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Author : Ho Yiu Cheng
Publisher :
ISBN 13 :
Total Pages : pages
Book Rating : 4.:/5 (13 download)
Download or read book Speckle And Motion Based Vascular Image Analysis for Optical Coherence Tomography written by Ho Yiu Cheng and published by . This book was released on 2015 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Josef F. Bille
Publisher : Springer
ISBN 13 : 3030166384
Total Pages : 407 pages
Book Rating : 4.0/5 (31 download)
Download or read book High Resolution Imaging in Microscopy and Ophthalmology written by Josef F. Bille and published by Springer. This book was released on 2019-08-13 with total page 407 pages. Available in PDF, EPUB and Kindle. Book excerpt: This open access book provides a comprehensive overview of the application of the newest laser and microscope/ophthalmoscope technology in the field of high resolution imaging in microscopy and ophthalmology. Starting by describing High-Resolution 3D Light Microscopy with STED and RESOLFT, the book goes on to cover retinal and anterior segment imaging and image-guided treatment and also discusses the development of adaptive optics in vision science and ophthalmology. Using an interdisciplinary approach, the reader will learn about the latest developments and most up to date technology in the field and how these translate to a medical setting. High Resolution Imaging in Microscopy and Ophthalmology – New Frontiers in Biomedical Optics has been written by leading experts in the field and offers insights on engineering, biology, and medicine, thus being a valuable addition for scientists, engineers, and clinicians with technical and medical interest who would like to understand the equipment, the applications and the medical/biological background. Lastly, this book is dedicated to the memory of Dr. Gerhard Zinser, co-founder of Heidelberg Engineering GmbH, a scientist, a husband, a brother, a colleague, and a friend.
Author : Wolfgang Drexler
Publisher : Springer Science & Business Media
ISBN 13 : 3540775501
Total Pages : 1346 pages
Book Rating : 4.5/5 (47 download)
Download or read book Optical Coherence Tomography written by Wolfgang Drexler and published by Springer Science & Business Media. This book was released on 2008-12-10 with total page 1346 pages. Available in PDF, EPUB and Kindle. Book excerpt: Optical coherence tomography (OCT) is the optical analog of ultrasound imaging and is emerging as a powerful imaging technique that enables non-invasive, in vivo, high resolution, cross-sectional imaging in biological tissue. This book introduces OCT technology and applications not only from an optical and technological viewpoint, but also from biomedical and clinical perspectives. The chapters are written by leading research groups, in a style comprehensible to a broad audience.
Author : Anton Sdobnov
Publisher : CRC Press
ISBN 13 : 1040144403
Total Pages : 123 pages
Book Rating : 4.0/5 (41 download)
Download or read book Dynamic Light Scattering Imaging written by Anton Sdobnov and published by CRC Press. This book was released on 2024-10-18 with total page 123 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book examines Dynamic Light Scattering (DLS) and its derivatives Laser Doppler Flowmetry (LDF), Diffusing Wave Spectroscopy (DWS), Laser Speckle Contrast Imaging (LSCI), and Doppler Optical Coherence Tomography (OCT) for characterizing particle motion in turbid mediums like suspensions and solutions. It focuses on non-invasive blood flow imaging in biological tissues, detailing technological advancements, practical applications, and inherent challenges. Essential for professionals in biomedical optics and medical fields, as well as physics and engineering students, the book highlights its use in brain, skin, and micro-circulation studies, providing key insights and practical guidance. Key Features: • Presents a deep dive into DLS and its derivative techniques. • Emphasizes practical applications, including brain blood flow monitoring, skin perfusion measurements, and micro-circulation characterization. • Delivers insights into the challenges and limitations associated with DLS-based blood flow imaging.
Author : Adrian Mariampillai
Publisher :
ISBN 13 : 9780494722183
Total Pages : 278 pages
Book Rating : 4.7/5 (221 download)
Download or read book Development of a High Resolution Microvascular Imaging Toolkit for Optical Coherence Tomography written by Adrian Mariampillai and published by . This book was released on 2010 with total page 278 pages. Available in PDF, EPUB and Kindle. Book excerpt: This thesis presents the development of new optical coherence tomography imaging systems and techniques to improve in vivo 3D microvascular imaging. Specifically these systems and techniques were proposed to address three main problems with 3D Doppler optical coherence tomography imaging: (a) Motion artefacts, (b) angle dependence of the signal, and (c) relatively high minimum detectable velocity of conventional color Doppler algorithms (∼500 mum/s). In order to overcome these limitations a multi-pronged strategy was employed: (1) Construction of a retrospectively gated OCT system for the mitigation of periodic motion artefacts. Proof of principle in vivo B-mode imaging of Xenopus Laevis (embryo of African clawed frog) cardiovascular function up to 1000 frames per second (fps) from data acquired at 12 fps. Additionally, 4D imaging of the Xenopus Laevis heart at 45 volumes per second was demonstrated. (2) Construction of a Fourier domain mode locked laser for high speed swept source optical coherence tomography imaging. This laser was capable of reaching sweep rates of 67 kHz and was optimized to function in the SNR limited phase noise regimes upto approximately 55 dB structural SNR. (3) Development of a novel speckle variance image processing algorithm for velocity and angle independent 3D microvascular imaging. The velocity and angle independence of the technique was validated through phantom studies.In vivo demonstration of the speckle variance algorithm was performed by imaging the capillary network in the dorsal skin-fold window chamber model, with the results being validated using fluorescence confocal microscopy.In the final part of this thesis, these newly developed technologies were applied to the assessment of anti-vascular and anti-angiogenic therapies in preclinical models, specifically, photodynamic therapy and targeted degradation of HIF-alpha.
Author : Andreas Maier
Publisher : Springer
ISBN 13 : 3319965204
Total Pages : 263 pages
Book Rating : 4.3/5 (199 download)
Download or read book Medical Imaging Systems written by Andreas Maier and published by Springer. This book was released on 2018-08-02 with total page 263 pages. Available in PDF, EPUB and Kindle. Book excerpt: This open access book gives a complete and comprehensive introduction to the fields of medical imaging systems, as designed for a broad range of applications. The authors of the book first explain the foundations of system theory and image processing, before highlighting several modalities in a dedicated chapter. The initial focus is on modalities that are closely related to traditional camera systems such as endoscopy and microscopy. This is followed by more complex image formation processes: magnetic resonance imaging, X-ray projection imaging, computed tomography, X-ray phase-contrast imaging, nuclear imaging, ultrasound, and optical coherence tomography.
Author : Simone Balocco
Publisher : Academic Press
ISBN 13 : 0128110198
Total Pages : 480 pages
Book Rating : 4.1/5 (281 download)
Download or read book Computing and Visualization for Intravascular Imaging and Computer-Assisted Stenting written by Simone Balocco and published by Academic Press. This book was released on 2016-12-12 with total page 480 pages. Available in PDF, EPUB and Kindle. Book excerpt: Computing and Visualization for Intravascular Imaging and Computer-Assisted Stenting presents imaging, treatment, and computed assisted technological techniques for diagnostic and intraoperative vascular imaging and stenting. These techniques offer increasingly useful information on vascular anatomy and function, and are poised to have a dramatic impact on the diagnosis, analysis, modeling, and treatment of vascular diseases. After setting out the technical and clinical challenges of vascular imaging and stenting, the book gives a concise overview of the basics before presenting state-of-the-art methods for solving these challenges. Readers will learn about the main challenges in endovascular procedures, along with new applications of intravascular imaging and the latest advances in computer assisted stenting. - Brings together scientific researchers, medical experts, and industry partners working in different anatomical regions - Presents an introduction to the clinical workflow and current challenges in endovascular Interventions - Provides a review of the state-of-the-art methodologies in endovascular imaging and their applications - Poses outstanding questions and discusses future research
Author : Zhongwei Zhi
Publisher :
ISBN 13 :
Total Pages : 135 pages
Book Rating : 4.:/5 (898 download)
Download or read book Development and Application of Multifunctional Optical Coherence Tomography written by Zhongwei Zhi and published by . This book was released on 2014 with total page 135 pages. Available in PDF, EPUB and Kindle. Book excerpt: Microcirculation refers to the functions of capillaries and the neighboring lymphatic vessels. It plays a vital role in the pathophysiology of disorders in many clinical areas including cardiology, dermatology, neurology and ophthalmology, and so forth. It is crucial to develop imaging technologies that can provide both qualitative and quantitative information as to how microcirculation responds to certain injury and/or disease, and its treatment. Optical coherence tomography (OCT) is a non-invasive optical imaging technique for high-resolution cross-sectional imaging of specimens, with many applications in clinical medicine. Current state-of-the-art OCT systems operate in the Fourier domain, using either a broadband light source with a spectrometer, known as spectral domain OCT (SDOCT), or a rapidly tunable laser, known as swept source OCT (SSOCT). The current Fourier domain OCT systems have dramatically improvement in sensitivity, resolution and speed compared to time domain OCT. In addition to the improvement in the OCT system hardware, different methods for functional measurements of tissue beds have been developed and demonstrated. This includes but not limited to, i) Phase-resolved Doppler OCT for quantifying the blood flow, ii) OCT angiography for visualization of microvasculature, iii) Polarization sensitive OCT for measuring the intrinsic optical property/ birefringence of tissue, iv) spectroscopic OCT for measuring blood oxygenation, etc. Functional OCT can provide important clinical information that is not available in the typical intensity based structural OCT images. Among these functional OCT modalities, Doppler OCT and OCT angiography attract great interests as they show high capability for in vivo study of microvascular pathology. By analyzing the Doppler effect of a flowing particle on light frequency, Doppler OCT allows the quantification of the blood flow speed and blood flow rate. The most popular approach for Doppler OCT is achieved through analysis of the phase term in complex OCT signal which termed as Phase-resolved Doppler OCT. However, as limited by the phase noise and motion, Phase-resolved Doppler OCT can only be applied for relative large blood vessels, such as arterioles and venules. On the other hand, in order to visualize the microcirculation network, a number of strategies to enable better contrast of microvasculature components, which we termed OCT angiography, have been introduced during recent years. As a variation of Fourier domain OCT, optical microangiography (OMAG) is one of earliest proposed OCT angiography technique which is capable of generating 3D images of dynamic blood perfusion distribution within microcirculatory tissue beds. The OMAG algorithm works by separating the static and moving elements by high pass filtering on complex valued interferometric data after Fourier transform. Based on the conventional OMAG algorithm, we further developed ultra-high sensitive OMAG (UHS-OMAG) by switching the high-pass filtering from fast scan direction (adjacent A-lines within one B-frame) to slow scan direction (adjacent B-frames), which has a dramatically improved performance for capillary network imaging and analysis. Apart from the microvascular study with current available functional OCT for, visualization of the lymphatic system (lymph nodes and lymphatic vessels) plays a significant role in assessing patients with various malignancies and lymphedema. However, there is a lack of label-free and noninvasive method for lymphangiography. Hence, a cutting edge research to investigate the capability of OCT as a tool for non-invasive and label-free lymphangiography would be highly desired. The objective of my thesis is to develop a multiple-functional SDOCT system to image the microcirculation and quantify the several important parameters of microcirculation within microcirculatory tissue beds, and further apply it for pre-clinical research applications. The multifunctional OCT system provides modalities including structural OCT, OCT angiography, Doppler OCT and Optical lymphangiography, for multi-parametric study of tissue microstructure, blood vessel morphology, blood flow and lymphatic vessel all together. The thesis mainly focus on two parts: first, development of multi-functional OCT/optical microangiography (OMAG) system and methods for volumetric imaging of microvasculature and quantitative measurement of blood flow, and its application for pathological research in ophthalmology on rodent eye models; second, development of ultra-high resolution OCT system and algorithm for simultaneous label free imaging of blood and lymphatic vessel, and its application in wound healing study on mouse ear flap model. Objectives of my research are achieved through the following specific aims: Aim 1: Improve the sensitivity of OMAG for microvasculature imaging; perform volumetric and quantitative imaging of vasculature with combined OMAG and Phase-resolved Doppler OCT for in vivo study of vascular physiology. Aim 2: Develop high speed high resolution OCT system and method for rodent eye imaging. Apply the combined OMAG and Phase-resolved Doppler OCT approach to investigate the impact of elevated intraocular pressure on retinal, choroidal and optic nerve head blood flow in rat eye model, which aids to the better understanding of the mechanism and development of glaucoma. Aim 3: Apply the developed OCT system and ultra-high sensitive OMAG algorithm for noninvasive imaging of retinal morphology and microvasculature in obese mice, which may play an important role in early diagnosis of Diabetic retinopathy. Aim 4: Developing an ultra-high resolution SDOCT system using broadband Supercontinuum light source to achieve ultra-high resolution microvasculature imaging of biological tissue. Aim 5: Develop methods for simultaneous label free optical imaging of blood and lymphatic vessel and demonstrate its capability by monitoring the blood and lymph response to wound healing on mouse ear pinna model.
Author : David Huang
Publisher : CRC Press
ISBN 13 : 1040141129
Total Pages : 322 pages
Book Rating : 4.0/5 (41 download)
Download or read book Optical Coherence Tomography Angiography of the Eye written by David Huang and published by CRC Press. This book was released on 2024-06-01 with total page 322 pages. Available in PDF, EPUB and Kindle. Book excerpt: Optical coherence tomography (OCT) angiography is an important new imaging modality that is already being used by ophthalmologists in retina centers worldwide. It uses motion as intrinsic contrast, thus obviating the need to inject any intravenous dye. It uses infrared light that is invisible to the patient, and only requires few seconds per scan. This makes it both easier to use and much better tolerated by patients than traditional dye-based fluorescein angiography (FA) and indocyanine green (ICG) angiography. Inside Optical Coherence Tomography Angiography of the Eye Drs. David Huang, Bruno Lumbroso, Yali Jia, and Nadia Waheed include detailed information on clinical applications and fundamental principles needed to understand and use this new technology. This includes information on high-speed OCT systems, algorithms to extract flow contrast, the appearance of the normal eye, the findings in myriad diseases, and tips on how to deal with artifact and pitfalls. The 3-dimensional nature of OCT angiography provides visualization that was not possible before with either FA or ICG and readers will come to appreciate how this enables the visualization of previously difficult to image vascular beds such as the 4 retinal vascular plexuses (radial peripapillary, superficial, intermediate, and deep), the choriocapillaris, and the deeper choroidal vessels. Given its noninvasive nature and ease of use, OCT angiography imaging is rapidly taking an important place in everyday ophthalmology and may soon replace fluorescein angiography in everyday practice. Optical Coherence Tomography Angiography of the Eye is designed to be the definitive text on this cutting-edge technology for the retina specialist and comprehensive ophthalmologist.
Author : F. Bandello
Publisher : Karger Medical and Scientific Publishers
ISBN 13 : 3318058300
Total Pages : 198 pages
Book Rating : 4.3/5 (18 download)
Download or read book OCT Angiography in Retinal and Macular Diseases written by F. Bandello and published by Karger Medical and Scientific Publishers. This book was released on 2016-03-21 with total page 198 pages. Available in PDF, EPUB and Kindle. Book excerpt: In only a short period of time, the innovative procedure of OCT angiography has become an essential macula imaging technique. Now that it is routinely used in clinical practice, the investigation of retinal and choroidal circulation is non-invasive, which significantly changes the professional’s approach to patients. In this volume, retina specialists and renowned experts share their experience with OCT angiography. They have included numerous color images and presented current ideas to form a base for further research and discussion. This book provides retina specialists, ophthalmologists, and researchers with a first glance at original research and clinical reports on this new methodology.
Author : Joel S. Schuman
Publisher : CRC Press
ISBN 13 : 1040138330
Total Pages : 1093 pages
Book Rating : 4.0/5 (41 download)
Download or read book Optical Coherence Tomography of Ocular Diseases written by Joel S. Schuman and published by CRC Press. This book was released on 2024-06-01 with total page 1093 pages. Available in PDF, EPUB and Kindle. Book excerpt: The most comprehensive text and definitive guide for nearly 30 years about optical coherence tomography (OCT) imaging in ophthalmology, Optical Coherence Tomography of Ocular Diseases, Fourth Edition covers a range of subjects, from principles and operation techniques to clinical interpretation and the latest innovations in OCT. Written by the pioneers of OCT technologies and the world-renowned OCT researchers Drs. Joel S. Schuman, James G. Fujimoto, Jay S. Duker, Hiroshi Ishikawa, and Gadi Wollstein, Optical Coherence Tomography of Ocular Diseases, Fourth Edition is an essential text for imaging technology. OCT now occupies a dominant role as a diagnostic tool for retinal conditions and glaucoma. At the same time, the technology continues to show potential for emerging clinical and research applications across all the ophthalmological subspecialties. To reflect these rapid advances, this new edition of Optical Coherence Tomography of Ocular Diseases features a complete and thorough revision of the existing text as well as the addition of cutting-edge content to bring this classic resource completely up to date. New content in the Fourth Edition includes: • OCT angiography • Swept-source OCT • OCT in multimodal imaging • Clinical utility of OCT in glaucoma prediction and progression detection • OCT for neuro-ophthalmology Optical Coherence Tomography of Ocular Diseases, Fourth Edition is the one and only book needed by practitioners who use OCT for clinical eye care.
Author : Mark Nixon
Publisher : Springer
ISBN 13 : 3319959212
Total Pages : 383 pages
Book Rating : 4.3/5 (199 download)
Download or read book Medical Image Understanding and Analysis written by Mark Nixon and published by Springer. This book was released on 2018-08-20 with total page 383 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book constitutes the refereed proceedings of the 22st Annual Conference on Medical Image Understanding and Analysis, MIUA 2018, held in Southampton, UK, in July 2018.The 34 revised full papers presented were carefully reviewed and selected from 49 submissions. The papers are organized in topical sections on liver analysis, medical image analysis, texture and image analysis, MRI: applications and techniques, segmentation in medical images, CT: learning and planning, ocular imaging analysis, applications of medical image analysis.
Author : Julie Rodman
Publisher : CRC Press
ISBN 13 : 1040135943
Total Pages : 281 pages
Book Rating : 4.0/5 (41 download)
Download or read book Optical Coherence Tomography Angiography Atlas written by Julie Rodman and published by CRC Press. This book was released on 2024-06-01 with total page 281 pages. Available in PDF, EPUB and Kindle. Book excerpt: Optical Coherence Tomography Angiography (OCTA) is a novel, non-invasive, dyeless imaging modality that has emerged as an indispensable tool in the fields of optometry and ophthalmology. OCTA provides three-dimensional volumetric images of the retinal and choroidal vasculature by using a motion-contrast decorrelation algorithm. This cutting-edge imaging technology has widespread clinical utility as a non-invasive alternative for visualizing microvasculature in detail, but there are no textbooks dedicated to its use and the interpretation of scans. To fill this need, Optical Coherence Tomography Angiography Atlas: A Case Study Approach, by Dr. Julie A. Rodman, is a richly illustrated, practical guide to OCTA. It provides detailed information on the fundamental principles behind the technology, as well as clinical applications critical for accurate interpretation. The first section of the book discusses the principles behind OCTA and provides an introduction into the interpretation of OCTA images, including a chapter devoted to terminology. The remainder of the book provides detailed analysis of a myriad of inner and outer retinal disorders, including diseases of the optic nerve head. Most importantly for the clinical setting, the cases are presented with numerous images and a multitude of arrows and callouts to assist in the recognition of various clinical findings. Case examples include: Vascular Occlusive Disease Pigment Epithelial Detachment Choroidal Neovascular Membrane Diabetic Retinopathy Optic Disc Edema Dr. Rodman’s emphasis on the clinical use of OCTA technology and step-by-step interpretation of images makes Optical Coherence Tomography Angiography Atlas: A Case Study Approach a must-have resource for physicians, residents, students, and ophthalmic technicians looking for a simple, comprehensive guide to OCTA.
Author : Miguel A. Quiroz-Reyes, Virgilio Lima-Gomez
Publisher : Bentham Science Publishers
ISBN 13 : 9815124102
Total Pages : 276 pages
Book Rating : 4.8/5 (151 download)
Download or read book Optical Coherence Tomography Angiography for Choroidal and Vitreoretinal Disorders - Part 1 written by Miguel A. Quiroz-Reyes, Virgilio Lima-Gomez and published by Bentham Science Publishers. This book was released on 2023-12-21 with total page 276 pages. Available in PDF, EPUB and Kindle. Book excerpt: This handbook covers Optical Coherence Tomography Angiography (OCT-A) with a specific focus on choroidal and vitreoretinal disorders. It serves as an invaluable resource for teaching and aiding daily clinical decision-making in the field. Book chapters dissect the fundamentals of angiography through OCT, offering guidance on OCT-A and insights into macular perfusional findings across various vitreoretinal and choroidal pathologies. From diabetic retinopathy to autoimmune diseases and neovascularization, the book addresses prevalent vascular entities encountered in routine practice. Furthermore, it explores innovative approaches, including antivascular endothelial growth factor molecules and extended-release delivery devices, contributing significantly to the diagnostic and decision-making processes in clinical and surgical retina care. Each chapter is contributed by experts in the relevant subspecialty. Key Features: Practical, patient-centered guide emphasizing a clinical approach. Demonstrative clinical cases for enhanced understanding. Evaluation of perfusional indices using noninvasive and noncontact imaging techniques. High histopathological correlation of structural tissue characterization with microvascular evaluation. Exploration of new perfusion concepts and their role in disease pathogenesis. Part 1 of the book focuses on OCT-A principles and applications in ophthalmology. It covers the basics of OCT-A, its contributions to eye disease study and treatment, and a comparative analysis with OCT for choroidal and vitreoretinal diseases. Additional information on nomenclature, normative datasets, and data analysis, presenting indices in different eye conditions is also presented. The emphasis is on macular perfusion in surgically resolved myopic foveoretinal detachment, postoperative evaluation in retinal detachment, and long-term analysis in diabetic retinopathy
Author : Robert Koprowski
Publisher : Robert Koprowski
ISBN 13 : 8362462027
Total Pages : 176 pages
Book Rating : 4.3/5 (624 download)
Download or read book Image Processing in Optical Coherence Tomography Using Matlab written by Robert Koprowski and published by Robert Koprowski. This book was released on 2011 with total page 176 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book covers the results of the creation of methods for ophthalmologists support in OCT images automated analysis. These methods, like the application developed on their basis, are used during routine examinations carried out in hospital. The monograph comprises proposals of new and also of known algorithms, modified by authors, for image analysis and processing, presented on the basis of example of Matlab environment with Image Processing tools. The results are not only obtained fully automatically, but also repeatable, providing doctors with quantitative information on the degree of pathology occurring in the patient. In this case the anterior and posterior eye segment is analysed, e.g. the measurement of the filtration angle or individual layers thickness. To introduce the Readers to subtleties related to the implementation of selected fragments of algorithms, the notation of some of them in the Matlab environment has been given. The presented source code is shown only in the form of example of implementable selected algorithm. In no way we impose here the method of resolution on the Reader and we only provide the confirmation of a possibility of its practical implementation.
Author : F. Bandello
Publisher : Karger Medical and Scientific Publishers
ISBN 13 : 3318066435
Total Pages : 146 pages
Book Rating : 4.3/5 (18 download)
Download or read book Clinical Applications of Optical Coherence Tomography Angiography written by F. Bandello and published by Karger Medical and Scientific Publishers. This book was released on 2020-12-07 with total page 146 pages. Available in PDF, EPUB and Kindle. Book excerpt: The recent introduction of optical coherence tomography angiography (OCTA) has remarkably expanded the knowledge of different retinal, chorioretinal, and optic disc disorders. OCTA is nowadays often used as a routine exam in clinical practice, which has significantly modified the approach to patients, granting the opportunity to easily and noninvasively investigate the retinal and choroidal circulation. Major experts in posterior eye imaging share in this publication their experiences, images and ideas using OCTA in various contexts including age-related macular degeneration, diabetic retinopathy and retinal dystrophies, thus providing an in-depth overview of the latest knowledge in this field.
Author : Arlie Glenn Capps
Publisher :
ISBN 13 : 9781369201628
Total Pages : pages
Book Rating : 4.2/5 (16 download)
Download or read book Visualization and Analysis of Microstructure in Images of the Living Human Retina written by Arlie Glenn Capps and published by . This book was released on 2016 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: This dissertation addresses challenges inherent in volume imaging of the human retina using optical coherence tomography (OCT). OCT is a standard imaging modality in eye clinics, yielding invaluable information about the structure of the retina, yet its images are limited in spatial extent and affected by fixational gaze movements that distort features present in the images. As OCT volumes increase in spatial resolution they usually decrease in size, and the disruption caused by fixational eye motion becomes more and more significant. This research presents four techniques designed to fulfill the promise of OCT, to allow the capture of an accurate, wide-field, high-resolution volume image with extracted vessel geometry. First, a method is developed for correcting the effects of eye motion based on simultaneous imaging with a different modality, scanning laser ophthalmoscopy. Building on the promise of volume images that accurately reflect the structures of the eye, a method of stitching and visualizing overlapping OCT images is presented. Blood vessels are among the most prominent features visible in images of the retina, and a method for extracting blood vessel geometry tailored to the specific requirements of OCT angiography images is presented next. Finally, the problem of OCT motion correction is revisited with a method to correct the effect of saccades using extracted vessel geometry and basic assumptions of vessel morphology.
