing on molecular biology or on the physics behind the techniques. This Research Topic aims to show how chemistry can offer molecular imaging the opportunity to express all its potential.

Luminescence of Lanthanide Ions in Coordination Compounds and Nanomaterials

Author : Ana de Bettencourt-Dias
Publisher : John Wiley & Sons
ISBN 13 : 1118682815
Total Pages : 408 pages
Book Rating : 4.1/5 (186 download)

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Book Synopsis Luminescence of Lanthanide Ions in Coordination Compounds and Nanomaterials by : Ana de Bettencourt-Dias

Download or read book Luminescence of Lanthanide Ions in Coordination Compounds and Nanomaterials written by Ana de Bettencourt-Dias and published by John Wiley & Sons. This book was released on 2014-09-08 with total page 408 pages. Available in PDF, EPUB and Kindle. Book excerpt: This comprehensive book presents the theoretical principles, current applications and latest research developments in the field of luminescent lanthanide complexes; a rapidly developing area of research which is attracting increasing interest amongst the scientific community. Luminescence of Lanthanide Ions in Coordination Compounds and Nanomaterials begins with an introduction to the basic theoretical and practical aspects of lanthanide ion luminescence, and the spectroscopic techniques used to evaluate the efficiency of luminescence. Subsequent chapters introduce a variety of different applications including: • Circularly polarized luminescence • Luminescence bioimaging with lanthanide complexes • Two-photon absorption of lanthanide complexes • Chemosensors • Upconversion luminescence • Excitation spectroscopy • Heterometallic complexes containing lanthanides Each chapter presents a detailed introduction to the application, followed by a description of experimental techniques specific to the area and an extensive review of recent literature. This book is a valuable introduction to the literature for scientists new to the field, as well as providing the more experienced researcher with a comprehensive resource covering the most relevant information in the field; a ‘one stop shop’ for all key references.

Lanthanide and Other Transition Metal Ion Complexes and Nanoparticles in Magnetic Resonance Imaging

Author : Carlos F.G.C. Geraldes
Publisher : CRC Press
ISBN 13 : 1040098797
Total Pages : 427 pages
Book Rating : 4.0/5 (4 download)

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Book Synopsis Lanthanide and Other Transition Metal Ion Complexes and Nanoparticles in Magnetic Resonance Imaging by : Carlos F.G.C. Geraldes

Download or read book Lanthanide and Other Transition Metal Ion Complexes and Nanoparticles in Magnetic Resonance Imaging written by Carlos F.G.C. Geraldes and published by CRC Press. This book was released on 2024-08-21 with total page 427 pages. Available in PDF, EPUB and Kindle. Book excerpt: Since the development of the first clinical MRI contrast agent, Gd(DTPA) (or Magnevist®) in the early 1980s, another three linear and three macrocyclic (eg. Gd(DOTA) (Dotarem®) have been introduced in the clinic and inspired a huge number of researchers worldwide to perform preclinical research to obtain contrast agents for many kinds of clinical applications, which are described in this book. The most current research has been assembled here and can be used by the scientific community to continue increasing the relevance of metal-containing molecules and nanomaterials for MRI-based diagnosis and thus increase the practical use of these systems. Presents the importance of metal-containing molecules and nanomaterials for MRI-based diagnosis and the practical use of these systems. Discusses the structure and dynamics of Ln-based contrast agents as well as computational studies related to these agents. Endorses and stimulates research in the vibrant field of biological inorganic chemistry. Reviews the most current research supporting the relevance of metal-containing molecules and nanomaterials for diagnosis and therapy. The authors are preeminent bioinorganic and medicinal inorganic chemists and review the most current research in this field.

Advances in Molecular Nanotechnology Research and Application: 2011 Edition

Author :
Publisher : ScholarlyEditions
ISBN 13 : 1464921172
Total Pages : 629 pages
Book Rating : 4.4/5 (649 download)

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Book Synopsis Advances in Molecular Nanotechnology Research and Application: 2011 Edition by :

Download or read book Advances in Molecular Nanotechnology Research and Application: 2011 Edition written by and published by ScholarlyEditions. This book was released on 2012-01-09 with total page 629 pages. Available in PDF, EPUB and Kindle. Book excerpt: Advances in Molecular Nanotechnology Research and Application: 2011 Edition is a ScholarlyEditions™ eBook that delivers timely, authoritative, and comprehensive information about Molecular Nanotechnology. The editors have built Advances in Molecular Nanotechnology Research and Application: 2011 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Molecular Nanotechnology in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Advances in Molecular Nanotechnology Research and Application: 2011 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.

Magnetic Nanoparticles in Biosensing and Medicine

Author : Nicholas J. Darton
Publisher : Cambridge University Press
ISBN 13 : 1108637876
Total Pages : 317 pages
Book Rating : 4.1/5 (86 download)

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Book Synopsis Magnetic Nanoparticles in Biosensing and Medicine by : Nicholas J. Darton

Download or read book Magnetic Nanoparticles in Biosensing and Medicine written by Nicholas J. Darton and published by Cambridge University Press. This book was released on 2019-02-14 with total page 317 pages. Available in PDF, EPUB and Kindle. Book excerpt: Drawing together topics from a wide range of disciplines, this text provides a comprehensive insight into the fundamentals of magnetic biosensors and the applications of magnetic nanoparticles in medicine. Internationally renowned researchers showcase topics ranging from the basic physical principles of magnetism to the detection and manipulation, synthesis protocols and natural occurrence of magnetic nanoparticles. Up-to-date examples of their clinical usage and research applications in the biomedical fields of sensing by diverse magnetic detection methods, in imaging by MRI and in therapeutic strategies such as hyperthermia, are also discussed, providing a thorough introduction to this rapidly developing field. Each chapter features questions with answers, highlighted definition boxes, and numerous illustrations which help readers grasp key concepts. Mathematical tools, together with key literature references, provide a strong underpinning for the material, making it ideal for graduate students, lecturers, medical researchers and industrial scientific strategists.

Contrast Agents I

Author : Werner Krause
Publisher : Springer
ISBN 13 : 354045733X
Total Pages : 251 pages
Book Rating : 4.5/5 (44 download)

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Book Synopsis Contrast Agents I by : Werner Krause

Download or read book Contrast Agents I written by Werner Krause and published by Springer. This book was released on 2003-07-01 with total page 251 pages. Available in PDF, EPUB and Kindle. Book excerpt: Extracellular MRI and X-ray contrast agents are characterized by their phar- cokinetic behaviour.After intravascular injection their plasma-level time curve is characeterized by two phases. The agents are rapidly distributed between plasma and interstitial spaces followed by renal elimination with a terminal half-live of approximatly 1–2 hours. They are excreted via the kidneys in unchanged form by glomerular filtration. Extracellular water-soluble contrast agents to be applied for X-ray imaging were introduced into clinical practice in 1923. Since that time they have proved to be most valuable tools in diagnostics.They contain iodine as the element of choice with a sufficiently high atomic weight difference to organic tissue. As positive contrast agents their attenuation of radiation is higher compared with the attenuation of the surrounding tissue. By this contrast enhancement X-ray diagnostics could be improved dramatically. In 2,4,6-triiodobenzoic acid derivatives iodine is firmly bound. Nowadays diamides of the 2,4,6-triiodo-5-acylamino-isophthalic acid like iopromide (Ultravist, Fig. 1) are used as non-ionic (neutral) X-ray contrast agents in most cases [1].

Theranostic Bionanomaterials

Author : Wenguo Cui
Publisher : Elsevier
ISBN 13 : 0128153423
Total Pages : 526 pages
Book Rating : 4.1/5 (281 download)

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Book Synopsis Theranostic Bionanomaterials by : Wenguo Cui

Download or read book Theranostic Bionanomaterials written by Wenguo Cui and published by Elsevier. This book was released on 2019-05-01 with total page 526 pages. Available in PDF, EPUB and Kindle. Book excerpt: Theranostic Bionanomaterials is an invaluable study of recent advances and trends in the development and application of functional bionanomaterials for theranostic applications. This book describes the design and characterization of nanomaterials which exhibit distinctive physical, chemical and biological properties and discusses how these functional nanomaterials enable the precise manipulation of architectural, physical and biochemical cell microenvironments in vitro. In addition, it covers how they can act as the carriers of diagnostic or therapeutic agents, thus providing new pathways or strategies for disease diagnosis and treatment. Specific chapters discuss protein delivery, drug delivery, tissue regeneration, bioimaging, biodetection, and much more. This book will be a critical resource for those involved in cutting-edge research in theranostics bionanomaterial. - Focuses on nanofabrication methods of bionanomaterials - Reviews the application of bionanomaterials, with a focus on drug delivery and diagnosis - Describes the design and characterization of nanomaterials which exhibit distinctive physical, chemical and biological properties