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Author : Sreedharan Sajikumar
Publisher : Springer Nature
ISBN 13 : 3031548647
Total Pages : 507 pages
Book Rating : 4.0/5 (315 download)
Download or read book Synaptic Tagging and Capture written by Sreedharan Sajikumar and published by Springer Nature. This book was released on with total page 507 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Jannik Luboeinski
Publisher :
ISBN 13 :
Total Pages : 201 pages
Book Rating : 4./5 ( download)
Download or read book The Role of Synaptic Tagging and Capture for Memory Dynamics in Spiking Neural Networks written by Jannik Luboeinski and published by . This book was released on 2021-09-02 with total page 201 pages. Available in PDF, EPUB and Kindle. Book excerpt: Memory serves to process and store information about experiences such that this information can be used in future situations. The transfer from transient storage into long-term memory, which retains information for hours, days, and even years, is called consolidation. In brains, information is primarily stored via alteration of synapses, so-called synaptic plasticity. While these changes are at first in a transient early phase, they can be transferred to a late phase, meaning that they become stabilized over the course of several hours. This stabilization has been explained by so-called synaptic tagging and capture (STC) mechanisms. To store and recall memory representations, emergent dynamics arise from the synaptic structure of recurrent networks of neurons. This happens through so-called cell assemblies, which feature particularly strong synapses. It has been proposed that the stabilization of such cell assemblies by STC corresponds to so-called synaptic consolidation, which is observed in humans and other animals in the first hours after acquiring a new memory. The exact connection between the physiological mechanisms of STC and memory consolidation remains, however, unclear. It is equally unknown which influence STC mechanisms exert on further cognitive functions that guide behavior. On timescales of minutes to hours (that means, the timescales of STC) such functions include memory improvement, modification of memories, interference and enhancement of similar memories, and transient priming of certain memories. Thus, diverse memory dynamics may be linked to STC, which can be investigated by employing theoretical methods based on experimental data from the neuronal and the behavioral level. In this thesis, we present a theoretical model of STC-based memory consolidation in recurrent networks of spiking neurons, which are particularly suited to reproduce biologically realistic dynamics. Furthermore, we combine the STC mechanisms with calcium dynamics, which have been found to guide the major processes of early-phase synaptic plasticity in vivo. In three included research articles as well as additional sections, we develop this model and investigate how it can account for a variety of behavioral effects. We find that the model enables the robust implementation of the cognitive memory functions mentioned above. The main steps to this are: 1. demonstrating the formation, consolidation, and improvement of memories represented by cell assemblies, 2. showing that neuromodulator-dependent STC can retroactively control whether information is stored in a temporal or rate-based neural code, and 3. examining interaction of multiple cell assemblies with transient and attractor dynamics in different organizational paradigms. In summary, we demonstrate several ways by which STC controls the late-phase synaptic structure of cell assemblies. Linking these structures to functional dynamics, we show that our STC-based model implements functionality that can be related to long-term memory. Thereby, we provide a basis for the mechanistic explanation of various neuropsychological effects. Keywords: synaptic plasticity; synaptic tagging and capture; spiking recurrent neural networks; memory consolidation; long-term memory
Author : Sreedharan Sajikumar
Publisher : Springer
ISBN 13 : 1493917617
Total Pages : 278 pages
Book Rating : 4.4/5 (939 download)
Download or read book Synaptic Tagging and Capture written by Sreedharan Sajikumar and published by Springer. This book was released on 2014-10-15 with total page 278 pages. Available in PDF, EPUB and Kindle. Book excerpt: Serves as a comprehensive introduction and overview of synaptic tagging and capture (STC) and covers the topic from molecular and cellular aspects to behavior. Circa 15 years ago the STC model was proposed to provide a conceptual basis for how short-term memories are transformed into long-term memories. Though the hypothesis remains unconfirmed due to technological limitations, the model is well consolidated and generally accepted in the field. Various researchers have investigated the cellular mechanisms for the formation of long-term memory using the STC model, but this is the first book-length treatments of STC. This volume features an introduction by Prof. Richard Morris and Prof. Cliff Abraham.
Author : Jannik Luboeinski
Publisher :
ISBN 13 :
Total Pages : 0 pages
Book Rating : 4.:/5 (126 download)
Download or read book The Role of Synaptic Tagging and Capture for Memory Dynamics in Spiking Neural Networks written by Jannik Luboeinski and published by . This book was released on 2021 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Memory serves to process and store information about experiences such that this information can be used in future situations. The transfer from transient storage into long-term memory, which retains information for hours, days, and even years, is called consolidation. In brains, information is primarily stored via alteration of synapses, so-called synaptic plasticity. While these changes are at first in a transient early phase, they can be transferred to a late phase, meaning that they become stabilized over the course of several hours. This stabilization has been explained by so-called syn...
Author : Bruno Miguel Ferreira Teixeira da Silva
Publisher :
ISBN 13 :
Total Pages : 196 pages
Book Rating : 4.:/5 (78 download)
Download or read book Synaptic Tagging and Capture Mechanisms During the Formation of Memory written by Bruno Miguel Ferreira Teixeira da Silva and published by . This book was released on 2009 with total page 196 pages. Available in PDF, EPUB and Kindle. Book excerpt: In everybody's lives, there are strong emotional or surprising events that, for being special, are vividly remembered for a lifetime. Sometimes, these memories include one-shot images or details of associated daily life events that, for being ordinary, should have been rapidly forgotten. Why and how does the brain form and retain detailed memories of trivial events? The synaptic tagging and capture (STC) hypothesis of memory formation (Frey & Morris, Nature 1997) provides a theoretical framework that might explain the formation of these flashbulb memories at a cellular level. The hypothesis suggests that strong events, producing long-lasting memories, might stabilise memory for weak events by up-regulating the synthesis of late-phase plasticity-related proteins in neurons encoding memory traces for both events. This thesis tests this prediction of the STC hypothesis during the formation of long-term place memory in rodents. First, two new behavioural tasks are developed which provide sensitive measures of rapidly acquired place memory persistence - a new one-trial place memory task in the "event arena" and a modified delayed matching-to-place (DMP) protocol in the watermaze. Persistence of place memory is assessed and compared in these tasks. Given the important role of NMDA receptor activation during STC mechanisms, the contribution of NMDA and AMPA receptor activation in the hippocampus for the encoding and retrieval of place memory, respectively, is also established. Finally, weak and strong encoding events, leading to the formation of either shortor long-lasting place memory in the watermaze DMP task, are characterized. A second series of experiments investigates the possibility of synergistic interactions between different encoding events that occur in two different watermazes. First, weak and strong encoding events are arranged to occur within a short time-window to test behavioural analogues of the "strong-before-weak" and "weak-before-strong" STC paradigms characterised in electrophysiological experiments in rat hippocampal slices (Frey and Morris, 1997, 1998b). Then, after establishing i) the time course and local specificity of protein synthesis inhibition by intra-hippocampal infusion of anisomycin in vivo, ii) the dependence of long-term memory for strong encoding events on protein synthesis in the hippocampus, and iii) the induction of transcriptional and translational mechanisms in the hippocampus by strong encoding events, a behavioural analogue of the "strong-before-strong" STC paradigm (Frey and Morris, 1997) is also investigated. The results of these experiments are supportive of i) a role for hippocampal NMDA receptor-mediated synaptic plasticity in the encoding of rapidly acquired place memory; ii) a role for hippocampal AMPA receptor-mediated synaptic transmission in both encoding and retrieval of memory; and iii) a role for transcriptional and translational mechanisms in the hippocampus in the stabilisation of place memory. However, no evidence could be found supporting the involvement of synaptic tagging and capture mechanisms during the formation of long-lasting place memory.
Author : Jung Whan Park
Publisher :
ISBN 13 :
Total Pages : 140 pages
Book Rating : 4.:/5 (885 download)
Download or read book Investigation of the Molecular Mechanisms of Synaptic Tagging and Capture written by Jung Whan Park and published by . This book was released on 2014 with total page 140 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Hanna Frances Nowers
Publisher :
ISBN 13 :
Total Pages : 58 pages
Book Rating : 4.:/5 (874 download)
Download or read book The Characterization of Synaptic Tagging and Capture in the Mouse written by Hanna Frances Nowers and published by . This book was released on 2012 with total page 58 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Hugo J. Bellen
Publisher : Oxford University Press, USA
ISBN 13 :
Total Pages : 466 pages
Book Rating : 4.3/5 (91 download)
Download or read book Neurotransmitter Release written by Hugo J. Bellen and published by Oxford University Press, USA. This book was released on 1999 with total page 466 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides the reader with background information on neurotransmitter release. Emphasis is placed on the rationale by which proteins are assigned specific functions rather than just providing facts about function.
Author : J. David Sweatt
Publisher : Academic Press
ISBN 13 : 0080959199
Total Pages : 362 pages
Book Rating : 4.0/5 (89 download)
Download or read book Mechanisms of Memory written by J. David Sweatt and published by Academic Press. This book was released on 2009-09-28 with total page 362 pages. Available in PDF, EPUB and Kindle. Book excerpt: This fully revised second edition provides the only unified synthesis of available information concerning the mechanisms of higher-order memory formation. It spans the range from learning theory, to human and animal behavioral learning models, to cellular physiology and biochemistry. It is unique in its incorporation of chapters on memory disorders, tying in these clinically important syndromes with the basic science of synaptic plasticity and memory mechanisms. It also covers cutting-edge approaches such as the use of genetically engineered animals in studies of memory and memory diseases. Written in an engaging and easily readable style and extensively illustrated with many new, full-color figures to help explain key concepts, this book demystifies the complexities of memory and deepens the reader's understanding. - More than 25% new content, particularly expanding the scope to include new findings in translational research. - Unique in its depth of coverage of molecular and cellular mechanisms - Extensive cross-referencing to Comprehensive Learning and Memory - Discusses clinically relevant memory disorders in the context of modern molecular research and includes numerous practical examples
Author : Roger Lluis Redondo Pena
Publisher :
ISBN 13 :
Total Pages : 416 pages
Book Rating : 4.:/5 (781 download)
Download or read book The Tagging and Capture Hypothesis of Synaptic Plasticity written by Roger Lluis Redondo Pena and published by . This book was released on 2010 with total page 416 pages. Available in PDF, EPUB and Kindle. Book excerpt: The aims of this thesis were (1) to learn about the identities of the molecules involved in the maintenance of long-term potentiation (LTP), and (2) to develop and test a behavioural paradigm capable of elucidating the interaction between these molecular processes and the persistence of long-term memories. By improving the stability of field recordings in in vitro electrophysiology, it was possible to investigate the molecular processes that determine the long-term changes in synaptic efficacy. In these experiments, the interactions between two convergent inputs onto the same neuronal population in the CA1 region of the hippocampus were monitored for over ten hours. Analytically powerful three-pathway protocols using sequential strong and weak tetanization in varying orders, and test stimulation over long periods of time after LTP-induction, enabled a pharmacological dissociation of potentially distinct roles of the calmodulin kinase (CaMK) pathways in LTP. This places constraints on the mechanisms by which synaptic potentiation, and possibly memories, become stabilized. The experiments show that tag setting is blocked by the CaMK inhibitor KN-93 that, at low concentration primarily blocks CaMKII, whereas a CaMKK inhibitor, STO-609, selectively limits the synthesis or the availability of plasticity related proteins (PRPs). To test whether memories can be subject to modulation by independent experiences, behavioural studies tested the possibility of lengthening the persistence of a relatively weak memory by pairing its induction with an event capable of inducing the synthesis of the required PRPs. Corticosterone-dependent stressful events like a cold swim proved to interfere and weaken spatial memories. On the other hand, the exploration of a novel environment succeeded in rescuing the decay of a weak memory. The effect of the exploration of the novel environment was dependent on NMDA and dopamine receptor activation, as well as protein synthesis. These results are discussed in relation to the synaptic tagging and capture hypothesis and a novel model of the neuronal mechanisms underlying synaptic plasticity is developed from them.
Author : Tim V. P. Bliss
Publisher :
ISBN 13 : 9780198530305
Total Pages : 440 pages
Book Rating : 4.5/5 (33 download)
Download or read book Long-term Potentiation written by Tim V. P. Bliss and published by . This book was released on 2004 with total page 440 pages. Available in PDF, EPUB and Kindle. Book excerpt: In the thirty years since its discovery by Terje Lomo and Tim Bliss, Long Term Potentiation (LTP) has become one of the most extensively studied topics in contemporary neuroscience. In LTP the strength of synapses between neurons is potentiated following brief but intense activation. LTP is thought to play a central role in learning and memory, though the exact nature of its role is less clear. In spite of years of research, there are many questions about LTP regarding its functional relevance that remain unanswered - for example, is it a model of memory formation, or is the actual neural mechanism used by the brain to store information?This volume presents a state of the art account of LTP. It begins with lively accounts, by the scientists most closely involved, of the discovery of LTP and of the experiments that established its basic properties and induction mechanisms. Later contributions contain reviews and new research that cover the range of molecular, cellular, physiological and behavioural approaches to the study of LTP. Provocative, accessible, and authoritative, this book makes it clear why LTP continues in equal measure to puzzle and beguile neuroscientists today.Advance praise for Long Term Potentiation: 'This book provides a definitive overview of the development of ideas about synaptic plasticity and about the wide range of current research in this fascinating field.' Colin Blakemore, University of OxfordReadership: Neuroscientists from postgraduate level upwards
Author : J.W. Donahoe
Publisher : Elsevier
ISBN 13 : 0080537367
Total Pages : 601 pages
Book Rating : 4.0/5 (85 download)
Download or read book Neural Network Models of Cognition written by J.W. Donahoe and published by Elsevier. This book was released on 1997-09-26 with total page 601 pages. Available in PDF, EPUB and Kindle. Book excerpt: This internationally authored volume presents major findings, concepts, and methods of behavioral neuroscience coordinated with their simulation via neural networks. A central theme is that biobehaviorally constrained simulations provide a rigorous means to explore the implications of relatively simple processes for the understanding of cognition (complex behavior). Neural networks are held to serve the same function for behavioral neuroscience as population genetics for evolutionary science. The volume is divided into six sections, each of which includes both experimental and simulation research: (1) neurodevelopment and genetic algorithms, (2) synaptic plasticity (LTP), (3) sensory/hippocampal systems, (4) motor systems, (5) plasticity in large neural systems (reinforcement learning), and (6) neural imaging and language. The volume also includes an integrated reference section and a comprehensive index.
Author : Eric Bertrand
Publisher : Springer Science & Business Media
ISBN 13 : 1402059434
Total Pages : 397 pages
Book Rating : 4.4/5 (2 download)
Download or read book Subcellular Proteomics written by Eric Bertrand and published by Springer Science & Business Media. This book was released on 2007-08-29 with total page 397 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume summarizes the new developments that made subcellular proteomics a rapidly expanding area. It examines the different levels of subcellular organization and their specific methodologies. In addition, the book includes coverage of systems biology that deals with the integration of the data derived from these different levels to produce a synthetic description of the cell as a system.
Author : Helmut L. Haas
Publisher : Springer Science & Business Media
ISBN 13 : 364273202X
Total Pages : 219 pages
Book Rating : 4.6/5 (427 download)
Download or read book Synaptic Plasticity in the Hippocampus written by Helmut L. Haas and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 219 pages. Available in PDF, EPUB and Kindle. Book excerpt: This is the second time that I have had the honor of opening an interna tional symposium dedicated to the functions of the hippocampus here in Pecs. It was a pleasure to greet the participants in the hope that their valuable contributions will make this meeting a tradition in this town. As one of the hosts of the symposium, I had the sorrowful duty to remind you of the absence of a dear colleague, Professor Graham God dard. His tragic and untimely death represents the irreparable loss of both a friend and an excellent researcher. This symposium is dedicated to his memory. If I compare the topics of the lectures of this symposium with those of the previous one, a striking difference becomes apparent. A dominating tendency of the previous symposium was to attempt to define hippocam pal function or to offer data relevant to supporting or rejecting existing theoretical positions. No such tendency is reflected in the titles of the present symposium, in which most of the contributions deal with hip pocampal phenomena at the most elementary level. Electrical, biochemi cal, biophysical, and pharmacological events at the synaptic, membrane, or intracellular level are analyzed without raising the question of what kind of integral functions these elementary phenomena are a part of.
Author : Per Andersen
Publisher : Oxford University Press
ISBN 13 : 9780195100273
Total Pages : 892 pages
Book Rating : 4.1/5 (2 download)
Download or read book The Hippocampus Book written by Per Andersen and published by Oxford University Press. This book was released on 2007 with total page 892 pages. Available in PDF, EPUB and Kindle. Book excerpt: The hippocampus is one of a group of remarkable structures embedded within the brain's medial temporal lobe. Long known to be important for memory, it has been a prime focus of neuroscience research for many years. The Hippocampus Book promises to facilitate developments in the field in a major way by bringing together, for the first time, contributions by leading international scientists knowledgeable about hippocampal anatomy, physiology, and function. This authoritative volume offers the most comprehensive, up-to-date account of what the hippocampus does, how it does it, and what happens when things go wrong. At the same time, it illustrates how research focusing on this single brain structure has revealed principles of wider generality for the whole brain in relation to anatomical connectivity, synaptic plasticity, cognition and behavior, and computational algorithms. Well-organized in its presentation of both theory and experimental data, this peerless work vividly illustrates the astonishing progress that has been made in unraveling the workings of the brain. The Hippocampus Book is destined to take a central place on every neuroscientist's bookshelf.
Author : Catherine Belzung
Publisher : Springer Science & Business Media
ISBN 13 : 364236232X
Total Pages : 447 pages
Book Rating : 4.6/5 (423 download)
Download or read book Neurogenesis and Neural Plasticity written by Catherine Belzung and published by Springer Science & Business Media. This book was released on 2014-07-08 with total page 447 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume brings together authors working on a wide range of topics to provide an up to date account of the underlying mechanisms and functions of neurogenesis and synaptogenesis in the adult brain. With an increasing understanding of the role of neurogenesis and synaptogenesis it is possible to envisage improvements or novel treatments for a number of diseases and the possibility of harnessing these phenomena to reduce the impact of ageing and to provide mechanisms to repair the brain.
Author : Jin-Hui Wang
Publisher : Springer Nature
ISBN 13 : 9811395012
Total Pages : 275 pages
Book Rating : 4.8/5 (113 download)
Download or read book Associative Memory Cells: Basic Units of Memory Trace written by Jin-Hui Wang and published by Springer Nature. This book was released on 2019-09-10 with total page 275 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book focuses on associative memory cells and their working principles, which can be applied to associative memories and memory-relevant cognitions. Providing comprehensive diagrams, it presents the author's personal perspectives on pathology and therapeutic strategies for memory deficits in patients suffering from neurological diseases and psychiatric disorders. Associative learning is a common approach to acquire multiple associated signals, including knowledge, experiences and skills from natural environments or social interaction. The identification of the cellular and molecular mechanisms underlying associative memory is important in furthering our understanding of the principles of memory formation and memory-relevant behaviors as well as in developing therapeutic strategies that enhance memory capacity in healthy individuals and improve memory deficit in patients suffering from neurological disease and psychiatric disorders. Although a series of hypotheses about neural substrates for associative memory has been proposed, numerous questions still need to be addressed, especially the basic units and their working principle in engrams and circuits specific for various memory patterns. This book summarizes the developments concerning associative memory cells reported in current and past literature, providing a valuable overview of the field for neuroscientists, psychologists and students.
