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Stereoselective Syntheses Of Non Natural Amino Acids And Peptidomimetics And Their Application As Reverse Turn Inducers
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Book Synopsis Stereoselective Syntheses of Non Natural Amino Acids and Peptidomimetics and Their Application as Reverse Turn Inducers by : Maria Salvati
Download or read book Stereoselective Syntheses of Non Natural Amino Acids and Peptidomimetics and Their Application as Reverse Turn Inducers written by Maria Salvati and published by . This book was released on 2006 with total page 120 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Asymmetric Synthesis of Non-Proteinogenic Amino Acids by : Ashot S. Saghyan
Download or read book Asymmetric Synthesis of Non-Proteinogenic Amino Acids written by Ashot S. Saghyan and published by John Wiley & Sons. This book was released on 2016-11-14 with total page 376 pages. Available in PDF, EPUB and Kindle. Book excerpt: Authored by two internationally recognized experts with an excellent track record, this much-needed reference summarizes latest research in the rapidly developing field of stereoselective synthesis of enantiomerically enriched amino acids, particularly of non-proteinogenic origin. It highlights several different catalytic and stoichiometric asymmetric methods for their synthesis and also provides information on origin, biological properties, different synthetic strategies and important applications in medicine and pharmacology. Essential reading for synthetic chemists working in the field of asymmetric synthesis, natural products and peptide synthesis, stereochemistry, medicinal chemistry, biochemistry, pharmacology, and biotechnology.
Book Synopsis Stereospecific Synthesis of Biologically Important Non-natural Amino Acids by : Konstantinos Papadopoulos
Download or read book Stereospecific Synthesis of Biologically Important Non-natural Amino Acids written by Konstantinos Papadopoulos and published by . This book was released on 2001 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Amino Acids, Peptides and Proteins by : J S Davies
Download or read book Amino Acids, Peptides and Proteins written by J S Davies and published by Royal Society of Chemistry. This book was released on 2007-10-31 with total page 347 pages. Available in PDF, EPUB and Kindle. Book excerpt: In an ever-increasing domain of activity, Amino Acids, Peptides and Proteins provides an annual compilation of the world's research effort into this important area of biological chemistry. Comprising a comprehensive review of significant developments at this biology/chemistry interface, each volume opens with an overview of amino acids and their applications. Work on peptides is reviewed over several chapters, ranging from current trends in their synthesis and conformational and structural analysis, to peptidomimetics and the discovery of peptide-related molecules in nature. The application of advanced techniques in structural elucidation is incorporated into all chapters, whilst periodic chapters on metal complexes of amino acids, peptides and beta-lactams extend the scope of coverage. Efficient searching of specialist topics is facilitated by the sub-division of chapters into discrete subject areas, allowing annual trends to be monitored. All researchers in the pharmaceutical and allied industries, and at the biology/chemistry interface in academia will find this an indispensable reference source. Volume 36 covers literature published during 2003.
Book Synopsis Stereoselective Synthesis by : Eckhard Ottow
Download or read book Stereoselective Synthesis written by Eckhard Ottow and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 147 pages. Available in PDF, EPUB and Kindle. Book excerpt: Devising methods and reagents for stereoselective synthesis is an intellectually demanding venture. Six experts on diastereo- and enantioselective synthesis contributed their papers to this volume. They were presented at a symposium on stereoselective synthesis to honour Professor Dr. Dr. h.c. Rudolf Wiechert's achievements in medicinal chemistry research. The symposium was organized by the Schering AG on the occasion of Professor Wiechert's 65th birthday.
Book Synopsis New Methodology for the Stereoselective Synthesis of Unnatural Alpha-amino Acids by : Lorna J. Drummond
Download or read book New Methodology for the Stereoselective Synthesis of Unnatural Alpha-amino Acids written by Lorna J. Drummond and published by . This book was released on 2011 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: New general methodology for the stereoselective synthesis of unnatural alpha-amino acids has been developed. Early work focussed on investigating methods for the generation of chiral allylic alcohols using cross-metathesis of a simple enone with various terminal alkenes, followed by an asymmetric ketone reduction. The allylic alcohols were then converted to protected allylic amines via Overman rearrangement chemistry. Oxidative alkene cleavage and hydrolysis of these intermediates generated a range of alpha-amino acid targets. Attempts were also made to apply the developed methodology to the synthesis of a simple alpha,alpha-disubstituted alpha-amino acid target. The Overman rearrangement was also applied to the generation of a late-stage intermediate which could be used in the synthesis of (2S,3S)-capreomycidine, a component of a number of peptides which exhibit antibacterial activity.
Book Synopsis Peptidomimetics Containing the Non-natural Amino Acid ACCA by : Anita Wester
Download or read book Peptidomimetics Containing the Non-natural Amino Acid ACCA written by Anita Wester and published by . This book was released on 2016 with total page 245 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Amino Acids, Peptides and Proteins by : Royal Society of Chemistry (Great Britain)
Download or read book Amino Acids, Peptides and Proteins written by Royal Society of Chemistry (Great Britain) and published by . This book was released on 2007 with total page 354 pages. Available in PDF, EPUB and Kindle. Book excerpt: In an ever-increasing domain of activity, Amino Acids, Peptides and Proteins provides an annual compilation of the world's research effort into this important area of biological chemistry. Comprising a comprehensive review of significant developments at this biology/chemistry interface, each volume opens with an overview of amino acids and their applications. Work on peptides is reviewed over several chapters, ranging from current trends in their synthesis and conformational and structural analysis, to peptidomimetics and the discovery of peptide-related molecules in nature. The application of advanced techniques in structural elucidation is incorporated into all chapters, whilst periodic chapters on metal complexes of amino acids, peptides and beta-lactams extend the scope of coverage. Efficient searching of specialist topics is facilitated by the sub-division of chapters into discrete subject areas, allowing annual trends to be monitored. All researchers in the pharmaceutical and allied industries, and at the biology/chemistry interface in academia will find this an indispensable reference source. Volume 36 covers literature published during 2003.
Book Synopsis Stereoselective Syntheses of Certain Natural Products and Their Analogues from Chiral-pool and Enzymatically-derived Building Blocks by : Joshua Neil Victor Timshell Buckler
Download or read book Stereoselective Syntheses of Certain Natural Products and Their Analogues from Chiral-pool and Enzymatically-derived Building Blocks written by Joshua Neil Victor Timshell Buckler and published by . This book was released on 2018 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: This thesis is comprised of six scientific articles and is preceded by an overview that contextualises all of this published/submitted work. The first section of this thesis is comprised of Publications 1-3 and is concerned with the synthesis of novel, oxygenated analogues of the natural and non-natural enantiomeric forms of the Amaryllidaceae alkaloid galanthamine, a reversible and selective acetylcholine esterase (AChE) inhibitor that is used clinically in the treatment of Alzheimer's disease. Specifically, Publication 1 is an invited book chapter that details synthetic approaches to galanthamine and certain analogues pursued by the Banwell Group. It contextualises the strategy employed in preparing oxygenated analogues of galanthamine by the author in latter part of the first section of this thesis. Publication 2 is an invited review article that showcases the methodologies that have been developed within the Banwell Group for manipulating enzymatically-derived and homochiral cis-1,2-dihydrocatechols so as to generate a significant range of biologically active natural products. Publication 3 describes the synthesis of certain oxygenated derivatives of both (+)- and (-)-galanthamine and the evaluation of these as AChE inhibitors. The second section of this thesis is comprised of Publications 4 and 5. These detail the synthesis of certain polyfunctionalized, cyclohexene-based chirons from L-(+)- and D-(-)-tartaric acid, respectively, and their elaboration into various natural product scaffolds. Specifically, Publication 4 describes the preparation of the aforementioned chirons from L-(+)-tartaric acid and its elaboration to the enantiomer of a key intermediate described in Publication 3 that is used to produce oxygenated analogues of (-)-galanthamine. Publication 5 further demonstrates the utility of these new chirons in total synthesis by employing the enantiomer of this chiron (prepared from D-(+)-tartaric acid) as a key intermediate in the first total synthesis of the structurally unusual natural product aspergillusol B. The final section of this thesis is comprised of Publication 6. This details work on the total synthesis of the four diastereomeric forms of the pro-angiogenic guaiacylglycerol 8-O-4ʹ-coniferyl ethers (GGCE) in an effort to establish the role stereochemistry plays on their capacities to act as pro-angiogenic agents. The syntheses feature an Evans/Seebach syn-aldol reaction utilising auxiliaries derived from either L-(+)- or D-(-)-valine. In the case of syntheses of the anti-compounds this was followed by a Mitsunobu inversion of the benzylic alcohol. The four diastereomers were assessed for their pro-angiogenic properties in a human microvascular endothelial cell tubule assay. Whilst they were all active, the compounds containing the 8S-ether linkage were the most potent.
Download or read book Stereoselective Synthesis written by and published by . This book was released on 1989 with total page 756 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Stereoselective Syntesis of Chiral Amine Building Blocks from Naturally Occurring Amino Acids and Application of Proline Derivatives on Organocatalytic Cyclizations by : Bernando Pezzati
Download or read book Stereoselective Syntesis of Chiral Amine Building Blocks from Naturally Occurring Amino Acids and Application of Proline Derivatives on Organocatalytic Cyclizations written by Bernando Pezzati and published by . This book was released on 2013* with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Stereoselective Synthesis by : M. Nógrádi
Download or read book Stereoselective Synthesis written by M. Nógrádi and published by Wiley-VCH. This book was released on 1987 with total page 380 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Stereoselective Synthesis of Heterocycles for Building Natural Products and Peptidomimetics by : Shengquan Duan
Download or read book Stereoselective Synthesis of Heterocycles for Building Natural Products and Peptidomimetics written by Shengquan Duan and published by . This book was released on 2003 with total page 666 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis The Stereoselective Synthesis of Amino Acids for Biosynthetic Studies by : Danny Thomas Davis
Download or read book The Stereoselective Synthesis of Amino Acids for Biosynthetic Studies written by Danny Thomas Davis and published by . This book was released on 1997 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis The Stereoselective Synthesis of Amino Acids for Biosynthetic Studies by :
Download or read book The Stereoselective Synthesis of Amino Acids for Biosynthetic Studies written by and published by . This book was released on 1997 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Stereoselective Strategies for the Construction of Cyclic Peptides, Depsipeptides, Sugars, and Alkenes by : Diane Nguyen Le
Download or read book Stereoselective Strategies for the Construction of Cyclic Peptides, Depsipeptides, Sugars, and Alkenes written by Diane Nguyen Le and published by . This book was released on 2017 with total page 302 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cyclic peptides have attracted attention due to their promising metabolic stability, conformational rigidity, and potential to mimic protein--protein interactions. We describe a method to access cyclic peptides using dehydrophenylalanine as a traceless turn inducer in the total synthesis of dichotomin E. The enamide facilitates ring-closing at high concentrations, and Rh-catalyzed hydrogenation of the unsaturated cyclic peptide results in selective formation of the natural product or its epimer, depending on our choice of phosphine ligand.In addition, we demonstrate how a simple amino acid sequence can be recognized by a Rh-catalyst in a process which initiates the sequential reduction of cyclic dehydropeptides. Molecular recognition of amino acid sequences plays a key role in enzyme-substrate specificity, the regulation of genes, and the treatment of diseases. While critical in biological processes, molecular recognition of amino acids using a transition metal catalyst also holds great promise in organic synthesis. We report experimental and theoretical evidence to support the unidirectional hydrogenation toward the synthesis of cyclic peptides.Like their peptide counterparts, depsipeptides are valuable therapeutic drug targets. These peptides are characterized by a combination of ester and amide linkages. To this end, we report the first enantioselective, intermolecular ketone hydroacylation of alpha-ketoamides with simple aldehydes for the construction of alpha-acyloxyamides in high yields and enantioselectivities.Carbohydrates find importance in cellular communication, structural recognition, and cancer treatment. Although many of these oligosaccharides are generated through chemical synthesis, the presence of multiple hydroxyl sites in the carbohydrate presents a synthetic challenge. Toward a solution to this challenge, we have achieved a Cu-catalyzed regioselective functionalization of monosaccharides.Constructing stereodefined alkenes is a longstanding challenge in organic synthesis. While methods to di- and trisubstituted alkenes have been reported, general protocols toward the synthesis of tetrasubstituted alkenes are underdeveloped. We describe a method toward the synthesis of stereodefined all-carbon tetrasubstituted alkenes from readily accessible ketones, first by a stereoselective enol tosylation followed by a Pd-catalyzed Suzuki-Miyaura cross coupling.
Book Synopsis Stereoselective Syntheses of Alpha, Beta-diamino Acids by : Vaughn Mark Nace
Download or read book Stereoselective Syntheses of Alpha, Beta-diamino Acids written by Vaughn Mark Nace and published by . This book was released on 1984 with total page 242 pages. Available in PDF, EPUB and Kindle. Book excerpt:
