Structure Determination Of Hiv 1 Tat Fluid Phase Membranes And Dmpc Ripple Phase Using X Ray Scattering

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Structure Determination of HIV-1 Tat/Fluid Phase Membranes and DMPC Ripple Phase Using X-Ray Scattering

Author : Kiyotaka Akabori
Publisher : Springer
ISBN 13 : 3319222104
Total Pages : 186 pages
Book Rating : 4.3/5 (192 download)

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Book Synopsis Structure Determination of HIV-1 Tat/Fluid Phase Membranes and DMPC Ripple Phase Using X-Ray Scattering by : Kiyotaka Akabori

Download or read book Structure Determination of HIV-1 Tat/Fluid Phase Membranes and DMPC Ripple Phase Using X-Ray Scattering written by Kiyotaka Akabori and published by Springer. This book was released on 2015-10-20 with total page 186 pages. Available in PDF, EPUB and Kindle. Book excerpt: This Thesis in biological physics has two components, describing the use of X-ray scattering techniques to study the structure of two different stacked lipid membrane systems. The first part focuses on the interaction between a short 11-mer peptide, Tat, which is part of the Tat protein in the HIV-1 virus. Although highly positively charged, the Tat protein has been shown to translocate through hydrocarbon lipid bilayers easily, without requiring the cell’s energy, which is counter to its Born self-energy. In this work Tat’s location in the headgroup region was demonstrated using a combined X-ray scattering and molecular dynamics approach. Bilayer thinning was observed as well as softening of different membrane mimics due to Tat. It was concluded that Tat’s headgroup location, which increases the area/lipid, and its bilayer softening likely reduce the energy barrier for passive translocation. The second part is a rigorous investigation of an enigmatic phase in the phase diagram of the lipid dimyristoylphosphatidylcholine (DMPC). The ripple phase has fascinated many researchers in condensed matter physics and physical chemistry as an example of periodically modulated phases, with many theoretical and simulation papers published. Despite systematic studies over the past three decades, molecular details of the structure were still lacking. By obtaining the highest resolution X-ray data so far, this work revealed the complex nature of the chain packing, as well as confirming that the major side is thicker than the minor side of the saw-tooth ripple structure. The new model shows that the chains in the major arm are tilted with respect to the bilayer normal and that the chains in the minor arm are slightly more disordered than all-trans gel-phase chains, i.e., the chains in the minor arm are more fluid-like. This work provides the highest resolution X-ray structure of the ripple phase to-date.

Lipid Domains

Author :
Publisher : Academic Press
ISBN 13 : 0128033274
Total Pages : 393 pages
Book Rating : 4.1/5 (28 download)

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Book Synopsis Lipid Domains by :

Download or read book Lipid Domains written by and published by Academic Press. This book was released on 2015-06-08 with total page 393 pages. Available in PDF, EPUB and Kindle. Book excerpt: Current Topics in Membranes is targeted toward scientists and researchers in biochemistry and molecular and cellular biology, providing the necessary membrane research to assist them in discovering the current state of a particular field and in learning where that field is heading. This volume offers an up to date presentation of current knowledge in the field of Lipid Domains. Written by leading experts Contains original material, both textual and illustrative, that should become a very relevant reference material The material is presented in a very comprehensive manner Both researchers in the field and general readers should find relevant and up-to-date information

Nanomedicine and Drug Delivery

Author : Mathew Sebastian
Publisher : CRC Press
ISBN 13 : 1926895177
Total Pages : 322 pages
Book Rating : 4.9/5 (268 download)

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Book Synopsis Nanomedicine and Drug Delivery by : Mathew Sebastian

Download or read book Nanomedicine and Drug Delivery written by Mathew Sebastian and published by CRC Press. This book was released on 2012-07-23 with total page 322 pages. Available in PDF, EPUB and Kindle. Book excerpt: This forward-looking book focuses on the recent advances in nanomedicine and drug delivery. It outlines the extraordinary new tools that have become available in nanomedicine and presents an integrated set of perspectives that describe where we are now and where we should be headed to put nanomedicine devices into applications as quickly as possible, while also considering the possible dangers of nanomedicine. The book considers the full range of nanomedicinal applications that employ molecular nanotechnology inside the human body, from the perspective of a future practitioner in an era of widely available nanomedicine. Written by some of the most innnovative minds in medicine and engineering, this unique volume will help professionals understand cutting-edge and futuristic areas of research that can have tremendous payoff in terms of improving human health. Readers will find insightful discussions of nanostructured intelligent materials and devices that are considered technically feasible and which have a high potential to produce advances in medicine in the near future. Topics include: Health benefits of phytochemicals and the application of colloidal delivery systems Study of non-covalent attachment of recombinant targeting proteins to polymer-modified Adenoviral gene delivery vectors The role of nanoparticles as adjuvants for mucosal vaccine delivery Poly(amido-amine)s as delivery styems for biologically active substances Antimicrobial activity of silver nanoparticles Nanomedicine in the use of cancer treatment Dendrimers, capsules based on lipid vesicles for drug delivery Many other recent achievements

Lipid Bilayers

Author : J. Katsaras
Publisher : Springer Science & Business Media
ISBN 13 : 366204496X
Total Pages : 304 pages
Book Rating : 4.6/5 (62 download)

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Book Synopsis Lipid Bilayers by : J. Katsaras

Download or read book Lipid Bilayers written by J. Katsaras and published by Springer Science & Business Media. This book was released on 2013-06-29 with total page 304 pages. Available in PDF, EPUB and Kindle. Book excerpt: Provides the reader with an up to date insight of the current state of the art in the field of lipid bilayer research and the important insights derived for the understanding of the complex and varied behaviour of biological membranes and its function.

Drug-Membrane Interactions

Author : Joachim K. Seydel
Publisher : John Wiley & Sons
ISBN 13 : 3527616497
Total Pages : 367 pages
Book Rating : 4.5/5 (276 download)

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Book Synopsis Drug-Membrane Interactions by : Joachim K. Seydel

Download or read book Drug-Membrane Interactions written by Joachim K. Seydel and published by John Wiley & Sons. This book was released on 2009-07-10 with total page 367 pages. Available in PDF, EPUB and Kindle. Book excerpt: Barrier, reservoir, target site - those are but some of the possible functions of biological lipid membranes in the complex interplay of drugs with the organism. A detailed knowledge of lipid membranes and of the various modes of drug-membrane interaction is therefore the prerequisite for a better understanding of drug action. Many of today's pharmaceuticals are amphiphilic or catamphiphilic, enabling them to interact with biological membranes. Crucial membrane properties are surveyed and techniques to elucidate drug-membrane interactions presented, including computer-aided predictions. Effects of membrane interaction on drug action and drug distribution are discussed, and numerous examples are given. This unique reference volume builds on the authors' long experience in the study of drug-membrane interaction. Recommended reading for everyone involved in pharmaceutical research.

Phase Transitions in Complex Fluids

Author : Pierre Toldano
Publisher : World Scientific
ISBN 13 : 9789810232603
Total Pages : 476 pages
Book Rating : 4.2/5 (326 download)

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Book Synopsis Phase Transitions in Complex Fluids by : Pierre Toldano

Download or read book Phase Transitions in Complex Fluids written by Pierre Toldano and published by World Scientific. This book was released on 1998 with total page 476 pages. Available in PDF, EPUB and Kindle. Book excerpt: This important and timely book deals with the theoretical and experimental investigation of the phase transitions which occur in complex fluid systems, namely lyotropic systems, microemulsions, colloids, gels, polymers, biological membranes, Langmuir monolayers, and ferrofluids. It contains 20-odd review papers from the major contributors to this rapidly growing field of research, summarizing the main results obtained in the description and understanding of the phase transitions taking place between the isotopic, nematic, cholesteric, lamellar, hexagonal, and cubic mesophases of complex fluids.

Computational Pharmaceutics

Author : Defang Ouyang
Publisher : John Wiley & Sons
ISBN 13 : 1118573994
Total Pages : 350 pages
Book Rating : 4.1/5 (185 download)

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Book Synopsis Computational Pharmaceutics by : Defang Ouyang

Download or read book Computational Pharmaceutics written by Defang Ouyang and published by John Wiley & Sons. This book was released on 2015-07-20 with total page 350 pages. Available in PDF, EPUB and Kindle. Book excerpt: Molecular modeling techniques have been widely used in drug discovery fields for rational drug design and compound screening. Now these techniques are used to model or mimic the behavior of molecules, and help us study formulation at the molecular level. Computational pharmaceutics enables us to understand the mechanism of drug delivery, and to develop new drug delivery systems. The book discusses the modeling of different drug delivery systems, including cyclodextrins, solid dispersions, polymorphism prediction, dendrimer-based delivery systems, surfactant-based micelle, polymeric drug delivery systems, liposome, protein/peptide formulations, non-viral gene delivery systems, drug-protein binding, silica nanoparticles, carbon nanotube-based drug delivery systems, diamond nanoparticles and layered double hydroxides (LDHs) drug delivery systems. Although there are a number of existing books about rational drug design with molecular modeling techniques, these techniques still look mysterious and daunting for pharmaceutical scientists. This book fills the gap between pharmaceutics and molecular modeling, and presents a systematic and overall introduction to computational pharmaceutics. It covers all introductory, advanced and specialist levels. It provides a totally different perspective to pharmaceutical scientists, and will greatly facilitate the development of pharmaceutics. It also helps computational chemists to look for the important questions in the drug delivery field. This book is included in the Advances in Pharmaceutical Technology book series.

Methods in Membrane Lipids

Author : Alex M. Dopico
Publisher : Springer Science & Business Media
ISBN 13 : 1588296628
Total Pages : 1265 pages
Book Rating : 4.5/5 (882 download)

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Book Synopsis Methods in Membrane Lipids by : Alex M. Dopico

Download or read book Methods in Membrane Lipids written by Alex M. Dopico and published by Springer Science & Business Media. This book was released on 2007-08-30 with total page 1265 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book presents a compendium of methodologies for the study of membrane lipids, varying from traditional lab bench experimentation to computer simulation and theoretical models. The volume provides a comprehensive set of techniques for studying membrane lipids with a strong biophysical emphasis. It compares the various available techniques including the pros and cons as seen by the experts.

Networking for Nerds

Author : Alaina G. Levine
Publisher : John Wiley & Sons
ISBN 13 : 1118663551
Total Pages : 256 pages
Book Rating : 4.1/5 (186 download)

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Book Synopsis Networking for Nerds by : Alaina G. Levine

Download or read book Networking for Nerds written by Alaina G. Levine and published by John Wiley & Sons. This book was released on 2015-05-13 with total page 256 pages. Available in PDF, EPUB and Kindle. Book excerpt: Networking for Nerds provides a step-by-step guide to understanding how to access hidden professional opportunities through networking. With an emphasis on practical advice on how and why to network, you will learn how to formulate and execute a strategic networking plan that is dynamic, multidimensional, and leverages social media platforms and other networking channels. An invaluable resource for both established and early-career scientists and engineers (as well as networking neophytes!), Networking for Nerds offers concrete insight on crafting professional networks that are mutually beneficial and support the advancement of both your career goals and your scholarly ambitions. “Networking” does not mean going to one reception or speaking with a few people at one conference, and never contacting them again. Rather, “networking” involves a spectrum of activities that engages both parties, ensures everyone’s value is appropriately communicated, and allows for the exploration of a win-win collaboration of some kind. Written by award-winning entrepreneur and strategic career planning expert Alaina G. Levine, Networking for Nerds is an essential resource for anyone working in scientific and engineering fields looking to enhance their professional planning for a truly fulfilling, exciting, and stimulating career. professional planning for a truly fulfilling, exciting, and stimulating career.Networking for Nerds provides a step-by-step guide to understanding how to access hidden professionalopportunities through networking. With an emphasis on practical advice on how and why to network, youwill learn how to formulate and execute a strategic networking plan that is dynamic, multidimensional, andleverages social media platforms and other networking channels.An invaluable resource for both established and early-career scientists and engineers (as well as networkingneophytes!), Networking for Nerds offers concrete insight on crafting professional networks that aremutually beneficial and support the advancement of both your career goals and your scholarly ambitions.“Networking” does not mean going to one reception or speaking with a few people at one conference, andnever contacting them again. Rather, “networking” involves a spectrum of activities that engages bothparties, ensures everyone’s value is appropriately communicated, and allows for the exploration of a win-wincollaboration of some kind.Written by award-winning entrepreneur and strategic career planning expert Alaina G. Levine, Networking forNerds is an essential resource for anyone working in scientific and engineering fields looking to enhance theirprofessional planning for a truly fulfilling, exciting, and stimulating career.

An Introduction to Biological Membranes

Author : William Stillwell
Publisher : Newnes
ISBN 13 : 0080931286
Total Pages : 379 pages
Book Rating : 4.0/5 (89 download)

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Book Synopsis An Introduction to Biological Membranes by : William Stillwell

Download or read book An Introduction to Biological Membranes written by William Stillwell and published by Newnes. This book was released on 2013-04-20 with total page 379 pages. Available in PDF, EPUB and Kindle. Book excerpt: An Introduction to Biological Membranes: From Bilayers to Rafts covers many aspects of membrane structure/function that bridges membrane biophysics and cell biology. Offering cohesive, foundational information, this publication is valuable for advanced undergraduate students, graduate students and membranologists who seek a broad overview of membrane science. Brings together different facets of membrane research in a universally understandable manner Emphasis on the historical development of the field Topics include membrane sugars, membrane models, membrane isolation methods, and membrane transport

Handbook of Models for Human Aging

Author : P. Michael Conn
Publisher : Elsevier
ISBN 13 : 0080460062
Total Pages : 1103 pages
Book Rating : 4.0/5 (84 download)

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Book Synopsis Handbook of Models for Human Aging by : P. Michael Conn

Download or read book Handbook of Models for Human Aging written by P. Michael Conn and published by Elsevier. This book was released on 2011-04-28 with total page 1103 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Handbook of Models for Human Aging is designed as the only comprehensive work available that covers the diversity of aging models currently available. For each animal model, it presents key aspects of biology, nutrition, factors affecting life span, methods of age determination, use in research, and disadvantages/advantes of use. Chapters on comparative models take a broad sweep of age-related diseases, from Alzheimer's to joint disease, cataracts, cancer, and obesity. In addition, there is an historical overview and discussion of model availability, key methods, and ethical issues. Utilizes a multidisciplinary approach Shows tricks and approaches not available in primary publications First volume of its kind to combine both methods of study for human aging and animal models Over 200 illustrations

Molecular Machines

Author : Benoît Roux
Publisher : World Scientific
ISBN 13 : 9814343463
Total Pages : 288 pages
Book Rating : 4.8/5 (143 download)

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Book Synopsis Molecular Machines by : Benoît Roux

Download or read book Molecular Machines written by Benoît Roux and published by World Scientific. This book was released on 2011 with total page 288 pages. Available in PDF, EPUB and Kindle. Book excerpt: Ch. 1. Molecular behavior in biological cells : the bacterial cytoplasm as a model system / Adrian H. Elcock and Andrew S. Thomas -- ch. 2. The light-harvesting apparatus in purple photosynthetic bacteria : introduction to a quantum biological device / Johan Strumpfer [und weitere] -- ch. 3. DNA polymerases : structure, function, and modeling / Tamar Schlick -- ch. 4. Information processing by nanomachines : decoding by the ribosome / Karissa Y. Sanbonmatsu, Scott C. Blanchard and Paul C. Whitford -- ch. 5. Chaperonins : the machines which fold proteins / Del Lucent, Martin C Stumpe and Vijay S Pande -- ch. 6. Muscle and myosin / Ronald S. Rock -- ch. 7. Protein kinases : phosphorylation machines / Elaine E. Thompson, Susan S. Taylor and J. Andrew McCammon -- ch. 8. Computational studies of Na+/H+ antiporter : structure, dynamics and function / Assaf Ganoth, Raphael Alhadeff and Isaiah T. Arkin -- ch. 9. Membrane transporters : molecular machines coupling cellular energy to vectorial transport across the membrane / Zhijian Huang [und weitere] -- ch. 10. ABC transporters / E.P. Coll and D.P. Tieleman -- ch. 11. Sodium-coupled secondary transporters : insights from structure-based computations / Elia Zomot [und weitere] -- ch. 12. Voltage-gated ion channels : the machines responsible for the nerve impulse / Benoit Roux and Francisco Bezanilla -- ch. 13. Voltage-gated channels and the heart / Jonathan R. Silva and Yoram Rudy

Methods of Biochemical Analysis, Volume 34

Author : Clarence H. Suelter
Publisher : John Wiley & Sons
ISBN 13 : 9780471613039
Total Pages : 0 pages
Book Rating : 4.6/5 (13 download)

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Book Synopsis Methods of Biochemical Analysis, Volume 34 by : Clarence H. Suelter

Download or read book Methods of Biochemical Analysis, Volume 34 written by Clarence H. Suelter and published by John Wiley & Sons. This book was released on 1990-03-06 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Biomedical Applications of Mass Spectrometry Edited by Clarence H. Suelter and J. Throck Watson This unusual text is not simply a compilation of mass spectrometric methods but provides, instead, insight into specific approaches mass spectroscopists use when applying the technique to a variety of biological problems. Each chapter provides guidance in using the appropriate methods for isolating and purifying the compound class prior to mass spectrometric analysis. Covered in-depth are the mass spectrometry of carbohydrates, peptide sequencing by mass spectrometry, mass spectrometry of nucleic acid components, and mass spectrometry in pharmacology. This definitive look at a growing facet of the science is an essential reference for biochemists, biological chemists, bioanalytical chemists, and students. 1990 (0-471-61303-7) 396 pp.

Oral Delivery of Insulin

Author : T.A. Sonia
Publisher : Elsevier
ISBN 13 : 1908818689
Total Pages : 361 pages
Book Rating : 4.9/5 (88 download)

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Book Synopsis Oral Delivery of Insulin by : T.A. Sonia

Download or read book Oral Delivery of Insulin written by T.A. Sonia and published by Elsevier. This book was released on 2014-12-11 with total page 361 pages. Available in PDF, EPUB and Kindle. Book excerpt: Diabetes Mellitus, a syndrome of disordered metabolism, characterised by abnormal elevation in blood glucose level, has become a life-threatening condition for many people. Current means of therapy for Diabetes Mellitus do not mimic the normal physiological pattern of insulin release. Oral delivery is the preferred route of administration due to its non-invasive nature. Oral delivery of insulin presents an overview of Diabetes Mellitus, and discusses the strategies and techniques adopted for oral delivery of insulin. This title begins with an introductory chapter on symptoms, complications and therapy for Diabetes Mellitus. Subsequent chapters cover the various routes for administering insulin; the challenges and strategies of oral delivery; experimental techniques in the development of an oral insulin carrier; lipids; inorganic nanoparticles and polymers in oral insulin delivery; and a summary and presentation of future perspectives on oral delivery of insulin. Presents an overview of Diabetes Mellitus Includes a discussion of various strategies and techniques adopted for oral delivery of insulin Presents an update of research in the field

An Introduction to Biological Membranes

Author : William Stillwell
Publisher : Elsevier
ISBN 13 : 0444637907
Total Pages : 592 pages
Book Rating : 4.4/5 (446 download)

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Book Synopsis An Introduction to Biological Membranes by : William Stillwell

Download or read book An Introduction to Biological Membranes written by William Stillwell and published by Elsevier. This book was released on 2016-06-30 with total page 592 pages. Available in PDF, EPUB and Kindle. Book excerpt: Introduction to Biological Membranes: Composition, Structure and Function, Second Edition is a greatly expanded revision of the first edition that integrates many aspects of complex biological membrane functions with their composition and structure. A single membrane is composed of hundreds of proteins and thousands of lipids, all in constant flux. Every aspect of membrane structural studies involves parameters that are very small and fast. Both size and time ranges are so vast that multiple instrumentations must be employed, often simultaneously. As a result, a variety of highly specialized and esoteric biochemical and biophysical methodologies are often utilized. This book addresses the salient features of membranes at the molecular level, offering cohesive, foundational information for advanced undergraduate students, graduate students, biochemists, and membranologists who seek a broad overview of membrane science. Significantly expanded coverage on function, composition, and structure Brings together complex aspects of membrane research in a universally understandable manner Features profiles of membrane pioneers detailing how contemporary studies originated Includes a timeline of important discoveries related to membrane science

Coffee in Health and Disease Prevention

Author : Victor R Preedy
Publisher : Academic Press
ISBN 13 : 0124167160
Total Pages : 1080 pages
Book Rating : 4.1/5 (241 download)

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Book Synopsis Coffee in Health and Disease Prevention by : Victor R Preedy

Download or read book Coffee in Health and Disease Prevention written by Victor R Preedy and published by Academic Press. This book was released on 2014-11-12 with total page 1080 pages. Available in PDF, EPUB and Kindle. Book excerpt: Coffee in Health and Disease Prevention presents a comprehensive look at the compounds in coffee, their reported benefits (or toxicity risks) and also explores them on a health-condition specific level, providing researchers and academics with a single-volume resource to help in identifying potential treatment uses. No other book on the market considers all the varieties of coffee in one volume, or takes the disease-focused approach that will assist in directing further research and studies. The book embraces a holistic approach and effectively investigates coffee and its specific compounds from the biochemical to the nutritional well-being of geographical populations. This book represents essential reading for researchers in nutrition, dietetics, food science, biochemistry, and public health. Presents one comprehensive, translational source for all aspects of how coffee plays a role in disease prevention and health Experts in nutrition, diet, and food chemistry (from all areas of academic and medical research) take readers from the bench research (cellular and biochemical mechanisms of vitamins and nutrients) to new preventive and therapeutic approaches Focuses on coffee composition; nutritional aspects of coffee; protective aspects of coffee-related compounds; specific coffee components and their effects on tissue and organ systems Features sections on both the general effects of coffee consumption on the body as well as the effects of specific coffee compounds on specific organ systems

Nanomedicine Manufacturing and Applications

Author : Francis Verpoort
Publisher : Elsevier
ISBN 13 : 0128209429
Total Pages : 408 pages
Book Rating : 4.1/5 (282 download)

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Book Synopsis Nanomedicine Manufacturing and Applications by : Francis Verpoort

Download or read book Nanomedicine Manufacturing and Applications written by Francis Verpoort and published by Elsevier. This book was released on 2021-06-22 with total page 408 pages. Available in PDF, EPUB and Kindle. Book excerpt: Nanomedicine explores the modification and enhancement of the properties and performances of typical drugs to treat various diseases. Nano-based medicines have advantages in several ways, such as in nanotherapeutics, nanotheranostics, and nanodiagnostics. Nanomedicine Manufacturing and Applications effectively explores the major manufacturing techniques and applications of nanomaterial-based medicine in the areas of chemotherapy, biochips, insulin pumps, and other treatment methods. This book explains how nanomedicines are developed from nanoparticles as well as their biomedical and other applications related to healthcare. This book is an important reference source for nanoscientists, biomaterials scientists, and biomedical engineers who want to learn more about how nano-based medicines are made and used. Outlines the process of making nanomedicine as well as nanodrug carriers, with a focus on nanomedicine for cancer treatment. Explains the formulation and manufacturing process of nanomedicines, showing how to build these materials. Demonstrates how nano-based medicines are being used to tackle a range of diseases in a way that conventional medicines cannot.