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Author : John Patrick Ryan
Publisher :
ISBN 13 :
Total Pages : 602 pages
Book Rating : 4.:/5 (22 download)
Download or read book Studies of the Metabolism and Viability of Preimplantation Mammalian Embryos written by John Patrick Ryan and published by . This book was released on 1990 with total page 602 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Barry D. Bavister
Publisher : Springer Science & Business Media
ISBN 13 : 1468453327
Total Pages : 389 pages
Book Rating : 4.4/5 (684 download)
Download or read book The Mammalian Preimplantation Embryo written by Barry D. Bavister and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 389 pages. Available in PDF, EPUB and Kindle. Book excerpt: With a few notable exceptions, mammalian preimplantation embryos grown in vitro are likely to exhibit sub-optimal or retarded development. This may be manifested in different ways, depending on the species and on the stage(s) of embryonic development that are being examined. For example, bovine embryos often experience difficulty in cleaving under in vitro conditions, and usually cease development at about the 8-cell stage (Wright and Bondioli, 1981). The block to development is stage-dependent; embryos cultured for 24 hr from the I-cell stage are much more capable of developing into viable blastocysts after transfer to oviducts than embryos cultured for 24 hr from the 4-cell stage prior to transfer (Eyestone et oZ. , 1985). Similar problems with in vitro embryo development are encountered in other species. Pig embryos can be grown up to the 4-cell stage in vitro but usually no further (Davis and Day, 1978). In the golden hamster, in the rat and in many outbred strains of mice, development of zygotes in vitro is blocked at the 2-cell stage (Yanagimachi and Chang, 1964; Whittingham, 1975). Even with some inbred mouse strains, embryo development is reduced if very early cleavage stages are used as the starting point for in vitro culture (Spielmann et oZ. , 1980). A common finding is that embryos grown in vitro have reduced cell counts (Harlow and Quinn, 1982; Kane, 1985) and their viability is reduced (Bowman and McLaren, 1970; Papaioannou and Ebert, 1986) compared to equivalent developmental stages recovered from mated animals.
Author : Kersti Lundin
Publisher : Cambridge University Press
ISBN 13 : 110887536X
Total Pages : 125 pages
Book Rating : 4.1/5 (88 download)
Download or read book Manual of Embryo Culture in Human Assisted Reproduction written by Kersti Lundin and published by Cambridge University Press. This book was released on 2021-05-06 with total page 125 pages. Available in PDF, EPUB and Kindle. Book excerpt: Whilst assisted reproduction techniques (ART) have become increasingly successful and largely standardized, there is still only a partial understanding of what constitutes a 'true' embryo environment. Replicating the varying physiological conditions of the in-vivo environment that the embryo travels through in the in-vitro culture is still a major challenge in ART. This practical volume details how to organize and operate an IVF laboratory in order to mimic these conditions for successful embryo culture. Environments and equipment that are essential for running safe and efficient facilities such as maintaining good air quality and hygiene protocols, and utilizing an effective layout are covered in detail. Other chapters discuss the different consumables needed, optimal handling techniques and parameter monitoring systems, as well as recent advances in the area including artificial intelligence and automation. This is an indispensable guide to understanding the background science of culturing embryos, crucial to successful outcomes in ART.
Author : David K. Gardner
Publisher : Springer Science & Business Media
ISBN 13 : 9780387952451
Total Pages : 312 pages
Book Rating : 4.9/5 (524 download)
Download or read book ART and the Human Blastocyst written by David K. Gardner and published by Springer Science & Business Media. This book was released on 2001 with total page 312 pages. Available in PDF, EPUB and Kindle. Book excerpt: The continued debate regarding the stage at which the human embryo conceived in the laboratory should be placed in the mother, combined with recent developments in culture media formulations, have brought the role of the human blastocyst in ART back into the spotlight. ART and the Human Blastocyst presents the proceedings of the International Symposium on ART and the Human Blastocyst held from March 30- April 2, 2000 in Dana Point, California. This book brings to the forefront the main issues raised with the transfer of embryos at the blastocyst stage, including the reduction of high order multiple gestations and the role of the blastocyst culture and transfer in facilitating successful single embryo transfer. Sections include gamete quality and pregnancy outcome, physiology of the embryo, blastocyst development in culture, blastocyst transfer and fate, and implantation. More than 40 illustrations and 25 tables complement the text.
Author : Shuetu Suzuki
Publisher : Ardent Media
ISBN 13 : 9780842270397
Total Pages : 200 pages
Book Rating : 4.2/5 (73 download)
Download or read book Preimplantation Mammalian Embryos in Vitro: Recent Studies written by Shuetu Suzuki and published by Ardent Media. This book was released on 1972 with total page 200 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : A. van Soom
Publisher : Springer Science & Business Media
ISBN 13 : 9401003432
Total Pages : 429 pages
Book Rating : 4.4/5 (1 download)
Download or read book Assessment of Mammalian Embryo Quality written by A. van Soom and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 429 pages. Available in PDF, EPUB and Kindle. Book excerpt: Thanks to enormous scientific efforts of the last decades, in vitro fertilization (IVF) and in vitro production (IVP) have now been introduced successfully in the practice of human infertility treatment and cattle breeding programs. This comprehensive book allows us to bridge the knowledge from both biomedical and veterinary fields of research. For the first time, studies concerning the human embryo as well as embryos from domestic species are brought together. The central theme of the book is "the assessment of mammalian embryo quality". In 15 chapters, written by well-known scientists, different aspects of the assessment of mammalian embryo quality are summarized. Non-invasive and invasive techniques to evaluate embryo quality are separated in two parts. In addition the book is provided with appendices on practical aspects and, thus, the book should be present in each laboratory for IVF and IVP.
Author : Barry D. Bavister
Publisher : Springer Science & Business Media
ISBN 13 : 1461393175
Total Pages : 359 pages
Book Rating : 4.4/5 (613 download)
Download or read book Preimplantation Embryo Development written by Barry D. Bavister and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 359 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume contains the Proceedings of the Serono Symposium on Pre implantation Embryo Development, held in Newton, Massachusetts, in 1991. The idea for the symposium grew out of the 1989 Serono Symposium on Fertilization in Mammals* at which preimplantation development was the predominant suggestion for a follow-up topic. This was indeed a timely subject in view of the recent resurgence of interest in this funda mental phase of embryogenesis and its relevance to basic research and applied fertility studies in humans, food-producing animals, and endangered species. The symposium brought together speakers from a broad range of disciplines in order to focus on key regulatory mechanisms in embryo development, using a wide variety of animal models, and on representative topics in human preimplantation embryogenesis. The culmination of preimplantation development is a blastocyst con taining the first differentiated embryonic tissues and capable of initiating and sustaining pregnancy. The central objective of the symposium was to throw light on the regulation of cellular and molecular events underlying blastocyst formation. It was particularly appropriate that the date of the symposium marked the 20th anniversary of the publication of the classic volume Biology of the Blastocyst, the proceedings of an international workshop held in 1970. This book, which summarized most of the information then available on this topic in mammals, was edited by the pioneer in blastocyst research, Dr. Richard B1andau, who was the guest speaker at the symposium.
Author :
Publisher : Academic Press
ISBN 13 : 0128016175
Total Pages : 512 pages
Book Rating : 4.1/5 (28 download)
Download or read book Mammalian Preimplantation Development written by and published by Academic Press. This book was released on 2016-07-26 with total page 512 pages. Available in PDF, EPUB and Kindle. Book excerpt: Mammalian Preimplantation Development, the latest volume in the Current Topics in Developmental Biology series covers mammalian preimplantation development, and includes contributions from an international board of authors. The book's chapters provide a comprehensive set of reviews covering such topics as cell proliferation, cell differentiation, and biological significance. Covers the area of mammalian preimplantation development Includes contributions from an International board of authors Provides a comprehensive set of reviews covering such topics as cell proliferation, cell differentiation, and biological significance
Author : Patrick Quinn
Publisher : Cambridge University Press
ISBN 13 : 1139917358
Total Pages : 307 pages
Book Rating : 4.1/5 (399 download)
Download or read book Culture Media, Solutions, and Systems in Human ART written by Patrick Quinn and published by Cambridge University Press. This book was released on 2014-03-27 with total page 307 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume describes culture media and solutions used in human ART; how they have been developed for in vitro human pre-implantation embryo development, the function and importance of the various components in media and solutions and how they interact, and how the systems in which these are used can influence outcomes. Chapters discuss inorganic solutes, energy substrates, amino acids, macromolecules, cytokines, growth factors, buffers, pH, osmolality, and the interaction of these parameters. The role of incubators and other physical factors are reviewed, along with the relevance and prospects of emerging technologies: morphokinetic analysis using time-lapse imaging and dynamic fluid incubation systems. Results of prospective randomized trials are emphasized to ascertain the added value of these techniques for selecting viable embryos. This comprehensive guide will be invaluable for embryologists, physicians and all personnel involved in the fluid products used in human ART seeking to optimize their successful use of these components.
Author : Fangtao Chi
Publisher :
ISBN 13 :
Total Pages : 183 pages
Book Rating : 4.:/5 (119 download)
Download or read book Metabolic Regulation of Preimplantation Mouse Embryo Development written by Fangtao Chi and published by . This book was released on 2020 with total page 183 pages. Available in PDF, EPUB and Kindle. Book excerpt: Preimplantation mammalian embryo is a critical stage in embryonic development, during which the totipotent zygote goes through zygotic genome activation (ZGA) at 2-cell stage, and then generates the first two cell lineages, trophectodem (TE), the inner cell mass (ICM) at the blastocyst stage. The nutritional requirements of the preimplantation embryo are minimal and are largely derived from the oviductal fluid in which it floats. An in vitro culture medium with only pyruvate, lactate, and glucose as nutrients, but lacking any amino acids, fats or proteins supports normal development through the 4.5 days of preimplantation stages. Extensive studies in the past have shown that lack of these metabolites during culture result in specific developmental phenotypes. Zygote cultured in the medium lacking pyruvate is viable but fails to develop beyond the 2-cell stage. Lack of glucose in the culture medium blocks preimplantation development at the morula stage. The mechanism by which specific nutrients control different developmental processes is still unclear. In this thesis, I interrogated the roles of pyruvate and glucose during mammalian embryogenesis. We found pyruvate mediated O-glycosylation and mitochondrial enzymes nuclear localization are critical steps in mammalian ZGA at 2-cell stage (Chapter 2), while glucose metabolism distinguishes TE from ICM fate at 8- to 16-cell stages (Chapter 3). In Chapter 2, we made the novel and surprising finding that a number of enzymatically active mitochondrial enzymes associated with the TCA cycle are transiently localized to the nucleus where they directly make the metabolites that are essential for ZGA and the associated global genome organization. We also found that pyruvate, O-glycosylation, and chaperones are essential for this nuclear localization. In Chapter 3, we found that at morula stage critical pathways of glucose catabolism are the pentose pathway (PPP) and the hexosamine biosynthetic pathway (HBP) and blocking these pathways recapitulate distinct aspects of the glucose phenotype. Analysis of the roles of the PPP and the HBP further showed that these pathways have non-over lapping roles in the regulation of specific transcription factors that are essential for the establishment of the TE fate.
Author : David K. Gardner
Publisher : CRC Press
ISBN 13 : 1498729479
Total Pages : 495 pages
Book Rating : 4.4/5 (987 download)
Download or read book Handbook of In Vitro Fertilization written by David K. Gardner and published by CRC Press. This book was released on 2017-06-26 with total page 495 pages. Available in PDF, EPUB and Kindle. Book excerpt: The new edition of this text admirably fills the need for a primer on the central topics involved in Human In Vitro Fertilization (IVF). Supplying a comprehensive and hands-on approach to IVF, this source presents established state-of-the-art procedures and techniques, as well as the most current research in the field. Expert contributors also discuss the history of IVF and the potential of future research. Offering essential information for reproductive endocrinologists, IVF practitioners and embryologists, this book guides readers though every step of human assisted conception, from patient pre-treatment to monitoring of outcomes.
Author : David K. Gardner
Publisher : Cambridge University Press
ISBN 13 : 1139501046
Total Pages : 363 pages
Book Rating : 4.1/5 (395 download)
Download or read book Human Assisted Reproductive Technology written by David K. Gardner and published by Cambridge University Press. This book was released on 2011-03-31 with total page 363 pages. Available in PDF, EPUB and Kindle. Book excerpt: Human Assisted Reproductive Technology: Future Trends in Laboratory and Clinical Practice offers a collection of concise, practical review articles on cutting-edge topics within reproductive medicine. Each article presents a balanced view of clinically relevant information and looks ahead to how practice will change over the next five years. The clinical section discusses advances in reproductive surgery and current use of robotic surgery for tubal reversal and removal of fibroids. It looks into the refinement of surgical procedures for fertility preservation purposes. Chapters also discuss non-invasive diagnosis of endometriosis with proteomics technology, new concepts in ovarian stimulation and in the management of polycystic ovary syndrome, and evidence-based ART. The embryology section discusses issues ranging from three-dimensional in-vitro ovarian follicle culture, and morphometric and proteomics analysis of embryos, to oocyte and embryo cyropreservation. This forward-looking volume of review articles is key reading for reproductive medicine physicians, gynecologists, reproductive endocrinologists, urologists and andrologists.
Author : Kevin Coward
Publisher : Cambridge University Press
ISBN 13 : 110727625X
Total Pages : 408 pages
Book Rating : 4.1/5 (72 download)
Download or read book Textbook of Clinical Embryology written by Kevin Coward and published by Cambridge University Press. This book was released on 2013-10-31 with total page 408 pages. Available in PDF, EPUB and Kindle. Book excerpt: The success of Assisted Reproductive Technology is critically dependent upon the use of well optimized protocols, based upon sound scientific reasoning, empirical observations and evidence of clinical efficacy. Recently, the treatment of infertility has experienced a revolution, with the routine adoption of increasingly specialized molecular biological techniques and advanced methods for the manipulation of gametes and embryos. This textbook – inspired by the postgraduate degree program at the University of Oxford – guides students through the multidisciplinary syllabus essential to ART laboratory practice, from basic culture techniques and micromanipulation to laboratory management and quality assurance, and from endocrinology to molecular biology and research methods. Written for all levels of IVF practitioners, reproductive biologists and technologists involved in human reproductive science, it can be used as a reference manual for all IVF labs and as a textbook by undergraduates, advanced students, scientists and professionals involved in gamete, embryo or stem cell biology.
Author : Shuetu Suzuki
Publisher :
ISBN 13 :
Total Pages : 204 pages
Book Rating : 4.:/5 (633 download)
Download or read book Preimplantation mammalian embryos in vitro written by Shuetu Suzuki and published by . This book was released on 1972 with total page 204 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Gabor Kovacs
Publisher : Cambridge University Press
ISBN 13 : 1108668461
Total Pages : 402 pages
Book Rating : 4.1/5 (86 download)
Download or read book How to Prepare the Egg and Embryo to Maximize IVF Success written by Gabor Kovacs and published by Cambridge University Press. This book was released on 2019-01-09 with total page 402 pages. Available in PDF, EPUB and Kindle. Book excerpt: This comprehensive review of the factors that affect the harvesting and preparation of oocytes and the management of embryos will allow practitioners to make evidence-based decisions for successful IVF. The book reviews and re-considers the value of strategies and outcomes in the management of fertility and conception rates, centred on the production of oocytes, and successful development of the embryo. Authored by leading experts in the field, chapters engage with treatments and strategies that affect the production of oocytes and embryos, optimizing outcomes in the management of female fertility, conception rates, and live births. This vital guide covers controlled ovarian hyperstimulation, the role of AMH in determining ovarian reserve, and primary stimulation agents and the use of adjuncts. Integral for all clinicians and embryologists working in reproductive medicine units, readers are provided with evidence-based, comprehensive advice and review of all factors affecting the management of oocytes and the embryo that are vital for successful IVF cycles.
Author : Gary D. Smith
Publisher : Humana Press
ISBN 13 : 9781493959204
Total Pages : 444 pages
Book Rating : 4.9/5 (592 download)
Download or read book Embryo Culture written by Gary D. Smith and published by Humana Press. This book was released on 2016-05-01 with total page 444 pages. Available in PDF, EPUB and Kindle. Book excerpt: This Methods in Molecular Biology book covers the complete range of contemporary methods for the study of human embryo culture. Includes lists of necessary materials and reagents, step-by-step laboratory protocols, and key tips on troubleshooting and pitfalls."
Author : Ralph L. Brinster
Publisher : Ardent Media
ISBN 13 : 9780842270380
Total Pages : 186 pages
Book Rating : 4.2/5 (73 download)
Download or read book Recent Studies on Preimplantation Mammalian Embryos In Vitro written by Ralph L. Brinster and published by Ardent Media. This book was released on 1972-07 with total page 186 pages. Available in PDF, EPUB and Kindle. Book excerpt:
