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Spectroscopic Studies Of Platinum Ii Complexes With N Donor Ligands
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Book Synopsis Platinum and Other Metal Coordination Compounds in Cancer Chemotherapy by : Stephen B. Howell
Download or read book Platinum and Other Metal Coordination Compounds in Cancer Chemotherapy written by Stephen B. Howell and published by Springer Science & Business Media. This book was released on 1991 with total page 563 pages. Available in PDF, EPUB and Kindle. Book excerpt: Taken together the data presented in this review, and work by many other investigators, support the notion that DNA excision repair is important in a tumor cell's resistance to platinum compounds. Inhibition of this repair system by combination chemotherapy with the excision repair inhibitors HU and Ara-C produces synergistic cell kills and increased levels and persistance of DNA interstrand crosslinks. The studies with cis-DDP and ~-DDP in combination with UV induced thymine dimers suggest that there may be competition for DNA repair enzymes between the dimer and the platinum lesion. Whether the competing lesion is an intrastrand crosslink, interstrand crosslink, or platinum monoadduct (or all of these lesions) cannot be determined. The similarity between an intrastrand crosslink and a cyclobutane dimer suggests that these lesions may compete for repair. However, the increased peak levels of interstrand crosslinks, and increased persistence of these lesions at later time points suggest that this lesion may also be a substrate for the repair system. These observations may be of clinical relevance. Recently Dr. Kathy Albain of our institution has completed a Phase III I study using a 12 hour pretreatment with HU and Ara-C in patients prior to their cis-DDP therapy. She observed a significant number of responders in this trial (54). She is currently completing a second Phase IIII study substituting IV HU for the oral formulation. We anticipate initiating other clinical trials based upon these observations.
Book Synopsis Annual Reports on NMR Spectroscopy by :
Download or read book Annual Reports on NMR Spectroscopy written by and published by Academic Press. This book was released on 2020-09-25 with total page 422 pages. Available in PDF, EPUB and Kindle. Book excerpt: Annual Reports on NMR Spectroscopy, has established itself as a premier resource for both specialists and non-specialists who are looking to become familiar with new techniques and applications pertaining to NMR spectroscopy. - Serves as the premier resource for learning the new techniques and applications of NMR spectroscopy - Provides a key reference for chemists and physicists using NMR spectroscopy to study the structure and dynamics of molecules - Covers all aspects of molecular science, including MRI (Magnetic Resonance Imaging)
Book Synopsis Transition Metal and Rare Earth Compounds III by : Hartmut Yersin
Download or read book Transition Metal and Rare Earth Compounds III written by Hartmut Yersin and published by Springer Science & Business Media. This book was released on 2004-11-18 with total page 312 pages. Available in PDF, EPUB and Kindle. Book excerpt: With contribution by numerous experts
Book Synopsis Spectroscopy of Biological Molecules by : Jean Claude Merlin
Download or read book Spectroscopy of Biological Molecules written by Jean Claude Merlin and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 642 pages. Available in PDF, EPUB and Kindle. Book excerpt: 6th European Conference on the Spectroscopy of Biological Molecules, 3--8 September 1995, Villeneuve d'Ascq, France
Book Synopsis 31P and 13C NMR of Transition Metal Phosphine Complexes by : Paul S. Pregosin
Download or read book 31P and 13C NMR of Transition Metal Phosphine Complexes written by Paul S. Pregosin and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 164 pages. Available in PDF, EPUB and Kindle. Book excerpt: For almost a quarter of a century the words "nuclear magnetic reso nance" were synonymous with proton I,leasurements. During this period the literature abounded with a seemingly infinite variety of 1H NHR studies concerned primarily with carbon chemistry. Occasionally a "novel" nucleus was studied and, even in those early days, the poten- 13 14 31 19 tial offered by C, N, P and F was clearly recognized. Despite the allure, the technical difficulties involved in measuring some of these nuclei were far from trivial. Small magnetic moments and low natural abundance in combination with spin-spin coupling from other nuclei, mostly protons, resulted in a signal-to-noise problem whose severity effectively excluded the study of metal complexes with unfa vorable solubility characteristics. The first important breakthrough came with the advent of broad band 1H-decoupling. For example, the featureless broad 31p resonance associated with the commonly used ligand triphenyl phosphine is converted to a sharp, more readily ob served singlet when wide-band decoupling is employed (see Fig. 1). Despite this improvement investigation of more interesting molecules, such as catalytically active complexes was forced to await the devel opment of Fourier Transform methods since only with relatively rapid signal averaging methods could sufficient signal-to-noise ratios be achieved.
Book Synopsis NMR in Organometallic Chemistry by : Paul S. Pregosin
Download or read book NMR in Organometallic Chemistry written by Paul S. Pregosin and published by John Wiley & Sons. This book was released on 2013-07-26 with total page 409 pages. Available in PDF, EPUB and Kindle. Book excerpt: The first and ultimate guide for anyone working in transition organometallic chemistry and related fields, providing the background and practical guidance on how to efficiently work with routine research problems in NMR. The book adopts a problem-solving approach with many examples taken from recent literature to show readers how to interpret the data. Perfect for PhD students, postdocs and other newcomers in organometallic and inorganic chemistry, as well as for organic chemists involved in transition metal catalysis.
Book Synopsis Comprehensive Coordination Chemistry II by : J. A. McCleverty
Download or read book Comprehensive Coordination Chemistry II written by J. A. McCleverty and published by Newnes. This book was released on 2003-12-03 with total page 11845 pages. Available in PDF, EPUB and Kindle. Book excerpt: Comprehensive Coordination Chemistry II (CCC II) is the sequel to what has become a classic in the field, Comprehensive Coordination Chemistry, published in 1987. CCC II builds on the first and surveys new developments authoritatively in over 200 newly comissioned chapters, with an emphasis on current trends in biology, materials science and other areas of contemporary scientific interest.
Book Synopsis Highly Efficient OLEDs by : Hartmut Yersin
Download or read book Highly Efficient OLEDs written by Hartmut Yersin and published by John Wiley & Sons. This book was released on 2019-01-04 with total page 604 pages. Available in PDF, EPUB and Kindle. Book excerpt: Dieses Fachbuch eines Pioniers in diesem schnell wachsenden Fachbereich fasst die jüngsten Erkenntnisse zur Optimierung von OLEDs zusammen. Die Theorie wird ausführlich beschrieben, ebenso verschiedene organische und anorganische emittierende Materialien, Display- und Lichtanwendungen.
Book Synopsis Annual Reports on NMR Spectroscopy by : Graham A. Webb
Download or read book Annual Reports on NMR Spectroscopy written by Graham A. Webb and published by Academic Press. This book was released on 2013-09-27 with total page 440 pages. Available in PDF, EPUB and Kindle. Book excerpt: Nuclear magnetic resonance (NMR) is an analytical tool used by chemists and physicists to study the structure and dynamics of molecules. In recent years, no other technique has gained such significance as NMR spectroscopy. It is used in all branches of science in which precise structural determination is required and in which the nature of interactions and reactions in solution is being studied. Annual Reports on NMR Spectroscopy has established itself as a premier means for the specialist and non-specialist alike to become familiar with new techniques and applications of NMR spectroscopy. - This volume of Annual Reports on NMR Spectroscopy focuses on the analytical tool used by chemists and physicists and inlcudes topics such as Profiling of Food Samples, Recent Advances in Solution NMR Studies and Magic Angle Spinning NMR Studies of Protein Assemblies
Book Synopsis Annual Reports in Inorganic and General Syntheses–1975 by : Hans Zimmer
Download or read book Annual Reports in Inorganic and General Syntheses–1975 written by Hans Zimmer and published by Elsevier. This book was released on 2013-09-11 with total page 355 pages. Available in PDF, EPUB and Kindle. Book excerpt: Annual Reports in Inorganic and General Syntheses–1975 presents an annual review of synthetically useful information that would prove beneficial to nearly all organic chemists, both specialist and nonspecialist in synthesis. It should help relieve some of the information storage burden of the specialist and should aid the nonspecialist who is seeking help with a specific problem to become rapidly aware of recent synthetic advances. This is the fourth volume of "ARIGS" and is organized along the lines used for the last volume. The authors were encouraged to use synthetic aspects as their primary guideline for the arrangement and preservation of the information; however, an occasional deviation to include structural or mechanistic features seemed to be justified in order to reflect the particular features of a given element's chemistry. Complex hydrides were dealt with under the particular elements. As a consequence there is no chapter on simple and complex metal hydrides of main groups I, II, and III in the present volume. As in previous issues of ARIGS, this volume presents an article of a timely subject of special interest. This year's special feature is the "Synthesis of Radiopharmaceuticals by the Reduction of 99m TcO4-."
Book Synopsis Metallotherapeutic Drugs and Metal-Based Diagnostic Agents by : Marcel Gielen
Download or read book Metallotherapeutic Drugs and Metal-Based Diagnostic Agents written by Marcel Gielen and published by John Wiley & Sons. This book was released on 2005-09-01 with total page 638 pages. Available in PDF, EPUB and Kindle. Book excerpt: There are an astonishing number and variety of roles that metals play in contemporary medicine. This book contains information on the medicinal uses of inorganics, that is, of elements such as boron, lithium, selenium, to name a few, as well as metal-containing species. In keeping with the notion that healthy mammals rely on (bio-essential) metals for the normal functioning of approximately a third of their proteins and enzymes, a large number of drugs are metal-based and considerable effort is being devoted to developing both second- and third-generation drugs as well as generating novel metal-based drugs. While there is no doubt that there is an emphasis on 'Metallotherapeutics' throughout the volume, the use of metals in medicine is not restricted to metal-based drugs. The following are also covered: non-invasive radiopharmaceuticals Magnetic Resonance Imaging (MRI) mineral supplements From the foregoing and, more importantly, from the contents of the various Chapters, the reader will gain an appreciation of the very real role metal-based drugs play in modern medicine and of the considerable effort being devoted to the development of novel complexes with greater efficacy as therapeutic and diagnostic agents.
Book Synopsis Spectroscopic Properties of Inorganic and Organometallic Compounds by : N N Greenwood
Download or read book Spectroscopic Properties of Inorganic and Organometallic Compounds written by N N Greenwood and published by Royal Society of Chemistry. This book was released on 2007-10-31 with total page 408 pages. Available in PDF, EPUB and Kindle. Book excerpt: Spectroscopic Properties of Inorganic and Organometallic Compounds provides a unique source of information on an important area of chemistry. Divided into sections mainly according to the particular spectroscopic technique used, coverage in each volume includes: NMR (with reference to stereochemistry, dynamic systems, paramagnetic complexes, solid state NMR and Groups 13-18); nuclear quadrupole resonance spectroscopy; vibrational spectroscopy of main group and transition element compounds and coordinated ligands; and electron diffraction. Reflecting the growing volume of published work in this field, researchers will find this Specialist Periodical Report an invaluable source of information on current methods and applications. Specialist Periodical Reports provide systematic and detailed review coverage in major areas of chemical research. Compiled by teams of leading experts in their specialist fields, this series is designed to help the chemistry community keep current with the latest developments in their field. Each volume in the series is published either annually or biennially and is a superb reference point for researchers. www.rsc.org/spr
Book Synopsis Index to Theses Accepted for Higher Degrees by the Universities of Great Britain and Ireland and the Council for National Academic Awards by : Geoffrey M. Paterson
Download or read book Index to Theses Accepted for Higher Degrees by the Universities of Great Britain and Ireland and the Council for National Academic Awards written by Geoffrey M. Paterson and published by . This book was released on 1982 with total page 416 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Biochemical and Biophysical Roles of Cell Surface Molecules by : Kausik Chattopadhyay
Download or read book Biochemical and Biophysical Roles of Cell Surface Molecules written by Kausik Chattopadhyay and published by Springer. This book was released on 2019-01-25 with total page 363 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cell surface small molecules and macromolecules, such as members of cholesterol family (including steroid hormones), the glycolipid family (sphingolipids), the glycoprotein family (both N-linked and O-linked), and a vast array of other receptors have been shown to be involved in normal and abnormal cellular processes. The 11th International Symposium on Cell Surface Macromolecules, held in Mohali, India, in February 2017 provided a comprehensive update on the major advances in this area. Presenting selected contributions from this meeting, this book comprises 24 chapters, which provide in-depth analyses of data on the role of cell surface macromolecules in cellular function and their alterations associated with pathological conditions. It includes comprehensive research papers and critical overviews of the functional role of cell surface molecules, discussing topics such as biochemical, biophysical, and cell biological approaches to study cell membrane molecules, and metabolism of glycoconjugates.
Download or read book Nuclear Science Abstracts written by and published by . This book was released on 1975-11 with total page 698 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Comprehensive Organometallic Chemistry II by : Richard J. Puddephatt
Download or read book Comprehensive Organometallic Chemistry II written by Richard J. Puddephatt and published by Elsevier. This book was released on 1995 with total page 670 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Comprehensive Chiroptical Spectroscopy, Volume 2 by : Nina Berova
Download or read book Comprehensive Chiroptical Spectroscopy, Volume 2 written by Nina Berova and published by John Wiley & Sons. This book was released on 2012-03-27 with total page 884 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides an introduction to the important methods of chiroptical spectroscopy in general, and circular dichroism (CD) in particular, which are increasingly important in all areas of chemistry, biochemistry, and structural biology. The book can be used as a text for undergraduate and graduate students and as a reference for researchers in academia and industry. Experimental methods and instrumentation are described with topics ranging from the most widely used methods (electronic and vibrational CD) to frontier areas such as nonlinear spectroscopy and photoelectron CD, as well as the theory of chiroptical methods and techniques for simulating chiroptical properties. Applications of chiroptical spectroscopy to problems in organic stereochemistry, inorganic stereochemistry, and biochemistry and structural biology are also discussed, and each chapter is written by one or more leading authorities with extensive experience in the field.
