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Steroid Hormones And Cell Cycle Regulation
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Book Synopsis Steroid Hormones and Cell Cycle Regulation by : Kerry L. Burnstein
Download or read book Steroid Hormones and Cell Cycle Regulation written by Kerry L. Burnstein and published by Springer Science & Business Media. This book was released on 2013-11-11 with total page 264 pages. Available in PDF, EPUB and Kindle. Book excerpt: From the tissue culture dish to genetically modified mice, this volume explores the long recognized role of steroid hormones in regulating cell proliferation and differentiation. Many striking effects of steroid hormones are apparent during development and neoplasia and these topics are covered extensively. Several chapters address the pharmacological uses of steroid and related hormones, their analogs and antagonists in controlling growth of endocrine cancers. This book also highlights the complex role of cross talk between steroid hormones and signals initiated at the cell surface in the regulation of cell cycle in hormone responsive tissues.
Book Synopsis Steroid Hormones and Cell Cycle Regulation by : Kerry L. Burnstein
Download or read book Steroid Hormones and Cell Cycle Regulation written by Kerry L. Burnstein and published by . This book was released on 2014-01-15 with total page 280 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Organ-Selective Actions of Steroid Hormones by : D.T. Baird
Download or read book Organ-Selective Actions of Steroid Hormones written by D.T. Baird and published by Springer Science & Business Media. This book was released on 2013-03-09 with total page 195 pages. Available in PDF, EPUB and Kindle. Book excerpt: Steroids regulate differentiation, growth and functioning of many tissues via a nuclear receptor gene activation mechanism. Molecular biology has opened the way for more detailed investigation of the complex set of intracellular interactions contributing to organ-selective actions of steroids and steroid-like compounds such as vitamin D. In this volume leading experts address basic molecular mechanisms of tissue specificity and related issue, with the goal of attaining a better understanding of the underlying mechanisms of organ selective actions of steroids. Discussed is the extent to which tissue specificity might selectively be modified by chemical modification of the hormones and how this may be applied towards improved therapies by taking advantage of tissue selectivity.
Book Synopsis Hormones and Cancer by : Wayne V. Vedeckis
Download or read book Hormones and Cancer written by Wayne V. Vedeckis and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 618 pages. Available in PDF, EPUB and Kindle. Book excerpt: The series, Hormones in Health and Disease, was launched in 1993 to provide a scientific platform for investigators engaged in research on the biological actions of hormones and to anticipate relevance for their findings in clinical applications. The first volume of the series was dedicated to the discussion and understanding of molecular mechanisms by which steroid hormones influence target cells in normal and pathological conditions. With the diversity of information and the vast amount of literature on steroid hormone physiology, a more thorough treatment of Hormones and Cancer was identified as a timely topic. In this second volume in the series, Dr. Wayne V. Vedeckis has success fully undertaken the monumental task of editing the findings of the leading investigators in hormone and cancer research. Dr. Vedeckis brings to this project two decades of research experience in hormone action; he is actively engaged in elucidating hormone and cancer interrelations. It is a pleasure to welcome him to the series as an editor and congratulate him and all contribu tors in presenting this comprehensive treatise. The 20 chapters include discussions on contemporary topics relating control of cell division and signal transduction to the basic mechanisms of carcinogenesis by cloning patient genes, and recognizing the importance of steroid receptors in treatment protocols of various endocrine abnormalities.
Book Synopsis Hormonal Control of Cell Cycle by : Shlomo Melmed
Download or read book Hormonal Control of Cell Cycle written by Shlomo Melmed and published by Springer Science & Business Media. This book was released on 2007-11-04 with total page 145 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book covers topics that range from fundamental studies of DNA replication, chromosomal and nuclear function through growth factor control of endocrine tumor initiation and progression. The basic and translational insights gained from Hormonal Control of Cell Cycle will be of interest to those studying the biology of endocrine tumors as well as those deriving novel therapeutic approaches for these benign and malignant disorders.
Book Synopsis Gene Regulation by Steroid Hormones IV by : Arun K. Roy
Download or read book Gene Regulation by Steroid Hormones IV written by Arun K. Roy and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 247 pages. Available in PDF, EPUB and Kindle. Book excerpt: The first Meadowbrook Symposium was held in 1978 and during the intervening ten years our knowledge concerning how steroid hormones function at the level of gene expression has advanced by leaps and bounds. In this volume, which sum marizes our fourth meeting, these advances are very evident. What seemed like science fiction ten years ago has become commonplace science. Who would have imagined that we could synthesize a nucleotide sequence that binds a specific steroid receptor and acts as a controlling element for gene expression? No one; but as is evident from the results reported in several chapters, this technique is yielding a wealth of information. Using these and other techniques it has become apparent that gene transcription is controlled by interactions between transacting factors and DNA recognition sequences (response elements). These transacting factors appear to be members of a large gene family that includes steroid hormone receptors, transcription factors, protooncogenes and homeobox proteins. Thus a great deal has been learned, but as usual, questions remain. Many of these questions are posed by the findings and observations found in several chapters in this volume. Non hormone binding forms of steroid receptors and their relevance to receptor down regulation, recycling and biological response remain a mystery. The quantitative relationship between receptor binding and biological response still presents agonizing problems. These and many other intriguing questions are discussed in this volume and set the stage for what should be a most rewarding time in endocrinology. Winter 1989 ARUN K.
Book Synopsis Gene Regulation by Steroid Hormones III by : Arun K. Roy
Download or read book Gene Regulation by Steroid Hormones III written by Arun K. Roy and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 312 pages. Available in PDF, EPUB and Kindle. Book excerpt: The field of steroid hormone action has continued to expand into the realm of molecular biology at a pace even faster than most of us ever imagined. techniques of molecular biology have made it possible to clone The hormone-regulated genes and to examine steroid-receptor interactions with these genes. Nucleotide sequences of these genes, which show preferential binding of steroid receptors, have been identified. These results are complemented by the identification of chromatin acceptor proteins, which also show preferential binding for steroid-receptor complexes. Thus, one can envision the day when cloned genes, purified acceptor proteins, and receptor-steroid complexes will be recombined in vitro to form a functional unit. Cellular localization of steroid receptors has undergone recent revision, and it now appears that receptors are localized primarily in the nuclear compartment. These findings, although controversial, will lead to a reassessment of many of the previous concepts of steroid-receptor interactions and regulation. The way in which these observations at the of physiology, molecular and cellular levels fit into the overall scheme development, and evolution are continuing to progress, and the future promises some very exciting syntheses of understanding at all levels of biological organization. The third Meadow Brook Conference on hormones was held in order to bring together investigators who will undoubtedly contribute heavily to this future synthesis and to permit a free exchange of ideas and concepts as they relate to the current state-of-the-art in molecular endocrinology. Spring 1986 ARUN K. Roy JAMES H. CLARK Contents Preface. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . v Contributors . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
Book Synopsis Aspects of Cell Regulation by : G. H. Bourne
Download or read book Aspects of Cell Regulation written by G. H. Bourne and published by Elsevier. This book was released on 2013-11-06 with total page 298 pages. Available in PDF, EPUB and Kindle. Book excerpt: Aspects of Cell Regulation deals with the various aspects of cellular control mechanisms. The book begins with a discussion of the role of hormones in the control of cell differentiation and biochemical control over the life of an organism. This is followed by separate chapters on an intracellular control problem, namely, the proper reproduction of cellular organelles and their apportionment between daughter cells at cell mitosis; cell mutants with different temporal order for macromolecular synthesis; and the control of a plant enzyme that converts triglycerides into carbohydrate during the early stages of postgerminative growth within seed cotyledon. Subsequent chapters deal with the possible role of mitochondria in changing the control mechanism of cells to that associated with carcinogenesis; the possibility of transforming genes being detectable in the genome after the transformation to neoplastic cell; the correlation between viruses and tumor cells; and whether viruses can originate from cells rather than coming before cells.
Book Synopsis Cell Cycle Regulation of Estrogen and Androgen Receptor by :
Download or read book Cell Cycle Regulation of Estrogen and Androgen Receptor written by and published by . This book was released on 2000 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: We seek to identify the phases in the cell cycle during which steroid-activated estrogen and androgen receptors are normally transcriptionally active and to determine whether this cell cycle regulation of receptor activity is maintained when cancer-inducing non- steroidal agents activate the receptors. Our hypothesis is that the activities of steroid-induced ER and AR are controlled by cell cycle regulators and that cancer-inducing, non-steroidal activators bypass or alter this regulation of receptor activity giving rise to aberrant ER and AR function. Through these studies we are gaining understanding of how estrogen and androgen receptors may contribute to the onset of tumors and to the development of hormone independent growth. We have found that the activity of the androgen and estrogen receptors is indeed regulated throughout the cell cycle with no activity of the androgen receptor in the G2/Phase phase and low activity of the estrogen receptor in cells which are mainly in S phase. Furthermore, our data indicate that non-steroidal activators of the receptors may act in a cell type and promoter dependent manner as we do not detect receptor activation by growth factors in our system.
Book Synopsis Gene Regulation by Steroid Hormones II by : A.K. Roy
Download or read book Gene Regulation by Steroid Hormones II written by A.K. Roy and published by Springer. This book was released on 1983-07-22 with total page 376 pages. Available in PDF, EPUB and Kindle. Book excerpt: Receptors and Gene Expression It is now more than three years since the last Meadow Brook Conference on Hormones, and a great deal has happened in the meantime. We have become comfortable with the totally unanticipated fact that the coding sequences of genes are in discontinuous arrangements and that the RNA transcribed from them must be extensively processed to form messenger RNA. We have also learned about the strategy of "mixing and matching" of genetic segments so that a small amount of DNA can go a long way in producing a huge variety of different proteins, as in the immunoglobulin system. The explosive effort directed toward DNA sequence analysis has led us to the conclusion that there are signals within the DNA that specify sites of transcription initiation and possibly sites for interacting with regulatory molecules such as hor mones and their receptors. The current intense interest in the structure of chromatin beyond the nucleosome-that is, the superstructural characteris tics of the genetic material-is finally yielding meaningful results that give promise for understanding the regulation of gene activity. ROBERT F. GOLDBERGER Preface Research on the molecular mechanism of steroid hormone action continues at an extraordinary pace and a great deal of progress has been made. Steroid hormones have been localized on target genes providing the long awaited evidence for the concept of a direct effect of the steroid-receptor complex on gene regulation. Purified steroid receptors have been dissected to identify different functional domains.
Book Synopsis Cell Cycle Dependent Regulation of Human Progesterone Receptor in Breast Cancer by :
Download or read book Cell Cycle Dependent Regulation of Human Progesterone Receptor in Breast Cancer written by and published by . This book was released on 2004 with total page 69 pages. Available in PDF, EPUB and Kindle. Book excerpt: Steroid hormones are required for normal breast development and play a key role in breast cancer. The steroid hormone progesterone regulates cell growth in the normal mammary gland and uterus by cell cycle phase-specific actions. Breast cancers are often characterized by increased growth factor signaling pathways and numerous cell cycle alterations, including decreased levels of p27 and increased levels of cyclins D1, D2 and E. Progestins, via the activation of progesterone receptor (PR), activate cyclin dependent kinase 2 (CDK2) and raise levels of cyclins D and E> PR are phosphorylated by CDK2 in vitro and in vivo at multiple sites including serine 400 (Ser400). In addition, breast cancer cell growth is controlled, in part by, cross-talk between steroid hormone and growth factor signaling pathways. The purpose of these studies is to investigate the role that growth factors and cell cycle molecules play on the regulation of PR by phosphorylation of Ser400.
Book Synopsis Non-Reproductive Actions of Sex Steroids by : Gregory R. Bock
Download or read book Non-Reproductive Actions of Sex Steroids written by Gregory R. Bock and published by John Wiley & Sons. This book was released on 2008-04-30 with total page 284 pages. Available in PDF, EPUB and Kindle. Book excerpt: Prominent clinicians and researchers from diverse disciplines discuss the basic cell and molecular biology of steroid action and sex steroids' effects on the nervous and immune systems. Provides an integrated evaluation of the advantages and disadvantages of hormone replacement therapy.
Download or read book Steroids written by Hassan Abduljabbar and published by BoD – Books on Demand. This book was released on 2012-01-11 with total page 248 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book explains the basic science of steroids and is targeted towards professionals engaged in health services. It should be noted that medical science evolves rapidly and some information like the understanding of steroids and their therapeutic use may change with new concepts quickly. Steroids are either naturally occurring or synthetic fat-soluble organic compounds. They are found in plants, animals, and fungi. They mediate a very diverse set of biological responses. The most widespread steroid in the body is cholesterol, an essential component of cell membranes, and the starting point for the synthesis of other steroids. Since the science of steroids has an enormous scope, we decided to put the clinical aspects of steroids in a different book titled "Steroids-Clinical Aspects". The two books complete each other. We hope that the reader will gain valuable information from both books and enrich their knowledge about this fascinating topic.
Download or read book Vitamins and Hormones written by and published by Academic Press. This book was released on 1995-11-22 with total page 481 pages. Available in PDF, EPUB and Kindle. Book excerpt: General Description of Volume:Volume 51 includes reviews papers on cyclic AMP, kinases, polypeptide hormones, steroid hormone receptors, related genes, and members of the gene family. General Description of Series:Under the capable and qualified editorial leadership of Dr. Gerald Litwack, Vitamins and Hormones continues to publish up-to-date synthetic reviews of interest to endocrinologists and biochemists. Others interested in the structure and function of biologically active molecules like hormones and vitamins will, as always, turn to this series for comprehensive reviews by leading contributors to this and related disciplines.First published in 1943, Vitamins and Hormones is the longest-running serial published by Academic Press. In the early days of the serial, the subjects of vitamins and hormones were quite distinct. Now, new discoveries have proved that several of the vitamins function as hormones and many of the substances inferred by the title of the Serial function in signal transduction processes. Accordingly, the editor-in-chief has expanded the scope of the serial to reflect this newer understanding of function-structure relationships in cellular communication. The newly modified editorial board now reflects expertise in the field of hormone action, vitamin action, X-ray crystal structure, physiology and enzyme mechanisms. Vitamins and Hormones continues to publish up-to-date synthetic reviews of interest to endocrinologists and biochemists. Others will increasingly turn to this series for comprehensive reviews by leading researchers in this and related disciplines.
Book Synopsis Diagnosis and Management of Ovarian Disorders by : Albert Altchek
Download or read book Diagnosis and Management of Ovarian Disorders written by Albert Altchek and published by Elsevier. This book was released on 2003-09-04 with total page 595 pages. Available in PDF, EPUB and Kindle. Book excerpt: This updated second edition of Diagnosis and Management of Ovarian Disorders provides thorough, yet succinct insight into the ever-changing realm of ovarian disorders. It presents a novel multidisciplinary approach to the subject as described by clinicians, surgeons, pathologists, basic scientists and related medical researchers. Topics covered include reproductive technology, early diagnosis of ovarian cancer, and management of menopause among others. The breadth of information provided by this book will appeal to clinicians and researchers involved in the study and treatment of ovarian disorders. KEY FEATURES* Includes updated information on early diagnosis of ovarian cancer* Reviews new diagnostic techniques for ovarian disorders* Discusses latest information on reproductive technology* Presents translational treatment linking laboratory research with clinical medicine
Book Synopsis Hormone Signaling by : Vincent Goffin
Download or read book Hormone Signaling written by Vincent Goffin and published by Springer Science & Business Media. This book was released on 2002-03-31 with total page 340 pages. Available in PDF, EPUB and Kindle. Book excerpt: Multicellular organisms require a means of intracellular communication to organize and develop the complex body plan that occurs during embryogenesis and then for cell and organ systems to access and respond to an ever changing environmental milieu. Mediators of this constant exchange of information are growth factors, neurotransmmitters, peptide and protein hormones which bind to cell surface receptors and transduce their signals from the extracellular space to the intracellular compartment. Via multiple signaling pathways, receptors of this general class affect growth, development and differentiation. Smaller hydrophobic signaling molecules, such as steroids and non-steroid hormones, vitamins and metabolic mediators interact with a large family of nuclear receptors. These receptors function as transcription factors affecting gene expression, to regulate the multiple aspects of animal and human physiology, including development, reproduction and homeostasis. The aim of this book is to cover various aspects of intracellular signaling involving hormone receptors.
Book Synopsis The Effects of Steroid Hormones on Urothelial Cell Proliferation by : Jian Teng
Download or read book The Effects of Steroid Hormones on Urothelial Cell Proliferation written by Jian Teng and published by . This book was released on 2007 with total page 196 pages. Available in PDF, EPUB and Kindle. Book excerpt:
