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Author : Coralie June Cornish
Publisher :
ISBN 13 :
Total Pages : 482 pages
Book Rating : 4.:/5 (221 download)
Download or read book Studies on Human Bone Alkaline Phosphatase written by Coralie June Cornish and published by . This book was released on 1973 with total page 482 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Thomas Harvey Cooper
Publisher :
ISBN 13 :
Total Pages : 86 pages
Book Rating : 4.:/5 (595 download)
Download or read book Studies on Human Liver and Bone Alkaline Phosphatases written by Thomas Harvey Cooper and published by . This book was released on 1970 with total page 86 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : José Luis Millan
Publisher : John Wiley & Sons
ISBN 13 : 3527607471
Total Pages : 337 pages
Book Rating : 4.5/5 (276 download)
Download or read book Mammalian Alkaline Phosphatases written by José Luis Millan and published by John Wiley & Sons. This book was released on 2006-12-13 with total page 337 pages. Available in PDF, EPUB and Kindle. Book excerpt: A review and discussion of new knowledge on the structure and function of mammalian alkaline phosphatases (APs) gained over the last 25 years. It covers: * The structure, regulation and expression of the AP genes * The three-dimensional structure of APs and mutagenesis work that further defined the structural/functional domains of the isozymes * The phenotypic abnormalities of the different AP knockout mice * Our current understanding of the in vivo role of the AP isozymes. The book also describes the possible use of APs as therapeutic agents and therapeutic targets and the many uses of these enzymes in clinical medicine and in biotechnology.
Author : Per Magnusson
Publisher :
ISBN 13 : 9789172190603
Total Pages : 98 pages
Book Rating : 4.1/5 (96 download)
Download or read book Human Bone Alkaline Phosphatase Isoforms written by Per Magnusson and published by . This book was released on 1998 with total page 98 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Victor R. Preedy
Publisher : Springer
ISBN 13 : 9789400776920
Total Pages : 0 pages
Book Rating : 4.7/5 (769 download)
Download or read book Biomarkers in Bone Disease written by Victor R. Preedy and published by Springer. This book was released on 2017-07-14 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: In the past decade there has been a major sea change in the way disease is diagnosed and investigated due to the advent of high throughput technologies, such as microarrays, lab on a chip, proteomics, genomics, lipomics, metabolomics etc. These advances have enabled the discovery of new and novel markers of disease relating to autoimmune disorders, cancers, endocrine diseases, genetic disorders, sensory damage, intestinal diseases etc. In many instances these developments have gone hand in hand with the discovery of biomarkers elucidated via traditional or conventional methods, such as histopathology or clinical biochemistry. Together with microprocessor-based data analysis, advanced statistics and bioinformatics these markers have been used to identify individuals with active disease or pathology as well as those who are refractory or have distinguishing pathologies. New analytical methods that have been used to identify markers of disease and is suggested that there may be as many as 40 different platforms. Unfortunately techniques and methods have not been readily transferable to other disease states and sometimes diagnosis still relies on single analytes rather than a cohort of markers. There is thus a demand for a comprehensive and focused evidenced-based text and scientific literature that addresses these issues. Hence the formulation of Biomarkers in Disease. The series covers a wide number of areas including for example, nutrition, cancer, endocrinology, cardiology, addictions, immunology, birth defects, genetics, and so on. The chapters are written by national or international experts and specialists.
Author : Robert B. McComb
Publisher : Springer
ISBN 13 :
Total Pages : 1010 pages
Book Rating : 4.3/5 (91 download)
Download or read book Alkaline Phosphatase written by Robert B. McComb and published by Springer. This book was released on 1979-12 with total page 1010 pages. Available in PDF, EPUB and Kindle. Book excerpt: There can be no doubt that alkaline phosphatase is one of the most extensively in vestigated of all enzymes. This has resulted from the ubiquity of its distribution, and from the ease and sensitivity with which its activity can be measured. Unfortunately, these wide-ranging but often superficial experimental studies have been followed up by intensive and systematic investigations in only a few limited areas of the biochemistry and chemical pathology of alkaline phosphatase. The result has been the accumulation of a scientific literature of intimidating proportions, and the inevitable rediscovery of already known facts about the enzyme. Scientists are taught early in their careers that, in the words of Sir John Herschel, "Hasty generalization is the bane of science. " Nevertheless, moments arrive in all spheres of scientific activity when generalization becomes essential, to codify and to select from the mass of data already accumulated, and to provide starting points for new developments and new lines of investigation. This is especially true in a field such as alkaline phosphatase research, in which very real dangers exist that the seeds of fundamental understanding will be lost amidst an unexamined harvest of empirical observations. The history of the study of alkaline phosphatase provides several instances when valuable generalizations have emerged. Occasionally, the conclusions drawn on the basis of available evidence were wrong; more frequently, they have stood the test of further experimentation, and always, they have provided new insights into the nature and proper ties of this enzyme.
Author :
Publisher : ScholarlyEditions
ISBN 13 : 1481673637
Total Pages : 85 pages
Book Rating : 4.4/5 (816 download)
Download or read book Bone Morphogenetic Proteins—Advances in Research and Application: 2013 Edition written by and published by ScholarlyEditions. This book was released on 2013-06-21 with total page 85 pages. Available in PDF, EPUB and Kindle. Book excerpt: Bone Morphogenetic Proteins—Advances in Research and Application: 2013 Edition is a ScholarlyBrief™ that delivers timely, authoritative, comprehensive, and specialized information about Bone Morphogenetic Protein 6 in a concise format. The editors have built Bone Morphogenetic Proteins—Advances in Research and Application: 2013 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Bone Morphogenetic Protein 6 in this book to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Bone Morphogenetic Proteins—Advances in Research and Application: 2013 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.
Author : D. G. Williams
Publisher :
ISBN 13 :
Total Pages : 0 pages
Book Rating : 4.:/5 (597 download)
Download or read book Studies in Human Intestinal Alkaline Phosphatase written by D. G. Williams and published by . This book was released on 1986 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : José Luis Millán
Publisher : Humana
ISBN 13 : 9781493960316
Total Pages : 0 pages
Book Rating : 4.9/5 (63 download)
Download or read book Phosphatase Modulators written by José Luis Millán and published by Humana. This book was released on 2016-08-23 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Driving further the research on mammalian alkaline phosphatase structure and function, Phosphatase Modulators collects expert contributions into one “how to” manual for basic scientists interested in initiating a drug discovery effort. While this book contains the traditional method chapters and some typical reviews on the structure and known functions of phosphatases, other contributions are meant to discuss approaches and alternatives useful in making “go/no-go” decisions in high throughput screening (HTS) and lead optimization campaigns. Many chapters focus on tissue-nonspecific alkaline phosphatase (TNAP) as well as protein phosphatases. Written for the highly successful Methods in Molecular Biology series, chapters in this volume include the kind of detail and key implementation advice that promotes reproducible results. Step-by-step and practical, Phosphatase Modulators offers a path to understanding many of the facets and complexities associated with undertaking a drug discovery effort and will serve as a roadmap to initiating those efforts.
Author : Peter Gordon Hill
Publisher :
ISBN 13 :
Total Pages : 214 pages
Book Rating : 4.:/5 (911 download)
Download or read book Studies on Alkaline Phosphatase and 5'-nucleotidase in Human Subjects in Health and Disease written by Peter Gordon Hill and published by . This book was released on 1967 with total page 214 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : G. David Roodman
Publisher : Springer Science & Business Media
ISBN 13 : 1607615541
Total Pages : 257 pages
Book Rating : 4.6/5 (76 download)
Download or read book Myeloma Bone Disease written by G. David Roodman and published by Springer Science & Business Media. This book was released on 2010-04-28 with total page 257 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book presents the forefront in the science and clinical management of myeloma bone disease. Coverage begins with sections on clinical presentation, imaging, and biochemical markers and goes on to discuss radiation, surgical, and medical therapies.
Author : Eru Kyeyune-Nyombi
Publisher :
ISBN 13 :
Total Pages : 318 pages
Book Rating : 4.:/5 (241 download)
Download or read book Molecular Mechanism of the Stimulation of Alkaline Phosphatase Activity in Human Bone Cells by 1,25(OH)2 written by Eru Kyeyune-Nyombi and published by . This book was released on 1991 with total page 318 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Rajesh V. Thakker
Publisher : Academic Press
ISBN 13 : 0128041986
Total Pages : 880 pages
Book Rating : 4.1/5 (28 download)
Download or read book Genetics of Bone Biology and Skeletal Disease written by Rajesh V. Thakker and published by Academic Press. This book was released on 2017-10-31 with total page 880 pages. Available in PDF, EPUB and Kindle. Book excerpt: Genetics of Bone Biology and Skeletal Disease, Second Edition, is aimed at students of bone biology and genetics and includes general introductory chapters on bone biology and genetics. More specific disease orientated chapters comprehensively summarize the clinical, genetic, molecular, animal model, molecular pathology, diagnostic, counseling, and treatment aspects of each disorder. The book is organized into five sections that each emphasize a particular theme, general background to bone biology, general background to genetics and epigenetics, disorders of bone and joint, parathyroid and related disorders, and vitamin D and renal disorders. The first section is specifically devoted to providing an overview of bone biology and structure, joint and cartilage biology, principles of endocrine regulation of bone, and the role of neuronal regulation and energy homeostasis. The second section reviews the principles and progress of medical genetics and epigenetics related to bone disease, including genome-wide association studies (GWAS), genomic profiling, copy number variation, prospects of gene therapy, pharmacogenomics, genetic testing and counseling, as well as the generation and utilizing of mouse models. The third section details advances in the genetics and molecular biology of bone and joint diseases, both monogenic and polygenic, as well as skeletal dysplasias, and rarer bone disorders. The fourth section highlights the central role of the parathyroids in calcium and skeletal homeostasis by reviewing the molecular genetics of: hyperparathyroidism, hypoparathyrodism, endocrine neoplasias, and disorders of the PTH and calcium-sensing receptors. The fifth section details molecular and cellular advances across associated renal disorders such as vitamin D and rickets. Identifies and analyzes the genetic basis of bone disorders in humans and demonstrates the utility of mouse models in furthering the knowledge of mechanisms and evaluation of treatments Demonstrates how the interactions between bone and joint biology, physiology, and genetics have greatly enhanced the understanding of normal bone function as well as the molecular pathogenesis of metabolic bone disorders Summarizes the clinical, genetic, molecular, animal model, molecular pathology, diagnostic, counseling, and treatment aspects of each disorder
Author : Amy Priscilla Block
Publisher :
ISBN 13 :
Total Pages : 318 pages
Book Rating : 4.:/5 (29 download)
Download or read book Studies on Intestinal Alkaline Phosphatase in Humans and in Rats written by Amy Priscilla Block and published by . This book was released on 1979 with total page 318 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Alfred W. Kopf
Publisher :
ISBN 13 :
Total Pages : 208 pages
Book Rating : 4.:/5 (648 download)
Download or read book Histochemical Studies on the Distribution of Alkaline Phosphatase in Normal and Pathologic Human Skin written by Alfred W. Kopf and published by . This book was released on 1955 with total page 208 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : William A. Peck
Publisher : Elsevier Science & Technology
ISBN 13 : 9780444903983
Total Pages : 440 pages
Book Rating : 4.9/5 (39 download)
Download or read book Bone and Mineral Research/4 written by William A. Peck and published by Elsevier Science & Technology. This book was released on 1986 with total page 440 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Nael Sudqi Abu-Hasan
Publisher :
ISBN 13 :
Total Pages : pages
Book Rating : 4.:/5 (593 download)
Download or read book Studies on Human Placental Alkaline Phosphatase written by Nael Sudqi Abu-Hasan and published by . This book was released on 1983 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
