Sumo Regulation Of Cellular Processes

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SUMO Regulation of Cellular Processes

Author : Van G. Wilson
Publisher : Springer
ISBN 13 : 3319500449
Total Pages : 413 pages
Book Rating : 4.3/5 (195 download)

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Book Synopsis SUMO Regulation of Cellular Processes by : Van G. Wilson

Download or read book SUMO Regulation of Cellular Processes written by Van G. Wilson and published by Springer. This book was released on 2017-02-13 with total page 413 pages. Available in PDF, EPUB and Kindle. Book excerpt: This is the second edition of a very well received book that details how the sumoylation system functions and how it modulates numerous cellular activities. SUMO is a post-translational modifier in the ubiquitin super-family that has gained recognition over the last twenty years as an essential and prevalent regulatory molecule. Individual chapters explore the biochemistry, molecular biology, and cell biology of the sumoylation system and its substrate proteins. The book is divided into three themed parts: Molecular Functions (I), Cell Growth Regulation (II), and Diseases (III). Parts I and II focus on the contribution of sumoylation to cellular activities in both the nuclear and cytoplasmic compartments. The nuclear activities covered include nucleic acid metabolism (both RNA and DNA), chromosome structure and replication, and nucleocytoplasmic transport. Cytoplasmic processes presented include regulation of membrane ion channels, general metabolism, and apoptotic signalling. Topics in Part III include the role of sumoylation in developmental abnormalities (craniofacial and cardiovascular), diabetes, neurodegenerative diseases, cancer, and infections with viruses and bacteria. Each of the corresponding chapter authors is an active researcher who has made significant contributions to understanding sumoylation. This second edition provides updates and revisions to most of the original chapters plus adds six new chapters to address important developing areas of sumoylation research. This volume is intended for a scientific audience from undergraduates to independent researchers. The content will serve as both a solid introduction for the novice reader and an in depth treatment for the advanced scholar.

Conjugation and Deconjugation of Ubiquitin Family Modifiers

Author : Marcus Groettrup
Publisher : Springer Science & Business Media
ISBN 13 : 1441966765
Total Pages : 270 pages
Book Rating : 4.4/5 (419 download)

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Book Synopsis Conjugation and Deconjugation of Ubiquitin Family Modifiers by : Marcus Groettrup

Download or read book Conjugation and Deconjugation of Ubiquitin Family Modifiers written by Marcus Groettrup and published by Springer Science & Business Media. This book was released on 2011-01-11 with total page 270 pages. Available in PDF, EPUB and Kindle. Book excerpt: † 1 a a 4 † 17 10 15 ubiquitin; and of 16 VCP 17 18 20 33 34 34 36 p domain. 41 42 42 43 P U 42 47 binding. C. elegans 16 In 21 22 50 51 52 53 13 and UFD 4 10 of Cdc48. 18 30 of Ufd2. COFACTORS 47 23 13 47 47 47 72 15 15 and of Spt23 p90. Ufd2 and Cdc48. In C. elegans 74 16 75 75 76 76 Ufd2 25 54 54 7 56 p47 7 7 80 30 30 81 82 82 but and CD3 26 DUB COFACTORS 30 UFD3 OTU1 4 Cdc48 30 4 OLE1. 15 27 87 REFERENCES 30 REGULATION OF UBIQUITIN MONOUBIQUITINATION UBIQUITINATION 1 32 7 S) d 33 12 13 14 15 18 19 15 20 21 35 15 15 27 15 31 32 31 33 36 monoubiquitination of pol pol 34 37 34 monoubiquitination. 20 35 trans 3 15 REFERENCES by monoubiquitination. Mol Cell; 2009. UBIQUITIN LIGASE ACTIVITY BY Nedd 1 2 of 41 5 6 8 fold. 9 13 14 edd 43 18 18 K M and k 18 22 23 K M 24 25 K M 26 edd 45 18 27 K M K D 18 25 . 8 10 M 21 28 MECHANISM AND REGULATION OF CRLs 34 41 34 edd 47 48 S. pombe 49 51 p27 and I by SCF and SCF 57 58 59 60 CTD CTD CTD CTD in Cul5 CTD CTD CTD 60 18

SUMO

Author : Manuel S. Rodriguez
Publisher : Humana
ISBN 13 : 9781493963560
Total Pages : 0 pages
Book Rating : 4.9/5 (635 download)

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Book Synopsis SUMO by : Manuel S. Rodriguez

Download or read book SUMO written by Manuel S. Rodriguez and published by Humana. This book was released on 2016-09-08 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume explores various methodologies to study biochemical, molecular, and cellular biology aspects of some processes regulated by protein SUMOylation. SUMO: Methods and Protocols is organized into four parts, and starts with an historical overview on protein SUMOylation and a presentation of the methods included in the book. The first part also includes a review on chromatin regulation by dynamic SUMO modifications. The second part focuses on in vitro techniques, including biochemical methods to study mechanistic aspects of protein SUMOylation. The third part includes protocols to be used with cell cultures, which often are the first approaches used in most laboratories. The final part includes methodologies adapted for the analysis in vivo using distinct model organisms. Written in the highly successful Methods in Molecular Biology series format, chapters include a brief introduction to the subject, a list of necessary materials and reagents, a step-by-step reproducible laboratory protocol ending with a Notes section on troubleshooting tips, and tips and strategies to avoid known pitfalls. Unique and cutting-edge, SUMO: Methods and Protocols provides a comprehensive source of protocols for specialists and researchers not familiar with this vital system.

Characterization and Profiling of the SUMO Conjugation Pathway in Populus

Author : Jon-Michael Reed
Publisher :
ISBN 13 :
Total Pages : pages
Book Rating : 4.:/5 (658 download)

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Book Synopsis Characterization and Profiling of the SUMO Conjugation Pathway in Populus by : Jon-Michael Reed

Download or read book Characterization and Profiling of the SUMO Conjugation Pathway in Populus written by Jon-Michael Reed and published by . This book was released on 2005 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: ABSTRACT: Covalent attachment of the Small Ubiquitin-like Modifier (SUMO) to proteins in eukaryotic cells has been demonstrated to be an important step in the regulation of a wide variety of cellular processes. Such processes include transcriptional regulation, mediating DNA/protein interaction, and increasing protein stability by interfering with the ubiquitin conjugation pathway in some cases. While much work has been done to characterize the SUMO pathway in yeast, insect, and mammalian systems, relatively little is known about the roles that SUMO conjugation plays in plants. In this study, I make use of the Populus model system to investigate the gene structures of the various family members of the SUMO pathway in plants, as well as demonstrate that the pathway is active in a number of tissue types. Additionally, we show that the SUMOylation is inducible through acute stress treatments such as desiccation, heat shock, and peroxide application. To further our understanding of the SUMOylation process, I have set out to identify SUMO-conjugated proteins from heat shock treated tissues through a multi-step purification process.

Investigating the Role of 14-3-3[zeta] SUMOylation

Author : Hoang Anh Phuc Nguyen
Publisher :
ISBN 13 :
Total Pages : 39 pages
Book Rating : 4.:/5 (863 download)

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Book Synopsis Investigating the Role of 14-3-3[zeta] SUMOylation by : Hoang Anh Phuc Nguyen

Download or read book Investigating the Role of 14-3-3[zeta] SUMOylation written by Hoang Anh Phuc Nguyen and published by . This book was released on 2013 with total page 39 pages. Available in PDF, EPUB and Kindle. Book excerpt: SUMO modification is involved in several cellular processes such as signal transduction, cell division, and regulation of protein subcellular localization, specifically including Ras signaling and protein nuclear import/export. Previous studies have demonstrated that 14-3-3[zeta], which is thought to have functions in both the nucleus and cytoplasm, is a SUMOylated protein and is required for Ras signaling. I have therefore sought to determine whether or not the SUMOylation of 14-3-3[zeta] promotes or inhibits its localization to the nucleus. Subcellular fractionation experiments fail to reveal a detectable change in the overall ratio of nuclear to cytoplasmic 14-3-3[zeta] upon knockdown of SUMO by RNAi in cultured Drosophila cells. However, immunofluorescence studies suggest that nuclear localization of this protein may increase in a subset of the SUMO knockdown cells.

SUMOylation and Ubiquitination

Author : Van G. Wilson
Publisher :
ISBN 13 : 9781912530120
Total Pages : 512 pages
Book Rating : 4.5/5 (31 download)

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Book Synopsis SUMOylation and Ubiquitination by : Van G. Wilson

Download or read book SUMOylation and Ubiquitination written by Van G. Wilson and published by . This book was released on 2019-09 with total page 512 pages. Available in PDF, EPUB and Kindle. Book excerpt: Most proteins undergo post-translational modifications altering physical and chemical properties, folding, conformation distribution, stability, activity and function. Ubiquitin and SUMOs are related small proteins that are members of the large ubiquitin superfamily of post-translational modifiers. Written by highly respected leaders in their fields under the expert guidance of the editor, this volume covers the principles of ubiquitination and SUMOylation, presents detailed reviews of current and emerging concepts and highlights new advances in all areas of SUMOylation and ubiquitination. Topics of note include: the ubiquitin superfamily, the ubiquitin toolbox, onco viral exploitation of the SUMO system, small molecule modulators of desumoylation, mass spectrometry, global proteomic profiling of SUMO and ubiquitin, biotin-based approaches, genetic screening, SUMOylation networks in humans, targets for ubiquitin ligases, regulation of p53, protein homeostasis, miRNAs, DNA replication, DNA damage response, telomere biology, intracellular trafficking, regulation of angiogenesis, brain ischemia, autophagy, assembly and activity, antiviral defense, HIV infection, amyloid and amyloid-like proteins, plant immunity. This comprehensive and up-to-date book is the definitive reference volume on all aspects of SUMOylation and ubiquitination and is an essential acquisition for anyone involved in this area of biology.

SUMO-1 Mapping in the Human Genome Andits Implications for Transcription Control

Author : Hui-Wen Liu
Publisher :
ISBN 13 :
Total Pages : pages
Book Rating : 4.:/5 (897 download)

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Book Synopsis SUMO-1 Mapping in the Human Genome Andits Implications for Transcription Control by : Hui-Wen Liu

Download or read book SUMO-1 Mapping in the Human Genome Andits Implications for Transcription Control written by Hui-Wen Liu and published by . This book was released on 2014 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: SUMOylation, a post-translational modification with SUMO proteins covalently conjugated to a variety of proteins, regulates a range of cellular processes, including cell proliferation and maintenance of genome stability. In this study, we investigated how SUMO-1 functions as a chromatin mark on the human genome during cell cycle progression by ChIP-seq approach. Surprisingly, despite the known repressive role of SUMOylation on histones, we found that SUMO-1 localizes to the promoters of constitutively active genes involved in protein translation and proliferation during interphase. For example, ribosomal protein genes; and SUMO-1 marks on these promoters were absent during mitosis. In addition, SUMO-1 association on the promoters recruits RNAPII, and depletion of SUMO-1 leads to down regulation of those ribosomal protein genes, suggesting a positive role of SUMO-1 in gene activation. To further elucidate how SUMOylation regulates transcription process related to protein synthesis, we identified that SUMO-1 marks the promoters via the Scaffold Associated Factor B (SAFB) protein. The results showed that SAFB is SUMOylated, and depletion of SAFB caused the decrease of SUMO-1 marks on the promoters of those housekeeping genes transcribed by RNAPII. In addition, depletion of SAFB decreased the splicing of the mRNAs and disrupted the organization of Cajal body, which is important for snRNP and snoRNP biogenesis. All these findings suggested that SUMOylation plays an important role in the regulatory process for transcription initiation and splicing of mRNA of ribosomal protein genes.

Ubiquitin Proteasome System

Author : Matthew Summers
Publisher : BoD – Books on Demand
ISBN 13 : 1838804900
Total Pages : 228 pages
Book Rating : 4.8/5 (388 download)

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Book Synopsis Ubiquitin Proteasome System by : Matthew Summers

Download or read book Ubiquitin Proteasome System written by Matthew Summers and published by BoD – Books on Demand. This book was released on 2019-06-19 with total page 228 pages. Available in PDF, EPUB and Kindle. Book excerpt: The human ubiquitin proteasome system (UPS) is comprised of nearly 1000 proteins. Although originally identified as a mechanism of protein destruction, the UPS has numerous additional functions and mediates central signaling events in myriad processes involved in both cellular and organismal health and homeostasis. Numerous pathways within the UPS are implicated in disease, ranging from cancer to neurodegenerative diseases such as Parkinson's. The goal of this book is to deliver a collection of synopses of current areas of UPS research that highlights the importance of understanding the biology of the UPS to identify disease-relevant pathways, and the need to elucidate the molecular machinations within the UPS to develop methods for therapeutic modulation of these pathways.

Characterization of Arabidopsis SUMO Conjugation as Orchestrator of Nuclear Bodies and Transcription

Author : Magdalena Julita Mazur
Publisher :
ISBN 13 :
Total Pages : 156 pages
Book Rating : 4.:/5 (16 download)

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Book Synopsis Characterization of Arabidopsis SUMO Conjugation as Orchestrator of Nuclear Bodies and Transcription by : Magdalena Julita Mazur

Download or read book Characterization of Arabidopsis SUMO Conjugation as Orchestrator of Nuclear Bodies and Transcription written by Magdalena Julita Mazur and published by . This book was released on 2016 with total page 156 pages. Available in PDF, EPUB and Kindle. Book excerpt: Small ubiquitin-like modifier (SUMO) is a conserved post-translational modification that regulates many biological processes in animal, yeast and plant cells. SUMO can be covalently attached to its target proteins at lysine residues present in short consensus peptide motifs. To date, hundreds of proteins have been identified as bona fide SUMO targets for mammals. In Arabidopsis, however, more studies are required to fully understand the extent of SUMO regulation in plant cells. In this study we focused on analyses and further study of SUMO proteome in Arabidopsis. In chapter 2 of this thesis we analyzed the cellular processes that are regulated by sumoylation as well as we reviewed current strategies to study sumoylation. In chapter 3 we characterized the interaction interface between SUMO peptide (SUMO1) and enzymes involved in sumoylation: SCE1 and SIZ1. We demonstrated that the SUMO1∙SCE1∙SIZ1 complex resides in nuclear bodies (NBs), along with the ubiquitin E3 ligase COP1, a master regulator of photomorphogenesis. In order to identify new SUMO interactors and SUMO substrate, we performed high-throughput yeast 2-hybrid assay using SUMO peptide paralogs as well as SUMO (de)conjugation enzymes as baits. We found that SUMO machinery interacts with many transcriptional regulators belonging to many transcription factors (TFs) families (chapter 4) and well as with some important proteins involved in plant immunity (chapter 5) in nuclear bodies. We further analyze the found interactions in chapters 4 and 5. In chapter 6 we summarized the current knowledge on sub-nuclear structures and the potential role of SUMO in their biology.

mRNA Processing and Metabolism

Author : Daniel R. Schoenberg
Publisher : Humana
ISBN 13 : 9781588292254
Total Pages : 270 pages
Book Rating : 4.2/5 (922 download)

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Book Synopsis mRNA Processing and Metabolism by : Daniel R. Schoenberg

Download or read book mRNA Processing and Metabolism written by Daniel R. Schoenberg and published by Humana. This book was released on 2004-02-05 with total page 270 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cells possess a wealth of posttranscriptional control mechanisms that impact on every conceivable aspect of the life of an mRNA. These processes are intimately intertwined in an almost baroque manner, where promoter context influences the recruitment of splicing factors, where the majority of pre-mRNAs undergo alternative splicing, and where proteins deposited during nuclear processing impact distal cytoplasmic processing, translation, and decay. If there is a unifying theme to mRNA Processing and Metabolism: Methods and Protocols, it is that mRNA processing and metabolism are integrated processes. Many of the techniques used to study mRNA have been described in a previous volume of this series (RNA–Protein Interaction Protocols, Susan Haynes, ed.) and specialized methods journals. In selecting topics for mRNA Processing and Metabolism: Methods and Protocols, I sought input on new and novel techniques and approaches that build on this foundation using technological advances in microscopy, whole genome sequencing, microarrays, mass spectrometry, fluorescent detection methodologies, and RNA interference. I have tried not to bias this book toward any single model organism, and approaches described in the various chapters use yeast, Drosophila, Xenopus, mice, plants, and cultured mammalian cells.

Handbook of Epigenetics

Author : Trygve Tollefsbol
Publisher : Academic Press
ISBN 13 : 0128054778
Total Pages : 682 pages
Book Rating : 4.1/5 (28 download)

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Book Synopsis Handbook of Epigenetics by : Trygve Tollefsbol

Download or read book Handbook of Epigenetics written by Trygve Tollefsbol and published by Academic Press. This book was released on 2017-07-10 with total page 682 pages. Available in PDF, EPUB and Kindle. Book excerpt: Handbook of Epigenetics: The New Molecular and Medical Genetics, Second Edition, provides a comprehensive analysis of epigenetics, from basic biology, to clinical application. Epigenetics is considered by many to be the new genetics in that many biological phenomena are controlled, not through gene mutations, but rather through reversible and heritable epigenetic processes. These epigenetic processes range from DNA methylation to prions. The biological processes impacted by epigenetics are vast and encompass effects in lower organisms and humans that include tissue and organ regeneration, X-chromosome inactivation, stem cell differentiation, genomic imprinting, and aging. The first edition of this important work received excellent reviews; the second edition continues its comprehensive coverage adding more current research and new topics based on customer and reader reviews, including new discoveries, approved therapeutics, and clinical trials. From molecular mechanisms and epigenetic technology, to discoveries in human disease and clinical epigenetics, the nature and applications of the science is presented for those with interests ranging from the fundamental basis of epigenetics, to therapeutic interventions for epigenetic-based disorders. Timely and comprehensive collection of fully up-to-date reviews on epigenetics that are organized into one volume and written by leading figures in the field Covers the latest advances in many different areas of epigenetics, ranging from basic aspects, to technologies, to clinical medicine Written at a verbal and technical level that can be understood by scientists and college students Updated to include new epigenetic discoveries, newly approved therapeutics, and clinical trials

Human Herpesviruses

Author : Ann Arvin
Publisher : Cambridge University Press
ISBN 13 : 1139461648
Total Pages : 1325 pages
Book Rating : 4.1/5 (394 download)

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Book Synopsis Human Herpesviruses by : Ann Arvin

Download or read book Human Herpesviruses written by Ann Arvin and published by Cambridge University Press. This book was released on 2007-08-16 with total page 1325 pages. Available in PDF, EPUB and Kindle. Book excerpt: This comprehensive account of the human herpesviruses provides an encyclopedic overview of their basic virology and clinical manifestations. This group of viruses includes human simplex type 1 and 2, Epstein–Barr virus, Kaposi's Sarcoma-associated herpesvirus, cytomegalovirus, HHV6A, 6B and 7, and varicella-zoster virus. The viral diseases and cancers they cause are significant and often recurrent. Their prevalence in the developed world accounts for a major burden of disease, and as a result there is a great deal of research into the pathophysiology of infection and immunobiology. Another important area covered within this volume concerns antiviral therapy and the development of vaccines. All these aspects are covered in depth, both scientifically and in terms of clinical guidelines for patient care. The text is illustrated generously throughout and is fully referenced to the latest research and developments.

SUMO Protocols

Author : Helle Ulrich
Publisher : Humana Press
ISBN 13 : 9781934115800
Total Pages : 0 pages
Book Rating : 4.1/5 (158 download)

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Book Synopsis SUMO Protocols by : Helle Ulrich

Download or read book SUMO Protocols written by Helle Ulrich and published by Humana Press. This book was released on 2008-10-23 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Post-translational protein modifications by members of the ubiquitin family are widely recognized as important regulatory control systems for a variety of biological pathways. Their influence on eukaryotic cellular metabolism is comparable to that of other modifi- tions such as phosphorylation, acetylation and methylation. The small ubiquitin-related modifier SUMO uses a conjugation and de-conjugation system closely related to that of ubiquitin itself; yet, the functions of the SUMO system are highly diverse and largely independent of the ubiquitin system. SUMO modification controls the activity of tr- scription factors and can influence protein stability, but it also contributes to nucleo-cy- plasmic transport, chromosome segregation and DNA damage repair. As a consequence, the SUMO system pervades virtually all areas of basic molecular and cell biology, and scientists from different backgrounds, including medical researchers, are likely to enco- ter SUMO in the course of their studies. This volume, SUMO Protocols, therefore aims at presenting a collection of methods relevant to SUMO research in order to make these tools available to biochemists, molecular and cell biologists as well as research-oriented clinicians not yet familiar with the system. In contrast to the ubiquitin system, which has been the subject of several reviews and methods collections, no practical compendium entirely devoted to SUMO has been p- lished.

Characterization of the Role of the Small Ubiquitin-like Modifier (SUMO) on Nuclear Localization and Proteolysis of the Thyroid Hormone Receptor (TR)

Download Characterization of the Role of the Small Ubiquitin-like Modifier (SUMO) on Nuclear Localization and Proteolysis of the Thyroid Hormone Receptor (TR) PDF Online Free

Author : Amanda M. Back
Publisher :
ISBN 13 :
Total Pages : pages
Book Rating : 4.:/5 (15 download)

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Book Synopsis Characterization of the Role of the Small Ubiquitin-like Modifier (SUMO) on Nuclear Localization and Proteolysis of the Thyroid Hormone Receptor (TR) by : Amanda M. Back

Download or read book Characterization of the Role of the Small Ubiquitin-like Modifier (SUMO) on Nuclear Localization and Proteolysis of the Thyroid Hormone Receptor (TR) written by Amanda M. Back and published by . This book was released on 2017 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: The small ubiquitin-like modifier (SUMO) is involved in post-translational modification of proteins and is characterized by its role in regulation of a variety of cellular processes. The objective of this thesis was to characterize the role SUMO has in modification of the thyroid hormone receptor (TR). TR is a regulatory transcription factor that, in most cases when the ligand (T3) is not bound, represses gene expression through the recruitment of co-repressors. When T3 is bound to TR, the co-repressors are released and co-activators are recruited, resulting in positive gene expression mediated by a particular thyroid hormone response element (TRE). Previous research has identified the import and export proteins involved in nuclear localization of TR. Post-translational modification, however, has only begun to be characterized. In terms of proteolysis, TR is degraded through poly-ubiquitination; but it is unclear whether ubiquitin binding is correlated with sumoylation. SUMO sites for TR have been previously identified, and their role in TR-mediated gene expression demonstrated. Here, the role SUMO plays in nuclear localization and proteolysis of TR through its interaction with ubiquitin binding is characterized. Mutant constructs of TR that could not be sumoylated were synthesized and cloned into GFP. For nuclear localization assays, the constructs were transfected into HeLa cells and quantitatively scored for the ratio of fluorescence intensity in the nucleus versus the cytosol using region of interest (ROI) analysis. Coimmunoprecipitation followed by western analysis, was conducted in order to identify the relationship between sumoylation and ubiquitination. The nuclear localization experiments showed no changes in nuclear localization of the SUMO-deficient TR compared to the wild-type TR. Coimmunoprecipitation suggested that there may be a higher level of ubiquitination when TR was not sumoylated. However, varying levels of cellular ubiquitin make this finding inconclusive. Overall, this thesis demonstrates that SUMO is not directly involved in nuclear localization of TR; however, it may play a role in enhancing the binding of ubiquitin, ultimately suggesting that sumoylation may be involved in proteolysis of TR.

Epigenetics in Psychiatry

Author : Jacob Peedicayil
Publisher : Academic Press
ISBN 13 : 0128235780
Total Pages : 848 pages
Book Rating : 4.1/5 (282 download)

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Book Synopsis Epigenetics in Psychiatry by : Jacob Peedicayil

Download or read book Epigenetics in Psychiatry written by Jacob Peedicayil and published by Academic Press. This book was released on 2021-08-21 with total page 848 pages. Available in PDF, EPUB and Kindle. Book excerpt: Epigenetics in Psychiatry, Second Edition covers all major areas of psychiatry in which extensive epigenetic research has been performed, fully encompassing a diverse and maturing field, including drug addiction, bipolar disorder, epidemiology, cognitive disorders, and the uses of putative epigenetic-based psychotropic drugs. Uniquely, each chapter correlates epigenetics with relevant advances across genomics, transcriptomics, and proteomics. The book acts as a catalyst for further research in this growing area of psychiatry. This new edition has been fully revised to address recent advances in epigenetic understanding of psychiatric disorders, evoking data consortia (e.g., CommonMind, ATAC-seq), single cell analysis, and epigenome-wide association studies to empower new research. The book also examines epigenetic effects of the microbiome on psychiatric disorders, and the use of neuroimaging in studying the role of epigenetic mechanisms of gene expression. Ongoing advances in epigenetic therapy are explored in-depth. Fully revised to discuss new areas of research across neuronal stem cells, cognitive disorders, and transgenerational epigenetics in psychiatric disease Relates broad advances in psychiatric epigenetics to a modern understanding of the genome, transcriptome, and proteins Catalyzes knowledge discovery in both basic epigenetic biology and epigenetic targets for drug discovery Provides guidance in research methods and protocols, as well how to employ data from consortia, single cell analysis, and epigenome-wide association studies (EWAS) Features chapter contributions from international leaders in the field

Enzymes of Epigenetics

Author :
Publisher : Elsevier
ISBN 13 : 0128119020
Total Pages : 440 pages
Book Rating : 4.1/5 (281 download)

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Book Synopsis Enzymes of Epigenetics by :

Download or read book Enzymes of Epigenetics written by and published by Elsevier. This book was released on 2016-07-14 with total page 440 pages. Available in PDF, EPUB and Kindle. Book excerpt: Enzymes of Epigenetics: Part B, one of two new volumes in the Methods in Enzymology series, continues the legacy of this premier serial with quality chapters authored by leaders in the field. This volume covers research methods that are employed in the study of epigenetic regulation, including structural, biochemical, molecular, biological, cellular, computational, and systems approaches. Topics include chromatin structure and histones, posttranslational histone modification enzymes and complexes, histone modification binders, DNA modifications and nucleic acid regulators, epigenetic technologies, and small molecule epigenetic regulators and biological connections. Continues the legacy of this premier serial with quality chapters authored by leaders in the field Contains two new volumes that cover research methods in enzymes of epigenetics Covers such topics as chromatin structure and histones, posttranslational histone modification enzymes and complexes, histone modification binders, DNA modifications and nucleic acid regulators, epigenetic technologies and small molecule epigenetic regulators, and biological connections

Co- and Post-Translational Modifications of Therapeutic Antibodies and Proteins

Author : T. Shantha Raju
Publisher : John Wiley & Sons
ISBN 13 : 1119053366
Total Pages : 293 pages
Book Rating : 4.1/5 (19 download)

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Book Synopsis Co- and Post-Translational Modifications of Therapeutic Antibodies and Proteins by : T. Shantha Raju

Download or read book Co- and Post-Translational Modifications of Therapeutic Antibodies and Proteins written by T. Shantha Raju and published by John Wiley & Sons. This book was released on 2019-03-15 with total page 293 pages. Available in PDF, EPUB and Kindle. Book excerpt: A Comprehensive Guide to Crucial Attributes of Therapeutic Proteins in Biological Pharmaceuticals With this book, Dr. Raju offers a valuable resource for professionals involved in research and development of biopharmaceutical and biosimilar drugs. This is a highly relevant work, as medical practitioners have increasingly turned to biopharmaceutical medicines in their search for safe and reliable treatments for complex diseases, while pharmaceutical researchers seek to expand the availability of biopharmaceuticals and create more affordable biosimilar alternatives. Readers receive a thorough overview of the major co-translational modifications (CTMs) and post-translational modifications (PTMs) of therapeutic proteins relevant to the development of biotherapeutics. The majority of chapters detail individual CTMs and PTMs that may affect the physicochemical, biochemical, biological, pharmacokinetic, immunological, toxicological etc. properties of proteins. In addition, readers are guided on the methodology necessary to analyze and characterize these modifications. Thus, readers gain not only an understanding of CTMs/PTMs, but also the ability to design and assess their own structure-function studies for experimental molecules. Specific features and topics include: Discussion of the research behind and expansion of biopharmaceuticals Twenty chapters detailing relevant CTMs and PTMs of proteins, such as glycosylation, oxidation, phosphorylation, methylation, proteolysis, etc. Each chapter offers an introduction and guide to the mechanisms and biological significance of an individual CTM or PTM, including practical guidance for experiment design and analysis An appendix of biologic pharmaceuticals currently on the market, along with an assessment of their PTMs and overall safety and efficacy This volume will prove a key reference on the shelves of industry and academic researchers involved in the study and development of biochemistry, molecular biology, biopharmaceuticals and proteins in medicine, particularly as biopharmaceuticals and biosimilars become ever more prominent tools in the field of healthcare.