Statistical Meta-Analysis with Applications

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Publisher : John Wiley & Sons
ISBN 13 : 1118210964
Total Pages : 215 pages
Book Rating : 4.1/5 (182 download)

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Book Synopsis Statistical Meta-Analysis with Applications by : Joachim Hartung

Download or read book Statistical Meta-Analysis with Applications written by Joachim Hartung and published by John Wiley & Sons. This book was released on 2011-09-20 with total page 215 pages. Available in PDF, EPUB and Kindle. Book excerpt: An accessible introduction to performing meta-analysis across various areas of research The practice of meta-analysis allows researchers to obtain findings from various studies and compile them to verify and form one overall conclusion. Statistical Meta-Analysis with Applications presents the necessary statistical methodologies that allow readers to tackle the four main stages of meta-analysis: problem formulation, data collection, data evaluation, and data analysis and interpretation. Combining the authors' expertise on the topic with a wealth of up-to-date information, this book successfully introduces the essential statistical practices for making thorough and accurate discoveries across a wide array of diverse fields, such as business, public health, biostatistics, and environmental studies. Two main types of statistical analysis serve as the foundation of the methods and techniques: combining tests of effect size and combining estimates of effect size. Additional topics covered include: Meta-analysis regression procedures Multiple-endpoint and multiple-treatment studies The Bayesian approach to meta-analysis Publication bias Vote counting procedures Methods for combining individual tests and combining individual estimates Using meta-analysis to analyze binary and ordinal categorical data Numerous worked-out examples in each chapter provide the reader with a step-by-step understanding of the presented methods. All exercises can be computed using the R and SAS software packages, which are both available via the book's related Web site. Extensive references are also included, outlining additional sources for further study. Requiring only a working knowledge of statistics, Statistical Meta-Analysis with Applications is a valuable supplement for courses in biostatistics, business, public health, and social research at the upper-undergraduate and graduate levels. It is also an excellent reference for applied statisticians working in industry, academia, and government.

Statistical Methods in Diagnostic Medicine

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Publisher : John Wiley & Sons
ISBN 13 : 1118626044
Total Pages : 597 pages
Book Rating : 4.1/5 (186 download)

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Book Synopsis Statistical Methods in Diagnostic Medicine by : Xiao-Hua Zhou

Download or read book Statistical Methods in Diagnostic Medicine written by Xiao-Hua Zhou and published by John Wiley & Sons. This book was released on 2014-08-21 with total page 597 pages. Available in PDF, EPUB and Kindle. Book excerpt: Praise for the First Edition " . . . the book is a valuable addition to the literature in the field, serving as a much-needed guide for both clinicians and advanced students."—Zentralblatt MATH A new edition of the cutting-edge guide to diagnostic tests in medical research In recent years, a considerable amount of research has focused on evolving methods for designing and analyzing diagnostic accuracy studies. Statistical Methods in Diagnostic Medicine, Second Edition continues to provide a comprehensive approach to the topic, guiding readers through the necessary practices for understanding these studies and generalizing the results to patient populations. Following a basic introduction to measuring test accuracy and study design, the authors successfully define various measures of diagnostic accuracy, describe strategies for designing diagnostic accuracy studies, and present key statistical methods for estimating and comparing test accuracy. Topics new to the Second Edition include: Methods for tests designed to detect and locate lesions Recommendations for covariate-adjustment Methods for estimating and comparing predictive values and sample size calculations Correcting techniques for verification and imperfect standard biases Sample size calculation for multiple reader studies when pilot data are available Updated meta-analysis methods, now incorporating random effects Three case studies thoroughly showcase some of the questions and statistical issues that arise in diagnostic medicine, with all associated data provided in detailed appendices. A related web site features Fortran, SAS®, and R software packages so that readers can conduct their own analyses. Statistical Methods in Diagnostic Medicine, Second Edition is an excellent supplement for biostatistics courses at the graduate level. It also serves as a valuable reference for clinicians and researchers working in the fields of medicine, epidemiology, and biostatistics.

Meta-Analysis

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Publisher : John Wiley & Sons
ISBN 13 : 1119993431
Total Pages : 402 pages
Book Rating : 4.1/5 (199 download)

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Book Synopsis Meta-Analysis by : Mike W.-L. Cheung

Download or read book Meta-Analysis written by Mike W.-L. Cheung and published by John Wiley & Sons. This book was released on 2015-05-06 with total page 402 pages. Available in PDF, EPUB and Kindle. Book excerpt: Presents a novel approach to conducting meta-analysis using structural equation modeling. Structural equation modeling (SEM) and meta-analysis are two powerful statistical methods in the educational, social, behavioral, and medical sciences. They are often treated as two unrelated topics in the literature. This book presents a unified framework on analyzing meta-analytic data within the SEM framework, and illustrates how to conduct meta-analysis using the metaSEM package in the R statistical environment. Meta-Analysis: A Structural Equation Modeling Approach begins by introducing the importance of SEM and meta-analysis in answering research questions. Key ideas in meta-analysis and SEM are briefly reviewed, and various meta-analytic models are then introduced and linked to the SEM framework. Fixed-, random-, and mixed-effects models in univariate and multivariate meta-analyses, three-level meta-analysis, and meta-analytic structural equation modeling, are introduced. Advanced topics, such as using restricted maximum likelihood estimation method and handling missing covariates, are also covered. Readers will learn a single framework to apply both meta-analysis and SEM. Examples in R and in Mplus are included. This book will be a valuable resource for statistical and academic researchers and graduate students carrying out meta-analyses, and will also be useful to researchers and statisticians using SEM in biostatistics. Basic knowledge of either SEM or meta-analysis will be helpful in understanding the materials in this book.

Methods for Meta-Analysis in Medical Research

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Publisher : Wiley-Blackwell
ISBN 13 :
Total Pages : 360 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis Methods for Meta-Analysis in Medical Research by : A. J. Sutton

Download or read book Methods for Meta-Analysis in Medical Research written by A. J. Sutton and published by Wiley-Blackwell. This book was released on 2000-12-19 with total page 360 pages. Available in PDF, EPUB and Kindle. Book excerpt: Major text including chapters on the following: defining outcome measures; assessing heterogeneity; using fixed effects methods and random effects models for combining study estimates; publication bias.

Introduction to Meta-Analysis

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Publisher : John Wiley & Sons
ISBN 13 : 1119964377
Total Pages : 350 pages
Book Rating : 4.1/5 (199 download)

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Book Synopsis Introduction to Meta-Analysis by : Michael Borenstein

Download or read book Introduction to Meta-Analysis written by Michael Borenstein and published by John Wiley & Sons. This book was released on 2011-08-24 with total page 350 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides a clear and thorough introduction to meta-analysis, the process of synthesizing data from a series of separate studies. Meta-analysis has become a critically important tool in fields as diverse as medicine, pharmacology, epidemiology, education, psychology, business, and ecology. Introduction to Meta-Analysis: Outlines the role of meta-analysis in the research process Shows how to compute effects sizes and treatment effects Explains the fixed-effect and random-effects models for synthesizing data Demonstrates how to assess and interpret variation in effect size across studies Clarifies concepts using text and figures, followed by formulas and examples Explains how to avoid common mistakes in meta-analysis Discusses controversies in meta-analysis Features a web site with additional material and exercises A superb combination of lucid prose and informative graphics, written by four of the world’s leading experts on all aspects of meta-analysis. Borenstein, Hedges, Higgins, and Rothstein provide a refreshing departure from cookbook approaches with their clear explanations of the what and why of meta-analysis. The book is ideal as a course textbook or for self-study. My students, who used pre-publication versions of some of the chapters, raved about the clarity of the explanations and examples. David Rindskopf, Distinguished Professor of Educational Psychology, City University of New York, Graduate School and University Center, & Editor of the Journal of Educational and Behavioral Statistics. The approach taken by Introduction to Meta-analysis is intended to be primarily conceptual, and it is amazingly successful at achieving that goal. The reader can comfortably skip the formulas and still understand their application and underlying motivation. For the more statistically sophisticated reader, the relevant formulas and worked examples provide a superb practical guide to performing a meta-analysis. The book provides an eclectic mix of examples from education, social science, biomedical studies, and even ecology. For anyone considering leading a course in meta-analysis, or pursuing self-directed study, Introduction to Meta-analysis would be a clear first choice. Jesse A. Berlin, ScD Introduction to Meta-Analysis is an excellent resource for novices and experts alike. The book provides a clear and comprehensive presentation of all basic and most advanced approaches to meta-analysis. This book will be referenced for decades. Michael A. McDaniel, Professor of Human Resources and Organizational Behavior, Virginia Commonwealth University

Meta-Analysis of Controlled Clinical Trials

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Publisher : John Wiley & Sons
ISBN 13 : 0470854197
Total Pages : 352 pages
Book Rating : 4.4/5 (78 download)

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Book Synopsis Meta-Analysis of Controlled Clinical Trials by : Anne Whitehead

Download or read book Meta-Analysis of Controlled Clinical Trials written by Anne Whitehead and published by John Wiley & Sons. This book was released on 2003-01-17 with total page 352 pages. Available in PDF, EPUB and Kindle. Book excerpt: Over the last twenty years there has been a dramatic upsurge in the application of meta-analysis to medical research. This has mainly been due to greater emphasis on evidence-based medicine and the need for reliable summaries of the vast and expanding volume of clinical research. At the same time there have been great strides in the development and refinement of the associated statistical methodology. This book describes the planning, conduct and reporting of a meta-analysis as applied to a series of randomized controlled clinical trials. * The various approaches are presented within a general unified framework. * Meta-analysis techniques are described in detail, from their theoretical development through to practical implementation. * Each topic discussed is supported by detailed worked examples. * A comparison of fixed and random effects approaches is included, as well as a discussion of Bayesian methods and cumulative meta-analysis. * Fully documented programs using standard statistical procedures in SAS are available on the Web. Ideally suited for practising statisticians and statistically-minded medical professionals, the book will also be of use to graduate students of medical statistics. The book is a self-contained and comprehensive account of the subject and an essential purchase for anyone involved in clinical trials.

Mixed Models

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Publisher : John Wiley & Sons
ISBN 13 : 0471726133
Total Pages : 732 pages
Book Rating : 4.4/5 (717 download)

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Book Synopsis Mixed Models by : Eugene Demidenko

Download or read book Mixed Models written by Eugene Demidenko and published by John Wiley & Sons. This book was released on 2005-01-28 with total page 732 pages. Available in PDF, EPUB and Kindle. Book excerpt: A rigorous, self-contained examination of mixed model theory and application Mixed modeling is one of the most promising and exciting areas of statistical analysis, enabling the analysis of nontraditional, clustered data that may come in the form of shapes or images. This book provides in-depth mathematical coverage of mixed models’ statistical properties and numerical algorithms, as well as applications such as the analysis of tumor regrowth, shape, and image. Paying special attention to algorithms and their implementations, the book discusses: Modeling of complex clustered or longitudinal data Modeling data with multiple sources of variation Modeling biological variety and heterogeneity Mixed model as a compromise between the frequentist and Bayesian approaches Mixed model for the penalized log-likelihood Healthy Akaike Information Criterion (HAIC) How to cope with parameter multidimensionality How to solve ill-posed problems including image reconstruction problems Modeling of ensemble shapes and images Statistics of image processing Major results and points of discussion at the end of each chapter along with "Summary Points" sections make this reference not only comprehensive but also highly accessible for professionals and students alike in a broad range of fields such as cancer research, computer science, engineering, and industry.

The R Book

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Publisher : John Wiley & Sons
ISBN 13 : 9780470515068
Total Pages : 953 pages
Book Rating : 4.5/5 (15 download)

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Book Synopsis The R Book by : Michael J. Crawley

Download or read book The R Book written by Michael J. Crawley and published by John Wiley & Sons. This book was released on 2007-06-13 with total page 953 pages. Available in PDF, EPUB and Kindle. Book excerpt: The high-level language of R is recognized as one of the mostpowerful and flexible statistical software environments, and israpidly becoming the standard setting for quantitative analysis,statistics and graphics. R provides free access to unrivalledcoverage and cutting-edge applications, enabling the user to applynumerous statistical methods ranging from simple regression to timeseries or multivariate analysis. Building on the success of the author’s bestsellingStatistics: An Introduction using R, The R Book ispacked with worked examples, providing an all inclusive guide to R,ideal for novice and more accomplished users alike. The bookassumes no background in statistics or computing and introduces theadvantages of the R environment, detailing its applications in awide range of disciplines. Provides the first comprehensive reference manual for the Rlanguage, including practical guidance and full coverage of thegraphics facilities. Introduces all the statistical models covered by R, beginningwith simple classical tests such as chi-square and t-test. Proceeds to examine more advance methods, from regression andanalysis of variance, through to generalized linear models,generalized mixed models, time series, spatial statistics,multivariate statistics and much more. The R Book is aimed at undergraduates, postgraduates andprofessionals in science, engineering and medicine. It is alsoideal for students and professionals in statistics, economics,geography and the social sciences.

Geostatistical Functional Data Analysis

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Publisher : John Wiley & Sons
ISBN 13 : 1119387841
Total Pages : 452 pages
Book Rating : 4.1/5 (193 download)

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Book Synopsis Geostatistical Functional Data Analysis by : Jorge Mateu

Download or read book Geostatistical Functional Data Analysis written by Jorge Mateu and published by John Wiley & Sons. This book was released on 2021-12-13 with total page 452 pages. Available in PDF, EPUB and Kindle. Book excerpt: Geostatistical Functional Data Analysis Explore the intersection between geostatistics and functional data analysis with this insightful new reference Geostatistical Functional Data Analysis presents a unified approach to modelling functional data when spatial and spatio-temporal correlations are present. The Editors link together the wide research areas of geostatistics and functional data analysis to provide the reader with a new area called geostatistical functional data analysis that will bring new insights and new open questions to researchers coming from both scientific fields. This book provides a complete and up-to-date account to deal with functional data that is spatially correlated, but also includes the most innovative developments in different open avenues in this field. Containing contributions from leading experts in the field, this practical guide provides readers with the necessary tools to employ and adapt classic statistical techniques to handle spatial regression. The book also includes: A thorough introduction to the spatial kriging methodology when working with functions A detailed exposition of more classical statistical techniques adapted to the functional case and extended to handle spatial correlations Practical discussions of ANOVA, regression, and clustering methods to explore spatial correlation in a collection of curves sampled in a region In-depth explorations of the similarities and differences between spatio-temporal data analysis and functional data analysis Aimed at mathematicians, statisticians, postgraduate students, and researchers involved in the analysis of functional and spatial data, Geostatistical Functional Data Analysis will also prove to be a powerful addition to the libraries of geoscientists, environmental scientists, and economists seeking insightful new knowledge and questions at the interface of geostatistics and functional data analysis.

Biostatistical Methods

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Publisher : John Wiley & Sons
ISBN 13 : 1118625846
Total Pages : 676 pages
Book Rating : 4.1/5 (186 download)

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Book Synopsis Biostatistical Methods by : John M. Lachin

Download or read book Biostatistical Methods written by John M. Lachin and published by John Wiley & Sons. This book was released on 2014-08-22 with total page 676 pages. Available in PDF, EPUB and Kindle. Book excerpt: Praise for the First Edition ". . . an excellent textbook . . . an indispensable reference for biostatisticians and epidemiologists." —International Statistical Institute A new edition of the definitive guide to classical and modern methods of biostatistics Biostatistics consists of various quantitative techniques that are essential to the description and evaluation of relationships among biologic and medical phenomena. Biostatistical Methods: The Assessment of Relative Risks, Second Edition develops basic concepts and derives an expanded array of biostatistical methods through the application of both classical statistical tools and more modern likelihood-based theories. With its fluid and balanced presentation, the book guides readers through the important statistical methods for the assessment of absolute and relative risks in epidemiologic studies and clinical trials with categorical, count, and event-time data. Presenting a broad scope of coverage and the latest research on the topic, the author begins with categorical data analysis methods for cross-sectional, prospective, and retrospective studies of binary, polychotomous, and ordinal data. Subsequent chapters present modern model-based approaches that include unconditional and conditional logistic regression; Poisson and negative binomial models for count data; and the analysis of event-time data including the Cox proportional hazards model and its generalizations. The book now includes an introduction to mixed models with fixed and random effects as well as expanded methods for evaluation of sample size and power. Additional new topics featured in this Second Edition include: Establishing equivalence and non-inferiority Methods for the analysis of polychotomous and ordinal data, including matched data and the Kappa agreement index Multinomial logistic for polychotomous data and proportional odds models for ordinal data Negative binomial models for count data as an alternative to the Poisson model GEE models for the analysis of longitudinal repeated measures and multivariate observations Throughout the book, SAS is utilized to illustrate applications to numerous real-world examples and case studies. A related website features all the data used in examples and problem sets along with the author's SAS routines. Biostatistical Methods, Second Edition is an excellent book for biostatistics courses at the graduate level. It is also an invaluable reference for biostatisticians, applied statisticians, and epidemiologists.

Mixed Models

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Publisher : John Wiley & Sons
ISBN 13 : 1118091574
Total Pages : 768 pages
Book Rating : 4.1/5 (18 download)

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Book Synopsis Mixed Models by : Eugene Demidenko

Download or read book Mixed Models written by Eugene Demidenko and published by John Wiley & Sons. This book was released on 2013-08-05 with total page 768 pages. Available in PDF, EPUB and Kindle. Book excerpt: Praise for the First Edition “This book will serve to greatly complement the growing number of texts dealing with mixed models, and I highly recommend including it in one’s personal library.” —Journal of the American Statistical Association Mixed modeling is a crucial area of statistics, enabling the analysis of clustered and longitudinal data. Mixed Models: Theory and Applications with R, Second Edition fills a gap in existing literature between mathematical and applied statistical books by presenting a powerful examination of mixed model theory and application with special attention given to the implementation in R. The new edition provides in-depth mathematical coverage of mixed models’ statistical properties and numerical algorithms, as well as nontraditional applications, such as regrowth curves, shapes, and images. The book features the latest topics in statistics including modeling of complex clustered or longitudinal data, modeling data with multiple sources of variation, modeling biological variety and heterogeneity, Healthy Akaike Information Criterion (HAIC), parameter multidimensionality, and statistics of image processing. Mixed Models: Theory and Applications with R, Second Edition features unique applications of mixed model methodology, as well as: Comprehensive theoretical discussions illustrated by examples and figures Over 300 exercises, end-of-section problems, updated data sets, and R subroutines Problems and extended projects requiring simulations in R intended to reinforce material Summaries of major results and general points of discussion at the end of each chapter Open problems in mixed modeling methodology, which can be used as the basis for research or PhD dissertations Ideal for graduate-level courses in mixed statistical modeling, the book is also an excellent reference for professionals in a range of fields, including cancer research, computer science, and engineering.

Network Meta-Analysis for Decision-Making

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Publisher : John Wiley & Sons
ISBN 13 : 1118647505
Total Pages : 484 pages
Book Rating : 4.1/5 (186 download)

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Book Synopsis Network Meta-Analysis for Decision-Making by : Sofia Dias

Download or read book Network Meta-Analysis for Decision-Making written by Sofia Dias and published by John Wiley & Sons. This book was released on 2018-03-19 with total page 484 pages. Available in PDF, EPUB and Kindle. Book excerpt: A practical guide to network meta-analysis with examples and code In the evaluation of healthcare, rigorous methods of quantitative assessment are necessary to establish which interventions are effective and cost-effective. Often a single study will not provide the answers and it is desirable to synthesise evidence from multiple sources, usually randomised controlled trials. This book takes an approach to evidence synthesis that is specifically intended for decision making when there are two or more treatment alternatives being evaluated, and assumes that the purpose of every synthesis is to answer the question "for this pre-identified population of patients, which treatment is 'best'?" A comprehensive, coherent framework for network meta-analysis (mixed treatment comparisons) is adopted and estimated using Bayesian Markov Chain Monte Carlo methods implemented in the freely available software WinBUGS. Each chapter contains worked examples, exercises, solutions and code that may be adapted by readers to apply to their own analyses. This book can be used as an introduction to evidence synthesis and network meta-analysis, its key properties and policy implications. Examples and advanced methods are also presented for the more experienced reader. Methods used throughout this book can be applied consistently: model critique and checking for evidence consistency are emphasised. Methods are based on technical support documents produced for NICE Decision Support Unit, which support the NICE Methods of Technology Appraisal. Code presented is also the basis for the code used by the ISPOR Task Force on Indirect Comparisons. Includes extensive carefully worked examples, with thorough explanations of how to set out data for use in WinBUGS and how to interpret the output. Network Meta-Analysis for Decision Making will be of interest to decision makers, medical statisticians, health economists, and anyone involved in Health Technology Assessment including the pharmaceutical industry.

Cochrane Handbook for Systematic Reviews of Interventions

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Publisher : Wiley
ISBN 13 : 9780470699515
Total Pages : 672 pages
Book Rating : 4.6/5 (995 download)

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Book Synopsis Cochrane Handbook for Systematic Reviews of Interventions by : Julian P. T. Higgins

Download or read book Cochrane Handbook for Systematic Reviews of Interventions written by Julian P. T. Higgins and published by Wiley. This book was released on 2008-11-24 with total page 672 pages. Available in PDF, EPUB and Kindle. Book excerpt: Healthcare providers, consumers, researchers and policy makers are inundated with unmanageable amounts of information, including evidence from healthcare research. It has become impossible for all to have the time and resources to find, appraise and interpret this evidence and incorporate it into healthcare decisions. Cochrane Reviews respond to this challenge by identifying, appraising and synthesizing research-based evidence and presenting it in a standardized format, published in The Cochrane Library (www.thecochranelibrary.com). The Cochrane Handbook for Systematic Reviews of Interventions contains methodological guidance for the preparation and maintenance of Cochrane intervention reviews. Written in a clear and accessible format, it is the essential manual for all those preparing, maintaining and reading Cochrane reviews. Many of the principles and methods described here are appropriate for systematic reviews applied to other types of research and to systematic reviews of interventions undertaken by others. It is hoped therefore that this book will be invaluable to all those who want to understand the role of systematic reviews, critically appraise published reviews or perform reviews themselves.

Meta Analysis

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Publisher : John Wiley & Sons
ISBN 13 : 0470028645
Total Pages : 293 pages
Book Rating : 4.4/5 (7 download)

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Book Synopsis Meta Analysis by : Elena Kulinskaya

Download or read book Meta Analysis written by Elena Kulinskaya and published by John Wiley & Sons. This book was released on 2008-04-14 with total page 293 pages. Available in PDF, EPUB and Kindle. Book excerpt: Meta Analysis: A Guide to Calibrating and Combining Statistical Evidence acts as a source of basic methods for scientists wanting to combine evidence from different experiments. The authors aim to promote a deeper understanding of the notion of statistical evidence. The book is comprised of two parts – The Handbook, and The Theory. The Handbook is a guide for combining and interpreting experimental evidence to solve standard statistical problems. This section allows someone with a rudimentary knowledge in general statistics to apply the methods. The Theory provides the motivation, theory and results of simulation experiments to justify the methodology. This is a coherent introduction to the statistical concepts required to understand the authors’ thesis that evidence in a test statistic can often be calibrated when transformed to the right scale.

Statistical Distributions

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Publisher : John Wiley & Sons
ISBN 13 : 1118097823
Total Pages : 206 pages
Book Rating : 4.1/5 (18 download)

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Book Synopsis Statistical Distributions by : Catherine Forbes

Download or read book Statistical Distributions written by Catherine Forbes and published by John Wiley & Sons. This book was released on 2011-03-21 with total page 206 pages. Available in PDF, EPUB and Kindle. Book excerpt: A new edition of the trusted guide on commonly used statistical distributions Fully updated to reflect the latest developments on the topic, Statistical Distributions, Fourth Edition continues to serve as an authoritative guide on the application of statistical methods to research across various disciplines. The book provides a concise presentation of popular statistical distributions along with the necessary knowledge for their successful use in data modeling and analysis. Following a basic introduction, forty popular distributions are outlined in individual chapters that are complete with related facts and formulas. Reflecting the latest changes and trends in statistical distribution theory, the Fourth Edition features: A new chapter on queuing formulas that discusses standard formulas that often arise from simple queuing systems Methods for extending independent modeling schemes to the dependent case, covering techniques for generating complex distributions from simple distributions New coverage of conditional probability, including conditional expectations and joint and marginal distributions Commonly used tables associated with the normal (Gaussian), student-t, F and chi-square distributions Additional reviewing methods for the estimation of unknown parameters, such as the method of percentiles, the method of moments, maximum likelihood inference, and Bayesian inference Statistical Distributions, Fourth Edition is an excellent supplement for upper-undergraduate and graduate level courses on the topic. It is also a valuable reference for researchers and practitioners in the fields of engineering, economics, operations research, and the social sciences who conduct statistical analyses.

Statistical Issues in Drug Development

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Publisher : John Wiley & Sons
ISBN 13 : 9780470723579
Total Pages : 523 pages
Book Rating : 4.7/5 (235 download)

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Book Synopsis Statistical Issues in Drug Development by : Stephen S. Senn

Download or read book Statistical Issues in Drug Development written by Stephen S. Senn and published by John Wiley & Sons. This book was released on 2008-02-28 with total page 523 pages. Available in PDF, EPUB and Kindle. Book excerpt: Drug development is the process of finding and producingtherapeutically useful pharmaceuticals, turning them into safe andeffective medicine, and producing reliable information regardingthe appropriate dosage and dosing intervals. With regulatoryauthorities demanding increasingly higher standards in suchdevelopments, statistics has become an intrinsic and criticalelement in the design and conduct of drug development programmes. Statistical Issues in Drug Development presents anessential and thought provoking guide to the statistical issues andcontroversies involved in drug development. This highly readable second edition has been updated toinclude: Comprehensive coverage of the design and interpretation ofclinical trials. Expanded sections on missing data, equivalence, meta-analysisand dose finding. An examination of both Bayesian and frequentist methods. A new chapter on pharmacogenomics and expanded coverage ofpharmaco-epidemiology and pharmaco-economics. Coverage of the ICH guidelines, in particular ICH E9,Statistical Principles for Clinical Trials. It is hoped that the book will stimulate dialogue betweenstatisticians and life scientists working within the pharmaceuticalindustry. The accessible and wide-ranging coverage make itessential reading for both statisticians and non-statisticiansworking in the pharmaceutical industry, regulatory bodies andmedical research institutes. There is also much to benefitundergraduate and postgraduate students whose courses include amedical statistics component.

Meta-Analysis with R

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Author :
Publisher : Springer
ISBN 13 : 3319214160
Total Pages : 256 pages
Book Rating : 4.3/5 (192 download)

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Book Synopsis Meta-Analysis with R by : Guido Schwarzer

Download or read book Meta-Analysis with R written by Guido Schwarzer and published by Springer. This book was released on 2015-10-08 with total page 256 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides a comprehensive introduction to performing meta-analysis using the statistical software R. It is intended for quantitative researchers and students in the medical and social sciences who wish to learn how to perform meta-analysis with R. As such, the book introduces the key concepts and models used in meta-analysis. It also includes chapters on the following advanced topics: publication bias and small study effects; missing data; multivariate meta-analysis, network meta-analysis; and meta-analysis of diagnostic studies.