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Download or read book Studies Related to the Synthesis of Strained Beta-Lactam Antibiotics written by and published by . This book was released on 1980 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Alle Bruggink
Publisher : Springer Science & Business Media
ISBN 13 : 9401008507
Total Pages : 328 pages
Book Rating : 4.4/5 (1 download)
Download or read book Synthesis of β-Lactam Antibiotics written by Alle Bruggink and published by Springer Science & Business Media. This book was released on 2011-06-27 with total page 328 pages. Available in PDF, EPUB and Kindle. Book excerpt: Penicillins and cephalosporins have a long history in combating bacterial infections. Despite new infectious diseases and occurring resistance, beta-lactam antibiotics will for many years to come continue to play a prominent role in our therapeutic arsenal. This book covers the industrial development of the chemical and biochemical processes used to manufacture these products, as well as looking ahead to possible future processes. The interplay between synthetic organic chemistry with the understanding and application of enzymes, modeling of fermentation processes and integration through (bio-) chemical process engineering is illustrated. In-depth scientific approaches to biocatalysis and biocatalyst development including enzyme kinetics, enzyme crystal studies and semi-rational enzyme mutations are also presented. Metabolic pathway analysis and modeling of fermentation process are treated as well as molecular precision in synthetic approaches to beta-lactams, their precursors and derivatives. Process technology studies including new reactor concepts, possible short-cut routes and improved down-stream-processing methods complete a broad view on the scope and limitations of the presently developed industrial processes including an intriguing insight into future process possibilities. This book represents an excellent case study on the transformation of traditional, stoïchiometric, organic synthesis and classical fermentations into modern (bio-) catalysis and biosynthesis based on insights in metabolic pathways and enzyme actions.
Author : R. W. McCabe
Publisher :
ISBN 13 :
Total Pages : 0 pages
Book Rating : 4.:/5 (135 download)
Download or read book Studies Related to the Synthesis of Strained Beta-lactum Antibiotics written by R. W. McCabe and published by . This book was released on 1980 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: The primary objective of this project was the synthesis of strained tricyclic ^-lactam antibiotics of the cephalosporin type (e.g. 27). During studies of the reaction of 2- substituted acrylic acids with dihydrothiazines we have discovered a novel synthesis of dihydropyrido [ 2,1 -b ][1,3 ]- thiazines. A detailed study of this synthesis has led to the finding of very interesting rearrangements. The synthesis was extended to give pyrido [ 2,1-b ][l,3 ] thiazines directly. Photochemical studies on the pyrido [2.1-bI 1,3] thiazines and on dihydrothiazines have yielded some very interesting rearrangements. Hydrolysis of pyrido [ 2,1--b][1,3 ] thiazine esters has given compounds whose photolysis has been studied. Some of the results suggest a possible direction for future work on the synthesis of the strained ^-lactam antibiotics related to cephalosporin.
Author : Bimal K. Banik
Publisher : Springer
ISBN 13 : 3319556215
Total Pages : 423 pages
Book Rating : 4.3/5 (195 download)
Download or read book Beta-Lactams written by Bimal K. Banik and published by Springer. This book was released on 2017-05-11 with total page 423 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book presents an essential overview of beta-lactams and their medicinal value and use in the preparation of other biologically active compounds. Written by internationally respected authors, the individual chapters explore beta-lactams’ synthesis, their mechanism of formation, biological effects, and function as base materials for other heterocycles of major importance.
Author : Kirsty A. Leonard
Publisher :
ISBN 13 :
Total Pages : pages
Book Rating : 4.:/5 (847 download)
Download or read book Studies Related to the Synthesis of Beta-lactams written by Kirsty A. Leonard and published by . This book was released on with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Nina Issam Sakhnini
Publisher :
ISBN 13 :
Total Pages : 0 pages
Book Rating : 4.:/5 (115 download)
Download or read book The Synthesis of Novel Compounds Related to Beta-lactam Antibiotics written by Nina Issam Sakhnini and published by . This book was released on 1994 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Mohammad Manasra
Publisher :
ISBN 13 :
Total Pages : 670 pages
Book Rating : 4.:/5 (12 download)
Download or read book Synthesis and Physico-chemical Studies of New Β-lactam Antibiotic Derivatives written by Mohammad Manasra and published by . This book was released on 1978 with total page 670 pages. Available in PDF, EPUB and Kindle. Book excerpt:
![Download Synthetic Studies Related to the Biosynthesis of the [beta]-lactam Antibiotics PDF Online Free](https://books.google.com/books/content/images/frontcover/34M3HQAACAAJ?fife=w200-h370)
Author : Stephen Robert Herchen
Publisher :
ISBN 13 :
Total Pages : 284 pages
Book Rating : 4.:/5 (385 download)
Download or read book Synthetic Studies Related to the Biosynthesis of the [beta]-lactam Antibiotics written by Stephen Robert Herchen and published by . This book was released on 1977 with total page 284 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Thorsteinn Loftsson
Publisher : Academic Press
ISBN 13 : 0124115624
Total Pages : 170 pages
Book Rating : 4.1/5 (241 download)
Download or read book Drug Stability for Pharmaceutical Scientists written by Thorsteinn Loftsson and published by Academic Press. This book was released on 2014-01-25 with total page 170 pages. Available in PDF, EPUB and Kindle. Book excerpt: Drug Stability for Pharmaceutical Scientists is a clear and easy-to-follow guide on drug degradation in pharmaceutical formulation. This book features valuable content on both aqueous and solid drug solutions, the stability of proteins and peptides, acid-base catalyzed and solvent catalyzed reactions, how drug formulation can influence drug stability, the influence of external factors on reaction rates and much more. Full of examples of real-life formulation problems and step-by-step calculations, this book is the ideal resource for graduate students, as well as scientists in the pharmaceutical and related industries. - Illustrates important theoretical concepts with numerous examples, figures, calculations, learning problems and questions for self-study and retention of material - Provides answers and explanations to test your knowledge - Enables you to better understand key concepts such as rate and order of reaction, reaction equilibrium, complex reaction mechanisms and more - Includes an in-depth discussion of both aqueous and solid drug solutions and contains the latest international regulatory requirements on drug stability
Download or read book The Synthesis of Acylating Systems Related to Beta-lactam Antibiotics written by and published by . This book was released on 1989 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : J. Michelle Leslie
Publisher :
ISBN 13 :
Total Pages : pages
Book Rating : 4.:/5 (173 download)
Download or read book N-Thiolated B-lactam Antibiotics written by J. Michelle Leslie and published by . This book was released on 2006 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: ABSTRACT: N-Thiolated beta-lactams are a new class of anti-MRSA and anti-Bacillus agents that have recently been reported by our laboratories. From previous studies performed in our laboratories, it is believed that the N-thiolated beta-lactams exert their antimicrobial activity through a unique mode of action that is completely unlike that of classical beta-lactam antibiotics. In the first chapter of this dissertation, a review of previously prepared N-thiolated beta-lactam analogues and their mode of action is presented. In the second chapter, the synthesis of seven different C3-oxygenated derivatives is described. These analogues were tested for antibacterial activity against Staphylococcus aureus, nine different strains of MRSA, and seven different species of Bacillus. The results of the antibacterial testing will be discussed in relation to the differences in the structures of the analogues. In chapter 3, the design and synthesis of two new, functionalized caprolactone monomers are presented. These monomers were subsequently cooligomerized with epsilon-caprolactone, as described in chapter 4. N-thiolated beta-lactams were attached to the functionalized oligomers. These antibiotic containing oligomers were then screened for activity against MSSA, MRSA, and Bacillus. The results of these biological tests and their implications for future experiments are discussed.
![Download Chemistry and Biology of [beta]-lactam Antibiotics PDF Online Free](https://books.google.com/books/content/images/frontcover/_LBFAQAAMAAJ?fife=w200-h370)
Author : Robert B. Morin
Publisher :
ISBN 13 :
Total Pages : 464 pages
Book Rating : 4.:/5 (41 download)
Download or read book Chemistry and Biology of [beta]-lactam Antibiotics written by Robert B. Morin and published by . This book was released on 1982 with total page 464 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : J.-M. Ghuysen
Publisher : Elsevier
ISBN 13 : 0080860877
Total Pages : 607 pages
Book Rating : 4.0/5 (88 download)
Download or read book Bacterial Cell Wall written by J.-M. Ghuysen and published by Elsevier. This book was released on 1994-02-09 with total page 607 pages. Available in PDF, EPUB and Kindle. Book excerpt: Studies of the bacterial cell wall emerged as a new field of research in the early 1950s, and has flourished in a multitude of directions. This excellent book provides an integrated collection of contributions forming a fundamental reference for researchers and of general use to teachers, advanced students in the life sciences, and all scientists in bacterial cell wall research. Chapters include topics such as: Peptidoglycan, an essential constituent of bacterial endospores; Teichoic and teichuronic acids, lipoteichoic acids, lipoglycans, neural complex polysaccharides and several specialized proteins are frequently unique wall-associated components of Gram-positive bacteria; Bacterial cells evolving signal transduction pathways; Underlying mechanisms of bacterial resistance to antibiotics.
Author : T. H. Khan
Publisher :
ISBN 13 :
Total Pages : 0 pages
Book Rating : 4.:/5 (597 download)
Download or read book Approaches to the Synthesis of Beta -lactam Antibiotics written by T. H. Khan and published by . This book was released on 1987 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Robert B. Morin
Publisher : Academic Press
ISBN 13 : 1483277194
Total Pages : 594 pages
Book Rating : 4.4/5 (832 download)
Download or read book Penicillins and Cephalosporins written by Robert B. Morin and published by Academic Press. This book was released on 2014-05-10 with total page 594 pages. Available in PDF, EPUB and Kindle. Book excerpt: Chemistry and Biology of ?-Lactam Antibiotics, Volume 1: Penicillins and Cephalosporins provides information pertinent to the study of antibiotics containing the ?-lactam moiety. This book discusses the occurrence of a group of ?-lactam antibiotics structurally related to cephalosporin C. Organized into five chapters, this volume begins with an overview of the mechanism of action of ?-lactam antibiotics that caused many microbiologists to develop screening tools for the detection of the ?-lactam moiety. This text then discusses the discovery of the nocardicins, the thienamycins, and olivanic acids. Other chapters provide a summary of the essential penicillin sulfoxide chemistry that gave rise to many compounds. This book discusses as well the ability of chemists to predict the level of biological activity of a compound from knowledge of its structure through theoretical and physicochemical studies. The final chapter deals with quantitative structure–activity relationships. This book is a valuable resource for microbiologists, chemists, and scientists.
Author : Terence Seeming Wan
Publisher :
ISBN 13 :
Total Pages : 326 pages
Book Rating : 4.:/5 (84 download)
Download or read book Studies on the Biosynthesis of Beta-lactam Antibiotics written by Terence Seeming Wan and published by . This book was released on 1981 with total page 326 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : J. Cuffe
Publisher :
ISBN 13 :
Total Pages : 0 pages
Book Rating : 4.:/5 (534 download)
Download or read book Some Approaches Towards the Synthesis of Beta-lactam Antibiotics written by J. Cuffe and published by . This book was released on 1983 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:
