Read Books Online and Download eBooks, EPub, PDF, Mobi, Kindle, Text Full Free.
Spectral Fourier Domain Doppler Optical Coherence Tomography In The Rodent Retina
Download Spectral Fourier Domain Doppler Optical Coherence Tomography In The Rodent Retina full books in PDF, epub, and Kindle. Read online Spectral Fourier Domain Doppler Optical Coherence Tomography In The Rodent Retina ebook anywhere anytime directly on your device. Fast Download speed and no annoying ads. We cannot guarantee that every ebooks is available!
Book Synopsis Spectral/ Fourier Domain Doppler Optical Coherence Tomography in the Rodent Retina by : Jonathan Jaoshin Liu
Download or read book Spectral/ Fourier Domain Doppler Optical Coherence Tomography in the Rodent Retina written by Jonathan Jaoshin Liu and published by . This book was released on 2008 with total page 69 pages. Available in PDF, EPUB and Kindle. Book excerpt: Optical Coherence Tomography (OCT) is an emerging imaging technique based on low-coherence interferometry for noninvasive, high- resolution, cross-sectional imaging in a variety of biomedical fields. In ophthalmology, OCT has rapidly become a standard clinical diagnostic tool for retinal diseases, providing visualization of the retina with unprecedented detail. However, conventional time domain OCT systems are limited by low imaging speeds. Conventional time domain OCT systems use a mechanically scanned reference mirror to adjust the reference arm path length in time. Spectral / Fourier domain OCT systems use a spectrometer to detect the interference spectrum and do not require mechanical scanning of the reference mirror. This technology significantly improves imaging speed and sensitivity. Spectral / Fourier domain OCT detection methods enable imaging speeds -50-100x faster than conventional time domain OCT systems, providing the capability for three dimensional retinal imaging and blood flow quantification using Doppler OCT measurements. A pre-objective scanning spectral / Fourier domain OCT system for in vivo rodent retinal imaging is designed and built. The system includes a broadband light source to achieve ~-3[mu]m resolution and a CCD camera spectrometer with imaging speed at 25,000 axial scans per second. Applications of spectral / Fourier domain OCT for in vivo rodent retinal imaging are illustrated, including three-dimensional OCT imaging of retinal structure, OCT imaging of the retina preand post-injection, and Doppler OCT imaging providing quantitative measurements of pulsatile blood flow in a retinal vessel. These results demonstrate the ability of spectral / Fourier domain OCT to visualize rodent retinal structure in vivo, perform longitudinal studies by evaluating disease progression in an individual animal, and quantitatively measure rodent retinal blood flow.
Book Synopsis High Resolution Imaging in Microscopy and Ophthalmology by : Josef F. Bille
Download or read book High Resolution Imaging in Microscopy and Ophthalmology written by Josef F. Bille and published by Springer. This book was released on 2019-08-13 with total page 407 pages. Available in PDF, EPUB and Kindle. Book excerpt: This open access book provides a comprehensive overview of the application of the newest laser and microscope/ophthalmoscope technology in the field of high resolution imaging in microscopy and ophthalmology. Starting by describing High-Resolution 3D Light Microscopy with STED and RESOLFT, the book goes on to cover retinal and anterior segment imaging and image-guided treatment and also discusses the development of adaptive optics in vision science and ophthalmology. Using an interdisciplinary approach, the reader will learn about the latest developments and most up to date technology in the field and how these translate to a medical setting. High Resolution Imaging in Microscopy and Ophthalmology – New Frontiers in Biomedical Optics has been written by leading experts in the field and offers insights on engineering, biology, and medicine, thus being a valuable addition for scientists, engineers, and clinicians with technical and medical interest who would like to understand the equipment, the applications and the medical/biological background. Lastly, this book is dedicated to the memory of Dr. Gerhard Zinser, co-founder of Heidelberg Engineering GmbH, a scientist, a husband, a brother, a colleague, and a friend.
Book Synopsis High-speed Fourier Domain Optical Coherence Tomography for Structural and Functional Imaging of the Retina by : Vivek Jay Srinivasan
Download or read book High-speed Fourier Domain Optical Coherence Tomography for Structural and Functional Imaging of the Retina written by Vivek Jay Srinivasan and published by . This book was released on 2008 with total page 468 pages. Available in PDF, EPUB and Kindle. Book excerpt: Optical Coherence Tomography (OCT) is an emerging optical biomedical imaging technology that enables cross-sectional imaging of scattering tissue with high sensitivity and micron-scale resolution. In conventional OCT, the reference arm path length in a Michelson interferometer is scanned in time to generate a profile of backscattering versus depth from the sample arm. In conventional OCT, a broadband, low coherence light source is used to achieve high axial resolution. However, clinical and research applications of conventional OCT have been limited by low imaging speeds. Recently, new Fourier domain OCT detection methods have enabled speeds of ~20,000-40,000 axial scans per second, which are ~50-100x faster than conventional OCT. These methods are called "Fourier domain" because they detect the interference spectrum and do not require mechanical scanning of the reference arm path length in time. In this thesis, two different technologies for Fourier domain OCT are investigated. The first technology, called spectral OCT, uses a broadband light source and a spectrometer to measure the interference spectrum. The second technology, called swept source OCT, uses a rapidly tunable narrowband laser to measure the interference spectrum over time. Applications of these new technologies for retinal imaging are illustrated, including three-dimensional retinal imaging in animal models, clinical imaging of retinal pathologies, quantification of photoreceptor morphology, and functional imaging of intrinsic stimulus-induced scattering changes in the retina. Finally, using a rapidly tunable laser, ultrahigh-speed swept source OCT imaging at 249,000 axial scans per second, roughly three orders of magnitude faster than conventional OCT, is demonstrated. This technology is applied for three-dimensional snapshots of the retina and optic nerve head and unprecedented visualization of retinal anatomy.
Book Synopsis Morphological and Doppler Optical Coherence Tomography by : Man Chun Tam
Download or read book Morphological and Doppler Optical Coherence Tomography written by Man Chun Tam and published by LAP Lambert Academic Publishing. This book was released on 2014 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: A high resolution spectral domain optical coherence tomography (SD-OCT) system was used to study in-vivo early morphological changes and optical nerve head (ONH) blood flow in Long Evans rat retina, induced by injection of sodium iodate (NaIO3). OCT images were acquired at the same retinal location from healthy rats and from rats at 1, 3, 6 12, 24, 72 and 168 hours post drug administration. Morphological OCT images showed the formation of a new low reflective layer between photoreceptor OS and RPE in all tested rats which was most likely fluid accumulation. A Doppler Optical Micro-Angiography (DOMAG) algorithm was used to carry out quantitative analysis of ONH blood flow. Estimation of flow rate on each ONH vessel was done by measurements of Doppler angle, vessel size and axial velocity. This study has demonstrated that the capability of UHR-OCT to observe optical reflectance and layer thickness changes, rearrangement and detachment of photoreceptor OS and RPE layers, together with flow rate estimation of retinal blood vessels. Therefore, it can serve as markers in future non-invasive, in-vivo studies of disease or drug induced retinal degeneration in ophthalmic research.
Book Synopsis Optical Coherence Tomography by : Wolfgang Drexler
Download or read book Optical Coherence Tomography written by Wolfgang Drexler and published by Springer Science & Business Media. This book was released on 2008-12-10 with total page 1346 pages. Available in PDF, EPUB and Kindle. Book excerpt: Optical coherence tomography (OCT) is the optical analog of ultrasound imaging and is emerging as a powerful imaging technique that enables non-invasive, in vivo, high resolution, cross-sectional imaging in biological tissue. This book introduces OCT technology and applications not only from an optical and technological viewpoint, but also from biomedical and clinical perspectives. The chapters are written by leading research groups, in a style comprehensible to a broad audience.
Book Synopsis Non-invasive Retinal Imaging in Mice with Fluorescent Scanning Laser Ophthalmoscopy and Fourier Domain Optical Coherence Tomography by : Nima Hossein-Javaheri
Download or read book Non-invasive Retinal Imaging in Mice with Fluorescent Scanning Laser Ophthalmoscopy and Fourier Domain Optical Coherence Tomography written by Nima Hossein-Javaheri and published by . This book was released on 2010 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Visualization of the internal structures of the retina is critical for clinical diagnosis and monitoring of pathology as well as for medical research investigating the root causes of retinal degeneration. The aim of this thesis is to develop multi-modal non-invasive imaging technology for studying retinal degeneration and gene therapy in mice. We have constructed a FD-OCT prototype and combined it with a Scanning Laser Ophthalmoscope (SLO) to permit real time alignment of the retinal field of view. Fluorescence detection was integrated with the SLO to enable the en face localization of a molecular contrast signal, which is important for retinal angiography and retinal auto-fluorescence imaging. The integrated FD-OCT/fSLO system was investigated for imaging the retina of mice In vivo. The results of this research have demonstrated that the state of art FD-OCT/fSLO system OCT is a powerful tool to conduct research retinal degeneration and gene therapy in mice.
Book Synopsis Non-invasive Imaging of Retinal Degeneration in Small Animals Using Fourier Domain Optical Coherence Tomography by : Jing Xu
Download or read book Non-invasive Imaging of Retinal Degeneration in Small Animals Using Fourier Domain Optical Coherence Tomography written by Jing Xu and published by . This book was released on 2009 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: A prototype spectrometer based on Fourier Domain Optical Coherence Tomography (FD OCT) system was used as a non-invasive depth resolved medical imaging tool for diagnostic visualization of the retinal structures In vivo. This thesis investigated so-called Spectral Domain (SD) OCT to detect and monitor pathological signs of retinal degeneration in small animals such as mice, rats and Xenopus laevis larvae. Non-invasive SD OCT imaging was validated against invasive retinal cross sectional images (histology) acquired from a nearby region for comparison of specific retinal layers. The retinal layers were manually segmented for quantitative thickness measurements, and followed by statistical analysis to determine the onset of detectable retinal degeneration. The results of this research have demonstrated that FD OCT is a powerful tool for quantitative in vivo measurement of retinal degeneration in small animals.
Book Synopsis Real-time Retinal Blood Flow Imaging with Fourier Domain Optical Coherence Tomography by : Jing Xu
Download or read book Real-time Retinal Blood Flow Imaging with Fourier Domain Optical Coherence Tomography written by Jing Xu and published by . This book was released on 2014 with total page 88 pages. Available in PDF, EPUB and Kindle. Book excerpt: Optical Coherence Tomography (OCT) is a non-invasive micrometer-resolution depth resolved medical imaging tool for diagnostic visualization of the retinal structures in vivo. In this thesis, we first describe the capability of OCT for providing structural information by quantitative retinal thickness measurements in animal models of diseases causing vision loss. In the rest of the work described in this thesis, we focus on the development of an extension of OCT called speckle variance (sv) OCT, which provides functional information such as detecting capillaries within in the retina. Retinal capillary networks are critically linked to retinal neuronal health and disease. The ability to perform accurate in vivo examination of human retinal capillary networks is therefore valuable for studying mechanisms that govern retinal homeostasis and retinal vascular diseases. A real-time implementation of the svOCT provided by the GPU acceleration was described to provide visualization of en-face vasculature networks during acquisition. A qualitative comparison study was described in this thesis by comparing the retinal vasculature images acquired from svOCT and Florescence Angiography (FA) for both healthy and diseased patients. The capability of svOCT with respect to quantifying capillary network information has been also validated in this thesis. The results of these studies suggest that this GPU accelerated svOCT has the potential to non-invasively provide useful quantitative information about human retinal capillary networks, and may have clinical and research applications for the management of retinal microvascular diseases, a major cause of vision loss worldwide. To further adapt the svOCT to be more clinical friendly, preliminary work on enhancing the real-time visualization of vascular information from distinct retinal capillary beds during acquisition was proposed and implemented in this thesis.
Book Synopsis Small Animal Imaging by : Fabian Kiessling
Download or read book Small Animal Imaging written by Fabian Kiessling and published by Springer. This book was released on 2017-05-22 with total page 871 pages. Available in PDF, EPUB and Kindle. Book excerpt: This textbook is a practical guide to the use of small animal imaging in preclinical research that will assist in the choice of imaging modality and contrast agent and in study design, experimental setup, and data evaluation. All established imaging modalities are discussed in detail, with the assistance of numerous informative illustrations. While the focus of the new edition remains on practical basics, it has been updated to encompass a variety of emerging imaging modalities, methods, and applications. Additional useful hints are also supplied on the installation of a small animal unit, study planning, animal handling, and cost-effective performance of small animal imaging. Cross-calibration methods and data postprocessing are considered in depth. This new edition of Small Animal Imaging will be an invaluable aid for researchers, students, and technicians involved in research into and applications of small animal imaging.
Book Synopsis Optical Coherence Tomography in Cardiovascular Research by : Evelyn Regar
Download or read book Optical Coherence Tomography in Cardiovascular Research written by Evelyn Regar and published by CRC Press. This book was released on 2007-03-06 with total page 384 pages. Available in PDF, EPUB and Kindle. Book excerpt: Given that for centuries, the standard tool to understand diseases in tissues was the microscope and that its major limitation was that only excised tissue could be used, recent technology now permits the examination of diseased tissue in vivo. Optical coherence tomography (OCT) has promising potential when applied to coronary artery disease. OCT h
Book Synopsis Handbook of Optical Coherence Tomography by : Brett Bouma
Download or read book Handbook of Optical Coherence Tomography written by Brett Bouma and published by CRC Press. This book was released on 2019-10-07 with total page 756 pages. Available in PDF, EPUB and Kindle. Book excerpt: This contemporary reference presents a comprehensive review of the most recent applications of optical coherence tomography (OCT) in biology, medicine, engineering, and applied physics-summarizing technological advances that led to the availability of viable imaging tools and modern methods of OCT for optical biopsy, surgical guidance, and quality control of advanced composites in situ.
Book Synopsis Enabling Technologies for Functional Optical Coherence Tomography in Retinal Disease by : ByungKun Lee
Download or read book Enabling Technologies for Functional Optical Coherence Tomography in Retinal Disease written by ByungKun Lee and published by . This book was released on 2018 with total page 150 pages. Available in PDF, EPUB and Kindle. Book excerpt: Optical coherence tomography (OCT) imaging of retinal function has become increasingly important because alterations in the function may reflect earlier changes in ocular diseases than the alterations in the structure. Since diagnostic markers in structural OCT using commercial instruments already underwent extensive investigations, novel markers in retinal function implying disease onset or progression are important for further development of novel markers in OCT diagnostics of ocular disease. Retinal OCT applications such as blood flow imaging and stimulus-response imaging often requires high imaging speed since repeated scans of the same position or densely sampled scans are used. Our group developed a high-speed swept-source/Fourier-domain OCT (SS-OCT) prototype to investigate retinal hemodynamics and vascular structures in major ocular diseases such as age-related macular degeneration (AMD), glaucoma, and diabetic retinopathy with OCT angiography or Doppler OCT. Our group also used an ultrahigh-resolution (UHR) spectral/Fourier-domain OCT (SD-OCT) instrument to investigate dark adaptation of the photoreceptors after a photobleach by measuring the changes in the distances between densely packed, bright bands in the outer retina. Dark adaptation can be an indicator of photoreceptor health and it is postulated that compromised dark adaptation is a manifestation of early AMD. The current thesis reports two technical advancements in OCT imaging of retinal function: image processing algorithm for total retinal blood flow (TRBF) calculation with en face Doppler OCT using the high-speed SS-OCT prototype and the instrumentation of the newly deployed UHR SD-OCT prototype with effective depth range extension using reference arm length modulation (ReALM). These techniques aim for operator-friendly, robust, and repeatable assessment of retinal blood flow or the photoreceptor layer to provide powerful tools for future investigations of retinal function. The contents of the current thesis includes hardware and software approaches that overcomes inherent limitations of OCT such as signal penetration and depth range as well as preliminary imaging results and pilot study findings.
Book Synopsis A Comprehensive Guide to Toxicology in Preclinical Drug Development by : Ali S. Faqi
Download or read book A Comprehensive Guide to Toxicology in Preclinical Drug Development written by Ali S. Faqi and published by Academic Press. This book was released on 2012-10-18 with total page 903 pages. Available in PDF, EPUB and Kindle. Book excerpt: A Comprehensive Guide to Toxicology in Preclinical Drug Development is a resource for toxicologists in industry and regulatory settings, as well as directors working in contract resource organizations, who need a thorough understanding of the drug development process. Incorporating real-life case studies and examples, the book is a practical guide that outlines day-to-day activities and experiences in preclinical toxicology. This multi-contributed reference provides a detailed picture of the complex and highly interrelated activities of preclinical toxicology in both small molecules and biologics. The book discusses discovery toxicology and the international guidelines for safety evaluation, and presents traditional and nontraditional toxicology models. Chapters cover development of vaccines, oncology drugs, botanic drugs, monoclonal antibodies, and more, as well as study development and personnel, the role of imaging in preclinical evaluation, and supporting materials for IND applications. By incorporating the latest research in this area and featuring practical scenarios, this reference is a complete and actionable guide to all aspects of preclinical drug testing. - Chapters written by world-renowned contributors who are experts in their fields - Includes the latest research in preclinical drug testing and international guidelines - Covers preclinical toxicology in small molecules and biologics in one single source
Book Synopsis Structural and Functional Imaging of the Human and Small Animal Eyes Using Ultrahigh Speed Fourier Domain Optical Coherence Tomography by : Woo Jhon Choi
Download or read book Structural and Functional Imaging of the Human and Small Animal Eyes Using Ultrahigh Speed Fourier Domain Optical Coherence Tomography written by Woo Jhon Choi and published by . This book was released on 2014 with total page 225 pages. Available in PDF, EPUB and Kindle. Book excerpt: Optical coherence tomography (OCT) is a non-invasive optical imaging technique that allows the three-dimensional structure of biological tissue to be visualized with micrometer resolution. In ophthalmology OCT has the unique advantage that it provides cross-sectional images of the retina and choroid noninvasively and in vivo, which have led OCT to be a clinical standard for the diagnosis of a variety of retinal diseases. Although current commercial Fourier domain OCT systems have high imaging speeds of 20-100kHz A-scan rates, these imaging speeds are not sufficient for more advanced structural and functional imaging techniques. Current state-of-the-art spectral domain and swept source OCT provide ultrahigh imaging speeds of >200kHz A-scan rates. These speeds enable functional imaging of retinal blood flow, OCT angiography of the retinal and choroidal microvasculature, and wide field volumetric structural imaging of the retina and choroid. In this thesis, advances in structural and functional ophthalmic imaging techniques for the human and small animal eyes are investigated using ultrahigh speed Fourier domain OCT. The following topics are discussed: (1) a method for numerically extracting and compensating dispersion mismatch in ultrahigh resolution spectral domain OCT, (2) ultrahigh speed spectral domain imaging in the small animal eye for measuring total retinal blood flow, (3) development of ultrahigh speed phase stable swept source OCT system for human retinal imaging, (4) OCT angiography of the choriocapillaris in the human eye, (5) clinical applications of OCT angiography in retinal diseases, including diabetic retinopathy and age-related macular degeneration, (6) small animal anesthesia protocol for functional hemodynamic imaging, and (7) imaging of neurovascular coupling in small animals using ultrahigh speed OCT.
Book Synopsis Neurophotonics and Brain Mapping by : Yu Chen
Download or read book Neurophotonics and Brain Mapping written by Yu Chen and published by CRC Press. This book was released on 2017-06-14 with total page 669 pages. Available in PDF, EPUB and Kindle. Book excerpt: Understanding how the brain works and developing effective therapeutics are important in advancing neuroscience and improving clinical patient care. Neurophotonics and Brain Mapping covers state-of-the-art research and development in optical technologies and applications for brain mapping and therapeutics. It provides a comprehensive overview of various methods developed using light, both microscopic and macroscopic techniques. Recent developments in minimally-invasive endoscopic imaging of deep brain structure and function, as well as light-based therapy are also reviewed.
Book Synopsis Selected Topics in Optical Coherence Tomography by : Gangjun Liu
Download or read book Selected Topics in Optical Coherence Tomography written by Gangjun Liu and published by BoD – Books on Demand. This book was released on 2012-02-08 with total page 296 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book includes different exciting topics in the OCT fields, written by experts from all over the world. Technological developments, as well as clinical and industrial applications are covered. Some interesting topics like the ultrahigh resolution OCT, the functional extension of OCT and the full field OCT are reviewed, and the applications of OCT in ophthalmology, cardiology and dentistry are also addressed. I believe that a broad range of readers, such as students, researchers and physicians will benefit from this book.
Book Synopsis Handbook of Pediatric Retinal OCT and the Eye-Brain Connection E-Book by : Cynthia A. Toth
Download or read book Handbook of Pediatric Retinal OCT and the Eye-Brain Connection E-Book written by Cynthia A. Toth and published by Elsevier Health Sciences. This book was released on 2019-05-04 with total page 371 pages. Available in PDF, EPUB and Kindle. Book excerpt: Optical Coherence Tomography (OCT) plays a vital role in pediatric retina diagnosis, often revealing unrecognized retinal disorders and connections to brain injury, disease, and delayed neurodevelopment. Handbook of Pediatric Retinal OCT and the Eye-Brain Connection provides authoritative, up-to-date guidance in this promising area, showing how to optimize imaging in young children and infants, how to accurately interpret these images, and how to identify links between these images and brain and developmental disorders. - Illustrates optimal methods of OCT imaging of children and infants, how to avoid pitfalls, and how to recognize and avoid artifacts - Explains how the OCT image may relate to brain disease and delayed neurodevelopment - Features more than 200 high-quality images and scans that depict the full range of disease in infants and young children - Provides guidance in identifying retinal layers and important abnormalities. - Covers the structural features of the retina and optic nerve head in developmental, acquired, or inherited conditions that affect the eye and visual pathways - Offers practical ways to set up imaging programs in the clinic, operating room, or neonatal nursery
