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Statistics And Experimental Design For Toxicologists
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Book Synopsis Statistics and Experimental Design for Toxicologists, Second Edition by : Shayne C. Gad
Download or read book Statistics and Experimental Design for Toxicologists, Second Edition written by Shayne C. Gad and published by CRC Press. This book was released on 1988 with total page 404 pages. Available in PDF, EPUB and Kindle. Book excerpt: Statistics and Experimental Design for Toxicologists has been designed as both a sourcebook for the practicing toxicologist and a textbook for the student toxicologist. Its function is to provide both with tools for the rigorous and critical analysis of experimental data. Assuming only basic mathematical skills, the volume provides a complete and exhaustive introduction to the statistical methods available to and used in the discipline. For each technique presented, a practical example is provided and a collection of problems is also included, together with appendices containing the necessary tables of test values.
Book Synopsis Statistics and Experimental Design for Toxicologists, Third Edition by : Shayne C. Gad
Download or read book Statistics and Experimental Design for Toxicologists, Third Edition written by Shayne C. Gad and published by CRC Press. This book was released on 1998-08-14 with total page 456 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book serves as a primary text for students of pharmacology, toxicology, and biology, and as a practical handbook to support the daily operations of the toxicology laboratory and researcher. This edition retains the structure of earlier editions, but has been extensively revised to provide both the student and the working toxicologist with the necessary tools for the rigorous and critical design of studies and analysis of experimental data. Assuming only basic mathematical skills as a starting point, Statistics and Experimental Design for Toxicologists provides a thorough and exhaustive introduction to the statistical methods available to and used in the discipline. A worked, practical example from the field is provided for each technique presented. Written from a toxicologist's perspective, this book provides both the methodological tools necessary to analyze experimental toxicology data and the insight to know when to use them.
Book Synopsis Statistics and Experimental Design for Toxicologists and Pharmacologists, Fourth Edition by : Shayne C. Gad
Download or read book Statistics and Experimental Design for Toxicologists and Pharmacologists, Fourth Edition written by Shayne C. Gad and published by CRC Press. This book was released on 2005-07-18 with total page 600 pages. Available in PDF, EPUB and Kindle. Book excerpt: Purposefully designed as a resource for practicing and student toxicologists, Statistics and Experimental Design for Toxicologists and Pharmacologists, Fourth Edition equips you for the regular statistical analysis of experimental data. Starting with the assumption of basic mathematical skills and knowledge, the author supplies a complete and systematic yet practical introduction to the statistical methodologists available for, and used in, the discipline. For every technique presented, a worked example from toxicology is also presented. See what's new in the Fourth Edition: The first practical guide to performing meta analysis allowing for using the power inherent in multiple similar studies Coverage of Bayesian analysis and data analysis in pharmacology and toxicology Almost 200 problems with solutions Discussion of analysis of receptor binding assays, safety pharmacology assays and other standard types conducted in pharmacology A new chapter explaining the basics of Good Laboratory Practices (GLPs) For those with computer skills, this edition has been enhanced with the addition of basic SAS Written specifically for toxicologists and pharmacologists, the author draws on more than 30 years of experience to provide understanding of the philosophical underpinnings for the overall structure of analysis. The book's organization fosters the ordered development of skills and yet still facilitates ease of access to information as needed. This Fourth Edition gives you the tools necessary to perform rigorous and critical analysis of experimental data and the insight to know when to use them.
Book Synopsis Statistics and Experimental Design for Toxicologists by : Taylor & Francis Group
Download or read book Statistics and Experimental Design for Toxicologists written by Taylor & Francis Group and published by . This book was released on 2018-09-30 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Statistics and Experimental Design for Toxicologists and Pharmacologists by : Shayne C. Gad
Download or read book Statistics and Experimental Design for Toxicologists and Pharmacologists written by Shayne C. Gad and published by . This book was released on 2005 with total page 567 pages. Available in PDF, EPUB and Kindle. Book excerpt: "This Fourth Edition provides tools for the rigorous and critical analysis of experimental data. Assuming only basic mathematical skills, the book provides a complete and exhaustive introduction to the statistical methods available and updates all material to cover current practices. The book also provides three entirely new and up-to-the-minute chapters. One provides the first practical guide to performing meta analysis allowing for using the power inherent in multiple similar studies; two others cover Bayesian analysis and data analysis in pharmacology, which discuss analysis of receptor binding assays, safety pharmacology assays, and other standard study types conducted in pharmacology."--Publisher's description.
Book Synopsis Statistical Methods in Toxicology by : Ludwig Hothorn
Download or read book Statistical Methods in Toxicology written by Ludwig Hothorn and published by Springer Science & Business Media. This book was released on 2013-03-08 with total page 158 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book contains selected papers from a workshop on modern statistical methods in toxicology held during the EUROTOX '90 conference in Leipzig. The papers deal with the biostatistical evaluation of the commonly used toxicological assays, i.e. mutagenicity, long-term carcinogenicity, embryotoxicity and chronic toxicity assays. The biological background is considered in detail, and most of the related statistical approaches described. In five overview papers, the present state of the art of the related topics is given, while in several contributed papers new approaches are discussed. The most important features are: - A new view on the per-litter analysis problem in em- bryotoxicity assays. - A highly sophisticated treatment of the so-called muta-tox problem in mutagenicity assays. - A detailed discussion of the multiplicity problem based on the closed testing procedure. This volume provides readers with an overview of modern biostatistical methods for several toxicological assays and is in part intended for direct, practical use.
Book Synopsis Experimental Design and Statistical Analysis for Pharmacology and the Biomedical Sciences by : Paul J. Mitchell
Download or read book Experimental Design and Statistical Analysis for Pharmacology and the Biomedical Sciences written by Paul J. Mitchell and published by John Wiley & Sons. This book was released on 2022-04-06 with total page 260 pages. Available in PDF, EPUB and Kindle. Book excerpt: Experimental Design and Statistical Analysis for Pharmacology and the Biomedical Sciences A practical guide to the use of basic principles of experimental design and statistical analysis in pharmacology Experimental Design and Statistical Analysis for Pharmacology and the Biomedical Sciences provides clear instructions on applying statistical analysis techniques to pharmacological data. Written by an experimental pharmacologist with decades of experience teaching statistics and designing preclinical experiments, this reader-friendly volume explains the variety of statistical tests that researchers require to analyze data and draw correct conclusions. Detailed, yet accessible, chapters explain how to determine the appropriate statistical tool for a particular type of data, run the statistical test, and analyze and interpret the results. By first introducing basic principles of experimental design and statistical analysis, the author then guides readers through descriptive and inferential statistics, analysis of variance, correlation and regression analysis, general linear modelling, and more. Lastly, throughout the textbook are numerous examples from molecular, cellular, in vitro, and in vivo pharmacology which highlight the importance of rigorous statistical analysis in real-world pharmacological and biomedical research. This textbook also: Describes the rigorous statistical approach needed for publication in scientific journals Covers a wide range of statistical concepts and methods, such as standard normal distribution, data confidence intervals, and post hoc and a priori analysis Discusses practical aspects of data collection, identification, and presentation Features images of the output from common statistical packages, including GraphPad Prism, Invivo Stat, MiniTab and SPSS Experimental Design and Statistical Analysis for Pharmacology and the Biomedical Sciences is an invaluable reference and guide for undergraduate and graduate students, post-doctoral researchers, and lecturers in pharmacology and allied subjects in the life sciences.
Book Synopsis Statistics in Toxicology by : Byron J. T. Morgan
Download or read book Statistics in Toxicology written by Byron J. T. Morgan and published by Oxford University Press. This book was released on 1996 with total page 250 pages. Available in PDF, EPUB and Kindle. Book excerpt: This collection of papers on aspects of statistics in toxicology is will be of interest to all medical statisticians. It offers findings from numerous leading experts from around the world including A. Whitehead and R. N. Connor (University of Reading), L. Ryan (Harvard), A. P. Grieve (Pfizer Research), K.J. Risko (Northern Telecom), and B.H. Margolin (University of North Carolina). This is the latest in the popular Royal Statistical Society Lecture Series, and will be essential reading for all those involved in this area.
Book Synopsis A Comprehensive Guide to Toxicology in Nonclinical Drug Development by : Ali S. Faqi
Download or read book A Comprehensive Guide to Toxicology in Nonclinical Drug Development written by Ali S. Faqi and published by Elsevier. This book was released on 2024-02-11 with total page 1074 pages. Available in PDF, EPUB and Kindle. Book excerpt: A Comprehensive Guide to Toxicology in Nonclinical Drug Development, Third Edition is a valuable reference providing a complete understanding of all aspects of nonclinical toxicology in pharmaceutical research. This updated edition has been expanded and re-developed covering a wide-range of toxicological issues in small molecules and biologics. Topics include ADME in drug discovery, pharmacokinetics, toxicokinetics, formulations, and genetic toxicology testing. The book has been thoroughly updated throughout to reflect the latest scientific advances and includes new information on antiviral drugs, anti-diabetic drugs, immunotherapy, and a discussion on post-pandemic drug development challenges and opportunities. This is an essential and practical resource for all toxicologists involved in nonclinical testing in industry, academic, and regulatory settings. - Provides updated, unique content not covered in one comprehensive resource, including chapters on stem cells, antiviral drugs, anti-diabetic drugs, and immunotherapy - Includes the latest international guidelines for nonclinical toxicology in both small and large molecules - Incorporates practical examples in order to illustrate day-to-day activities and expectations associated with working in nonclinical toxicology
Book Synopsis Hayes' Principles and Methods of Toxicology by : A. Wallace Hayes
Download or read book Hayes' Principles and Methods of Toxicology written by A. Wallace Hayes and published by CRC Press. This book was released on 2023-07-03 with total page 2143 pages. Available in PDF, EPUB and Kindle. Book excerpt: Hayes’ Principles and Methods of Toxicology has long been established as a reliable and informative reference for the concepts, methodologies, and assessments integral to toxicology. The new edition contains updated and new chapters with the addition of new authors while maintaining the same high standards that have made this book a benchmark resource in the field. Key Features: The comprehensive yet concise coverage of various aspects of fundamental and applied toxicology makes this book a valuable resource for educators, students, and professionals. Questions provided at the end of each chapter allow readers to test their knowledge and understanding of the material covered. All chapters have been updated and over 60 new authors have been added to reflect the dynamic nature of toxicological sciences New topics in this edition include Safety Assessment of Cosmetics and Personal Care Products, The Importance of the Dose/Rate Response, Novel Approaches and Alternative Models, Epigenetic Toxicology, and an Expanded Glossary. The volume is divided into 4 major sections, addressing fundamental principles of toxicology (Section I. "Principles of Toxicology"), major classes of established chemical hazards (Section II. "Agents"), current methods used for the assessment of various endpoints indicative of chemical toxicity (Section III. "Methods"), as well as toxicology of specific target systems and organs (Section IV. "Organ- and System-Specific Toxicology"). This volume will be a valuable tool for the audience that wishes to broaden their understanding of hazards and mechanisms of toxicity and to stay on top of the emerging methods and concepts of the rapidly advancing field of toxicology and risk assessment.
Book Synopsis Acute Toxicology Testing by : Shayne C. Gad
Download or read book Acute Toxicology Testing written by Shayne C. Gad and published by CRC Press. This book was released on 1988-12-15 with total page 558 pages. Available in PDF, EPUB and Kindle. Book excerpt: Acute toxicology testing constitutes the first line of defense against potentially dangerous chemicals. This book provides a detailed presentation of protocols for each of the common designs, reviews their development and objectives, discusses the types of data they generate, and examines the current status of alternative test designs and models. F
Book Synopsis Hayes' Principles and Methods of Toxicology, Sixth Edition by : A. Wallace Hayes
Download or read book Hayes' Principles and Methods of Toxicology, Sixth Edition written by A. Wallace Hayes and published by CRC Press. This book was released on 2014-10-10 with total page 2186 pages. Available in PDF, EPUB and Kindle. Book excerpt: Hayes’ Principles and Methods of Toxicology has long been established as a reliable reference to the concepts, methodologies, and assessments integral to toxicology. The new sixth edition has been revised and updated while maintaining the same high standards that have made this volume a benchmark resource in the field. With new authors and new chapters that address the advances and developments since the fifth edition, the book presents everything toxicologists and students need to know to understand hazards and mechanisms of toxicity, enabling them to better assess risk. The book begins with the four basic principles of toxicology—dose matters, people differ, everything transforms, and timing is crucial. The contributors discuss various agents of toxicity, including foodborne, solvents, crop protection chemicals, radiation, and plant and animal toxins. They examine various methods for defining and measuring toxicity in a host of areas, including genetics, carcinogenicity, toxicity in major body systems, and the environment. This new edition contains an expanded glossary reflecting significant changes in the field. New topics in this edition include: The importance of dose–response Systems toxicology Food safety The humane use and care of animals Neurotoxicology The comprehensive coverage and clear writing style make this volume an invaluable text for students and a one-stop reference for professionals.
Book Synopsis Toxicology and Risk Assessment by : Helmut Greim
Download or read book Toxicology and Risk Assessment written by Helmut Greim and published by John Wiley & Sons. This book was released on 2008-04-15 with total page 698 pages. Available in PDF, EPUB and Kindle. Book excerpt: This new book, written by two outstanding scientists in the field, describes the basic principles of toxic mechanisms and organ toxicity, providing detailed information on specific mechanisms or chemicals for exemplification. The goal is to provide sufficient information that the reader becomes familiar with the basic concepts in toxicology to enable him or her to understand the basic principles in toxicology and to evaluate the risks at given exposures. With this basic understanding the reader also will be able to critically evaluate the available information on a chemical and to identify data gaps. In addition to the introductory chapters the book will offer the following systematic information, presented in six special sections: Principles in Toxicology Organ Toxicology Methods in Toxicology Risk Assessment Risk Management Toxicity of Chemicals Fulfilling a demand for such a book, this will be a welcomed introductory text for students and non-experts alike to focus on and understand the principles of hazard identification and risk assessment of toxicants. Relevant to all those studying toxicology, biochemistry, biology, medicine and chemistry, as well as toxicologists in hospitals, universities and in industry.
Book Synopsis A Practical Guide to Understanding, Managing, and Reviewing Environmental Risk Assessment Reports by : Sally L. Benjamin
Download or read book A Practical Guide to Understanding, Managing, and Reviewing Environmental Risk Assessment Reports written by Sally L. Benjamin and published by CRC Press. This book was released on 2001-02-21 with total page 515 pages. Available in PDF, EPUB and Kindle. Book excerpt: A Practical Guide to Understanding, Managing and Reviewing Environmental Risk Assessment Reports provides team leaders and team members with a strategy for developing the elements of risk assessment into a readable and beneficial report. The authors believe that successful management of the risk assessment team is a key factor is quality repor
Book Synopsis Fundamentals Of Aquatic Toxicology by : Gary M. Rand
Download or read book Fundamentals Of Aquatic Toxicology written by Gary M. Rand and published by CRC Press. This book was released on 2020-08-06 with total page 1152 pages. Available in PDF, EPUB and Kindle. Book excerpt: This text is divided into three parts. The first part describes basic toxicological concepts and methodologies used in aquatic toxicity testing, including the philosophies underlying testing strategies now required to meet and support regulatory standards. The second part of the book discusses various factors that affect transport, transformation, ultimate distribution, and accumulation of chemicals in the aquatic environment, along with the use of modelling to predict fate.; The final section of the book reviews types of effects or endpoints evaluated in field studies and the use of structure-activity relationships in aquatic toxicology to predict biological activity and physio-chemical properties of a chemical. This section also contains an extensive background of environmental legislation in the USA and within the European Community, and an introduction to hazard/risk assessment with case studies.
Book Synopsis Statistical Analysis of Ecotoxicity Studies by : John W. Green
Download or read book Statistical Analysis of Ecotoxicity Studies written by John W. Green and published by John Wiley & Sons. This book was released on 2018-07-04 with total page 411 pages. Available in PDF, EPUB and Kindle. Book excerpt: A guide to the issues relevant to the design, analysis, and interpretation of toxicity studies that examine chemicals for use in the environment Statistical Analysis of Ecotoxicity Studies offers a guide to the design, analysis, and interpretation of a range of experiments that are used to assess the toxicity of chemicals. While the book highlights ecotoxicity studies, the methods presented are applicable to the broad range of toxicity studies. The text contains myriad datasets (from laboratory and field research) that clearly illustrate the book's topics. The datasets reveal the techniques, pitfalls, and precautions derived from these studies. The text includes information on recently developed methods for the analysis of severity scores and other ordered responses, as well as extensive power studies of competing tests and computer simulation studies of regression models that offer an understanding of the sensitivity (or lack thereof) of various methods and the quality of parameter estimates from regression models. The authors also discuss the regulatory process indicating how test guidelines are developed and review the statistical methodology in current or pending OECD and USEPA ecotoxicity guidelines. This important guide: Offers the information needed for the design and analysis to a wide array of ecotoxicity experiments and to the development of international test guidelines used to assess the toxicity of chemicals Contains a thorough examination of the statistical issues that arise in toxicity studies, especially ecotoxicity Includes an introduction to toxicity experiments and statistical analysis basics Includes programs in R and excel Covers the analysis of continuous and Quantal data, analysis of data as well as Regulatory Issues Presents additional topics (Mesocosm and Microplate experiments, mixtures of chemicals, benchmark dose models, and limit tests) as well as software Written for directors, scientists, regulators, and technicians, Statistical Analysis of Ecotoxicity Studies provides a sound understanding of the technical and practical issues in designing, analyzing, and interpreting toxicity studies to support or challenge chemicals for use in the environment.
Book Synopsis A Comprehensive Guide to Toxicology in Preclinical Drug Development by : Ali S. Faqi
Download or read book A Comprehensive Guide to Toxicology in Preclinical Drug Development written by Ali S. Faqi and published by Academic Press. This book was released on 2012-11-02 with total page 904 pages. Available in PDF, EPUB and Kindle. Book excerpt: A Comprehensive Guide to Toxicology in Preclinical Drug Development is designed for toxicologists who need a thorough understanding of the drug development process. This multi-contributed reference will provide a detailed picture of the complex and highly interrelated activities of preclinical toxicology in both small molecules and biologics --
