Spinal Interneurons

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Spinal Interneurons

Author : Lyandysha Viktorovna Zholudeva
Publisher : Academic Press
ISBN 13 : 0128192615
Total Pages : 476 pages
Book Rating : 4.1/5 (281 download)

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Book Synopsis Spinal Interneurons by : Lyandysha Viktorovna Zholudeva

Download or read book Spinal Interneurons written by Lyandysha Viktorovna Zholudeva and published by Academic Press. This book was released on 2022-11-29 with total page 476 pages. Available in PDF, EPUB and Kindle. Book excerpt: The spinal cord is comprised of four types of neurons: motor neurons, pre-ganglionic neurons, ascending projection neurons, and spinal interneurons. Interneurons are neurons that process information within local circuits, and have an incredible ability for neuroplasticity, whether due to persistent activity, neural injury, or in response to disease. Although, by definition, their axons are restricted to the same structure as the soma (in this case the spinal cord), spinal interneurons are capable of sprouting and rewiring entire neural circuits, and contribute to some restoration of disrupted neural communication after injury to the spinal cord (i.e., “bypassing the lesion site). Spinal Interneurons provides a focused overview of how scientists classify interneurons in general, the techniques used to identify subsets of interneurons, their roles in specific neural circuits, and the scientific evidence for their neuroplasticity. Understanding the capacity for neuroplasticity and identity of specific spinal interneurons that are optimal for recovery, may help determine cellular candidates for developing therapies. Spinal Interneurons provides neuroscientists, clinicians, and trainees a reference book exclusively concentrating on spinal interneurons, the techniques and experiments employed to identify and study these cells as part of normal and compromised neural circuits, and highlights the therapeutic potential of these cells by presenting the relevant pre-clinical and clinical work to date. People in industry will also benefit from this book, which compiles the latest in therapeutic strategies for targeting spinal interneurons, what considerations there are for the development and use of treatments, and how such treatments can not only be translated to the clinic, but how existing treatments should be appropriately reverse-translated to the bench. Comprehensive overview of techniques used to identify, characterize, and classify spinal interneurons and their role in neural circuits Description of the role that spinal interneurons play in mediating plasticity after compromise to spinal neural networks In-depth discussion of therapeutic potential of spinal interneurons for spinal cord injury and/or disease

Jasper's Basic Mechanisms of the Epilepsies

Author : Jeffrey Noebels
Publisher : OUP USA
ISBN 13 : 0199746540
Total Pages : 1258 pages
Book Rating : 4.1/5 (997 download)

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Book Synopsis Jasper's Basic Mechanisms of the Epilepsies by : Jeffrey Noebels

Download or read book Jasper's Basic Mechanisms of the Epilepsies written by Jeffrey Noebels and published by OUP USA. This book was released on 2012-06-29 with total page 1258 pages. Available in PDF, EPUB and Kindle. Book excerpt: Jasper's Basic Mechanisms, Fourth Edition, is the newest most ambitious and now clinically relevant publishing project to build on the four-decade legacy of the Jasper's series. In keeping with the original goal of searching for "a better understanding of the epilepsies and rational methods of prevention and treatment.", the book represents an encyclopedic compendium neurobiological mechanisms of seizures, epileptogenesis, epilepsy genetics and comordid conditions. Of practical importance to the clinician, and new to this edition are disease mechanisms of genetic epilepsies and therapeutic approaches, ranging from novel antiepileptic drug targets to cell and gene therapies.

Breathe, Walk and Chew

Author :
Publisher : Elsevier
ISBN 13 : 044453623X
Total Pages : 243 pages
Book Rating : 4.4/5 (445 download)

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Book Synopsis Breathe, Walk and Chew by :

Download or read book Breathe, Walk and Chew written by and published by Elsevier. This book was released on 2010-12-03 with total page 243 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume focuses on the interplay of mind and motion-the bidirectional link between thought and action. In particular, it investigates the implications that this coupling has for decision making. How do we anticipate the consequences of choices and how is the brain able to represent these choice options and their potential consequences? How are different options evaluated and how is a preferred option selected and implemented? This volume addresses these questions not only through an extensive body of knowledge consisting of individual chapters by international experts, but also through integrative group reports that pave a runway into the future. The understanding of how people make decisions is of common interest to experts working in fields such as psychology, economics, movement science, cognitive neuroscience, neuroinformatics, robotics, and sport science. So far, however, it has mainly been advanced in isolation within distinct research disciplines; in contrast, this book results from a deliberate assembly of multidisciplinary teams. It offers intense, focused, and genuine interdisciplinary perspective. It conveys state-of-the-art and outlines future research directions on the hot topic of Mind and Motion (or embodied cognition). It includes contributions from psychologists, neuroscientists, movement scientists, economists, and others.

Spinal Interneurons in Sensorimotor Integration

Author : Ting Ting Liu
Publisher :
ISBN 13 :
Total Pages : 271 pages
Book Rating : 4.:/5 (757 download)

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Book Synopsis Spinal Interneurons in Sensorimotor Integration by : Ting Ting Liu

Download or read book Spinal Interneurons in Sensorimotor Integration written by Ting Ting Liu and published by . This book was released on 2009 with total page 271 pages. Available in PDF, EPUB and Kindle. Book excerpt: Even though spinal cord research has expanded enormously during the past decades, we still lack a precise understanding of how spinal interneuron networks perfectly integrate sensory feedback with motor control, and how these neuron circuits give rise to specific functions. The present study thus has three basic aims: (1) to investigate propriospinal interneurons connecting rostral and caudal lumbar spinal cord in the rat; (2) to investigate input properties of identified spinal interneurons interposed in different pathways; (3) to investigate cholinergic terminals in the ventral horn of adult rat and cat. There was no evidence to support the presence of vesicular glutamate transporters in motoneuron axon terminals of either species. In addition, there was no obvious relationship between motoneuron terminals and R2 subunit of the AMPA receptor (GluR2). However, a population of cholinergic terminals in lamina VII, which did not originate from motoneurons, was found to be immunoreactive for VGLUT2 and formed appositions with GluR2 subunits. These terminals were smaller than motoneuron terminals and, unlike them, formed no relationship with Renshaw cells. The evidence suggests that glutamate does not act as a cotransmitter with acetylcholine at central synapses of motoneurons in the adult cat and rat. However, glutamate is present in a population of cholinergic terminals which probably originate from interneurons where its action is via an AMPA receptor. In conclusion, the present studies add to the understanding of the organization of neuronal networks involved in sensorimotor integration. Propriospinal interneurons located within the lumbar segments have extensive intra-segmental projections to motor nuclei. First order interneurons interposed in reflex pathways and descending pathways receive a significantly different pattern of inputs. A similar proportion of monosynaptic excitatory input from primary afferents has been found in both excitatory and inhibitory interneurons and these two types of cells are subject to presynaptic inhibitory control of this input.

Peripheral and Spinal Mechanisms in the Neural Control of Movement

Author : M.D. Binder
Publisher : Elsevier
ISBN 13 : 0080862489
Total Pages : 499 pages
Book Rating : 4.0/5 (88 download)

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Book Synopsis Peripheral and Spinal Mechanisms in the Neural Control of Movement by : M.D. Binder

Download or read book Peripheral and Spinal Mechanisms in the Neural Control of Movement written by M.D. Binder and published by Elsevier. This book was released on 1999-12-17 with total page 499 pages. Available in PDF, EPUB and Kindle. Book excerpt: In the last decade, we have witnessed a striking maturation of our understanding of how neurons in the spinal cord control muscular activity and movement. Paradoxically, a host of new findings have revealed an unexpected versatility in the behavior of these well-studied neural elements and circuits. In this volume, the world's leading experts review the current state of our knowledge of motor control, outline their latest results and developments, and delineate the seminal unresolved questions in this vibrant field of research. The volume begins with a commentary and overview of our current understanding of the peripheral and spinal basis of motor control. The remainder of the volume is divided into seven sections, each focused on a different problem. The first chapter in each section provides some historical review and presages the experimental findings and hypotheses that are discussed in subsequent chapters.Topics include the biomechanics of neuromuscular systems, the properties of motoneurons and the muscle units they control, spinal interneurons, pattern generating circuits, locomotion, descending control of spinal circuits, comparative physiology of motor systems, and motor systems neurophysiology studied in man. The book serves as a unique reference volume and should be essential reading for anyone interested in motor systems. Moreover, the volume's comprehensive coverage of a wide range of topics make it an effective textbook for graduate level courses in motor control neurobiology, kinesiology, physical therapy, and rehabilitation medicine.

Spinal Muscular Atrophy

Author : Charlotte J Sumner
Publisher : Academic Press
ISBN 13 : 0128036869
Total Pages : 508 pages
Book Rating : 4.1/5 (28 download)

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Book Synopsis Spinal Muscular Atrophy by : Charlotte J Sumner

Download or read book Spinal Muscular Atrophy written by Charlotte J Sumner and published by Academic Press. This book was released on 2016-10-24 with total page 508 pages. Available in PDF, EPUB and Kindle. Book excerpt: Spinal Muscular Atrophy: Disease Mechanisms and Therapy provides the latest information on a condition that is characterized by motoneuron loss and muscle atrophy, and is the leading genetic cause of infant mortality. Since the identification of the gene responsible for SMA in 1995, there have been important advances in the basic understanding of disease mechanisms, and in therapeutic development. This book provides a comprehensive accounting of recent advances in basic and clinical research that covers SMA clinical features and standards of care, multifaceted aspects of SMN protein functions and SMA disease pathology, various animal models, and biomarkers, as well as current therapeutic development. This title is ideal for graduate students/postdocs and principal investigators who are already in the SMA field and need to keep updated on recent findings and approaches, and for those who are new to, or would like to join, the field. Likewise, users will find an excellent source of reading for biotech/pharma scientists, clinical researchers, and practitioners, regulators, and patients and their advocacy organizations. Furthermore, this book is a handy reference for researchers and clinicians who may want to apply the research strategies and therapeutic approaches in SMA to other rare diseases. Provides comprehensive, up-to-date reviews by leading investigators on diverse topics of SMA, including clinical features and patient care, SMN genetics and protein functions, animal models, disease pathology and mechanisms, biomarkers, current therapeutic development, and the role of non-profit organizations in therapeutic development Written to bridge multiple disciplines and promote better communications among basic scientists, clinical researchers, and health care providers on the latest developments in SMA Includes outstanding questions and perspectives for future investigations and key references for additional detailed study

Neuroproteomics

Author : Oscar Alzate
Publisher : CRC Press
ISBN 13 : 1420076264
Total Pages : 356 pages
Book Rating : 4.4/5 (2 download)

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Book Synopsis Neuroproteomics by : Oscar Alzate

Download or read book Neuroproteomics written by Oscar Alzate and published by CRC Press. This book was released on 2009-10-26 with total page 356 pages. Available in PDF, EPUB and Kindle. Book excerpt: In this, the post-genomic age, our knowledge of biological systems continues to expand and progress. As the research becomes more focused, so too does the data. Genomic research progresses to proteomics and brings us to a deeper understanding of the behavior and function of protein clusters. And now proteomics gives way to neuroproteomics as we beg

The Circuitry of the Human Spinal Cord

Author : Emmanuel Pierrot-Deseilligny
Publisher : Cambridge University Press
ISBN 13 : 9781139445641
Total Pages : 676 pages
Book Rating : 4.4/5 (456 download)

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Book Synopsis The Circuitry of the Human Spinal Cord by : Emmanuel Pierrot-Deseilligny

Download or read book The Circuitry of the Human Spinal Cord written by Emmanuel Pierrot-Deseilligny and published by Cambridge University Press. This book was released on 2005-06-08 with total page 676 pages. Available in PDF, EPUB and Kindle. Book excerpt: Studies of human movement have proliferated in recent years, and there have been many studies of spinal pathways in humans, their role in movement, and their dysfunction in neurological disorders. This comprehensive reference surveys the literature related to the control of spinal cord circuits in human subjects, showing how they can be studied, their role in normal movement, and how they malfunction in disease states. Chapters are highly illustrated and consistently organised, reviewing, for each pathway, the experimental background, methodology, organisation and control, role during motor tasks, and changes in patients with CNS lesions. Each chapter concludes with a helpful resume that can be used independently of the main text to provide practical guidance for clinical studies. This will be essential reading for research workers and clinicians involved in the study, treatment and rehabilitation of movement disorders.

The Interneuron

Author : Mary A. B. Brazier
Publisher : Univ of California Press
ISBN 13 : 0520324269
Total Pages : 1174 pages
Book Rating : 4.5/5 (23 download)

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Book Synopsis The Interneuron by : Mary A. B. Brazier

Download or read book The Interneuron written by Mary A. B. Brazier and published by Univ of California Press. This book was released on 2023-11-10 with total page 1174 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Neurology of Sexual and Bladder Disorders

Author : David B. Vodusek
Publisher : Elsevier
ISBN 13 : 0444632549
Total Pages : 518 pages
Book Rating : 4.4/5 (446 download)

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Book Synopsis Neurology of Sexual and Bladder Disorders by : David B. Vodusek

Download or read book Neurology of Sexual and Bladder Disorders written by David B. Vodusek and published by Elsevier. This book was released on 2015-05-21 with total page 518 pages. Available in PDF, EPUB and Kindle. Book excerpt: The neurology of sex and bladder disorders requires specialized knowledge and represents a challenge for clinical neurologists focused on the neurological condition. Sex and bladder disorders are often related to more general neurological disorders like Parkinson’s disease and multiple sclerosis, and often the sex and bladder disorders are passed to specialists in urology. Neurology of Sexual and Bladder Disorders: Handbook of Clinical Neurology is a focused, yet comprehensive overview that provides complete tutorial reference to the science, diagnosis and treatment of sex and bladder disorders from a neurologic perspective. Comprehensive coverage of the neurology of sex and bladder disorders Details the latest techniques for the study, diagnosis and treatment of sex and bladder dysfunction from a neurological perspective A focused reference for clinical practitioners and neurology research communities

Itch

Author : E. Carstens
Publisher : CRC Press
ISBN 13 : 1466505435
Total Pages : 482 pages
Book Rating : 4.4/5 (665 download)

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Book Synopsis Itch by : E. Carstens

Download or read book Itch written by E. Carstens and published by CRC Press. This book was released on 2014-02-25 with total page 482 pages. Available in PDF, EPUB and Kindle. Book excerpt: Advances in itch research have elucidated differences between itch and pain but have also blurred the distinction between them. There is a long debate about how somatic sensations including touch, pain, itch, and temperature sensitivity are encoded by the nervous system. Research suggests that each sensory modality is processed along a fixed, direct-line communication system from the skin to the brain. Itch: Mechanisms and Treatment presents a timely update on all aspects of itch research and the clinical treatment of itch that accompanies many dermatological conditions including psoriasis, neuropathic itch, cutaneous t-cells lymphomas, and systemic diseases such as kidney and liver disease and cancer. Composed of contributions from distinguished researchers around the world, the book explores topics such as: Neuropathic itch Peripheral neuronal mechanism of itch The role of PAR-2 in neuroimmune communication and itch Mrgprs as itch receptors The role of interleukin-31 and oncostatin M in itch and neuroimmune communication Spinal coding of itch and pain Spinal microcircuits and the regulation of itch Examining new findings on cellular and molecular mechanisms, the book is a compendium of the most current research on itch, its prevalence in society, and the problems associated with treatment.

Motor Neurobiology of the Spinal Cord

Author : Timothy C. Cope
Publisher : CRC Press
ISBN 13 : 1420042645
Total Pages : 359 pages
Book Rating : 4.4/5 (2 download)

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Book Synopsis Motor Neurobiology of the Spinal Cord by : Timothy C. Cope

Download or read book Motor Neurobiology of the Spinal Cord written by Timothy C. Cope and published by CRC Press. This book was released on 2001-06-26 with total page 359 pages. Available in PDF, EPUB and Kindle. Book excerpt: Motor Neurobiology of the Spinal Cord provides a comprehensive description of the experimental tools available for investigating the neuronal properties that allow populations of spinal cord neurons to control muscles responsible for limb movements and posture control. By integrating data from many new approaches, this text demonstrates how spinal cord circuits operate under a variety conditions and explores the new and exciting developments that are being made in motor neurobiology of the spinal cord. It also elucidates concepts and principles relevant to function and structure throughout the nervous system and presents information about changes induced by injury and disease.

How Brain-like is the Spinal Cord?

Author : Uwe Windhorst
Publisher : Springer Science & Business Media
ISBN 13 : 3642511201
Total Pages : 352 pages
Book Rating : 4.6/5 (425 download)

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Book Synopsis How Brain-like is the Spinal Cord? by : Uwe Windhorst

Download or read book How Brain-like is the Spinal Cord? written by Uwe Windhorst and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 352 pages. Available in PDF, EPUB and Kindle. Book excerpt: "Theorizing about brain functions is often considered slightly disreputable and anyhow a waste of time -perhaps even 'philoso- ical'" 1 P. S. CHURCHLAND At present there are no unanimously accepted general con cepts of brain operation and function. This is especially the case with regard to so-called "higher" functions such as per ception, memory or the coupling between sensory input and motor output. There are a number of different reasons for this. Some may be related to experimental limitations allowing the simultaneous recording of the activities of only a restricted number of neurones. But there are also conceptual difficulties hindering the transition from "single-neurone" schemes, in which neurones are assigned relatively specific tasks (such as feature detection), to more complex schemes of nerve cell as semblies (for a discussion of some of the difficulties see Abeles 1982; von der Malsburg 1981; Kriiger 1983). Whilst much is known about the basic properties and functions of single neu rones, whose operations we hope to understand in the foresee able future, this does not hold true in the same way for the working of large assemblies of neurones.

Neural Control of Locomotion

Author : Robert Herman
Publisher : Springer
ISBN 13 : 1475709641
Total Pages : 814 pages
Book Rating : 4.4/5 (757 download)

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Book Synopsis Neural Control of Locomotion by : Robert Herman

Download or read book Neural Control of Locomotion written by Robert Herman and published by Springer. This book was released on 2017-05-04 with total page 814 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Feline Behavioral Health and Welfare

Author : Ilona Rodan
Publisher : Elsevier Health Sciences
ISBN 13 : 1455774014
Total Pages : 479 pages
Book Rating : 4.4/5 (557 download)

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Book Synopsis Feline Behavioral Health and Welfare by : Ilona Rodan

Download or read book Feline Behavioral Health and Welfare written by Ilona Rodan and published by Elsevier Health Sciences. This book was released on 2015-08-24 with total page 479 pages. Available in PDF, EPUB and Kindle. Book excerpt: Learn to manage the physical and psychological well-being of your feline patients with Feline Behavioral Medicine: Prevention and Treatment. From house soiling problems to aggression, this all-new reference offers detailed guidance on assessing, treating, and preventing the full spectrum of feline behavioral problems. Material is organized by both topic and life stage for quick access to the information you need. Plus its incorporation of patient education materials, instructive images, and the latest AAFP guidelines, makes it an invaluable addition to any vet clinician?s library. "This book ... will undoubtedly become THE reference in that very specific field." Reviewed by: Fabienne Dethioux on behalf of Royal Canin: Vets Today, January 2016 UNIQUE! Focus on the prevention of behavior problems is found throughout the majority of the book to show clinicians how to incorporate behavioral considerations into general practice. Comprehensive, holistic care fusing the physical and psychological well-being of feline patients serves as a foundation for all content. International team of expert contributors provides in-depth, authoritative guidance using the most up-to-date information available. Updated information on preventive advice and treatment recommendations follows the guidelines set forth by the AAFP. Client handouts and behavior questionnaires in the book help vets clearly communicate with clients about their cat's behavior.

Pain Modulation

Author : Howard L. Fields
Publisher : Elsevier Publishing Company
ISBN 13 : 9780444809841
Total Pages : 454 pages
Book Rating : 4.8/5 (98 download)

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Book Synopsis Pain Modulation by : Howard L. Fields

Download or read book Pain Modulation written by Howard L. Fields and published by Elsevier Publishing Company. This book was released on 1988-01-01 with total page 454 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume represents edited material that was presented at a conference on brainstem modulation of spinal nociception held in Beaune, France during July, 1987. Pain Modulation, Volume 77 in the series Progress in Brain Research reviews, analyses and suggests new research strategies on several relevant topics including: the endogenous opioid peptides; sites of action of opiates; the role of biogenic animes and non-opioid peptides in analgesia; dorsal horn circuitry; behavioural factors in the activation of pain modulating networks and clinical studies of nociceptive modulation.

Movement Control

Author : Paul Cordo
Publisher : Cambridge University Press
ISBN 13 : 9780521456074
Total Pages : 296 pages
Book Rating : 4.4/5 (56 download)

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Book Synopsis Movement Control by : Paul Cordo

Download or read book Movement Control written by Paul Cordo and published by Cambridge University Press. This book was released on 1994-05-27 with total page 296 pages. Available in PDF, EPUB and Kindle. Book excerpt: Movement is arguably the most fundamental and important function of the nervous system. Purposive movement requires the coordination of actions within many areas of the cerebral cortex, cerebellum, basal ganglia, spinal cord, and peripheral nerves and sensory receptors, which together must control a highly complex biomechanical apparatus made up of the skeleton and muscles. Beginning at the level of biomechanics and spinal reflexes and proceeding upward to brain structures in the cerebellum, brainstem and cerebral cortex, the chapters in this book highlight the important issues in movement control. Commentaries provide a balanced treatment of the articles that have been written by experts in a variety of areas concerned with movement, including behaviour, physiology, robotics, and mathematics.